Advanced search
Publication Cover
Clinical Interventions in Aging Volume 3, 2008 - Issue 2
Submit an article Journal homepage
198
Views
61
CrossRef citations to date
0
Altmetric
Review

Becaplermin gel in the treatment of diabetic neuropathic foot ulcers

Nikolaos PapanasOutpatient Clinic of Obesity, Diabetes and Metabolism at the Second Department of Internal Medicine, Democritus University of ThraceGreeceCorrespondence[email protected]
&
Efstratios MaltezosOutpatient Clinic of Obesity, Diabetes and Metabolism at the Second Department of Internal Medicine, Democritus University of ThraceGreece
Pages 233-240 | Published online: 06 Jun 2008

Citations (61)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Ioanna Eleftheriadou, Anastasios Tentolouris, Nikolaos Tentolouris & Nikolaos Papanas. (2019) Advancing pharmacotherapy for diabetic foot ulcers. Expert Opinion on Pharmacotherapy 20:9, pages 1153-1160.
Read now
E. Öhnstedt, H. Lofton Tomenius, E. Vågesjö & M. Phillipson. (2019) The discovery and development of topical medicines for wound healing. Expert Opinion on Drug Discovery 14:5, pages 485-497.
Read now
Peter Blume, Melinda Bowlby, Brian M Schmidt & Ryan Donegan. (2014) Safety and efficacy of Becaplermin gel in the treatment of diabetic foot ulcers. Chronic Wound Care Management and Research 1, pages 11-14.
Read now
Ying Zhuge, Zhao-Jun Liu, Bianca Habib & Omaida C Velazquez. (2010) Diabetic foot ulcers: effects of hyperoxia and SDF-1α on endothelial progenitor cells. Expert Review of Endocrinology & Metabolism 5:1, pages 113-125.
Read now

Articles from other publishers (57)

Anna L. Worsley, Dennis H. Lui, Winnie Ntow‐Boahene, Wenhui Song, Liam Good & Janice Tsui. (2022) The importance of inflammation control for the treatment of chronic diabetic wounds. International Wound Journal 20:6, pages 2346-2359.
Crossref
Yushu Zhu, Jianyu Lu, Siqiao Wang, Dayuan Xu, Minjuan Wu, Shuyuan Xian, Wei Zhang, Xirui Tong, Yifan Liu, Jie Huang, Luofeng Jiang, Xinya Guo, Sujie Xie, Minyi Gu, Shuxin Jin, Yicheng Ma, Runzhi Huang, Shichu Xiao & Shizhao Ji. (2023) Mapping intellectual structure and research hotspots in the field of fibroblast-associated DFUs: a bibliometric analysis. Frontiers in Endocrinology 14.
Crossref
Jui-Yung Yang, Cha-Chun Chen, Shun-Cheng Chang, Jiun-Ting Yeh, Hui-Fu Huang, Hwang-Chi Lin, Shang-Hsi Lin, Yu-Hsien Lin, Lin-Gwei Wei, Tom J. Liu, Shih-Yuan Hung, Hui-Mei Yang, Hui-Hsiu Chang, Chih-Hsin Wang, Yuan-Sheng Tzeng, Chieh-Huei Huang, Chang-Yi Chou, Ying-Sheng Lin, Shih-Yi Yang, Han-Min Chen, Jiun-Tsai Lin, Yi-Fang Cheng, Guang-Huar Young, Chun-Fang Huang, Ya-Chun Kuo & Niann-Tzyy Dai. (2022) ENERGI-F703 gel, as a new topical treatment for diabetic foot and leg ulcers: A multicenter, randomized, double-blind, phase II trial. eClinicalMedicine 51, pages 101497.
Crossref
Christine Tkaczyk, Omari Jones-Nelson, Yue Yue Shi, David E. Tabor, Lily Cheng, Tianhui Zhang & Bret R. Sellman. (2022) Neutralizing Staphylococcus aureus Virulence with AZD6389, a Three mAb Combination, Accelerates Closure of a Diabetic Polymicrobial Wound. mSphere 7:3.
Crossref
Maximillian A. Weigelt, Hadar A. Lev-TovMarjana Tomic-Canic, W. David LeeRyan WilliamsDavid StrasfeldRobert S. KirsnerIra M. Herman. (2022) Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine. Advances in Wound Care 11:6, pages 330-359.
Crossref
Shuyi Ning, Jie Zang, Bingyang Zhang, Xinchi Feng & Feng Qiu. (2022) Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties. Frontiers in Pharmacology 13.
Crossref
Martyna Schönborn, Patrycja Łączak, Paweł Pasieka, Sebastian Borys, Anna Płotek & Paweł Maga. (2021) Pro- and Anti-Angiogenic Factors: Their Relevance in Diabetic Foot Syndrome—A Review. Angiology 73:4, pages 299-311.
