67
Views
58
CrossRef citations to date
0
Altmetric
Original Article

Low Levels of Nasal Nitric Oxide (NO) Correlate to Impaired Mucociliary Function in the Upper Airways

, &
Pages 728-734 | Received 25 Jul 1996, Accepted 29 Nov 1996, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jens A. Andersson, Anders Cervin, Sven Lindberg, Rolf Uddman & Lars Olaf Cardell. (2002) A Decrease in Maxillary Sinus Pressure, as Seen in Upper Airway Allergy or Infection, Results in an Increase in Upper Airway Nitric Oxide Levels. Acta Oto-Laryngologica 122:5, pages 520-523.
Read now
Masanobu Imada, Satoshi Nonaka, Yoshihumi Kobayashi & Jun Iwamoto. (2002) Functional Roles of Nasal Nitric Oxide in Nasal Patency and Mucociliary Function. Acta Oto-Laryngologica 122:5, pages 513-519.
Read now
Deborah A. Gentile, William J. Doyle, Sergei Belenky, Halee Ranck, Betty Angelini & David P. Skoner. (2002) Nasal and Oral Nitric Oxide Levels During Experimental Respiratory Syncytial Virus Infection of Adults. Acta Oto-Laryngologica 122:1, pages 61-66.
Read now
Jens A. Andersson, Rolf Uddman, Janos Tajti & Lars-Olaf Cardell. (2002) Heme Oxygenase and Nitric Oxide Synthase in Human Middle Ear Epithelium Indicates Local Carbon Monoxide and Nitric Oxide Production. Acta Oto-Laryngologica 122:6, pages 634-637.
Read now

Articles from other publishers (54)

June K. Marthin, Kim G. Nielsen & Jann Mortensen. (2023) Quantitative 99m Tc-albumin colloid nasal mucociliary clearance as an outcome in primary ciliary dyskinesia . ERJ Open Research 9:5, pages 00345-2023.
Crossref
Jim Bartley. 2023. Nasal Physiology and Pathophysiology of Nasal Disorders. Nasal Physiology and Pathophysiology of Nasal Disorders 551 557 .
Palak P. Oza & Khosrow Kashfi. (2022) Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise. Nitric Oxide 128, pages 72-102.
Crossref
Daniel J. Lee, Jonathan Yip & John M. Lee. (2020) Nasal nitric oxide as a long‐term monitoring and prognostic biomarker of mucosal health in chronic rhinosinusitis. International Forum of Allergy & Rhinology 10:8, pages 971-977.
Crossref
Tetsuji Takabayashi & Robert P. Schleimer. (2020) Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin. Journal of Allergy and Clinical Immunology 145:3, pages 740-750.
Crossref
Valentina Agnese Ferraro, Stefania Zanconato, Eugenio Baraldi & Silvia Carraro. (2019) Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusitis and Asthma. Journal of Clinical Medicine 8:11, pages 1783.
Crossref
Kanako Yoshida, Tetsuji Takabayashi, Yoshimasa Imoto, Masafumi Sakashita, Norihiko Narita & Shigeharu Fujieda. (2019) Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis. Allergology International 68:2, pages 225-232.
Crossref
Gerard M. Murray, Rónan G. O’Neill, Alison M. Lee, Máire C. McElroy, Simon J. More, Aisling Monagle, Bernadette Earley & Joseph P. Cassidy. (2017) The bovine paranasal sinuses: Bacterial flora, epithelial expression of nitric oxide and potential role in the in-herd persistence of respiratory disease pathogens. PLOS ONE 12:3, pages e0173845.
Crossref
Myrofora Goutaki, Elisabeth Maurer, Florian S. Halbeisen, Israel Amirav, Angelo Barbato, Laura Behan, Mieke Boon, Carmen Casaulta, Annick Clement, Suzanne Crowley, Eric Haarman, Claire Hogg, Bulent Karadag, Cordula Koerner-Rettberg, Margaret W. Leigh, Michael R. Loebinger, Henryk Mazurek, Lucy Morgan, Kim G. Nielsen, Heymut Omran, Nicolaus Schwerk, Sergio Scigliano, Claudius Werner, Panayiotis Yiallouros, Zorica Zivkovic, Jane S. Lucas & Claudia E. Kuehni. (2017) The international primary ciliary dyskinesia cohort (iPCD Cohort): methods and first results. European Respiratory Journal 49:1, pages 1601181.
