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REVIEW

The adverse effects profile of levetiracetam in epilepsy: a more detailed look

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Pages 627-634 | Received 09 Sep 2013, Accepted 13 Nov 2013, Published online: 18 Dec 2013

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Zhan-Miao Yi, 1–3, Cheng Wen, Ting Cai, Lu Xu, Xu-Li Zhong, Si-Yan Zhan & Suo-Di Zhai. (2019) Levetiracetam for epilepsy: an evidence map of efficacy, safety and economic profiles. Neuropsychiatric Disease and Treatment 15, pages 1-19.
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Jeroen G. V. Habets, Albert F. G. Leentjens & Olaf E. M. G. Schijns. (2017) Serious and reversible levetiracetam-induced psychiatric symptoms after resection of frontal low-grade glioma: two case histories. British Journal of Neurosurgery 31:4, pages 471-473.
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Johan A.F. Koekkoek, Linda Dirven & Martin J.B. Taphoorn. (2017) The withdrawal of antiepileptic drugs in patients with low-grade and anaplastic glioma. Expert Review of Neurotherapeutics 17:2, pages 193-202.
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Articles from other publishers (48)

Ying Wang, Wenting Huang, Jia Li, Shumin Mao, Wenqiang Fang & Huiqin Xu. (2023) A case of Gitelman syndrome with homozygous SLC12A3 deletion presenting with epilepsy. Acta Epileptologica 5:1.
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Jacob S Kazmi, Nabila Albarghouthy & Randy Ramsaywak. (2023) Levetiracetam-Induced Rhabdomyolysis Reversed by Discontinuation: A Case Report. Cureus.
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Corina Andrei, Dragos Paul Mihai, Georgiana Nitulescu, Anca Ungurianu, Denisa Marilena Margina, George Mihai Nitulescu, Octavian Tudorel Olaru, Radu Mihai Busca & Anca Zanfirescu. (2023) Cetirizine and Levetiracetam as Inhibitors of Monoacylglycerol Lipase: Investigating Their Repurposing Potential as Novel Osteoarthritic Pain Therapies. Pharmaceuticals 16:11, pages 1563.
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Jon Davis Perkins, Mohamed S. Abdelmoneim, Stacy Schantz Wilkins, Saadat Kamran, Boulenouar Mesraoua, Gayane Melikyan, Abdulraheem Alrabi, Ahmed El-Bardissy, Osama Elalamy & Hassan Jassim Al Hail. (2023) Dosage, time, and polytherapy dependent effects of different levetiracetam regimens on cognitive function. Epilepsy & Behavior 148, pages 109453.
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Jane Marice S. Pascual, Karen Joy B. Adiao & Mario B. PradoJrJr. (2023) Efficacy and Safety of Levetiracetam on the Treatment of Spasticity in Neurologic Disorders: a Systematic Review. SN Comprehensive Clinical Medicine 5:1.
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Arvinpreet Kour & Ajaydeep Singh. (2023) Levetiracetam-induced drug reaction: violaceous discrete maculopapular rash: A case report. Apollo Medicine 20:1, pages 83.
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Maryam Rahman, Stephan Eisenschenk, Kaitlyn Melnick, Yu Wang, Shelley Heaton, Ashley Ghiaseddin, Marcia Hodik, Nina McGrew, Jessica Smith, Greg Murad, Steven Roper & Jean Cibula. (2023) Duration of Prophylactic Levetiracetam After Surgery for Brain Tumor: A Prospective Randomized Trial. Neurosurgery 92:1, pages 68-74.
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Niklas Gremke, Marcel Printz, Leona Möller, Conrad Ehrenberg, Karel Kostev & Matthias Kalder. (2022) Association between anti-seizure medication and the risk of lower urinary tract infection in patients with epilepsy. Epilepsy & Behavior 135, pages 108910.
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Ángel JM Gargiulo, Mercedes Sarudiansky, Alejandro Videla, Nicolás Lombardi, Guido P Korman, Silvia Oddo & Luciana D´Alessio. (2022) Perceived stress, resilience, and stress coping in patients with drug resistant epilepsy and functional dissociative seizures. Seizure 101, pages 141-148.
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Khadija M Alshehabi, Sumayah Askandarani & Zainab A Alkhalifah. (2022) Suspected Levetiracetam-Induced Acute Rhabdomyolysis in a Patient With Retinoblastoma: A Case Report and Literature Review. Cureus.
