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Research Article

Role of Melatonin in the Prevention of Morphine-Induced Hyperalgesia and Spinal Glial Activation in Rats: Protein Kinase C Pathway Involved

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Pages 154-163 | Received 26 Jul 2011, Published online: 02 Dec 2011

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Shuhui Jia, Xuantong Guo, Zuxin Chen, Shupeng Li & Xin-an Liu. (2022) The roles of the circadian hormone melatonin in drug addiction. Pharmacological Research 183, pages 106371.
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Fahad S. Alshehri, Badrah S. Alghamdi, Alqassem Y. Hakami, Abdullah A. Alshehri & Yusuf S. Althobaiti. (2021) Melatonin attenuates morphine‐induced conditioned place preference in Wistar rats. Brain and Behavior 11:12.
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Ling-Yan Su, Qianjin Liu, Lijin Jiao & Yong-Gang Yao. (2021) Molecular Mechanism of Neuroprotective Effect of Melatonin on Morphine Addiction and Analgesic Tolerance: an Update. Molecular Neurobiology 58:9, pages 4628-4638.
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Lisa L. Wilson, Soumen Chakraborty, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Chloe A. Simons, Rajendra Uprety, Susruta Majumdar & Jay P. McLaughlin. (2021) Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal. Cellular and Molecular Neurobiology 41:5, pages 1131-1143.
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Karim Hemati, Mohammad Hossein Pourhanifeh, Ehsan Dehdashtian, Iman Fatemi, Saeed Mehrzadi, Russel J. Reiter & Azam Hosseinzadeh. (2020) Melatonin and morphine: potential beneficial effects of co‐use. Fundamental & Clinical Pharmacology 35:1, pages 25-39.
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Yan Zhang & Hongyin Zhai. (2020) Bilobalide assuages morphine‐induced addiction in hippocampal neuron cells through upregulation of microRNA‐101. Journal of Biochemical and Molecular Toxicology 34:7.
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Yu‑Che ChengRu‑Yin TsaiYen‑Tseng SungIng‑Jung ChenTzu‑Yi TuYa‑Yuan MaoChih‑Shung Wong. (2018) Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression. International Journal of Molecular Medicine.
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Ye-song Wang, Yuan-yuan Li, Wei Cui, Li-bin Li, Zhao-cai Zhang, Bao-ping Tian & Gen-sheng Zhang. (2017) Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain. Inflammation 40:6, pages 2052-2061.
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Yuchao Fan, Xiao Liang, Rurong Wang & Li Song. (2017) Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats. Brain Research Bulletin 135, pages 105-112.
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Joanna Ripoll Rozisky, Vanessa Leal Scarabelot, Carla de Oliveira, Isabel Cristina de Macedo, Alícia Deitos, Gabriela Laste, Wolnei Caumo & Iraci L.S. Torres. (2016) Melatonin as a potential counter-effect of hyperalgesia induced by neonatal morphine exposure. Neuroscience Letters 633, pages 77-81.
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María Pilar García-Pardo, Concepción Roger-Sanchez, Marta Rodríguez-Arias, Jose Miñarro & María Asunción Aguilar. (2016) Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates. European Journal of Pharmacology 781, pages 10-24.
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Sheng-Hsiung Lin, Ya-Ni Huang, Jen-Hsin Kao, Lu-Tai Tien, Ru-Yin Tsai & Chih-Shung Wong. (2016) Melatonin reverses morphine tolerance by inhibiting microglia activation and HSP27 expression. Life Sciences 152, pages 38-43.
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Li Song, Chaoran Wu & Yunxia Zuo. (2015) Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors. BMC Anesthesiology 15:1.
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Richard J. Bodnar. (2014) Endogenous opiates and behavior: 2013. Peptides 62, pages 67-136.
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Qiong Xiang, Chang-Lin Wang, Shuo Song & Rui Jing. (2013) RETRACTED: Interaction of Somatostatin receptor-2 and Neuropeptide Y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model. Pharmacology Biochemistry and Behavior 105, pages 71-75.
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ZeJun Niu, JiaGui Ma, HaiChen Chu, Yang Zhao, Wei Feng & YongWei Cheng. (2012) Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat. Neuroscience Letters 529:2, pages 112-117.
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