745
Views
55
CrossRef citations to date
0
Altmetric
Research Article

Signaling Pathways Involved in Endoplasmic Reticulum Stress-Induced Neuronal Apoptosis

, &
Pages 155-162 | Received 20 Sep 2012, Published online: 21 Dec 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Yan Feng, Jiadong Lang, Boyu Sun, Zhongjie Yan, Zongmao Zhao & Guozhu Sun. (2023) Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice. Neurological Research 45:6, pages 590-602.
Read now

Articles from other publishers (54)

Melike D. Unlu, Halil Asci, M. Yusuf Tepebasi, Melih Arlioglu, Ibrahim Huseynov, Ozlem Ozmen, Serdar Sezer & Serpil Demirci. (2023) The ameliorative effects of cannabidiol on methotrexate‐induced neuroinflammation and neuronal apoptosis via inhibiting endoplasmic reticulum and mitochondrial stress. Journal of Biochemical and Molecular Toxicology.
Crossref
Xiaoqin Zhou, Chuntong Liu & Daolin Xia. (2023) Sevoflurane‐induced P300 promotes neuron apoptosis via Sp1/ CDK9 pathway . Clinical and Experimental Pharmacology and Physiology 50:7, pages 541-553.
Crossref
Min Yao, Gan Li, Long-yun Zhou, Zhong Zheng, Yue-li Sun, Shu-fen Liu, Yong-jun Wang & Xue-jun Cui. (2022) Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. Cell Biology and Toxicology 39:3, pages 907-928.
Crossref
Adalberto Merighi & Laura Lossi. (2022) Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death. International Journal of Molecular Sciences 23:23, pages 15186.
Crossref
Huawu Gao, Xin Lei, Shu Ye, Ting Ye, Rupeng Hua, Guoquan Wang, Hang Song, Peng Zhou, Yan Wang & Biao Cai. (2022) Genistein attenuates memory impairment in Alzheimer's disease via ERS-mediated apoptotic pathway in vivo and in vitro. The Journal of Nutritional Biochemistry 109, pages 109118.
Crossref
Ying Wang, Zhenzhen Liu, Juanru Wei, Lei Di, Sheng Wang, Tingni Wu & Ning Li. (2022) Norlignans and phenolics from genus Curculigo protect corticosterone-injured neuroblastoma cells SH-SY5Y by inhibiting endoplasmic reticulum stress-mitochondria pathway. Journal of Ethnopharmacology 296, pages 115430.
Crossref
Niklas Reich & Christian Hölscher. (2022) The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review. Frontiers in Neuroscience 16.
Crossref
Zhichao Yan, Mingying Lai, Yu Jia, Caibin Deng & Yehong Zhuo. (2022) CircXPO5 Plays a Neuroprotective Function in the Lateral Geniculate Nucleus of Glaucoma by Regulating GRIN2A. Brain Sciences 12:6, pages 780.
Crossref
Mei Chou Lai, Wayne Young Liu, Shorong-Shii Liou & I-Min Liu. (2022) Diosmetin Targeted at Peroxisome Proliferator-Activated Receptor Gamma Alleviates Advanced Glycation End Products Induced Neuronal Injury. Nutrients 14:11, pages 2248.
Crossref
Xiang Yin, Peng Zhang, Ning Xia, Shaoqiu Wu, Bingyan Liu, Li Weng & Mingyi Shang. (2022) GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway. Cellular Signalling 93, pages 110307.
Crossref
Mei-Chou Lai, Wayne-Young Liu, Shorong-Shii Liou & I-Min Liu. (2022) The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress. Nutrients 14:4, pages 745.
Crossref
Chenhao Liu, Yiwei Zeng, Yulong Wen, Xinggui Huang & Yi Liu. (2022) Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis. Frontiers in Pharmacology 13.
Crossref
Ping Song, Huiqi Huang, Yuanren Ma, Chaoqun Wu, Xinzhou Yang & Ho-Young Choi. (2021) Davidone C Induces the Death of Hepatocellular Carcinoma Cells by Promoting Apoptosis and Autophagy. Molecules 26:17, pages 5219.
