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Research Article

Genetic Polymorphisms and Drug Interactions Leading to Clopidogrel Resistance: Why the Asian Population Requires Special Attention

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Pages 143-154 | Received 28 May 2012, Published online: 06 Dec 2012

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Rakhmad Hidayat, Al Rasyid, Salim Harris, Alida Harahap, Herqutanto, Melva Louisa, Erlin Listiyaningsih, Aldy Safruddin Rambe & Tonny Loho. (2023) Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients. Vascular Health and Risk Management 19, pages 53-61.
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Li-Jun Zhang, Yan-Qun Zhang, Xia Han, Zeng-Tang Zhang & Zhi-Qiang Zhang. (2016) Association of VEGFR-2 Gene Polymorphisms With Clopidogrel Resistance in Patients With Coronary Heart Disease. American Journal of Therapeutics 23:6, pages e1663-e1670.
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Min Soo Kim, Kyung Il Jo, Je Young Yeon, Jong Soo Kim, Keon Ha Kim, Pyoung Jeon & Seung Chyul Hong. (2016) Safety and efficacy of antiplatelet response assay and drug adjustment in coil embolization: a propensity score analysis. Neuroradiology 58:11, pages 1125-1134.
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H. Zhang, D. A. Lauver, H. Wang, D. Sun, P. F. Hollenberg, Y. E. Chen, Y. Osawa & D. T. Eitzman. (2016) Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis. Journal of Pharmacology and Experimental Therapeutics 359:1, pages 11-17.
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Pan Li, Ying Gu, Yawei Yang, Lizhi Chen, Junmei Liu, Lihong Gao, Yongwen Qin, Quancai Cai, Xianxian Zhao, Zhuo Wang & Liping Ma. (2016) Low-dose ticagrelor yields an antiplatelet efficacy similar to that of standard-dose ticagrelor in healthy subjects: an open-label randomized controlled trial. Scientific Reports 6:1.
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Rui Liu, Zi-yi Zhou, Yi-bei Chen, Jia-li Li, Wei-bang Yu, Xin-meng Chen, Min Zhao, Yuan-qi Zhao, Ye-feng Cai, Jing Jin & Min Huang. (2016) Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke. Acta Pharmacologica Sinica 37:7, pages 882-888.
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Sam S. Oh, Marquitta J. White, Christopher R. Gignoux & Esteban G. Burchard. (2016) Making Precision Medicine Socially Precise. Take a Deep Breath. American Journal of Respiratory and Critical Care Medicine 193:4, pages 348-350.
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Hua Shao, Jia Lu, Yun-Ting Xu, Ying Zhan, Guo-Ming Chen & Hong-Jian Zhang. (2016) Metabolic Interaction Potential between Clopidogrel and Sulfonylurea Antidiabetic Agents: Effects on Clopidogrel Bioactivation. Pharmacology 97:1-2, pages 18-24.
Crossref
Mark Y. Chan, Xin Du, David Eccleston, Changsheng Ma, Padinhare P. Mohanan, Manabu Ogita, Kou-Gi Shyu, Bryan P. Yan & Young-Hoon Jeong. (2016) Acute coronary syndrome in the Asia-Pacific region. International Journal of Cardiology 202, pages 861-869.
Crossref
Xi-Ling Jiang, Snehal Samant, Joshua P. Lewis, Richard B. Horenstein, Alan R. Shuldiner, Laura M. Yerges-Armstrong, Lambertus A. Peletier, Lawrence J. Lesko & Stephan Schmidt. (2016) Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults. European Journal of Pharmaceutical Sciences 82, pages 64-78.
Crossref
Khalid Bin Thani, Fajer Al-Moosa, Eman Murad, Aisha Al-Moosa, Mohamed E. Alalawi & Hind Al-Sindi. (2015) Stent Thrombosis after Rescue Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction. The Open Cardiovascular Medicine Journal 9:1, pages 127-132.
Crossref
Emad Ahmed & Ayman El-Menyar. (2014) South Asian Ethnicity and Cardiovascular Risk. Angiology 66:5, pages 405-415.
Crossref
Xi-Ling Jiang, Snehal Samant, Lawrence J. Lesko & Stephan Schmidt. (2015) Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel. Clinical Pharmacokinetics 54:2, pages 147-166.
Crossref
Shijun Zhang, Xinqiang Lai, Wenxian Li, Zhen Jing, Zhilin Xiong, Anding Xu, Yiwen Ruan & Li'an Huang. (2014) VASP phosphorylation and genetic polymorphism for clopidogrel resistance in Chinese patients with non-cardioembolic ischemic stroke. Thrombosis Research 134:6, pages 1272-1277.
Crossref
Anene Ukaigwe, Paras Karmacharya, Maryam Mahmood, Ranjan Pathak, Madan Raj Aryal, Leena Jalota & Anthony A. Donato. (2014) Meta-Analysis on Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography. The American Journal of Cardiology 114:9, pages 1295-1302.
Crossref
Y. Hiasa, R. Teng & H. Emanuelsson. (2014) Pharmacodynamics, pharmacokinetics and safety of ticagrelor in Asian patients with stable coronary artery disease. Cardiovascular Intervention and Therapeutics 29:4, pages 324-333.
Crossref
Charles V. PollackJr.Jr., Alpesh Amin, Tomas Villanueva, Frank Peacock, Richard Summers, George Davatelis & Scott Kaatz. (2014) Rationale for Upstream Dual Antiplatelet Therapy in Non-ST-Segment Elevation Myocardial Infarction. Current Emergency and Hospital Medicine Reports 2:1, pages 76-89.
Crossref
Hong-Guang Xie & Ying-Dong Zhang. 2013. Omics for Personalized Medicine. Omics for Personalized Medicine 469 506 .

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