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International Journal of Neuroscience Volume 122, 2012 - Issue 2
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Research Article

Melanocortin 4 Receptor Induces Hyperalgesia and Allodynia After Chronic Constriction Injury by Activation of p38 MAPK in DRG

Haichen ChuDepartment of Anesthesiology, Affiliate Hospital of Qingdao University Medical College, Qingdao, Shandong Province, ChinaCorrespondence[email protected]
,
Jiangling XiaDepartment of Anesthesiology, Affiliate Hospital of Qingdao University Medical College, Qingdao, Shandong Province, China
,
Zhao YangQingdao Institute for Drug Control, Qingdao, Shandong Province, China
&
Jie GaoDepartment of Anesthesiology, Affiliate Hospital of Qingdao University Medical College, Qingdao, Shandong Province, China
Pages 74-81 | Received 28 May 2011, Published online: 24 Nov 2011

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Read on this site (2)

Haichen Chu, Junzhi Sun, Hongmei Xu, Zejun Niu & Mei Xu. (2012) Effect of periaqueductal gray melanocortin 4 receptor in pain facilitation and glial activation in rat model of chronic constriction injury. Neurological Research 34:9, pages 871-888.
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Shailendra Kapoor. (2012) Letter to the Editor: Melanocortin 4 Receptor Antagonists and Their Emerging Role in Pain Management. International Journal of Neuroscience 122:9, pages 547-547.
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Articles from other publishers (17)

Olga Anna Korczeniewska, Kalyani Tatineni, Shanzae Faheem, Wilner Fresin, Jalen Bonitto, Junad Khan, Eli Eliav & Rafael Benoliel. (2023) Effects of intra-nasal melanocortin-4 receptor antagonist on trigeminal neuropathic pain in male and female rats. Neuroscience Letters 796, pages 137054.
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Nathan M. Sharfman, Leslie K. Kelley, Maria E. Secci & Nicholas W. Gilpin. (2022) Melanocortin-4 receptor signaling in the central amygdala mediates chronic inflammatory pain effects on nociception. Neuropharmacology 210, pages 109032.
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Nathan Sharfman & Nicholas W. Gilpin. (2021) The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure. Frontiers in Psychiatry 12.
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Narmeen Shikdar & Faisal Alghamdi. (2021) Influence of Selective Melanocortin-4 Receptor Antagonist HS014 on Hypersensitivity After Nervous System Injuries in a Model of Rat Neuropathic Pain: A Narrative Review of the Literature. Cureus.
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Olga A. Korczeniewska, Divya Kohli, Giannina Katzmann Rider, Carlos Zaror, Veronica Iturriaga & Rafael Benoliel. (2021) Effects of melanocortin‐4 receptor (MC4R) antagonist on neuropathic pain hypersensitivity in rats – A systematic review and meta‐analysis. European Journal of Oral Sciences 129:4.
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Anna Piotrowska, Joanna Starnowska-Sokół, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Dagmara Tymecka, Angelika Ignaczak, Beata Wilenska, Aleksandra Misicka & Barbara Przewłocka. (2021) Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Pain 162:2, pages 432-445.
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Joanna Starnowska-Sokół, Anna Piotrowska, Joanna Bogacka, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Magda Godlewska, Jowita Osiejuk, Sandra Gątarz, Aleksandra Misicka & Barbara Przewłocka. (2020) Novel hybrid compounds, opioid agonist+melanocortin 4 receptor antagonist, as efficient analgesics in mouse chronic constriction injury model of neuropathic pain. Neuropharmacology 178, pages 108232.
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Lijia Mai, Xiao Zhu, Fang Huang, Hongwen He & Wenguo Fan. (2020) p38 mitogen-activated protein kinase and pain. Life Sciences 256, pages 117885.
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Weibo Zhang & Yue Wu. (2020) Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells. NeuroReport Publish Ahead of Print.
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Hua Wang, Yuan WeiYichen PuDongsheng Jiang, Xinghong Jiang, Yuan Zhang & Jin Tao. (2019) Brain-derived neurotrophic factor stimulation of T-type Ca 2+ channels in sensory neurons contributes to increased peripheral pain sensitivity . Science Signaling 12:600.
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Yang Zhao, Yan Xin & Haichen Chu. (2019) MC4R Is Involved in Neuropathic Pain by Regulating JNK Signaling Pathway After Chronic Constriction Injury. Frontiers in Neuroscience 13.
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Yuan Zhang, Dongsheng Jiang, Hua Li, Yufang Sun, Xinghong Jiang, Shan Gong, Zhiyuan Qian & Jin Tao. (2019) Melanocortin type 4 receptor–mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats. Journal of Biological Chemistry 294:14, pages 5496-5507.
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Zhi-Xiao Li, Bao-Wen Liu, Zhi-Gang He & Hong-Bing Xiang. (2017) Melanocortin-4 receptor regulation of pain. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:10, pages 2515-2522.
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D. Ramírez, J. Saba, L. Carniglia, D. Durand, M. Lasaga & C. Caruso. (2015) Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus. Molecular and Cellular Endocrinology 411, pages 28-37.
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Da-Wei Ye, Cheng Liu, Tao-Tao Liu, Xue-Bi Tian & Hong-Bing Xiang. (2014) Motor Cortex-Periaqueductal Gray-Spinal Cord Neuronal Circuitry May Involve in Modulation of Nociception: A Virally Mediated Transsynaptic Tracing Study in Spinally Transected Transgenic Mouse Model. PLoS ONE 9:2, pages e89486.
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Vanni Caruso, Malin C. Lagerström, Pawel K. Olszewski, Robert Fredriksson & Helgi B. Schiöth. (2014) Synaptic changes induced by melanocortin signalling. Nature Reviews Neuroscience 15:2, pages 98-110.
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ZeJun Niu, JiaGui Ma, HaiChen Chu, Yang Zhao, Wei Feng & YongWei Cheng. (2012) Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat. Neuroscience Letters 529:2, pages 112-117.
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