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Original Article

Ototoxic mechanisms: A Working Hypothesis

Pages 383-393 | Published online: 07 Jul 2009

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Read on this site (11)

Mario Pellegatti & Sabrina Pagliarusco. (2011) Drug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review. Expert Opinion on Drug Metabolism & Toxicology 7:2, pages 137-146.
Read now
Elisa Corbacella, Irene Lanzoni, Lucia Bertolaso, Stavros Hatzopoulos, Maurizio Previati & Alessandro Martini. (2006) Protective effects of minocycline and MDL 28170 in gentamicin ototoxicity. Audiological Medicine 4:3, pages 134-143.
Read now
Graziella Soulban, Michael H. Smolensky & Allan Yonovitz. (1990) Gentamicin-Induced Chronotoxicity: Use of Body Temperature as a Orcadian Marker Rhythm. Chronobiology International 7:5-6, pages 393-402.
Read now
J. P. Griffin. (1988) Drug-induced ototoxicity. British Journal of Audiology 22:3, pages 195-210.
Read now
M. Sakagami, M. Sano, T. Harada, T. Kubo, T. Matsunaga & S. Sakai. (1986) Morphological Study of Blood-Labyrinth Barrier in the Vestibular Organs under Normal and Experimental Acute Hypertensive and Acute Hypotensive Conditions. Acta Oto-Laryngologica 101:3-4, pages 165-171.
Read now
Kennet R. Henry, Michael B. Guess & Richard A. Chole. (1983) Hyperthermia Increases Aminoglycoside Ototoxicity. Acta Oto-Laryngologica 95:1-4, pages 323-327.
Read now
Ernest S. Harpur & Igor Gonda. (1982) Analysis of the Phamacokinetics of Ribostamycin in Serum and Perilymph of Guinea Pigs after Single and Multiple Doses. British Journal of Audiology 16:2, pages 95-99.
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Ernest S. Harpur. (1982) The Pharmacology of Ototoxic Drugs. British Journal of Audiology 16:2, pages 81-93.
Read now
K. Rejtö L. Pálfalvi & V. Komora. (1982) Pure-Tone and Speech Intelligibility Disturbances in Patients with Ototoxic Disorders. Audiology 21:2, pages 159-176.
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G. Dumas & R. Charachon. (1982) Ototoxicity of Kanamycin in Developing Guinea Pigs. Acta Oto-Laryngologica 94:1-6, pages 203-212.
Read now
S. K. Juhn & L. P. Rybak. (1981) Labyrinthine Barriers and Cochlear Homeostasis. Acta Oto-Laryngologica 91:1-6, pages 529-534.
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Articles from other publishers (43)