Crossref
Hui Shi, Ying Yu, Yucheng Wang, Xiaoxiao Liu, Yong Yu, Minghui Li, Yunzeng Zou, Ruizhen Chen & Junbo Ge. (2021) Inhibition of Calpain Alleviates Apoptosis in Coxsackievirus B3-induced Acute Virus Myocarditis Through Suppressing Endoplasmic Reticulum Stress. International Heart Journal 62:4, pages 900-909.
Crossref
Sara Marmolejo-Martínez-Artesero, Caty Casas & David Romeo-Guitart. (2021) Endogenous Mechanisms of Neuroprotection: To Boost or Not to Be. Cells 10:2, pages 370.
Crossref
Milad Ashrafizadeh, Shima Tavakol, Reza Mohammadinejad, Zahra Ahmadi, Habib Yaribeygi, Tannaz Jamialahmadi, Thomas P. Johnston & Amirhossein Sahebkar. 2021. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health 137 160 .
Monruedee Sukprasansap, Pithi Chanvorachote & Tewin Tencomnao. (2020) Cyanidin-3-glucoside activates Nrf2-antioxidant response element and protects against glutamate-induced oxidative and endoplasmic reticulum stress in HT22 hippocampal neuronal cells. BMC Complementary Medicine and Therapies 20:1.
Crossref
Guang-Chan JING, Di LIU, Yu-Qin LIU & Meng-Ren ZHANG. (2020) Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro. Chinese Journal of Natural Medicines 18:9, pages 704-713.
Crossref
Qinqin Wu, Haihong Zhang, Hu Nie & Zhi Zeng. (2019) Anti‑Nogo‑A antibody promotes brain function recovery after cardiopulmonary resuscitation in rats by reducing apoptosis. Molecular Medicine Reports.
Crossref
Yu‑Hui Li, Wei‑Li Zhang, Hao‑Ying Zhou, Da‑Wei Yu, Xiao‑Ning Sun & Qin Hu. (2019) Halofuginone protects against advanced glycation end products‑induced injury of H9C2 cells via alleviating endoplasmic reticulum stress‑associated apoptosis and inducing autophagy. Molecular Medicine Reports.
Crossref
D Lu, X Peng, S Jia, G Li & N Tan. (2019) Carbonic Anhydrase I modifies SOD1-induced motor neuron toxicity in Drosophila via ER stress pathway. Journal of Neuroscience and Neurological Disorders 3:2, pages 135-144.
Crossref
Andrew Ghaly, Yohei Maki, Karen Nygard, Robert Hammond, Daniel B. Hardy & Bryan S. Richardson. (2018) Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with increased brain apoptosis. Pediatric Research 85:1, pages 105-112.
Crossref
Seon-Hwa Kim, Soo-Na Cho, Yun-Ji Lim, Ji-Ae Choi, Junghwan Lee, Dam Go & Chang-Hwa Song. (2018) Phagocytosis influences the intracellular survival of Mycobacterium smegmatis via the endoplasmic reticulum stress response. Cell & Bioscience 8:1.
Crossref
Hui Bian, Xinbo Song, Ning Li, Huizi Man & Yi Xiao. (2018) Quantitatively monitoring oxygen variation in endoplasmic reticulum with a fluorophore–phosphor energy transfer cassette. Journal of Materials Chemistry B 6:11, pages 1699-1705.
Crossref
Menizibeya Osain WelcomeMenizibeya Osain Welcome. 2018. Gastrointestinal Physiology. Gastrointestinal Physiology 107 199 .
Agnieszka Wnuk & Małgorzata Kajta. (2017) Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System. International Journal of Molecular Sciences 18:11, pages 2394.
Crossref
Qin Xu, Chuanben Chen, An Lin & Yunqing Xie. (2017) Endoplasmic reticulum stress-mediated membrane expression of CRT/ERp57 induces immunogenic apoptosis in drug-resistant endometrial cancer cells. Oncotarget 8:35, pages 58754-58764.
Crossref
Bok Soon Go, Jieun Kim, Ju Hwan Yang & Eun Sang Choe. (2016) Psychostimulant-Induced Endoplasmic Reticulum Stress and Neurodegeneration. Molecular Neurobiology 54:6, pages 4041-4048.
