65
Views
86
CrossRef citations to date
0
Altmetric
Original Article

Inner ear concentrations and ototoxicity of different antibiotics in local and systemic application

, , , &
Pages 350-363 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (16)

Joshua G Yorgason, William Luxford & Federico Kalinec. (2011) In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem. Expert Opinion on Drug Metabolism & Toxicology 7:12, pages 1521-1534.
Read now
Joshua G Yorgason, Jose N Fayad & Federico Kalinec. (2006) Understanding drug ototoxicity: molecular insights for prevention and clinical management. Expert Opinion on Drug Safety 5:3, pages 383-399.
Read now
J. Davidson, G. Wright, L. McIlmoyl, R. J. Canter & H. O. Barber. (1988) The reproducibility of caloric tests of vestibular function in young and old subjects. Acta Oto-Laryngologica 106:3-4, pages 264-268.
Read now
Hideo Yamane, Yoshiaki Nakai & Kazuo Konishi. (1988) Furosemide-induced Alteration of Drug Pathway to Cochlea. Acta Oto-Laryngologica 105:sup447, pages 28-35.
Read now
S. Bjurström, N. Slepecky & C. Angelborg. (1987) A Histopathological Study of the Inner Ear after the Administration of Hyaluronan into the Middle Ear of the Guinea Pig. Acta Oto-Laryngologica 104:sup442, pages 62-65.
Read now
Ö. Tjernström, T. Denneberg, S. Harris, L. Nordström & N. G. Toremalm. (1982) Ototoxicity of Netilmicin. Acta Oto-Laryngologica 94:1-6, pages 421-429.
Read now
Teruzo Konishi & Philip E. Hamrick. (1979) The Uptake of Methyl Mercury in Guinea Pig Cochlea in Relation to its Ototoxic Effect. Acta Oto-Laryngologica 88:1-6, pages 203-210.
Read now
Teruzo Konishi. (1979) Effects of Local Application of Ototoxic Antibiotics on Cochlear Potentials in Guinea Pigs. Acta Oto-Laryngologica 88:1-6, pages 41-46.
Read now
M. Anniko & A. R. Møller. (1978) A Physiological and Morphological Study of the Cochlea of the Rat Following Treatment with Atoxyl and Neomycin. Acta Oto-Laryngologica 86:1-6, pages 201-211.
Read now
W. Wicke, B. Welleschik, W. Firbas & H. Sinzinger. (1978) Zur Streptomycinschädigung Des Ganglion Spirale. Acta Oto-Laryngologica 85:1-6, pages 360-362.
Read now
M. Anniko & L. Sarkady. (1978) Cochlear Pathology Following Exposure To Mercury. Acta Oto-Laryngologica 85:1-6, pages 213-224.
Read now
M. Anniko & L. Sarkady. (1978) Cochlear Pathology Following Exposure to Mercury. Acta Oto-Laryngologica 85:3-4, pages 213-224.
Read now
Lars Herngren, Lars O. Boréaus, Birgitta Jalling & Rutger Lagercrantz. (1977) Pharmacokinetic Aspects of Streptomycin Treatment of Neonatal Septicemia. Scandinavian Journal of Infectious Diseases 9:4, pages 301-308.
Read now
T. Morizono & B. M. Johnstone. (1975) Ototoxicity Of Topically Applied Gentamicin Using A Statistical Analysis Of Electrophysiological Measurement. Acta Oto-Laryngologica 80:1-6, pages 389-393.
Read now

Articles from other publishers (70)

Britt ten Wolde, Frits J.H. van den Wildenberg, Fatih Polat, Johannes H.W. de Wilt & Luc J.A. Strobbe. (2018) Can Gentamicin-collagen Sponges Prevent Seroma Formation Following Mastectomy?. Clinical Breast Cancer 18:5, pages e1023-e1026.
Crossref
Susanna Esposito, Maria Paola Canevini & Nicola Principi. (2017) Complications associated with antibiotic administration: neurological adverse events and interference with antiepileptic drugs. International Journal of Antimicrobial Agents 50:1, pages 1-8.
