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Original Research

PI3K/AKT/mTOR pathway promotes progestin resistance in endometrial cancer cells by inhibition of autophagy

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Pages 2865-2871 | Published online: 06 Jun 2017

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Laura Devis-Jauregui, Núria Eritja, Meredith Leigh Davis, Xavier Matias-Guiu & David Llobet-Navàs. (2021) Autophagy in the physiological endometrium and cancer. Autophagy 17:5, pages 1077-1095.
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Daniela Madanes, Mariela A. Bilotas, Juan I. Bastón, José J. Singla, Gabriela F. Meresman, Rosa I. Barañao & Analía G. Ricci. (2020) PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage. Gynecological Endocrinology 36:5, pages 436-440.
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Articles from other publishers (36)

Shiyuan Qi, Huiyan Feng & Xiaomao Li. (2023) LncRNAs signatures associated with cuproptosis predict the prognosis of endometrial cancer. Frontiers in Genetics 14.
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Lina Wei, Xiaohong Ma, Yixin Hou, Tianyi Zhao, Rui Sun, Chunping Qiu, Yao Liu, Ziyi Qiu, Zhiming Liu & Jie Jiang. (2023) Verteporfin reverses progestin resistance through YAP/TAZ-PI3K-Akt pathway in endometrial carcinoma. Cell Death Discovery 9:1.
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Xiaohong Ma, Min Xia, Lina Wei, Kui Guo, Rui Sun, Yao Liu, Chunping Qiu & Jie Jiang. (2022) ABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL. Cell Death & Disease 13:12.
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Mu Lv, Peiqin Chen, Mingzhu Bai, Yan Huang, Linxia Li, Youji Feng, Hong Liao, Wenxin Zheng, Xiaojun Chen & Zhenbo Zhang. (2022) Progestin Resistance and Corresponding Management of Abnormal Endometrial Hyperplasia and Endometrial Carcinoma. Cancers 14:24, pages 6210.
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Minglin Liang, Cong Liu, Tao Lei, Shiyi Guo & Jie Min. (2022) Effect of integrin α7 on cell proliferation, invasion, apoptosis and the PI3K/AKT pathway, and its association with clinicopathological features in endometrial cancer. Oncology Letters 25:1.
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Olivia Jeong, Russell R. Broaddus, Bruce A. Lessey, John I. Risinger, Mark I. Hunter & Tae Hoon Kim. (2022) MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer. International Journal of Molecular Sciences 23:23, pages 14596.
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Bingtao Ren, Jieyun Zhou, Yingyi Hu, Ruihua Zhong, Qiaoying Lv, Shuwu Xie, Guoting Li, Bingyi Yang, Xiaojun Chen & Yan Zhu. (2022) Thyroid Hormone Receptor β Knockdown Reduces Suppression of Progestins by Activating the mTOR Pathway in Endometrial Cancer Cells. International Journal of Molecular Sciences 23:20, pages 12517.
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Shiyang Li, Junan Pan, Yanyu Zhang, Yan Tang, Xiaobing Zeng, Shihai Wang, Dengxuan Wu, Yuyong Liu, Dawen Xu, Jianjun Lan & Dong Hu. (2022) An eleven autophagy-related genes-based prognostic signature for endometrial carcinoma. Journal of the Egyptian National Cancer Institute 34:1.
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Vidushi S. Neergheen, Annaelle Hip Kam, Yeshna Pem, Srishti Ramsaha & Theeshan Bahorun. (2022) Regulation of cancer cell signaling pathways as key events for therapeutic relevance of edible and medicinal mushrooms. Seminars in Cancer Biology 80, pages 145-156.
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Pooja Popli, Ally J. Sun & Ramakrishna Kommagani. (2021) The Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease. Reproductive Sciences 29:4, pages 1054-1067.
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Tomohiko Fukuda & Osamu Wada-Hiraike. (2022) The Two-Faced Role of Autophagy in Endometrial Cancer. Frontiers in Cell and Developmental Biology 10.
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Xiaoting Zhang, Yue Ming, Xiaozhe Fu, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Lihui Liu & Ningqiu Li. (2022) PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses. Fish & Shellfish Immunology 120, pages 648-657.
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Somenath Das & Bhanu Prakash. 2022. Research and Technological Advances in Food Science. Research and Technological Advances in Food Science 269 300 .
Federica Rascio, Federica Spadaccino, Maria Teresa Rocchetti, Giuseppe Castellano, Giovanni Stallone, Giuseppe Stefano Netti & Elena Ranieri. (2021) The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review. Cancers 13:16, pages 3949.
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Ni-Hao Gu, Guo-Jing Li, Bing-Xin Yang, Min You, Yu Lin, Feng Sun & Hong Xu. (2021) Hypo-Expression of Tuberin Promotes Adenomyosis via the mTOR1-Autophagy Axis. Frontiers in Cell and Developmental Biology 9.
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Molly Dore, Sara Filoche, Kirsty Danielson & Claire Henry. (2021) Efficacy of the LNG-IUS for treatment of endometrial hyperplasia and early stage endometrial cancer: Can biomarkers predict response?. Gynecologic Oncology Reports 36, pages 100732.
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Altaf A. Shah, Mohammad A. Kamal & Salman Akhtar. (2021) Tumor Angiogenesis and VEGFR-2: Mechanism, Pathways and Current Biological Therapeutic Interventions. Current Drug Metabolism 22:1, pages 50-59.
