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Review

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

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Pages 3325-3339 | Published online: 29 Jun 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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Pietro Castellan, Roberto Castellucci, Michele Marchioni, Cosimo De Nunzio, Giorgia Tema, Giulia Primiceri, Luigi Schips & Luca Cindolo. (2019) A drug safety evaluation of abiraterone acetate in the treatment of prostate cancer. Expert Opinion on Drug Safety 18:9, pages 759-767.
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Subo Qian, Jia Xia, Hailong Liu, Yu Zhang, Lin Zhang & Yongjiang Yu. (2018) Integrative transcriptome analysis identifies genes and pathways associated with enzalutamide resistance of prostate cancer. The Aging Male 21:4, pages 231-237.
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Jianhong Zhu, Rifang Liao, Chen Su, Dan Liang, Junyan Wu, Kaifeng Qiu & Jianfang Li. (2018) Toxicity profile characteristics of novel androgen-deprivation therapy agents in patients with prostate cancer: a meta-analysis. Expert Review of Anticancer Therapy 18:2, pages 193-198.
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Axel S Merseburger, Antonio Alcaraz & Christoph A von Klot. (2016) Androgen deprivation therapy as backbone therapy in the management of prostate cancer. OncoTargets and Therapy 9, pages 7263-7274.
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Chiara Ciccarese, Elisabetta Nobili, Donatella Grilli, Laura Casolari, Karim Rihawi, Francesco Gelsomino, Giampaolo Tortora & Francesco Massari. (2016) The safety and efficacy of enzalutamide in the treatment of advanced prostate cancer. Expert Review of Anticancer Therapy 16:7, pages 681-696.
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Lucas Germain, Camille Lafront, Virginie Paquette, Bertrand Neveu, Jean-Sébastien Paquette, Frédéric Pouliot & Étienne Audet-Walsh. (2023) Preclinical models of prostate cancer — modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo. Nature Reviews Urology 20:8, pages 480-493.
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Xiangguo Meng, Siju Bi, Shixin Jin, Kai Wu, Shanchao Wu, Lei Shao, Pierre-Antoine Bonnet & Chunquan Sheng. (2023) A novel route for the synthesis of androgen receptor antagonist enzalutamide. Chinese Chemical Letters 34:6, pages 108096.
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Liliana Burlibasa, Alina-Teodora Nicu, Mariana Carmen Chifiriuc, Cosmin Medar, Amelia Petrescu, Viorel Jinga & Ileana Stoica. (2023) H3 histone methylation landscape in male urogenital cancers: from molecular mechanisms to epigenetic biomarkers and therapeutic targets. Frontiers in Cell and Developmental Biology 11.
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Julia Kallenbach, Golnaz Atri Roozbahani, Mehdi Heidari Horestani & Aria Baniahmad. (2022) Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer. Cell & Bioscience 12:1.
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Wu Du. (2022) Advances in AR-targeting chimeras: a case study of proteolysis-targeting chimeras from bench to bedside. Future Medicinal Chemistry 14:20, pages 1471-1489.
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Xin Han & Yi Sun. (2022) Strategies for the discovery of oral PROTAC degraders aimed at cancer therapy. Cell Reports Physical Science 3:10, pages 101062.
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Daiki Yamamoto, Katsumasa Sasaki, Takeo Kosaka, Mototsugu Oya & Toshinori Sato. (2022) Functional analysis of GCNT3 for cell migration and EMT of castration-resistant prostate cancer cells . Glycobiology.
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Andrea Leith, Jeri Kim, Amanda Ribbands, Emily Clayton, Lingfeng Yang & Sameer R. Ghate. (2022) Real-World Treatment Patterns in Metastatic Castration-Resistant Prostate Cancer Across Europe (France, Germany, Italy, Spain, and the United Kingdom) and Japan. Advances in Therapy 39:5, pages 2236-2255.
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Jae Duck Choi, Tae Jin Kim, Byong Chang Jeong, Hwang Gyun Jeon, Seong Soo Jeon, Min Yong Kang, Seon Yong Yeom & Seong Il Seo. (2021) ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT). Scientific Reports 11:1.
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Shunsuke Tsuzuki, Shotaro Nakanishi, Mitsuyoshi Tamaki, Takuma Oshiro, Jun Miki, Hiroki Yamada, Tatsuya Shimomura, Takahiro Kimura, Nozomu Furuta, Seiichi Saito & Shin Egawa. (2021) Initial dose reduction of enzalutamide does not decrease the incidence of adverse events in castration-resistant prostate cancer. PLOS ONE 16:10, pages e0258160.
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Xin Han, Lijie Zhao, Weiguo Xiang, Chong Qin, Bukeyan Miao, Donna McEachern, Yu Wang, Hoda Metwally, Lu Wang, Aleksas Matvekas, Bo Wen, Duxin Sun & Shaomeng Wang. (2021) Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. Journal of Medicinal Chemistry 64:17, pages 12831-12854.