Crossref
Yi Ru, Ying Zhang, Yan-wei Xiang, Ying Luo, Yue Luo, Jing-si Jiang, Jian-kun Song, Xiao-ya Fei, Dan Yang, Zhan Zhang, Hui-ping Zhang, Tai-yi Liu, Shuang-yi Yin, Bin Li & Le Kuai. (2022) Gene set enrichment analysis and ingenuity pathway analysis to identify biomarkers in Sheng-ji Hua-yu formula treated diabetic ulcers. Journal of Ethnopharmacology 285, pages 114845.
Crossref
Rosalinda D’Amico, Camilla Malucelli, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Priscilla S Briquez, Jeffrey A Hubbell, Thomas Wolff, Lorenz Gürke, Edin Mujagic, Roberto Gianni-Barrera & Andrea Banfi. (2022) Therapeutic arteriogenesis by factor-decorated fibrin matrices promotes wound healing in diabetic mice. Journal of Tissue Engineering 13, pages 204173142211196.
Crossref
James R. Bardill, Melissa R. Laughter, Michael Stager, Kenneth W. Liechty, Melissa D. Krebs & Carlos Zgheib. (2022) Topical gel-based biomaterials for the treatment of diabetic foot ulcers. Acta Biomaterialia 138, pages 73-91.
Crossref
Simin Nazarnezhad, Saeid Kargozar & Michael R Hamblin. 2022. Biomaterials for Vasculogenesis and Angiogenesis. Biomaterials for Vasculogenesis and Angiogenesis 439 463 .
Luciana Y. Daikuara, Xifang Chen, Zhilian Yue, Danielle Skropeta, Fiona M. Wood, Mark W. Fear & Gordon G. Wallace. (2021) 3D Bioprinting Constructs to Facilitate Skin Regeneration. Advanced Functional Materials 32:3, pages 2105080.
Crossref
Ana Maria Dascalu, Dragos Serban, Nikolaos Papanas, Peter Kempler, Manfredi Rizzo, Daniela Stana, Gabriela Roman & Anca Pantea Stoian. 2021. Type 2 Diabetes - From Pathophysiology to Cyber Systems. Type 2 Diabetes - From Pathophysiology to Cyber Systems.
Ioanna Eleftheriadou, Georgia Samakidou, Anastasios Tentolouris, Nikolaos Papanas & Nikolaos Tentolouris. (2020) Nonpharmacological Management of Diabetic Foot Ulcers: An Update. The International Journal of Lower Extremity Wounds 20:3, pages 188-197.
Crossref
May BarakatLuisa A. DiPietroLin Chen. (2021) Limited Treatment Options for Diabetic Wounds: Barriers to Clinical Translation Despite Therapeutic Success in Murine Models. Advances in Wound Care 10:8, pages 436-460.
Crossref
Ana S. Macedo, Francisca Mendes, Patrícia Filipe, Salette Reis & Pedro Fonte. (2021) Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing. Materials 14:15, pages 4257.
Crossref
Yanwei Xiang, Le Kuai, Yi Ru, Jingsi Jiang, Xin Li, Fulun Li, Qilong Chen & Bin Li. (2021) Transcriptional profiling and circRNA-miRNA-mRNA network analysis identify the biomarkers in Sheng-ji Hua-yu formula treated diabetic wound healing. Journal of Ethnopharmacology 268, pages 113643.
Crossref
Severin Mühleder, Macarena Fernández-Chacón, Irene Garcia-Gonzalez & Rui Benedito. (2020) Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology. Cellular and Molecular Life Sciences 78:4, pages 1329-1354.
Crossref
Neha Raina, Radha Rani & Madhu Gupta. 2021. Endothelial Signaling in Vascular Dysfunction and Disease. Endothelial Signaling in Vascular Dysfunction and Disease 77 90 .
Deepti Singh & Hifzur R. Siddique. 2021. Diabetic Foot Ulcer. Diabetic Foot Ulcer 233 249 .
Maria Azevedo, Carmen Lisboa & Acácio Rodrigues. (2020) Chronic wounds and novel therapeutic approaches. British Journal of Community Nursing 25:Sup12, pages S26-S32.
Crossref
Kuldeep Rajpoot, Maliheh Safavi, Nagaraja Sreeharsha & Rakesh K. Tekade. 2020. The Future of Pharmaceutical Product Development and Research. The Future of Pharmaceutical Product Development and Research 367 412 .
Austin P. Veith, Kayla Henderson, Adrianne Spencer, Andrew D. Sligar & Aaron B. Baker. (2019) Therapeutic strategies for enhancing angiogenesis in wound healing. Advanced Drug Delivery Reviews 146, pages 97-125.
