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Acta Odontologica Scandinavica Volume 40, 1982 - Issue 5
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Original Article

The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibro-blasts in vitro

Thomas Modéer The departments of Pedodontics and Periodontology, Odontological Faculty, Karolinska Institute, Stockholm, Sweden
,
Göran Dahllöf The departments of Pedodontics and Periodontology, Odontological Faculty, Karolinska Institute, Stockholm, Sweden
&
Per Otteskog The departments of Pedodontics and Periodontology, Odontological Faculty, Karolinska Institute, Stockholm, Sweden
Pages 353-357 | Received 04 Jan 1982, Published online: 02 Jul 2009

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Thomas Modéer, GÖRan Dahllöf & Per Otteskog. (1988) Potentiation of fibroblast spreading by extracellular matrix from fibroblasts derived from phenytoin-induced gingival overgrowth. Acta Odontologica Scandinavica 46:2, pages 101-104.
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Articles from other publishers (41)

Mohammad A. Assaggaf, Alpdogan Kantarci, Siddika S. Sume & Philip C. Trackman. (2015) Prevention of Phenytoin-Induced Gingival Overgrowth by Lovastatin in Mice. The American Journal of Pathology 185:6, pages 1588-1599.
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Surena Vahabi, Bahareh Nazemi Salman, Fahimeh Rezazadeh & Mahshid Namdari. (2014) Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study. Journal of Basic and Clinical Physiology and Pharmacology 25:2.
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Nozomi Ohuchi, Kazuhiko Hayashi, Keishi Iwamoto, Katsuo Koike, Yasuo Kizawa, Michiyoshi Nukaga, Tomohito Kakegawa & Hajime Murakami. (2009) Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts. Fundamental & Clinical Pharmacology 24:4, pages 501-508.
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Nurcan Buduneli, Eralp Buduneli, Sema Çınar, David Lappin & Denis F. Kinane. (2007) Immunohistochemical Evaluation of Ki‐67 Expression and Apoptosis in Cyclosporin A‐Induced Gingival Overgrowth. Journal of Periodontology 78:2, pages 282-289.
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Helena Domeij, Tulay Yucel-Lindberg & Thomas Modeer. (2006) Cell interactions between human gingival fibroblasts and monocytes stimulate the production of matrix metalloproteinase-1 in gingival fibroblasts. Journal of Periodontal Research 41:2, pages 108-117.
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Helena Domeij, Thomas Modéer, Hernán Concha Quezada & Tülay Yucel-Lindberg. (2005) Cell expression of MMP-1 and TIMP-1 in co-cultures of human gingival fibroblasts and monocytes: The involvement of ICAM-1. Biochemical and Biophysical Research Communications 338:4, pages 1825-1833.
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Naoto Sato, Hiroko Matsumoto, Yoshiaki Akimoto & Akira Fujii. (2005) The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts. Journal of Oral Science 47:2, pages 105-110.
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M. Mustafa, B. Wondimu, T. Yucel-Lindberg, A. T. Kats-Hallstrom, A. S. Jonsson & T. Modeer. (2005) Triclosan reduces microsomal prostaglandin E synthase-1 expression in human gingival fibroblasts. Journal of Clinical Periodontology 32:1, pages 6-11.
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P. C. TrackmanA. Kantarci. (2016) C onnective T issue M etabolism and G ingival O vergrowth . Critical Reviews in Oral Biology & Medicine 15:3, pages 165-175.
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Manal Mustafa, Biniyam Wondimu, Kjell Hultenby, Tülay Yucel-Lindberg & Thomas Modéer. (2003) Uptake, Distribution and Release of 14C-Triclosan in Human Gingival Fibroblasts. Journal of Pharmaceutical Sciences 92:8, pages 1648-1653.
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Helena Domeij, Tülay Yucel‐Lindberg & Thomas Modéer. (2002) Signal pathways involved in the production of MMP‐1 and MMP‐3 in human gingival fibroblasts. European Journal of Oral Sciences 110:4, pages 302-306.