Crossref
Bradley J. Walters & Jian Zuo. (2015) A Sox10rtTA/+ Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear. Journal of the Association for Research in Otolaryngology 16:3, pages 331-345.
Crossref
Alan M. Robinson, Irena Vujanovic & Claus-Peter Richter. (2015) Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils. BioMed Research International 2015, pages 1-8.
Crossref
Brandon C. Cox, Jennifer A. Dearman, Joseph Brancheck, Frederique Zindy, Martine F. Roussel & Jian Zuo. (2014) Generation of Atoh1-rtTA transgenic mice: a tool for inducible gene expression in hair cells of the inner ear. Scientific Reports 4:1.
Crossref
Avik Banerjee & Lorne S. Parnes. (2004) The biology of intratympanic drug administration and pharmacodynamics of round window drug absorption. Otolaryngologic Clinics of North America 37:5, pages 1035-1051.
Crossref
Peter S. Roland, Leonard Rybak, Maureen Hannley, Greg Matz, Michael G. Stewart, Spiros Manolidis, Rick Friedman, Peter Weber & Fred Owens. (2016) Animal Ototoxicity of Topical Antibiotics and the Relevance to Clinical Treatment of Human Subjects. Otolaryngology–Head and Neck Surgery 130:S3.
Crossref
Kai Ming Chow, Cheuk Chun Szeto, Andrew Che-Fai Hui & Philip Kam-Tao Li. (2004) Mechanisms of antibiotic neurotoxicity in renal failure. International Journal of Antimicrobial Agents 23:3, pages 213-217.
Crossref
Zoran Becvarovski, Dennis I. Bojrab, Elias M. Michaelides, Jack M. Kartush, John J. Zappia & Michael J. LaRouere. (2002) Round Window Gentamicin Absorption: An In Vivo Human Model. The Laryngoscope 112:9, pages 1610-1613.
Crossref
R. Dauman & D. Dulon. (2000) Ototoxicidad medicamentosa. EMC - Otorrinolaringología 29:1, pages 1-12.
Crossref
A. SERRA, D. L. GRASSO, S. COCUZZA, L. TROMBETTA & I. LA MANTIA. (2006) Normal and Altered Cytoarchitecture of the Inner Ear. Annals of the New York Academy of Sciences 884:1, pages 69-84.
Crossref
Eric D. Bizjak, Marcus T. HaugIIIIII, Robert J. Schilz, Bipin D. Sarodia & Janna M. Dresing. (2012) Intravenous Azithromycin‐Induced Ototoxicity. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 19:2, pages 245-248.
Crossref
Cuneyt M. Alper, Margaretha L. Casselbrant, Joseph E. Dohar, Elizabeth A. McI. Rose, Margaret A. Kenna, William J. Doyle & Charles D. Bluestone. (2016) Treatment of Chronic Suppurative Otitis Media with Topical Ciprofloxacin. Annals of Otology, Rhinology & Laryngology 107:10, pages 865-871.
Crossref
Brendan J. Conlon, S. David McSwain & David W. Smith. (1998) Topical gentamicin and ethacrynic acid: Effects on cochlear function. The Laryngoscope 108:7, pages 1087-1089.
Crossref
Toshimitsu Kobayashi, Daniel C. Marcus, You Rong, Kenji Ohyama, Toshihiko Chiba & Tomonori Takasaka. (2016) Ototoxic Effect of Erythromycin on Cochlear Potentials in the Guinea Pig. Annals of Otology, Rhinology & Laryngology 106:7, pages 599-603.
Crossref
J. Lance Pickard, Jeffrey O. Phillips, Stephen H. Weinstein & Walter R. Holloway. (1995) Adult urology. Urology 45:6, pages 1042-1045.
Crossref
Desouky F. Fayed & Nabil S. Dahmash. (2016) Erythromycin-Induced Ototoxicity: Case Report. Journal of Pharmacy Technology 10:4, pages 169-171.