Crossref
Kritika Iyer, Zhuo Chen, Teja Ganapa, Benjamin M. Wu, Bill Tawil & Chase S. Linsley. (2018) Keratinocyte Migration in a Three-Dimensional In Vitro Wound Healing Model Co-Cultured with Fibroblasts. Tissue Engineering and Regenerative Medicine 15:6, pages 721-733.
Crossref
Julie Ye Rin BangCaleb TingPeter WangTed KimKenneth Kezhi WangTheodore KeeDarron MiyaDean HoDong-Keun Lee. (2018) Synthesis and Characterization of Nanodiamond–Growth Factor Complexes Toward Applications in Oral Implantation and Regenerative Medicine. Journal of Oral Implantology 44:3, pages 207-211.
Crossref
Xing Yuan, Lin Han, Peng Fu, Huawu Zeng, Chao Lv, Wanlin Chang, R. Scott Runyon, Momoko Ishii, Liwen Han, Kechun Liu, Taiping Fan, Weidong Zhang & Runhui Liu. (2018) Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways. Laboratory Investigation 98:6, pages 783-798.
Crossref
D Lindarto. (2018) Holistic management of diabetic foot. IOP Conference Series: Earth and Environmental Science 125:1, pages 012162.
Crossref
Ashang Luwang Laiva, Fergal J. O'Brien & Michael B. Keogh. (2018) Innovations in gene and growth factor delivery systems for diabetic wound healing. Journal of Tissue Engineering and Regenerative Medicine 12:1, pages e296-e312.
Crossref
Daniel W. Long, Noah R. Johnson, Eric M. Jeffries, Hidetaka Hara & Yadong Wang. (2017) Controlled delivery of platelet-derived proteins enhances porcine wound healing. Journal of Controlled Release 253, pages 73-81.
Crossref
Ashlesha P. Pandit, Saurabh A. Patel, Vandana P. Bhanushali, Vinit S. Kulkarni & Vrushali D. Kakad. (2016) Nebivolol-Loaded Microsponge Gel for Healing of Diabetic Wound. AAPS PharmSciTech 18:3, pages 846-854.
Crossref
Rebecca J. Linger, Esther J. Belikoff, Ying Yan, Fang Li, Holly A. Wantuch, Helen L. Fitzsimons & Maxwell J. Scott. (2016) Towards next generation maggot debridement therapy: transgenic Lucilia sericata larvae that produce and secrete a human growth factor. BMC Biotechnology 16:1.
Crossref
Subhamoy Das & Aaron B. Baker. (2016) Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing. Frontiers in Bioengineering and Biotechnology 4.
Crossref
Curtis R. WaycasterAdrienne M. GilliganTravis A. Motley. (2016) Cost-Effectiveness of Becaplermin Gel on Diabetic Foot Ulcer Healing. Journal of the American Podiatric Medical Association 106:4, pages 273-282.
Crossref
Mahmoud Ali Kaykhaei, Mohammad Reza Shahraki, Mahdi Mohammadi, Bahador Moshtaghian & Majid Zandkarimi. (2016) The Effects of Topical Application of Thyroid Hormone (Liothyronine, T3) on Skin Wounds in Diabetic Wistar Rats. Zahedan Journal of Research in Medical Sciences In Press:In Press.
Crossref
J. Cundell. 2016. Smart Bandage Technologies. Smart Bandage Technologies 37 61 .
Anthony R. Sheets, Catalina K. Hwang & Ira M. Herman. 2016. Translating Regenerative Medicine to the Clinic. Translating Regenerative Medicine to the Clinic 251 264 .
Angelo S. Mao & David J. Mooney. (2015) Regenerative medicine: Current therapies and future directions. Proceedings of the National Academy of Sciences 112:47, pages 14452-14459.
Crossref
Arturo J Martí-Carvajal, Christian Gluud, Susana Nicola, Daniel Simancas-Racines, Ludovic Reveiz, Patricio Oliva & Jorge Cedeño-Taborda. (2015) Growth factors for treating diabetic foot ulcers. Cochrane Database of Systematic Reviews 2015:10.
Crossref
Frank L. Bowling, S. Tawqeer Rashid & Andrew J. M. Boulton. (2015) Preventing and treating foot complications associated with diabetes mellitus. Nature Reviews Endocrinology 11:10, pages 606-616.
Crossref
Noah R. Johnson & Yadong Wang. (2015) Coacervate delivery of HB-EGF accelerates healing of type 2 diabetic wounds. Wound Repair and Regeneration 23:4, pages 591-600.
Crossref
Adrienne M. Gilligan, Curtis R. Waycaster & Travis A. Motley. (2015) Cost‐effectiveness of becaplermin gel on wound healing of diabetic foot ulcers. Wound Repair and Regeneration 23:3, pages 353-360.