Crossref
Monruedee Sukprasansap, Pithi Chanvorachote & Tewin Tencomnao. (2017) Cleistocalyx nervosum var. paniala berry fruit protects neurotoxicity against endoplasmic reticulum stress-induced apoptosis. Food and Chemical Toxicology 103, pages 279-288.
Crossref
Anna Bal-Price, Pamela J. Lein, Kimberly P. Keil, Sunjay Sethi, Timothy Shafer, Marta Barenys, Ellen Fritsche, Magdalini Sachana & M.E. (Bette) Meek. (2017) Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. NeuroToxicology 59, pages 240-255.
Crossref
Wanida Tungkum, Pichaya Jumnongprakhon, Chainarong Tocharus, Piyarat Govitrapong & Jiraporn Tocharus. (2017) Melatonin suppresses methamphetamine-triggered endoplasmic reticulum stress in C6 cells glioma cell lines. The Journal of Toxicological Sciences 42:1, pages 63-71.
Crossref
Min-Hui Li, Ping Yang, Tai Yang, Kun Zhang, Yang Liu, Jin Liu, Li-Mei Li, Xing-Yan Luo, Shu-Xia Yang, Qiang Zou & Chong-Jie Zhang. (2016) A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. International Journal of Oncology 49:5, pages 2127-2134.
Crossref
Patricia Santofimia-Castaño, Alicia Izquierdo-Alvarez, Irene de la Casa-Resino, Antonio Martinez-Ruiz, Marcos Perez-Lopez, Juan C. Portilla, Gines M. Salido & Antonio Gonzalez. (2016) Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes. Toxicology 357-358, pages 74-84.
Crossref
Tan Lu, Chao Zhang, Mingxiang Chai & Yongbo An. (2016) Isoquercetin ameliorates tunicamycin-induced apoptosis in rat dorsal root ganglion neurons via suppressing ROS-dependent endoplasmic reticulum stress. Biomedicine & Pharmacotherapy 80, pages 343-351.
Crossref
Guo-zhu Sun, Fen-fei Gao, Zong-mao Zhao, Hai Sun, Wei Xu, Li-wei Wu & Yong-chang He. (2016) Endoplasmic reticulum stress-induced apoptosis in the penumbra aggravates secondary damage in rats with traumatic brain injury. Neural Regeneration Research 11:8, pages 1260.
Crossref
Xinyu Yu, Shanlei Qiao, Di Wang, Jiayong Dai, Jun Wang, Rutan Zhang, Li Wang & Lei Li. (2016) A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model. RSC Advances 6:31, pages 25751-25765.
Crossref
Aungkana Krajarng, Masaya Imoto, Etsu Tashiro, Takahiro Fujimaki, Satoko Shinjo & Ramida Watanapokasin. (2015) Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid. BMC Complementary and Alternative Medicine 15:1.
Crossref
H. Fan, H.-B. Tang, J. Kang, L. Shan, H. Song, K. Zhu, J. Wang, G. Ju & Y.-Z. Wang. (2015) Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury. Neuroscience 311, pages 362-373.
Crossref
MINGZHI SHEN, LIN WANG, XIAOWANG GUO, QIAO XUE, CONG HUO, XING LI, LI FAN & XIAOMING WANG. (2015) A novel endoplasmic reticulum stress-induced apoptosis model using tunicamycin in primary cultured neonatal rat cardiomyocytes. Molecular Medicine Reports 12:4, pages 5149-5154.
Crossref
Wenwen Wang, Yu Sun, Sen Chen, Xingxing Zhou, Xia Wu, Wen Kong & Weijia Kong. (2015) Impaired unfolded protein response in the degeneration of cochlea cells in a mouse model of age-related hearing loss. Experimental Gerontology 70, pages 61-70.
Crossref
Qiukui Deng, Chuanxiu Xu, Rencai Wang, Jianying Zheng, Shuai Li, Qunhua Jin & Yapei Yang. (2015) RETRACTED ARTICLE: TN-2 Ameliorates Tunicamycin-Induced Mitochondria and Endoplasmic Reticulum Stress-Associated Apoptosis in Rat Dorsal Root Ganglion Neurons. Journal of Molecular Neuroscience 57:2, pages 314-314.
