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Clinical Lipidology Volume 7, 2012 - Issue 5
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Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer’s disease?

Michelle M MielkeDivision of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN55905, USACorrespondence[email protected]
&
Norman J HaugheyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD21287, USA
Pages 525-536 | Published online: 18 Jan 2017

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Marcie A Glicksman. (2014) The 14th International Conference on Alzheimer's Drug Discovery, 9 – 10 September 2013, in Jersey City, New Jersey. Expert Opinion on Drug Discovery 9:2, pages 215-220.
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Luciana M. Pujol-Lereis. (2019) Alteration of Sphingolipids in Biofluids: Implications for Neurodegenerative Diseases. International Journal of Molecular Sciences 20:14, pages 3564.
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Crossref
Matthew W. Wong, Nady Braidy, Anne Poljak & Perminder S. Sachdev. (2017) The application of lipidomics to biomarker research and pathomechanisms in Alzheimer's disease. Current Opinion in Psychiatry 30:2, pages 136-144.
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Mitchell K. P. Lai, Wee Siong Chew, Federico Torta, Angad Rao, Greg L. Harris, Jerold Chun & Deron R. Herr. (2016) Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs. NeuroMolecular Medicine 18:3, pages 396-414.
Crossref
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Crossref
Yi Xing, Yi Tang, Lina Zhao, Qi Wang, Wei Qin, Jin-Lan Zhang & Jianping Jia. (2016) Plasma Ceramides and Neuropsychiatric Symptoms of Alzheimer’s Disease. Journal of Alzheimer's Disease 52:3, pages 1029-1035.
Crossref
Satoshi Mizuno, Soichi Ogishima, Kazuyuki Kitatani, Masataka Kikuchi, Hiroshi Tanaka, Nobuo Yaegashi & Jun Nakaya. (2016) Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer’s Disease. PLOS ONE 11:2, pages e0148431.
Crossref
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Crossref
Maja Jazvinšćak Jembrek, Patrick R. Hof & Goran Šimić. (2015) Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and A β Accumulation . Oxidative Medicine and Cellular Longevity 2015, pages 1-17.
Crossref
Michelle M. Mielke, Norman J. Haughey, Veera.V.R. Bandaru, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson, Sterling C. Johnson, Carey E. Gleason, Hanna M. Blazel, Luigi Puglielli, Mark A. Sager, Sanjay Asthana & Cynthia M. Carlsson. (2014) Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiology of Aging 35:11, pages 2486-2494.
Crossref
Eugenia Trushina & Michelle M. Mielke. (2014) Recent advances in the application of metabolomics to Alzheimer's Disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:8, pages 1232-1239.
Crossref
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Crossref
Maja Jembrek, Mirjana Babić, Nela Pivac, Patrick Hof & Goran Šimić. (2013) Hyperphosphorylation of tau by GSK-3β in Alzheimer’s disease: The interaction of Aβ and sphingolipid mediators as a therapeutic target. Translational Neuroscience 4:4, pages 466-476.
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