Crossref
M. Löndahl, L. Tarnow, T. Karlsmark, R. Lundquist, A.M. Nielsen, M. Michelsen, A. Nilsson, M. Zakrzewski & B. Jörgensen. (2015) Use of an autologous leucocyte and platelet-rich fibrin patch on hard-to-heal DFUs: a pilot study. Journal of Wound Care 24:4, pages 172-178.
Crossref
Richard J. Watters, Roger F. Brown & Delbert E. Day. (2015) Angiogenic Effect of Bioactive Borate Glass Microfibers and Beads in the Hairless Mouse. Biomedical glasses 1:1.
Crossref
Xiao-hong Zhao, Hai-feng Gu, Zhe-rong Xu, Qin Zhang, Xue-ying Lv, Xiao-jun Zheng & Yun-mei Yang. (2014) Efficacy of topical recombinant human platelet-derived growth factor for treatment of diabetic lower-extremity ulcers: Systematic review and meta-analysis. Metabolism 63:10, pages 1304-1313.
Crossref
Svetlana N Zykova, Ksenia A Balandina, Natalia V Vorokhobina, Alla V Kuznetsova, Rolf Engstad & Tatiana A Zykova. (2013) Macrophage stimulating agent soluble yeast β‐1,3/1,6‐glucan as a topical treatment of diabetic foot and leg ulcers: A randomized, double blind, placebo‐controlled phase II study . Journal of Diabetes Investigation 5:4, pages 392-399.
Crossref
Jean-Baptiste Demoulin & Ahmed Essaghir. (2014) PDGF receptor signaling networks in normal and cancer cells. Cytokine & Growth Factor Reviews 25:3, pages 273-283.
Crossref
Christian Schmidt, Deon Bezuidenhout, Peter Zilla & Neil H Davies. (2013) A slow-release fibrin matrix increases adeno-associated virus transduction of wound repair cells in vivo. Journal of Biomaterials Applications 28:9, pages 1408-1418.
Crossref
Kathryn Futrega, Myfanwy King, William B. Lott & Michael R. Doran. (2014) Treating the whole not the hole: necessary coupling of technologies for diabetic foot ulcer treatment. Trends in Molecular Medicine 20:3, pages 137-142.
Crossref
Nicholas A. Richmond, Alejandra C. Vivas & Robert S. Kirsner. (2013) Topical and Biologic Therapies for Diabetic Foot Ulcers. Medical Clinics of North America 97:5, pages 883-898.
Crossref
Gui-Qiu Shan, Ya-Ni Zhang, Jing Ma, Yan-Hui Li, Da-Ming Zuo, Jin-lang Qiu, Biao Cheng & Zheng-Liang Chen. (2013) Evaluation of the Effects of Homologous Platelet Gel on Healing Lower Extremity Wounds in Patients With Diabetes. The International Journal of Lower Extremity Wounds 12:1, pages 22-29.
Crossref
Ginevra Pertusi, Rossana Tiberio, Francesca Graziola, Paolo Boggio, Enrico Colombo & Chiarella Bozzo. (2012) Selective release of cytokines, chemokines, and growth factors by minced skin in vitro supports the effectiveness of autologous minced micrografts technique for chronic ulcer repair. Wound Repair and Regeneration 20:2, pages 178-184.
Crossref
Ying Zhuge, Sharyce Gonzalez & Omaida C. Velazquez. 2012. The Diabetic Foot. The Diabetic Foot 217 229 .
Jillian E. TengoodRyan RidenourRoss BrodskyAlan J. RussellSteven R. Little. (2011) Sequential Delivery of Basic Fibroblast Growth Factor and Platelet-Derived Growth Factor for Angiogenesis. Tissue Engineering Part A 17:9-10, pages 1181-1189.
Crossref
Guy P. Marti, Lixin Liu, Xianjie Zhang, Dongmei Xing, Denise C. King, Angela R. Kohli, Maura Reinblatt, William B. Greenough & John W. Harmon. 2011. Principles and Practice of Geriatric Surgery. Principles and Practice of Geriatric Surgery 107 127 .
Arturo J Martí-Carvajal, Maria Ximena Rojas-Reyes, Ludovic Reveiz, Nelcy Rodriguez-Malagon & Jorge Cedeño-Taborda. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Nikolaos Papanas & Efstratios Maltezos. (2010) Benefit-Risk Assessment of Becaplermin in the Treatment of Diabetic Foot Ulcers. Drug Safety 33:6, pages 455-461.
Crossref
Min Jeong KwonJeong Hyun Park. (2009) Impaired Wound Healing in Diabetes Mellitus. Korean Diabetes Journal 33:2, pages 83.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.