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Ziwei Wang, Jun Zhang, Yan Liu, Rong Zhao, Xing Zhou & Hongbo Wang. (2020) An Integrated Autophagy-Related Long Noncoding RNA Signature as a Prognostic Biomarker for Human Endometrial Cancer: A Bioinformatics-Based Approach. BioMed Research International 2020, pages 1-12.
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Yu Wang, Lili Yin & Xiaofei Sun. (2020) CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway. Journal of Experimental & Clinical Cancer Research 39:1.
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Hui Wang, Xiaoling Ma, Jinhui Liu, Yicong Wan, Yi Jiang, Yankai Xia & Wenjun Cheng. (2020) Prognostic value of an autophagy-related gene expression signature for endometrial cancer patients. Cancer Cell International 20:1.
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Guoliang Li, Thanigaivelan Kanagasabai, Wenfu Lu, Mike R. Zou, Shang-Min Zhang, Sherly I. Celada, Michael G. Izban, Qi Liu, Tao Lu, Billy R. Ballard, Xinchun Zhou, Samuel E. Adunyah, Robert J. Matusik, Qin Yan & Zhenbang Chen. (2020) KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis. Cancer Research 80:21, pages 4633-4643.
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Nicolai Skovbjerg Arildsen & Ingrid Hedenfalk. (2020) Simvastatin is a potential candidate drug in ovarian clear cell carcinomas. Oncotarget 11:40, pages 3660-3674.
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Ketankumar Panchal, Prakash Koringa, Pritesh Sabara, Dhruv Bhatia, Subhash Jakhesara & Chaitanya Joshi. (2020) Expression profiling revealed keratins and interleukins as potential biomarkers in squamous cell carcinoma of horn in Indian bullocks (Bos indicus). 3 Biotech 10:3.
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Danica Sims, Hapiloe Mabaruti Maranyane, Victoria Damerell, Dhirendra Govender, Ashwin W. Isaacs, Jade Peres & Sharon Prince. (2020) The c-Myc/AKT1/TBX3 Axis Is Important to Target in the Treatment of Embryonal Rhabdomyosarcoma. Cancers 12:2, pages 501.
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Zhenru Xu, Xu Han, Daming Ou, Ting Liu, Zunxiong Li, Guanmin Jiang, Jing Liu & Ji Zhang. (2019) Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy. Applied Microbiology and Biotechnology 104:2, pages 575-587.
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Wenzhi Li, Shufen Wang, Chunping Qiu, Zhiming Liu, Qing Zhou, Deshui Kong, Xiaohong Ma & Jie Jiang. (2019) Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line. Journal of Translational Medicine 17:1.
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Wenjiao Cao, Wuyuan Gao, Panchan Zheng, Xiao Sun & Lihua Wang. (2019) Medroxyprogesterone acetate causes the alterations of endoplasmic reticulum related mRNAs and lncRNAs in endometrial cancer cells. BMC Medical Genomics 12:1.
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Stephanie I. Nuñez-Olvera, Dolores Gallardo-Rincón, Jonathan Puente-Rivera, Yarely M. Salinas-Vera, Laurence A. Marchat, Raúl Morales-Villegas & César López-Camarillo. (2019) Autophagy Machinery as a Promising Therapeutic Target in Endometrial Cancer. Frontiers in Oncology 9.
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Haizhen Wang, Zhenghua Tang, Ting Li, Menglu Liu, Yong Li & Baoling Xing. (2019) CRISPR/Cas9-Mediated Gene Knockout of ARID1A Promotes Primary Progesterone Resistance by Downregulating Progesterone Receptor B in Endometrial Cancer Cells. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27:9, pages 1051-1060.
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Rehana Omar, Aretha Cooper, Hapiloe Mabaruti Maranyane, Luiz Zerbini & Sharon Prince. (2019) COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration. Cancer Letters 459, pages 227-239.
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Can Cao, Jie-yun Zhou, Shu-wu Xie, Xiang-jie Guo, Guo-ting Li, Yi-juan Gong, Wen-jie Yang, Zhao Li, Rui-hua Zhong, Hai-hao Shao & Yan Zhu. (2019) Metformin Enhances Nomegestrol Acetate Suppressing Growth of Endometrial Cancer Cells and May Correlate to Downregulating mTOR Activity In Vitro and In Vivo. International Journal of Molecular Sciences 20:13, pages 3308.
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Qiongyan Lin, Hui Chen, Minfen Zhang, Hanzhen Xiong & Qingping Jiang. (2019) Knocking down FAM83B inhibits endometrial cancer cell proliferation and metastasis by silencing the PI3K/AKT/mTOR pathway. Biomedicine & Pharmacotherapy 115, pages 108939.
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Xiang Shi, Jingjing Wang, Yu Lei, Caofan Cong, Dailin Tan & Xianrong Zhou. (2019) Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review). Molecular Medicine Reports.
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Guang Yang, Yueran Bai, Xueyan Wu, Xiance Sun, Ming Sun, Xiaofang Liu, Xiaofeng Yao, Cong Zhang, Qian Chu, Liping Jiang & Shaopeng Wang. (2018) Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells. Chemico-Biological Interactions 288, pages 24-31.
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Mengjia Qian, Xiaocong Fang & Xiangdong Wang. (2017) Autophagy and inflammation. Clinical and Translational Medicine 6:1.
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Sarita Das, Anmada Nayak, Sumit Siddharth, Deepika Nayak, Satya Narayan & Chanakya Nath Kundu. (2017) TRAIL enhances quinacrine-mediated apoptosis in breast cancer cells through induction of autophagy via modulation of p21 and DR5 interactions. Cellular Oncology 40:6, pages 593-607.
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