Crossref
William J. Richtsmeier & Peter S. Roland. (2016) Clinical Ototoxicity of Topical Antibiotic Drops. Otolaryngology–Head and Neck Surgery 110:6, pages 598-602.
Crossref
P. M. J. SCOTT & M. V. GRIFFITHS. (1994) A CLINICAL REVIEW OF OTOTOXICITY. Clinical Otolaryngology 19:1, pages 3-8.
Crossref
Antonio Moral, Miguel Navasa, Antonio Rimola, Juan Carlos García-Valdecasas, Luis Grande, Josep Visa & Joan Rodés. (1994) Erythromycin ototoxicity in liver transplant patients. Transplant International 7:1, pages 62-64.
Crossref
G. Peytavin, B. Baune, A. Fichelle, R. Farinotti, S. Calvat & B. Regnier. (1994) Étude du passage systémique de l'érythromycine base lors de la décontamination digestive sélective en réanimation. Réanimation Urgences 3:3, pages 249-254.
Crossref
Robert E. Brummett. (1993) Ototoxic Liability of Erythromycin and Analogues. Otolaryngologic Clinics of North America 26:5, pages 811-819.
Crossref
Gregory N. Rohn, William L. Meyerhoff & Charles G. Wright. (1993) Ototoxicity of Topical Agents. Otolaryngologic Clinics of North America 26:5, pages 747-758.
Crossref
José A. Sacristán, Javier A. Soto & María A. de Cos. (2016) Erythromycin-Induced Hypoacusis: 11 New Cases and Literature Review. Annals of Pharmacotherapy 27:7-8, pages 950-955.
Crossref
F. J. AL-Saffar, K. J. Balash & A. K. AL-Shaikhly. (1992) OTOTOXICITY OF STREPTOMYCIN AND GENTAMICIN IN IRAQI RAMS. The Iraqi Journal of Veterinary Medicine 16:1, pages 1-11.
Crossref
A. J. DuvallIIIIII, K. S. Robinson & S. J. Feist. (1991) Cochlear permeability of neomycin and gentamicin: an immunohistochemical study. European Archives of Oto-Rhino-Laryngology 248:6, pages 319-325.
Crossref
Sharon M. Stiefeld, Amy L. Graziani, Rob Roy MacGregor & John L. EsterhaiJrJr. (1991) Toxicities of Antimicrobial Agents Used to Treat Osteomyelitis. Orthopedic Clinics of North America 22:3, pages 439-465.
Crossref
A R BeaubienE OrmsbyA BayneK CarrierG CrossfieldM DownesR HenriM Hodgen. (1991) Evidence that amikacin ototoxicity is related to total perilymph area under the concentration-time curve regardless of concentration. Antimicrobial Agents and Chemotherapy 35:6, pages 1070-1074.
Crossref
D. Mulherin, J. Fahy, W. Grant, Mary Keogan, B. Kavanagh & M. FitzGerald. (1991) Aminoglycoside induced ototoxicity in patients with cystic fibrosis. Irish Journal of Medical Science 160:6, pages 173-175.
Crossref
May Y. Huang & Jochen Schacht. (2012) Drug-Induced Ototoxicity. Medical Toxicology and Adverse Drug Experience 4:6, pages 452-467.
Crossref
R E BrummettK E Fox. (1989) Vancomycin- and erythromycin-induced hearing loss in humans. Antimicrobial Agents and Chemotherapy 33:6, pages 791-796.
Crossref
Leonard R. Proctor & Yehia El-Kashef. (1989) The use of streptomycin to induce unilateral ablation of vestibular function in the rat: A preliminary report. American Journal of Otolaryngology 10:3, pages 188-197.
Crossref
Odd Spandow, Matti Anniko & Aage R. Møller. (1988) The round window as access route for agents injurious to the inner ear. American Journal of Otolaryngology 9:6, pages 327-335.
Crossref
D. Tettenborn. 1988. Antituberculosis Drugs. Antituberculosis Drugs 307 398 .
M. W. Yung. (2007) Intratympanic ototoxicity: influence of post-injection survival period. The Journal of Laryngology & Otology 101:10, pages 1011-1019.
