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Infection and Drug Resistance Volume 7, 2014 - Issue
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Review

Approaches to hepatitis C treatment and cure using NS5A inhibitors

James J Kohler1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
,
James H Nettles1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
,
Franck Amblard1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
,
Selwyn J Hurwitz1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
,
Leda Bassit1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
,
Richard A Stanton1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
,
Maryam Ehteshami1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
&
Raymond F Schinazi1 Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USACorrespondence[email protected]
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Pages 41-56 | Published online: 05 Mar 2014

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Christine Hong Ting Yang, Aparna Goel & Aijaz Ahmed. (2018) Clinical utility of ledipasvir/sofosbuvir in the treatment of adolescents and children with hepatitis C. Adolescent Health, Medicine and Therapeutics 9, pages 103-110.
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Aravindhan Ganesan & Khaled Barakat. (2017) Applications of computer-aided approaches in the development of hepatitis C antiviral agents. Expert Opinion on Drug Discovery 12:4, pages 407-425.
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Yan A. Ivanenkov, Vladimir A. Aladinskiy, Nikolay A. Bushkov, Andrey A. Ayginin, Alexander G. Majouga & Alexandre V. Ivachtchenko. (2017) Small-molecule inhibitors of hepatitis C virus (HCV) non-structural protein 5A (NS5A): a patent review (2010-2015). Expert Opinion on Therapeutic Patents 27:4, pages 401-414.
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Muhammad Usman Mirza, Noor-Ul-Huda Ghori, Nazia Ikram, Abdur Rehman Adil & Sadia Manzoor. (2015) Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors. Drug Design, Development and Therapy 9, pages 1825-1841.
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Annarosa Floreani. (2015) Perspectives of fixed daily dose of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C. Expert Opinion on Pharmacotherapy 16:6, pages 801-804.
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Ana Matošević & Anita Bosak. (2020) Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents. Archives of Industrial Hygiene and Toxicology 71:4, pages 285-299.
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Karen K. Kyuregyan, Vera S. Kichatova, Anastasiya A. Karlsen, Olga V. Isaeva, Sergei A. Solonin, Stefan Petkov, Morten Nielsen, Maria G. Isaguliants & Mikhail I. Mikhailov. (2020) Factors Influencing the Prevalence of Resistance-Associated Substitutions in NS5A Protein in Treatment-Naive Patients with Chronic Hepatitis C. Biomedicines 8:4, pages 80.
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Alaa R. S. Leila, Mai H. A. Mousa, Efseveia Frakolaki, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Mohammad Abdel-Halim & Ashraf H. Abadi. (2019) Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties, and Conformational Aspects of Core Scaffolds. ACS Omega 4:7, pages 11440-11454.
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Keivan Zandi, Leda Bassit, Franck Amblard, Bryan D. Cox, Pouya Hassandarvish, Ehsan Moghaddam, Andrew Yueh, Gisele Olinto Libanio Rodrigues, Ingredy Passos, Vivian V. Costa, Sazaly AbuBakar, Longhu Zhou, James Kohler, Mauro M. Teixeira & Raymond F. Schinazi. (2019) Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses. Antimicrobial Agents and Chemotherapy 63:7.
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Serap Beldar, Malathy Sony Subramanian Manimekalai, Nam-Joon Cho, Kwanghee Baek, Gerhard Grüber & Ho Sup Yoon. (2018) Self-association and conformational variation of NS5A domain 1 of hepatitis C virus. Journal of General Virology 99:2, pages 194-208.
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Steven W. Johnson, Dorothea K. Thompson & Brianne Raccor. (2017) Hepatitis C Virus-Genotype 3: Update on Current and Emergent Therapeutic Interventions. Current Infectious Disease Reports 19:6.
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Marawan Ahmed, Abhishek Pal, Michael Houghton & Khaled Barakat. (2016) A Comprehensive Computational Analysis for the Binding Modes of Hepatitis C Virus NS5A Inhibitors: The Question of Symmetry. ACS Infectious Diseases 2:11, pages 872-881.
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Shanshan Wang, Yongzhi Chen, Chunfeng Li, Yaoxing Wu, Lei Guo, Changwei Peng, Yueping Huang, Genhong Cheng & F. Xiao-Feng Qin. (2016) TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein. Scientific Reports 6:1.
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Javier Ampuero. (2016) Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options. World Journal of Gastroenterology 22:22, pages 5285.
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Akihiro Tamori, Masaru Enomoto & Norifumi Kawada. (2016) Recent Advances in Antiviral Therapy for Chronic Hepatitis C. Mediators of Inflammation 2016, pages 1-11.
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Daniele Serranti, Giuseppe Indolfi & Massimo Resti. (2014) New treatments for chronic hepatitis C: An overview for paediatricians. World Journal of Gastroenterology 20:43, pages 15965.
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