Crossref
Seong Ho Cho, Dae Woo Kim & Philippe Gevaert. (2016) Chronic Rhinosinusitis without Nasal Polyps. The Journal of Allergy and Clinical Immunology: In Practice 4:4, pages 575-582.
Crossref
. 2016. Toxicology of the Nose and Upper Airways. Toxicology of the Nose and Upper Airways 32 58 .
John M. Lee, Carmen L. McKnight, Theresa Aves, Jonathan Yip, Amandeep S. Grewal & Samir Gupta. (2015) Nasal nitric oxide as a marker of sinus mucosal health in patients with nasal polyposis. International Forum of Allergy & Rhinology 5:10, pages 894-899.
Crossref
Seung-Kyu Chung, Gyehwan Jo, Sung Kyun Kim & Yang Na. (2014) The effect of a middle meatal antrostomy on nitric oxide ventilation in the maxillary sinus. Respiratory Physiology & Neurobiology 192, pages 7-16.
Crossref
Wai Sum O, Hang Wun Raymond Li, Su-Bin Liao, Annie Nga Yin Cheung, Ernest Hung Yu Ng, William Shu Biu Yeung, James Chung-Man Ho & Fai Tang. (2013) Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy. Fertility and Sterility 100:2, pages 459-463.e1.
Crossref
Cedar J. Fowler, Kenneth N. Olivier, Janice M. Leung, Caroline C. Smith, Andrea G. Huth, Heather Root, Douglas B. Kuhns, Carolea Logun, Adrian Zelazny, Cathleen A. Frein, Janine Daub, Carissa Haney, James H. Shelhamer, Clare E. Bryant & Steven M. Holland. (2013) Abnormal Nasal Nitric Oxide Production, Ciliary Beat Frequency, and Toll-like Receptor Response in Pulmonary Nontuberculous Mycobacterial Disease Epithelium. American Journal of Respiratory and Critical Care Medicine 187:12, pages 1374-1381.
Crossref
Peter J. Catalano. (2013) Balloon Dilation Technology: Let the Truth Be Told. Current Allergy and Asthma Reports 13:2, pages 250-254.
Crossref
Adriana Mayoral-Mariles, Carmen Cruz-Revilla, Xochitl Vega-Manriquez, Rebeca Aguirre-Hernández, Patricia Severiano-Pérez, Eric Aburto-Arciniega, Araceli Jiménez-Mendoza & Rosalinda Guevara-Guzmán. (2012) Plasma Amino Acid Levels Discriminate Between Control Subjects and Mildly Depressed Elderly Women. Archives of Medical Research 43:5, pages 375-382.
Crossref
Raewyn Campbell. (2012) Managing upper respiratory tract complications of primary ciliary dyskinesia in children. Current Opinion in Allergy & Clinical Immunology 12:1, pages 32-38.
Crossref
Fuad M. Baroody. 2012. Sleep Disordered Breathing in Children. Sleep Disordered Breathing in Children 37 55 .
J. Pawsey, A.B. Lansley & M.I. Lethem. (2011) Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors. Pulmonary Pharmacology & Therapeutics 24:5, pages 602-609.
Crossref
Scott D. Sagel. (2011) Nasal Nitric Oxide: Diagnostic Value and Physiological Significance in Primary Ciliary Dyskinesia. The Journal of Pediatrics 159:3, pages 363-365.
Crossref
Catherine E. Rennie, Christina M. Hood, Esther J. S. M. Blenke, Robert S. Schroter, Denis J. Doorly, Hazel Jones, David Towey & Neil S. Tolley. (2011) Physical and Computational Modeling of Ventilation of the Maxillary Sinus. Otolaryngology–Head and Neck Surgery 145:1, pages 165-170.
Crossref
P. Seamus Phillips, Raymond Sacks, George N. Marcells, Noam A. Cohen & Richard J. Harvey. (2011) Nasal Nitric Oxide and Sinonasal Disease. Otolaryngology–Head and Neck Surgery 144:2, pages 159-169.
Crossref
Peter A. Williamson, Sriram Vaidyanathan, Karine Clearie, Munro Stewart & Brian J. Lipworth. (2010) Relationship between fractional exhaled nitric oxide and nasal nitric oxide in airways disease. Annals of Allergy, Asthma & Immunology 105:2, pages 162-167.