Crossref
. (2017) Drug Information Analysis Service. Drug Intelligence & Clinical Pharmacy 20:10, pages 762-766.
Crossref
Takehiko Harada, Yoshitaka Nagai, Masao Iwamori & Yasuya Nomura. (2016) Ototoxicity of Neomycin and its Penetration through the round Window Membrane into the Perilymph. Annals of Otology, Rhinology & Laryngology 95:4, pages 404-408.
Crossref
D Dulon, J M Aran, G Zajic & J Schacht. (1986) Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Antimicrobial Agents and Chemotherapy 30:1, pages 96-100.
Crossref
David J. Lim. (1986) Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review. American Journal of Otolaryngology 7:2, pages 73-99.
Crossref
Richard L. Wynn. (1985) Gentamycin for prophylaxis of bacterial endocarditis: A review for the dentist. Oral Surgery, Oral Medicine, Oral Pathology 60:2, pages 159-165.
Crossref
S Desjardins-Giasson, A R Beaubien & M J Cauchy. (1985) Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs. Antimicrobial Agents and Chemotherapy 27:5, pages 720-723.
Crossref
R.K. Shepherd & G.M. Clark. (1985) Progressive ototoxicity of neomycin monitored using derived brainstem response audiometry. Hearing Research 18:2, pages 105-110.
Crossref
Richard C. Haydon, James W. Thelin & William E. Davis. (1984) Erythromycin Ototoxicity: Analysis and Conclusions Based on 22 Case Reports. Otolaryngology–Head and Neck Surgery 92:6, pages 678-684.
Crossref
S Desjardins-Giasson & A R Beaubien. (1984) Correlation of amikacin concentrations in perilymph and plasma of continuously infused guinea pigs. Antimicrobial Agents and Chemotherapy 26:1, pages 87-90.
Crossref
Jean Philipppe Mery & Alain Kanfer. (1984) To The Editor. American Journal of Kidney Diseases 4:1, pages 95.
Crossref
E. Lehnhardt. 1984. Verhandlungsbericht 1984 der Deutschen Gesellschaft für Hals- Nasen- Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Verhandlungsbericht 1984 der Deutschen Gesellschaft für Hals- Nasen- Ohren-Heilkunde, Kopf- und Hals-Chirurgie 58 218 .
Yehoash Raphael, Amos Fein & Laslo Nebel. (1983) Transplacental kanamycin ototoxicity in the guinea pigTransplazentare Kanamyzinototoxizit�t beim Meerschweinchen. Archives of Oto-Rhino-Laryngology 238:1, pages 45-51.
Crossref
Cesar D. Fermin & Makoto Igarashi. (1983) Aminoglycoside ototoxicity in the chick (Gallus domesticus) inner ear. American Journal of Otolaryngology 4:3, pages 174-183.
Crossref
Eric J. Lien, Lawrence R. Lipsett & Linda L. Lien. (1983) STRUCTURE SIDE-EFFECT SORTING OF DRUGS VI. OTOTOXICITIES. Journal of Clinical Pharmacy and Therapeutics 8:1, pages 15-33.
Crossref
R. M. Gabrielson & Martin J. Jinks. (2016) Colistin and Ototoxicity. Drug Intelligence & Clinical Pharmacy 17:1, pages 48-48.
Crossref
J.B. Vermorken, T.S. Kapteijn, A.A.M. Hart & H.M. Pinedo. (1983) Ototoxicity of cis-diamminedichloroplatinum (II): Influence of dose, schedule and mode of administration. European Journal of Cancer and Clinical Oncology 19:1, pages 53-58.
Crossref
M Chung, L Parravicini, B M Assael, G Cavanna, E Radwanski & S Symchowicz. (1982) Comparative pharmacokinetics of aminoglycoside antibiotics in guinea pigs. Antimicrobial Agents and Chemotherapy 22:6, pages 1017-1021.
Crossref
Janie C. Park & Glenn M. Cohen. (1982) Vestibular ototoxicity in the chick. American Journal of Otolaryngology 3:2, pages 117-127.