Jinkyung Kim, Sriram Hemachandran, Alan G. Cheng & Anthony J. Ricci. (2022) Identifying targets to prevent aminoglycoside ototoxicity. Molecular and Cellular Neuroscience 120, pages 103722.
Crossref
Leonard P. Rybak, Debashree Mukherjea & Vickram Ramkumar. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 732 754 .
Junhao Wu, Jing Ye, Weili Kong, Shouyue Zhang & Yun Zheng. (2020) Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis. Cell Proliferation 53:11.
Crossref
Mi-Jin Choi, Hyunsook Kang, Yun Yeong Lee, Oak-Sung Choo, Jeong Hun Jang, Sung-Hee Park, Jong-Seok Moon, Seong Jun Choi & Yun-Hoon Choung. (2019) Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis. Cells 8:5, pages 409.
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Mary E. O’Sullivan, Adela Perez, Randy Lin, Autefeh Sajjadi, Anthony J. Ricci & Alan G. Cheng. (2017) Towards the Prevention of Aminoglycoside-Related Hearing Loss. Frontiers in Cellular Neuroscience 11.
Crossref
William McKinney, Al Yonovitz & Michael H. Smolensky. (2015) Circadian variation of gentamicin toxicity in rats. The Laryngoscope 125:7, pages E252-E256.
Crossref
Leonard P. Rybak & Michael J. Brenner. 2015. Free Radicals in ENT Pathology. Free Radicals in ENT Pathology 195 216 .
Jochen Schacht & Michael G. Leitner. 2014. In Vitro Toxicology Systems. In Vitro Toxicology Systems 199 222 .
Jochen Schacht, Andra E. Talaska & Leonard P. Rybak. (2012) Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 295:11, pages 1837-1850.
Crossref
Jing Xie, Andra E. Talaska & Jochen Schacht. (2011) New developments in aminoglycoside therapy and ototoxicity. Hearing Research 281:1-2, pages 28-37.
Crossref
Leonard P. Rybak. 2010. Cummings Otolaryngology - Head and Neck Surgery. Cummings Otolaryngology - Head and Neck Surgery 2169 2178 .
Leonard P. Rybak, Andra E. Talaska & Jochen Schacht. 2008. Auditory Trauma, Protection, and Repair. Auditory Trauma, Protection, and Repair 219 256 .
Takeshi Kusunoki, Sebahattin Cureoglu, Patricia A. Schachern, Kazuyasu Baba, Shin Kariya & Michael M. Paparella. (2016) Age‐Related Histopathologic Changes in the Human Cochlea: A Temporal Bone Study. Otolaryngology–Head and Neck Surgery 131:6, pages 897-903.
Crossref
Anita Gáborján, György Halmos, Gábor Répássy & E. Sylvester Vizi. (2001) A new aspect of aminoglycoside ototoxicity: impairment of cochlear dopamine release. Neuroreport 12:15, pages 3327-3330.
Crossref
Zhi-Jian Zhang, Takehisa Saito, Yuichi Kimura, Chizuru Sugimoto, Toshio Ohtsubo & Hitoshi Saito. (2000) Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood–inner ear barrier in mice. Brain Research 852:1, pages 116-126.
Crossref
A. SERRA, D. L. GRASSO, S. COCUZZA, L. TROMBETTA & I. LA MANTIA. (2006) Normal and Altered Cytoarchitecture of the Inner Ear. Annals of the New York Academy of Sciences 884:1, pages 69-84.
Crossref
Mitsuya Suzuki, Tatsuya Yamasoba & Kimitaka Kaga. (1998) Development of the blood-labyrinth barrier in the rat. Hearing Research 116:1-2, pages 107-112.
Crossref
Takehisa Saito, Zhi Jian Zhang, Hideaki Tsuzuki, Toshio Ohtsubo, Takechiyo Yamada, Takehito Yamamoto & Hitoshi Saito. (1997) Expression of P-glycoprotein in inner ear capillary endothelial cells of the guinea pig with special reference to blood–inner ear barrier. Brain Research 767:2, pages 388-392.
Crossref
Tatsuya Yamasoba, Mitsuya Suzuki & Kimitaka Kaga. (1996) Influence of chronic kanamycin administration on basement membrane anionic sites in the labyrinth. Hearing Research 102:1-2, pages 116-124.
Crossref
Susan L. Garetz & Jochen Schacht. 1996. Clinical Aspects of Hearing. Clinical Aspects of Hearing 116 154 .
D. Mulherin, J. Fahy, W. Grant, Mary Keogan, B. Kavanagh & M. FitzGerald. (1991) Aminoglycoside induced ototoxicity in patients with cystic fibrosis. Irish Journal of Medical Science 160:6, pages 173-175.
