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OncoTargets and Therapy Volume 8, 2015 - Issue
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Original Research

Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells

Alexandra Iulia Irimie1 Department of Prosthodontics and Dental Materials, Faculty of Dental Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
,
Cornelia Braicu2 Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
,
Oana Zanoaga2 Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
,
Valentina Pileczki2 Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania;3 Department of Analytical Chemistry, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
,
Claudia Gherman2 Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania;4 Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof Dr. Ion Chiricuta”, Cluj-Napoca, Romania
,
Ioana Berindan-Neagoe2 Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania;4 Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof Dr. Ion Chiricuta”, Cluj-Napoca, Romania;5 Department of Immunology, Faculty of Medicine, University of Medicine and Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania;6 Department of Experimental Therapeutics MD Anderson Cancer Center Houston, TX, USACorrespondence[email protected]
&
Radu Septimiu Campian7 Department of Oral Rehabilitation, Faculty of Dental Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
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Pages 461-470 | Published online: 20 Feb 2015

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Revathy Sahadevan, Satyam Singh, Anupama Binoy & Sushabhan Sadhukhan. (2023) Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects. Critical Reviews in Food Science and Nutrition 63:30, pages 10382-10411.
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Titus Chukwuemeka Obasi, Cornelia Braicu, Bogdan Cezar Iacob, Ede Bodoki, Ancuta Jurj, Lajos Raduly, Ilioara Oniga, Ioana Berindan-Neagoe & Radu Oprean. (2018) Securidaca–saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells. Cancer Management and Research 10, pages 5709-5724.
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Feng Li, Yongli Wang, Dapeng Li, Yilun Chen, Xuguang Qiao, Rania Fardous, Ashton Lewandowski, Jinbao Liu, Tak-Hang Chan & Q. Ping Dou. (2018) Perspectives on the recent developments with green tea polyphenols in drug discovery. Expert Opinion on Drug Discovery 13:7, pages 643-660.
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Ren-You Gan, Hua-Bin Li, Zhong-Quan Sui & Harold Corke. (2018) Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review. Critical Reviews in Food Science and Nutrition 58:6, pages 924-941.
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Islam Rady, Hadir Mohamed, Mohamad Rady, Imtiaz A. Siddiqui & Hasan Mukhtar. (2018) Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea. Egyptian Journal of Basic and Applied Sciences 5:1, pages 1-23.
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Adrianne S. Chesser, Veena Ganeshan, Jonathan Yang & Gail V. W. Johnson. (2016) Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutritional Neuroscience 19:1, pages 21-31.
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Jack T. Burcher, Lindsay K. DeLiberto, Andrea M. Allen, Kaitlyn L. Kilpatrick & Anupam Bishayee. (2023) Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation. Medicinal Research Reviews 43:6, pages 2025-2085.
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Madhav Kumar & Abhimanyu Kumar Jha. (2023) Exploring the potential of dietary factors and plant extracts as chemopreventive agents in oral squamous cell carcinoma treatment. Frontiers in Oral Health 4.
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Handan VURAL & Sacide DUMAN. (2021) Çocuklarda Yeşil Çay Kullanımının Dental ve Periodontal Sağlığa Etkileri. OSMANGAZİ JOURNAL OF MEDICINE 00.
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Ming Guan Ng, Chew Hee Ng, Khuen Yen Ng, Soi Moi Chye, Anna Pick Kiong Ling & Rhun Yian Koh. (2021) Anticancer Properties of Strobilanthes crispus: A Review. Processes 9:8, pages 1370.
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Anjali P. Patni, M. K. Harishankar, Joel P. Joseph, Bhuvanadas Sreeshma, Rama Jayaraj & Arikketh Devi. (2021) Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications. Cellular Oncology 44:3, pages 473-494.
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Zeni Liu, Yuxiu Lin, Xiaolin Fang, Jingwen Yang & Zhi Chen. (2021) Epigallocatechin-3-Gallate Promotes Osteo-/Odontogenic Differentiation of Stem Cells from the Apical Papilla through Activating the BMP–Smad Signaling Pathway. Molecules 26:6, pages 1580.
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Clara Bretaudeau, Stéphanie Baud, Aurélie Dupont-Deshorgue, Rémi Cousin, Bertrand Brassart & Sylvie Brassart-Pasco. (2020) AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner. Biomolecules 11:1, pages 39.
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Md. Ataur Rahman, MD. Hasanur Rahman, Md. Shahadat Hossain, Partha Biswas, Rokibul Islam, Md Jamal Uddin, Md. Habibur Rahman & Hyewhon Rhim. (2020) Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention. Biomedicines 8:11, pages 517.
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Xiang-Yun Lan, Tzu-Ting Chung, Chien-Ling Huang, Yi-Jang Lee & Wan-Chun Li. (2020) Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis. Biomolecules 10:9, pages 1321.
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Monica Benvenuto, Loredana Albonici, Chiara Focaccetti, Sara Ciuffa, Sara Fazi, Loredana Cifaldi, Martino Tony Miele, Fernando De Maio, Ilaria Tresoldi, Vittorio Manzari, Andrea Modesti, Laura Masuelli & Roberto Bei. (2020) Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies. International Journal of Molecular Sciences 21:18, pages 6635.
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Simone Belobrov, Christine Seers, Eric Reynolds, Nicola Cirillo & Michael McCullough. (2019) Functional and molecular effects of a green tea constituent on oral cancer cells. Journal of Oral Pathology & Medicine 48:7, pages 604-610.
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Çığır BİRAY AVCI & Bakiye GÖKER BAĞCA. (2019) Epigallokateşin-3- gallat uygulamasına bağlı olarak kronik miyeloid lösemi hücrelerinde genetik ve epigenetik otofaji regülatörlerinin ekspresyon değişimlerinin değerlendirilmesiEvaluation of expression changes of genetic and epigenetic autophagy regulators in chronic myeloid leukemia cells due to epigallocatechin-3-gallate treatment. SDÜ Tıp Fakültesi Dergisi 26:1, pages 57-66.
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Song Gao, Zhiying Zhao, Rong Wu, Lina Wu, Xin Tian & Zhenyong Zhang. (2018) MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway. Aging 10:8, pages 2113-2121.
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Diana Gulei, Alexandra Iulia Irimie, Roxana Cojocneanu-Petric, Joachim L. Schultze & Ioana Berindan-Neagoe. (2018) Exosomes—Small Players, Big Sound. Bioconjugate Chemistry 29:3, pages 635-648.
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Ming-Ju Hsieh, Chiao-Wen Lin, Mu-Kuan Chen, Su-Yu Chien, Yu-Sheng Lo, Yi-Ching Chuang, Yi-Ting Hsi, Chia-Chieh Lin, Jui-Chieh Chen & Shun-Fa Yang. (2017) Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways. Scientific Reports 7:1.
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Adriana Grozav, Ovidiu Balacescu, Loredana Balacescu, Thomas Cheminel, Ioana Berindan-Neagoe & Bruno Therrien. (2015) Synthesis, Anticancer Activity, and Genome Profiling of Thiazolo Arene Ruthenium Complexes. Journal of Medicinal Chemistry 58:21, pages 8475-8490.
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