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Ruixin Wang & Xiaoqi Liu. (2020) Epigenetic regulation of prostate cancer. Genes & Diseases 7:4, pages 606-613.
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Holger H. H. Erb, Julia Bodenbender, Florian Handle, Tamara Diehl, Lukas Donix, Igor Tsaur, Martin Gleave, Axel Haferkamp, Johannes Huber, Susanne Fuessel, Eva Juengel, Zoran Culig & Christian Thomas. (2020) Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer. PLOS ONE 15:8, pages e0237248.
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Miriam Kokal, Kimia Mirzakhani, Thanakorn Pungsrinont & Aria Baniahmad. (2020) Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer. Cancers 12:7, pages 1833.
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Cheng Hu, Hongyan Xia, Shanshan Bai, Jianlei Zhao, Holly Edwards, Xinyu Li, Yanrong Yang, Jing Lyu, Guan Wang, Yang Zhan, Yan Dong & Yubin Ge. (2020) CUDC‐907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action. Journal of Cellular and Molecular Medicine 24:13, pages 7239-7253.
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Xianling Yuan, Jiayan Shen, Xinyue Zhang, Wenqing Tu, Zhengwei Fu & Yuanxiang Jin. (2020) Imidacloprid disrupts the endocrine system by interacting with androgen receptor in male mice. Science of The Total Environment 708, pages 135163.
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Andrea Eigentler, Piotr Tymoszuk, Johanna Zwick, Arndt A. Schmitz, Andreas Pircher, Florian Kocher, Andreas Schlicker, Ralf Lesche, Georg Schäfer, Igor Theurl, Helmut Klocker & Isabel Heidegger. (2020) The Impact of Cand1 in Prostate Cancer. Cancers 12:2, pages 428.
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Romina Armando, Diego Mengual G�mez & Daniel Gomez. (2020) New drugs are not enough‑drug repositioning in oncology: An update. International Journal of Oncology.
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Yunfeng Bai, Zhuangzhuang Zhang, Lijun Cheng, Ruixin Wang, Xiaoliang Chen, Yifan Kong, Feng Feng, Nihal Ahmad, Lang Li & Xiaoqi Liu. (2019) Inhibition of enhancer of zeste homolog 2 (EZH2) overcomes enzalutamide resistance in castration-resistant prostate cancer. Journal of Biological Chemistry 294:25, pages 9911-9923.
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Pedro C. Barata & A. Oliver Sartor. (2019) Metastatic castration‐sensitive prostate cancer: Abiraterone, docetaxel, or…. Cancer 125:11, pages 1777-1788.
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Cora N Sternberg. (2019) Enzalutamide, an oral androgen receptor inhibitor for treatment of castration-resistant prostate cancer. Future Oncology 15:13, pages 1437-1457.
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Yifan Kong, Lijun Cheng, Fengyi Mao, Zhuangzhuang Zhang, Yanquan Zhang, Elia Farah, Jacob Bosler, Yunfeng Bai, Nihal Ahmad, Shihuan Kuang, Lang Li & Xiaoqi Liu. (2018) Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC). Journal of Biological Chemistry 293:37, pages 14328-14341.
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Neal D. Shore, Teuvo L. Tammela, Christophe Massard, Petri Bono, John Aspegren, Mika Mustonen & Karim Fizazi. (2018) Safety and Antitumour Activity of ODM-201 (BAY-1841788) in Chemotherapy-naïve and CYP17 Inhibitor-naïve Patients: Follow-up from the ARADES and ARAFOR Trials. European Urology Focus 4:4, pages 547-553.
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Kelly Stratton & Michael Cookson. (2017) Castration-Resistant Prostate Cancer. Urologic Clinics of North America 44:4, pages 647-655.
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Junlong Wu, Guowen Lin, Yao Zhu, Hailiang Zhang, Guohai Shi, Yijun Shen, Yiping Zhu, Bo Dai & Dingwei Ye. (2017) Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status. Scientific Reports 7:1.
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Giuseppe Galletti, Benjamin I. Leach, Linda Lam & Scott T. Tagawa. (2017) Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer. Cancer Treatment Reviews 57, pages 16-27.
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Jie Li, Ruixin Wang, Yifan Kong, Meaghan M. Broman, Colin Carlock, Long Chen, Zhiguo Li, Elia Farah, Timothy L. Ratliff & Xiaoqi Liu. (2017) Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics 16:3, pages 469-479.
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Long Chen, Jie Li, Elia Farah, Sukumar Sarkar, Nihal Ahmad, Sanjay Gupta, James Larner & Xiaoqi Liu. (2016) Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer. Molecular Cancer Therapeutics 15:9, pages 2107-2118.
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F. Labrize, L. Cany, C. Massard, Y. Loriot, P. Sargos, M. Gross-Goupil & G. Roubaud. (2016) Enzalutamide and sleep apnea: an emerging central nervous system side-effect?. Annals of Oncology 27:1, pages 206.
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Juan Fernando Uribe Arcila. (2016) Vía trasera de la síntesis de testosterona (backdoor pathway). Urología Colombiana 25:1, pages 25-30.
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