Crossref
Neil E. Farber, Paul S. Pagel & David C. Warltier. 2010. Miller's Anesthesia. Miller's Anesthesia 561 594 .
Edwin Tamashiro, Caroline A. Banks & Noam A. Cohen. 2010. Nasal Polyposis. Nasal Polyposis 175 183 .
Jon O. Lundberg. (2008) Nitric Oxide and the Paranasal Sinuses. The Anatomical Record 291:11, pages 1479-1484.
Crossref
Steven B. Cannady, Pete S. Batra, Rachel Leahy, Martin J. Citardi, Allison Janocha, Kristin Ricci, Suzy A.A. Comhair, Melanie Bodine, Zeneng Wang, Stanley L. Hazen & Serpil C. Erzurum. (2007) Signal transduction and oxidative processes in sinonasal polyposis. Journal of Allergy and Clinical Immunology 120:6, pages 1346-1353.
Crossref
N. Kubo & K. Yoshinaga. (2007) Physiological and pathological significance of nitric oxide and carbon monoxide in exhalation and their origin. Clinical & Experimental Allergy Reviews 7:1, pages 27-31.
Crossref
S. M. Ragab, V. J. Lund, H. A. Saleh & G. Scadding. (2006) Nasal nitric oxide in objective evaluation of chronic rhinosinusitis therapy. Allergy 61:6, pages 717-724.
Crossref
Bruno Mahut, Estelle Escudier, Jacques de Blic, Françoise Zerah-Lancner, André Coste, Alain Harf & Christophe Delclaux. (2006) Impairment of Nitric Oxide Output of Conducting Airways in Primary Ciliary Dyskinesia. Pediatric Pulmonology 41:2, pages 158-163.
Crossref
Eun‐ju Jeon, Yong‐Soo Park, Seung Kyun Lee, Sang‐Won Yeo, Shi Nae Park & Ki‐Hong Chang. (2016) Effect of Nitric Oxide and Peroxynitrite on Mucociliary Transport Function of Experimental Otitis Media. Otolaryngology–Head and Neck Surgery 134:1, pages 126-131.
Crossref
V. M. D. Struben, M. H. Wieringa, C. J. Mantingh, S. M. Bruinsma, J. C. de Jongste & L. Feenstra. (2005) Silent and humming nasal NO measurements in adults aged 18-70 years. European Journal of Clinical Investigation 35:10, pages 653-657.
Crossref
. (2005) ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005. American Journal of Respiratory and Critical Care Medicine 171:8, pages 912-930.
Crossref
Irena Gertsberg, Vardit Hellman, Michal Fainshtein, Simy Weil, Shai D. Silberberg, Michael Danilenko & Zvi Priel. (2004) Intracellular Ca2+ Regulates the Phosphorylation and the Dephosphorylation of Ciliary Proteins Via the NO Pathway. The Journal of General Physiology 124:5, pages 527-540.
Crossref
J??rgen Alberty, Christian August, Wolfgang Stoll & Claudia Rudack. (2004) The Effect of Endogenous Nitric Oxide on Cholinergic Ciliary Stimulation of Human Nasal Mucosa. The Laryngoscope 114:9, pages 1642-1647.
Crossref
Jamie L. Wooldridge, Gail H. Deutsch, Marci K. Sontag, Iris Osberg, Daniel R. Chase, Philip E. Silkoff, Jeffery S. Wagener, Steven H. Abman & Frank J. Accurso. (2004) NO pathway in CF and non‐CF children. Pediatric Pulmonology 37:4, pages 338-350.
Crossref
Celil Uslu, R.Murat Karasen, Fikrettin Sahin, Seyithan Taysi & Fatih Akcay. (2003) Effects of aqueous extracts of Satureja hortensis L. on rhinosinusitis treatment in rabbit. Journal of Ethnopharmacology 88:2-3, pages 225-228.
Crossref
Xinhua Zhan, Dechun Li & Roger A. Johns. (2016) Expression of Endothelial Nitric Oxide Synthase in Ciliated Epithelia of Rats. Journal of Histochemistry & Cytochemistry 51:1, pages 81-87.