Crossref
Sheng Chen, Xiao‐Jie Zhang, Wen‐Jie Xie, Hong‐Yan Qiu, Hui Liu & Wei‐Dong Le. (2015) A New VMAT ‐2 Inhibitor NBI ‐641449 in the Treatment of Huntington Disease . CNS Neuroscience & Therapeutics 21:8, pages 662-671.
Crossref
Antero Salminen, Annakaisa Haapasalo, Anu Kauppinen, Kai Kaarniranta, Hilkka Soininen & Mikko Hiltunen. (2015) Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Progress in Neurobiology 131, pages 1-20.
Crossref
Rong Guo, Weijing Liu, Baoxin Liu, Buchun Zhang, Weiming Li & Yawei Xu. (2015) SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism. International Journal of Cardiology 191, pages 36-45.
Crossref
Patricia Santofimia-Castaño, Lourdes Garcia-Sanchez, Deborah Clea Ruy, Beatriz Sanchez-Correa, Miguel Fernandez-Bermejo, Raquel Tarazona, Gines M. Salido & Antonio Gonzalez. (2015) Melatonin induces calcium mobilization and influences cell proliferation independently of MT1/MT2 receptor activation in rat pancreatic stellate cells. Cell Biology and Toxicology 31:2, pages 95-110.
Crossref
Michael K. Wong, Catherine J. Nicholson, Alison C. Holloway & Daniel B. Hardy. (2015) Maternal Nicotine Exposure Leads to Impaired Disulfide Bond Formation and Augmented Endoplasmic Reticulum Stress in the Rat Placenta. PLOS ONE 10:3, pages e0122295.
Crossref
Lu Liu, Ying Zhang, Hefeng Gu, Kaiqiang Zhang & Lin Ma. (2014) Fluorosis Induces Endoplasmic Reticulum Stress and Apoptosis in Osteoblasts In Vivo. Biological Trace Element Research 164:1, pages 64-71.
Crossref
Tao Luo, Jin Kyung Kim, Baihe Chen, Ahmed Abdel-Latif, Masafumi Kitakaze & Liang Yan. (2015) Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis. Chemico-Biological Interactions 225, pages 90-98.
Crossref
Junli Ye, Yantao Han, Xuehong Chen, Jing Xie, Xiaojin Liu, Shunhong Qiao & Chunbo Wang. (2014) l-Carnitine attenuates H2O2-induced neuron apoptosis via inhibition of endoplasmic reticulum stress. Neurochemistry International 78, pages 86-95.
Crossref
Lei-Chin Chen, Jong-C. Wu, Yen-Fan Tuan, Yi-Kuan Tseng, You-Cheng Hseu & Ssu-Ching Chen. (2014) Molecular mechanisms of 3,3′-dichlorobenzidine-mediated toxicity in HepG2 cells. Environmental and Molecular Mutagenesis 55:5, pages 407-420.
Crossref
DI LIU, HONG ZHANG, WENJUAN GU, YUQIN LIU & MENGREN ZHANG. (2014) Ginsenoside Rb1 protects hippocampal neurons from high glucose-induced neurotoxicity by inhibiting GSK3β-mediated CHOP induction. Molecular Medicine Reports 9:4, pages 1434-1438.
Crossref
Jing Chen, Hu Guo, Guo Zheng & Zhong-Nan Shi. (2013) Region-specific vulnerability to endoplasmic reticulum stress-induced neuronal death in rat brain after status epilepticus. Journal of Biosciences 38:5, pages 877-886.
Crossref
Di Liu, Hong Zhang, Wenjuan Gu, Yuqin Liu & Mengren Zhang. (2013) Neuroprotective Effects of Ginsenoside Rb1 on High Glucose-Induced Neurotoxicity in Primary Cultured Rat Hippocampal Neurons. PLoS ONE 8:11, pages e79399.
Crossref
YUNBAO PAN, JIAN XIAO, GUANG LIANG, MENGYAO WANG, DUJUAN WANG, SUMEI WANG & HUILING YANG. (2013) A new curcumin analogue exhibits enhanced antitumor activity in nasopharyngeal carcinoma. Oncology Reports 30:1, pages 239-245.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.