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International Journal of Neuroscience Volume 120, 2010 - Issue 4
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Research Article

Celastrol Suppresses Morphological and Transcriptional Responses in Microglial Cells Upon Stimulation with Double-Stranded RNA

Kazuo NakamichiLaboratory of Neurovirology, Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo, JapanCorrespondence[email protected]
,
Hiroshi KitaniTransgenic Animal Research Center, National Institute of Agrobiological Sciences, Ibaraki, Japan
,
Mutsuyo Takayama-ItoLaboratory of Neurovirology, Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
,
Kinjiro MorimotoFaculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan
,
Ichiro KuraneLaboratory of Neurovirology, Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
&
Masayuki SaijoLaboratory of Neurovirology, Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
Pages 252-257 | Received 16 Nov 2009, Published online: 08 Apr 2010

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Mahmoud Youns, Momen Askoura, Hisham A Abbas, Gouda H Attia, Ahdab N Khayyat, Reham M Goda, Ahmad J Almalki, El-Sayed Khafagy & Wael A H Hegazy. (2021) Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation. OncoTargets and Therapy 14, pages 3849-3860.
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Dandan Liu, Qian Zhang, Piao Luo, Liwei Gu, Shengnan Shen, Huan Tang, Ying Zhang, Ming Lyu, Qiaoli Shi, Chuanbin Yang & Jigang Wang. (2022) Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets. Aging and disease 13:3, pages 815.
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Xue Bai, Rui-Jia Fu, Shuo Zhang, Shi-Jun Yue, Yan-Yan Chen, Ding-Qiao Xu & Yu-Ping Tang. (2021) Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases. Biomedicine & Pharmacotherapy 139, pages 111551.
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Bin Hui, Liping Zhang, Qinhua Zhou & Ling Hui. (2017) Pristimerin Inhibits LPS-Triggered Neurotoxicity in BV-2 Microglia Cells Through Modulating IRAK1/TRAF6/TAK1-Mediated NF-κB and AP-1 Signaling Pathways In Vitro. Neurotoxicity Research 33:2, pages 268-283.
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Jayanta Das, Antara Sarkar & Pranab Ghosh. (2018) Friedelane triterpenoids: transformations toward A-ring modifications including 2- homo derivatives . New Journal of Chemistry 42:9, pages 6673-6688.
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Yun‑Tian Yang & Shan Jin. (2017) Effect of PrP105‑132 on the secretion of interleukin‑6 and interleukin‑8 from microglial cells in�vitro. Experimental and Therapeutic Medicine.
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Minjuan Bian, Xiaoye Du, Jingang Cui, Peiwei Wang, Wenjian Wang, Weiliang Zhu, Teng Zhang & Yu Chen. (2016) Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation. Journal of Neuroinflammation 13:1.
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Kathleen Borgmann & Anuja Ghorpade. (2015) HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads. Frontiers in Microbiology 6.
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Wei‐Guang Shan, Li‐Wen Zhang, Jia‐Gui Xiang & Zha‐Jun Zhan. (2013) Natural Friedelanes. Chemistry & Biodiversity 10:8, pages 1392-1434.
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Sebastien Boridy, Ghareb M Soliman & Dusica Maysinger. (2012) Modulation of inflammatory signaling and cytokine release from microglia by celastrol incorporated into dendrimer nanocarriers. Nanomedicine 7:8, pages 1149-1165.
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