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Nozomi Ohuchi, Katsuo Koike, Masakazu Sano, Tadashi Kusama, Yasuo Kizawa, Kazuhiko Hayashi, Yumiko Taniguchi, Masami Ohsawa, Keishi Iwamoto & Hajime Murakami. (2002) Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 132:4, pages 451-460.
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Tülay Yucel‐Lindberg, Gustaf Brunius, Biniyam Wondimu, Ingegerd Andurén & Thomas Modéer. (2001) Enhanced cyclooxygenase‐2 mRNA expression in human gingival fibroblasts induced by cell contact with human lymphocytes. European Journal of Oral Sciences 109:3, pages 187-192.
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Manal Mustafa, Biniyam Wondimu, Moiz Bakhiet & Thomas Modéer. (2003) Production of Rantes/CCL5 in human gingival fibroblasts challenged with tumor necrosis factor α. European Journal of Oral Sciences 109:1, pages 44-49.
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Manal Mustafa, Biniyam Wondimu, Moiz Bakhiet & Thomas Modéer. (2000) INDUCTION OF INTERFERON γ IN HUMAN GINGIVAL FIBROBLASTS CHALLENGED WITH PHYTOHAEMAGGLUTININ. Cytokine 12:4, pages 368-373.
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Tülay Yucel-Lindberg, Harri Ahola, Jan Carlstedt-Duke & Thomas Modéer. (1999) Involvement of Tyrosine Kinases on Cyclooxygenase Expression and Prostaglandin E2Production in Human Gingival Fibroblasts Stimulated with Interleukin-1β and Epidermal Growth Factor. Biochemical and Biophysical Research Communications 257:2, pages 528-532.
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T. Yucel-Lindberg, S. Nilsson & T. Modéer. (2016) Signal Transduction Pathways Involved in the Synergistic Stimulation of Prostaglandin Production by Interleukin-1β and Tumor Necrosis Factor a in Human Gingival Fibroblasts. Journal of Dental Research 78:1, pages 61-68.
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Biniyam Wondimu & Thomas Modéer. (2006) Cyclosporin A upregulates prostaglandin E 2 production in human gingival fibroblasts challenged with tumor necrosis factor alpha in vitro . Journal of Oral Pathology & Medicine 26:1, pages 11-16.
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T. Modéer, I. Andurén, A. Bengtsson & G. Andersson. (2006) lnterleukin‐1β and phenytoin reduce α1 (1) procollagen mRNA expression in human gingival fibroblasts. Journal of Periodontal Research 31:8, pages 563-569.
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T. Modéer, A. Bengisson & G. Rölla. (2005) Triclosan reduces prostaglandin biosynthesis in human gingival fibroblasts challenged with interleukin‐1 in vitro. Journal of Clinical Periodontology 23:10, pages 927-933.
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Gustaf Brunius, Tülay Yucel‐Lindberg, Keiji Shinoda & Thomas Modéer. (2007) Effect of phenytoin on interleukin‐1β production in human gingival fibroblasts challenged to tumor necrosis factor α in vitro . European Journal of Oral Sciences 104:1, pages 27-33.
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T�lay Yucel-Lindberg, Harri Ahola, Stefan Nilsson, Jan Carlstedt-Duke & Thomas Mod�er. (1995) Interleukin-1? induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts. Inflammation 19:5, pages 549-560.
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T. Yucel-Lindberg, U.H. Lerner & T. Modeer. (1995) Effects and interactions of tumour necrosis factor alpha and bradykinin on interleukin-1 production in gingival fibroblasts. Journal of Periodontal Research 30:3, pages 186-191.
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A. Fujii, H. Matsumoto, S. Nakao, H. Teshigawara & Y. Akimoto. (1994) Effect of calcium-channel blockers on cell proliferation, DNA synthesis and collagen synthesis of cultured gingival fibroblasts derived from human nifedipine responders and non-responders. Archives of Oral Biology 39:2, pages 99-104.