Crossref
Gary C. Yee & William E. Evans. (2012) Reappraisal of Guidelines for Pharmacokinetic Monitoring of Aminoglycosides. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 1:1, pages 55-75.
Crossref
John W. Coleman, Joseph F. Artusio, Frank Yao, John H. McGovern & Susan R. Jalandoni. (1981) Neomycin-induced neuromuscular blockade. Urology 17:3, pages 265-267.
Crossref
R. Matthias & M. Handrock. (1980) Zur Wirkung ototoxischer Substanzen bei intratympanaler ApplikationThe effect of intratympanic application of ototoxic substances. Archives of Oto-Rhino-Laryngology 227:3-4, pages 417-420.
Crossref
Pamela S. Huber, Irwin A. Ginsberg & Michael D. Rudnick. (2016) IV. Influence of Vestibular Stimulation. Annals of Otology, Rhinology & Laryngology 89:6_suppl3, pages 25-28.
Crossref
Irwin A. Ginsberg, Michael D. Rudnick & Pamela S. Huber. (2016) III. Comparative Quantitative Analysis. Annals of Otology, Rhinology & Laryngology 89:6_suppl3, pages 17-24.
Crossref
Tetsuo Morizono, Michael M. Paparella & Steven K. Juhn. (1980) Ototoxicity of propylene glycol in experimental animals. American Journal of Otolaryngology 1:5, pages 393-399.
Crossref
Willard E. FeeJR.JR.. (1980) AMINOGLYCOSIDE OTOTOXICITY IN THE HUMAN. The Laryngoscope 90:S24, pages 1-19.
Crossref
Bruce M. Smith & Martin G. Myers. (2016) The Penetration of Gentamicin and Neomycin into Perilymph Across the Round Window Membrane. Otolaryngology–Head and Neck Surgery 87:6, pages 888-891.
Crossref
. (1979) Ototoxic Drugs and the Detection of Ototoxicity. New England Journal of Medicine 301:4, pages 213-214.
Crossref
Terry L. Fry, Benjamin Chen, Newton D. Fischer & Scott Y. Pharr. (2009) Evaluation of otic drops on infection and healing of traumatic tympanic membrane perforations. The Laryngoscope 89:5, pages 818-821.
Crossref
Robert E. Brummett, Robert F. Harris & John A. Lindgren. (2009) Detection of ototoxicity from drugs applied topically to the middle ear space. The Laryngoscope 86:8, pages 1177-1187.
Crossref
. (1976) EAR-DROPS. The Lancet 307:7965, pages 896.
Crossref
. (1976) A.D.A. DEFICIENCY. The Lancet 307:7965, pages 895-896.
Crossref
E. de Boer, W. K. Connor, H. Davis, J. J. Eggermont, R. Galambos, C. D. Geisler, G. M. Gerken, H. E. von Gierke, C. S. Hallpike, E. HawkinsJr.Jr., S. A. Hillyard, W. D. Keidel, D. E. Parker, T. W. Picton, W. Rudmose, F. B. Simmons, G. Stange, C. R. Steele, J. Tonndorf, M. E. Wigand & F. ZöllnerJ. E. HawkinsJr.Jr.. 1976. Auditory System. Auditory System 707 748 .
V. Kepenis, N. Yuda, G. Gordon, H.F. Diermeier & B.M. Sparano. (1975) Assessment of ototoxic potential of minocycline in guinea pigs. Toxicology and Applied Pharmacology 34:2, pages 327-339.
Crossref
E. S. Harpur & P. F. D'Arcy. (1975) The influence of pigmentation of rats and guinea-pigs on the ototoxicity of kanamycin and neomycin. Experientia 31:11, pages 1323-1325.
Crossref
Tetsuo Morizono & Brian M. Johnstone. (2019) OTOTOXICITY OF CHLORAMPHENICOL EAR DROPS WITH PROPYLENE GLYCOL AS SOLVENT. Medical Journal of Australia 2:16, pages 634-638.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.