Crossref
BO Paulsson, Sven Lindberg & Per Ohlin. (2016) Washout of 133-Xenon as an Objective Assessment of Paranasal Sinus Ventilation in Endoscopic Sinus Surgery. Annals of Otology, Rhinology & Laryngology 111:8, pages 710-717.
Crossref
Anders Cervin, Olof Kalm, Per Sandkull & Sven Lindberg. (2016) One‐Year Low‐Dose Erythromycin Treatment of Persistent Chronic Sinusitis after Sinus Surgery: Clinical Outcome and Effects on Mucociliary Parameters and Nasal Nitric Oxide. Otolaryngology–Head and Neck Surgery 126:5, pages 481-489.
Crossref
Wei Qian, Reni Sabo, Mikael Ohm, James S. J. Haight & Ron S. Fenton. (2009) Nasal Nitric Oxide and the Nasal Cycle. The Laryngoscope 111:9, pages 1603-1607.
Crossref
Jeong-Whun Kim, Yang-Gi Min, Chae-Seo Rhee, Chul-Hee Lee, Young Yull Koh, Chan Rhyoo, Tae-Young Kwon & Seok-Won Park. (2001) Regulation of Mucociliary Motility by Nitric Oxide and Expression of Nitric Oxide Synthase in the Human Sinus Epithelial Cells. The Laryngoscope 111:2, pages 246-250.
Crossref
Per G. Djupesland, Jose M. Chatkin, W. Qian & James S.J. Haight. (2001) Nitric oxide in the nasal airway: A new dimension in otorhinolaryngology. American Journal of Otolaryngology 22:1, pages 19-32.
Crossref
HITOSHI NAKANO, HIROSHI IDE, MASANOBU IMADA, SHINOBU OSANAI, TORU TAKAHASHI, KENJIROU KIKUCHI & JUN IWAMOTO. (2000) Reduced Nasal Nitric Oxide in Diffuse Panbronchiolitis. American Journal of Respiratory and Critical Care Medicine 162:6, pages 2218-2220.
Crossref
Rodney J. Schlosser, William D. Spotnitz, Edward J. Peters, Kezhong FangBenjamin GastonCharles W. Gross. (2016) Third Place—Resident Basic Science Award 1999 Elevated Nitric Oxide Metabolite Levels in Chronic Sinusitis. Otolaryngology–Head and Neck Surgery 123:4, pages 357-362.
Crossref
P.J. Conboy & N.S. Jones. (2000) The nose and nitric oxide: a review. Clinical Otolaryngology and Allied Sciences 25:5, pages 337-341.
Crossref
Dechun Li, Gotaro Shirakami, Xinhua Zhan & Roger A. Johns. (2000) Regulation of Ciliary Beat Frequency by the Nitric Oxide–Cyclic Guanosine Monophosphate Signaling Pathway in Rat Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 23:2, pages 175-181.
Crossref
JOSÉ MIGUEL CHATKIN, PER DJUPESLAND, WEI QIAN, JAMES HAIGHT & NOE ZAMEL. (2000) Óxido nítrico exalado no diagnóstico e acompanhamento das doenças respiratórias. Jornal de Pneumologia 26:1, pages 36-43.
Crossref
J. TAMAOKI, M. TAIRA, K. NISHIMURA, J. NAKATA & A. NAGAI. (2000) Impairment of Airway Mucociliary Transport in Patients with Sinobronchial Syndrome: Role of Nitric Oxide. Journal of Aerosol Medicine 13:3, pages 239-244.
Crossref
Eddie Weitzberg & Jon Lundberg. 2000. Nitric Oxide. Nitric Oxide 947 961 .
Kjell Alving, Jon O. N. Lundberg, Johan Rinder & Eddie Weitzberg. 2000. Nitric Oxide in Pulmonary Processes: Role in Physiology and Pathophysiology of Lung Disease. Nitric Oxide in Pulmonary Processes: Role in Physiology and Pathophysiology of Lung Disease 185 199 .
. (1999) Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children—1999. American Journal of Respiratory and Critical Care Medicine 160:6, pages 2104-2117.
Crossref
Xinhua Zhan, Dechun Li & Roger A. Johns. (2016) Immunohistochemical Evidence for the NO cGMP Signaling Pathway In Respiratory Ciliated Epithelia of Rat. Journal of Histochemistry & Cytochemistry 47:11, pages 1369-1374.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.