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Drug Design, Development and Therapy Volume 12, 2018 - Issue
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Original Research

Antioxidative stress effects of vitamins C, E, and B12, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Farah M Abdulkhaleq1 Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan, [email protected]
,
Tawfiq M Alhussainy1 Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan, [email protected]
,
Mujtaba M Badr2 University of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan, [email protected]
,
Asad A Abu Khalil2 University of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan, [email protected]
,
Omar Gammoh3 Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, Madaba, Jordan
,
Bayan Y Ghanim2 University of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan, [email protected]
&
Nidal A Qinna1 Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan, [email protected];2 University of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan, [email protected]Correspondence[email protected]
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Pages 3525-3533 | Published online: 18 Oct 2018

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Selçuk Kaplan & Ahmet Türk. (2022) Effects of vitamin B12 on rat ovary with ischemia-reperfusion injury. Biotechnic & Histochemistry 97:4, pages 284-289.
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Articles from other publishers (25)

Yujin Fu, Xianfa Du, Yingchun Cui, Ke Xiong & Jinyu Wang. (2023) Nutritional intervention is promising in alleviating liver injury during tuberculosis treatment: a review. Frontiers in Nutrition 10.
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Mylanayakanahosahalli Chandrashekar Indumathi, Kamatam Swetha, Kandahalli Venkataranganayaka Abhilasha, Shiva Siddappa, Shivamadhaiah Manjula Kumar, Govinda Keerthi Prasad, Chu-Huang Chen & Gopal Kedihithlu Marathe. (2023) Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice. Biological Trace Element Research.
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Azza A. Attia, Huda A. Hamad, M. Adel Fawzy & Samar R. Saleh. (2023) The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats. Molecules 28:11, pages 4302.
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Zhenqi Chang, Jiangwei Qiu, Kai Wang, Xiaowei Liu, Ling Fan, Xiuying Liu, Yi Zhao & Yuhong Zhang. (2023) The relationship between co-exposure to multiple heavy metals and liver damage. Journal of Trace Elements in Medicine and Biology 77, pages 127128.
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Arinze Linus Ezugwu, Emeka Godwin Anaduaka, Christian Chiazor Chibuogwu & Timothy Prince Chidike Ezeorba. (2023) Meat tenderization using acetaminophen (paracetamol/APAP): A review on deductive biochemical mechanisms, toxicological implications and strategies for mitigation. Heliyon 9:5, pages e15628.
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Wanting XuYan LiuQun LiuHuan Chen, Langhuan Lei, Xiaojia ShenLi Liu. (2023) Procyanidins Ameliorate Acetaminophen-induced Acute Liver Injury via Activating the Nrf-2/SOD-1 Signal Pathway. Pharmacognosy Magazine 19:1, pages 176-185.
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Xubiao Nie, Jianwei Ding, Yiyang He, Chunmei Ren, Hui Lin, Chaoqiang Fan, Liang Wang, Dingrong Chen, Airui Jiang, Xue Peng, Jing Yu, Xin Yang, Xi Liu, Haiyan Zhao, Jianjun Li, Yong Gao, Yuanyuan Zhou, Qiujian Qiao, Ying Zuo, Zhen Yang, Lu Liu, Zhongrong Wang, En Liu, Shiming Yang, Liangbi Xu, Liming Wen & Jianying Bai. (2022) Effectiveness of Vitamin C Solution in Reducing Adverse Reactions Caused by Painless Lugol Chromoendoscopy. Journal of Clinical Gastroenterology 56:8, pages 688-696.
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Hamid Reza Talari, Mohamad Reza Molaqanbari, Milad Mokfi, Mohsen Taghizadeh, Fereshteh Bahmani, Seyed Mohammad Hossein Tabatabaei & Nasrin Sharifi. (2022) The effects of vitamin B12 supplementation on metabolic profile of patients with non-alcoholic fatty liver disease: a randomized controlled trial. Scientific Reports 12:1.
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Gamze TAŞKIN ŞENOL, Halil Mahir KAPLAN, Neslihan BOYAN, Özkan OĞUZ & Ergin ŞİNGİRİK. (2022) Effect of geraniol and vitamin C on diethylnitrosamine induced experimental hepatocellular carcinogenesisGeraniol ve vitamin C’nin dietilnitrozamin kaynaklı deneysel hepatoselüler karsinogenez üzerindeki etkisi. Cukurova Medical Journal 47:2, pages 738-746.
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Bayan Y. Ghanim & Nidal A. Qinna. (2022) Nrf2/ARE axis signalling in hepatocyte cellular death. Molecular Biology Reports 49:5, pages 4039-4053.