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T. Modéer, T. Yucel-Lindberg, M. Iinuma, U.H. Lerner & G. Andersson. (1993) Epidermal growth factor potentiates interleukin 1 and tumour necrosis factor-induced prostaglandin biosynthesis in human gingival fibroblasts. Cytokine 5:3, pages 198-204.
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G. Brunius, M. Iinuma, I. Andurén, U.H. Lerner & T. Modéer. (1993) The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1. Life Sciences 53:6, pages 503-515.
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U. H. Lerner, G. Brunius, I. Anduren, P. -O. Berggren, L. Juntti-Berggren & T. Modéer. (1992) Bradykinin induces a B2 receptor-mediated calcium signal linked to prostanoid formation in human gingival fibroblastsin vitro. Agents and Actions 37:1-2, pages 44-52.
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Ulf H. Lerner, Gustaf Brunius & Thomas Modeer. (1992) On the signal transducing mechanisms involved in the synergistic interaction between interleukin-1 and bradykinin on prostaglandin biosynthesis in human gingival fibroblasts. Bioscience Reports 12:4, pages 263-271.
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T. Modéer, I. Anduren & U. H. Lerner. (2006) Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin. Journal of Oral Pathology & Medicine 21:6, pages 251-255.
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Thomas Modéer, Gustaf Brunius, Mitsuo Iinuma & Ulf H. Lerner. (1992) Phenytoin potentiates interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts. British Journal of Pharmacology 106:3, pages 574-578.
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Ulf H. Lerner & Thomas Mod�er. (1991) Bradykinin B1 and B2 receptor agonists synergistically potentiate interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts. Inflammation 15:6, pages 427-436.
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THOMAS MODÉER, GUSTAF BRUNIUS, CARLOS MENDEZ, LISA JUNTTI‐BERGGREN & PER‐OLOF BERGGREN. (2007) Influence of phenytoin on cytoplasmic free Ca 2+ level in human gingival fibroblasts . European Journal of Oral Sciences 99:4, pages 310-315.
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T. Modéer, Ö. Ljunggren & U. H. Lerner. (2006) Bradykinin‐2 receptor‐mediated release of 3 H‐arachidonic acid and formation of prostaglandin E 2 in human gingival fibroblasts . Journal of Periodontal Research 25:6, pages 358-363.
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Thomas Modeer & Goran Andersson. (1990) Regulation of epidermal growth factor receptor metabolism in gingival fibroblasts by phenytoin in vitro. Journal of Oral Pathology and Medicine 19:4, pages 188-191.
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T. Modéer, C. Mendez, G. Dahllöf, I. Andurén & G. Andersson. (2006) Effect of phenytoin medication on the metabolism of epidermal growth factor receptor in cultured gingival fibroblasts. Journal of Periodontal Research 25:2, pages 120-127.
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D.F. Kinane, J.R. Drummond & D.M. Chisholm. (1990) Langerhans cells in human chronic gingivitis and phenytoin-induced gingival hyperplasia. Archives of Oral Biology 35:7, pages 561-564.
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D F Kinane. 1990. Advances in Mucosal Immunology. Advances in Mucosal Immunology 491 492 .
Gustaf Brunius & Thomas Modáer. (2006) Effect of phenytoin on intracellular 45 Ca 2+ accumulation in gingival fibroblasts in vitro . Journal of Oral Pathology & Medicine 18:8, pages 485-489.
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R. A. Seymour & P. A. Heasman. (2005) Drugs and the periodontium. Journal of Clinical Periodontology 15:1, pages 1-16.
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Q.T. Smith & J.E. Hinrichs. (2016) Phenytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin do not Alter the Effects of Bacterial and Amplified Plaque Extracts on Cultures of Fibroblasts from Normal and Overgrown Gingivae. Journal of Dental Research 66:8, pages 1393-1398.
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Craig Laughton. (1984) Quantification of attached cells in microtiter plates based on Coomassie brilliant blue G-250 staining of total cellular protein. Analytical Biochemistry 140:2, pages 417-423.
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