Crossref
Gregory J. Matz. (2016) Clinical Perspectives on Ototoxic Drugs. Annals of Otology, Rhinology & Laryngology 99:6_suppl, pages 39-41.
Crossref
Ernest M. WalkerJr.Jr., Mary A. Fazekas-May & William R. Bowen. (1990) Nephrotoxic and Ototoxic Agents. Clinics in Laboratory Medicine 10:2, pages 323-354.
Crossref
J. Syka. 1989. Progress in Sensory Physiology 9. Progress in Sensory Physiology 9 97 170 .
E.S. Harpur. 1988. Perspectives in Basic and Applied Toxicology. Perspectives in Basic and Applied Toxicology 42 69 .
D. Tettenborn. 1988. Antituberculosis Drugs. Antituberculosis Drugs 307 398 .
A. Forge, A. Wright & S.J. Davies. (1987) Analysis of structural changes in the stria vascularis following chronic gentamicin treatment. Hearing Research 31:3, pages 253-265.
Crossref
Andrew Forge & Milo Fradis. (1985) Structural abnormalities in the stria vascularis following chronic gentamicin treatment. Hearing Research 20:3, pages 233-244.
Crossref
Eric J. Lien, Lawrence R. Lipsett & Linda L. Lien. (1983) STRUCTURE SIDE-EFFECT SORTING OF DRUGS VI. OTOTOXICITIES. Journal of Clinical Pharmacy and Therapeutics 8:1, pages 15-33.
Crossref
KENNETH R. HENRY. 1983. Development of Auditory and Vestibular Systems. Development of Auditory and Vestibular Systems 273 308 .
R. A. Tange, E. A. J. G. Conijn, L. G. P. M. Zeijl & E. H. Huizing. (1982) Pattern of gentamicin-induced cochlear degeneration in the guinea pigDurch Gentamyzin verursachte Degeneration in der Schnecke des Meerschweinchens. Archives of Oto-Rhino-Laryngology 236:2, pages 173-184.
Crossref
Janie C. Park & Glenn M. Cohen. (1982) Vestibular ototoxicity in the chick. American Journal of Otolaryngology 3:2, pages 117-127.
Crossref
Pamela S. Huber, Irwin A. Ginsberg & Michael D. Rudnick. (2016) IV. Influence of Vestibular Stimulation. Annals of Otology, Rhinology & Laryngology 89:6_suppl3, pages 25-28.
Crossref
Irwin A. Ginsberg, Michael D. Rudnick & Pamela S. Huber. (2016) III. Comparative Quantitative Analysis. Annals of Otology, Rhinology & Laryngology 89:6_suppl3, pages 17-24.
Crossref
Michael D. Rudnick, Irwin A. Ginsberg & Pamela S. Huber. (2016) I. Experimental Approach and Histological Criteria for Evaluating Drug Effects. Annals of Otology, Rhinology & Laryngology 89:6_suppl3, pages 1-9.
Crossref
Willard E. FeeJR.JR.. (1980) AMINOGLYCOSIDE OTOTOXICITY IN THE HUMAN. The Laryngoscope 90:S24, pages 1-19.
Crossref
E. S. Harpur & J. B. Bridges. (2007) An evaluation of the use of scanning and transmission electronmicroscopy in a study of the gentamicin-damaged guinea-pig organ of Corti. The Journal of Laryngology & Otology 93:1, pages 7-23.
Crossref
Conrad Proctor. (1977) Diagnosis, prevention and treatment of hereditary sensorineural hearing loss. The Laryngoscope 87:S7, pages 1-60.
Crossref
Alf Axelsson. (1977) Histology of the cochlear vessels in the guinea pig. Archives of Oto-Rhino-Laryngology 217:3, pages 313-319.
Crossref
E. S. Harpur & P. F. D'Arcy. (1976) Comparison of the ototoxic effect of kanamycin on albino and pigmented rats, studied using an operant method. Experientia 32:12, pages 1562-1564.
Crossref
James G. McCormick & Alfred L. Nuttall. 1976. The Biology of the Guinea Pig. The Biology of the Guinea Pig 281 303 .
E. de Boer, W. K. Connor, H. Davis, J. J. Eggermont, R. Galambos, C. D. Geisler, G. M. Gerken, H. E. von Gierke, C. S. Hallpike, E. HawkinsJr.Jr., S. A. Hillyard, W. D. Keidel, D. E. Parker, T. W. Picton, W. Rudmose, F. B. Simmons, G. Stange, C. R. Steele, J. Tonndorf, M. E. Wigand & F. ZöllnerJ. E. HawkinsJr.Jr.. 1976. Auditory System. Auditory System 707 748 .
E. S. Harpur & P. F. D'Arcy. (1975) The influence of pigmentation of rats and guinea-pigs on the ototoxicity of kanamycin and neomycin. Experientia 31:11, pages 1323-1325.
Crossref

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