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Asma Saidi, Leila Hambaba, Burak Kucuk, Ercan Cacan & Ramazan Erenler. (2022) Phenolic Profile, Acute Toxicity, and Hepatoprotective and Antiproliferative Activities of Algerian Ruta tuberculata Forssk. Current Bioactive Compounds 18:3.
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Muhammad Yusuf, Muhammad Ikrar Hermanadi, Muhammad Faris Rizqhilmi, Rani Wardani Hakim, Siti Farida & Erni Hernawati Purwaningsih. The effect of Centella asiatica ethanolic extract on liver superoxide dismutase and glutathione levels of aged Sprague-Dawley rats. The effect of Centella asiatica ethanolic extract on liver superoxide dismutase and glutathione levels of aged Sprague-Dawley rats.
Filomena Mottola, Renata Finelli, Concetta Iovine, Maria Carannante, Marianna Santonastaso & Lucia Rocco. (2021) Anti-Genotoxicity Evaluation of Ellagic Acid and Curcumin—An In Vitro Study on Zebrafish Blood Cells. Applied Sciences 11:17, pages 8142.
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KS Filimonova, NYu Rogovskaya, PP Beltyukov & VN Babakov. (2021) Assessing hepatoprotective effects of antioxidants on amiodarone-induced cytotoxicity in human hepatoma HepaRG cell line. Medicine of Extreme Situations:2021(3).
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Aliah R. Alshanwani, Azza M. Mohamed, Laila M. Faddah, Sameerah Shaheen, Maha M. Arafah, Hanan Hagar, Ahlam M. Alhusaini, Fatima M.B. Alharbi, Alaa AlHarthii & Amira M. Badr. (2021) Cyanocobalamin and/or calcitriol mitigate renal damage-mediated by tamoxifen in rats: Implication of caspase-3/NF-κB signaling pathways. Life Sciences 277, pages 119512.
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Amany Behairy, Wafaa A. M. Mohamed, Lamiaa L. M. Ebraheim, Mohamed Mohamed Soliman, Yasmina M. Abd-Elhakim, Nabela I. El-Sharkawy, Taghred M. Saber & Maha M. El Deib. (2021) Boldenone Undecylenate-Mediated Hepatorenal Impairment by Oxidative Damage and Dysregulation of Heat Shock Protein 90 and Androgen Receptors Expressions: Vitamin C Preventive Role. Frontiers in Pharmacology 12.
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H.G. Ağalar. 2021. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases 175 191 .
Abdulrahman Khazim Al-Asmari, Mansour S. Al-Said, Rajamohamed Abbasmanthiri, Ahmed Al-Buraidi, Khalid Elfaki Ibrahim & Syed Rafatullah. (2020) Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats. Clinical Phytoscience 6:1.
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Duochen Jin, Jun Wang, Qiang Zhan, Keting Huang, Hui Wang, Guoqiang Zhang, Yinghong Xu, Jian Yao, Rong Sun, Qin Huang, Feng Ye & Guoxin Zhang. (2020) The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial. Gastrointestinal Endoscopy 92:3, pages 554-564.
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Naoya Yamada, Tadayoshi Karasawa & Masafumi Takahashi. (2020) Role of ferroptosis in acetaminophen-induced hepatotoxicity. Archives of Toxicology 94:5, pages 1769-1770.
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Yuka Ikeda, Mutsumi Murakami, Yukie Nakagawa, Ai Tsuji, Yasuko Kitagishi & Satoru Matsuda. (2020) Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling (Review). Biomedical Reports.
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Ali Akbar Moghadamnia. (2020) Response to the Letter to the Editor by Hartmut Jaeschke and Anup Ramachandran Concerning Our Article “Chrysin Effect in Prevention of Acetaminophen-Induced Hepatotoxicity in Rat”. Chemical Research in Toxicology 33:3, pages 691-692.
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Laddawan Lalert, Wilawan Ji-au, Sirinapa Srikam, Tipthanan Chotipinit, Sompol Sanguanrungsirikul, Anan Srikiatkhachorn & Supang Maneesri-le Grand. (2019) Alterations in Synaptic Plasticity and Oxidative Stress Following Long-Term Paracetamol Treatment in Rat Brain. Neurotoxicity Research 37:2, pages 455-468.
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Mongi Saoudi, Rabeb Ben Slama-Ben Salem, Mariem Ben Salem, Noura Brahmi, Riadh Badraoui, Moncef Nasri & Abdelfattah El Feki. (2019) Beneficial effects of crataegus oxyacantha extract on neurobehavioral deficits and brain tissue damages induced by an insecticide mixture of deltamethrin and chlorpyrifos in adult wistar rats. Biomedicine & Pharmacotherapy 114, pages 108795.
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Anmar M. Abdulrazzaq, Mujtaba Badr, Omar Gammoh, Asad A. Abu Khalil, Bayan Y. Ghanim, Tawfiq M. Alhussainy & Nidal A. Qinna. (2019) Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats. Medicina 55:5, pages 181.
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