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Paige Coughlin, Goonja Patel, Jessica Vadaketh & Ramesh Pandit. (2022) A Rare Case of Levetiracetam-Induced Refractory Hypokalemia. Cureus.
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Brittany M. Kasturiarachi, Rashi Krishnan, Diana L. Alsbrook, Brittany Hudson, Hallie Kelly, Caitlin E. Moran, Khalid Alsherbini & G. Morgan Jones. (2022) Evaluation of the Safety of Rapid Administration of Undiluted High-Dose Intravenous Levetiracetam. The Neurohospitalist 12:2, pages 227-230.
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J James, J Jose & VA Gafoor. (2022) Levetiracetam-induced gingival hyperplasia. Journal of Postgraduate Medicine 68:3, pages 168.
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Tatiani Soultana Ilia, Pinelopi Dragoumi, Stavroula Papanikolopoulou, Dimitrios G. Goulis, Evangelos Pavlou & Dimitrios Zafeiriou. (2022) Is the prevalence of thyroid disease higher in children receiving antiepileptic medication? A systematic review and meta-analysis. Seizure 94, pages 117-125.
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Seung Yeon Jung, Yoon Young Yi & Joon Won Kang. (2021) Once-Daily Extended-Release Levetiracetam Improves Medication Compliance in Adolescent Epilepsy Patients. Annals of Child Neurology 29:2, pages 61-67.
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Maria Luiza Giraldes de MANREZA, Tatiane Amaral PAN, Eduardo Quinalha CARBONE, Antonio Carlos Amedeo VATTIMO, Renata HERRERA, Douglas Costa MORAIS, Rita Antonelli CARDOSO, Glenda Corrêa Borges de LACERDA, Katia LIN, Frederico Nakane NAKANO, Pedro André KOWACS, André Luis Fernandes PALMINI, Adélia Maria de Miranda Henriques SOUZA, Stevin ZUNG & Elza Márcia Targas YACUBIAN. (2021) Efficacy and safety of levetiracetam as adjunctive therapy for refractory focal epilepsy. Arquivos de Neuro-Psiquiatria 79:4, pages 290-298.
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Alejandro Ballvé, Javier Salas‐Puig, Manuel Quintana, Daniel Campos, Arnau Llauradó, Miquel Raspall, Elena Fonseca, Laura Abraira, Estevo Santamarina & Manuel Toledo. (2021) Levetiracetam as first‐line monotherapy for Idiopathic Generalized Epilepsy in women. Acta Neurologica Scandinavica 143:4, pages 407-412.
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Jana Heidemann, Bettina Schmitz & Karel Kostev. (2021) Association between antiseizure medication use and risk of urinary tract infection: A case–control study. Epilepsy & Behavior 115, pages 107502.
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Ljiljana Djekic, Bojan Marković, Ana Micov, Maja Tomić, Uroš Pecikoza & Radica Stepanović-Petrović. (2020) Percutaneous delivery of levetiracetam as an alternative to topical nonsteroidal anti-inflammatory drugs: formulation development, in vitro and in vivo characterization. Drug Delivery and Translational Research 11:1, pages 227-241.
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Meltem Direk, Serdar Epcacan, Zerrin Epcacan, Didem Derici Yildirim & Cetin Okuyaz. (2020) Efficacy of levetiracetam in the treatment of Sydenham chorea. Pediatrics International 62:11, pages 1264-1268.
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Camila Cortes & Carla Manterola. (2020) Behavioral alterations associated with levetiracetam in pediatric epilepsy. Epilepsy & Behavior 112, pages 107472.
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Joshua M. DeMott, Giles W. Slocum, Michael Gottlieb & Gary D. Peksa. (2020) Levetiracetam vs. phenytoin as 2nd-line treatment for status epilepticus: A systematic review and meta-analysis. Epilepsy & Behavior 111, pages 107286.
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Oluwaseun Ogunsakin, Terence Tumenta, Scarlet Louis-Jean, Ayesha Mahbub, Peterson Rabel, Tolu Olupona & Shaheen Alam. (2020) Levetiracetam Induced Behavioral Abnormalities in a Patient with Seizure Disorder: A Diagnostic Challenge. Case Reports in Psychiatry 2020, pages 1-4.
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Ying Xu, Maree L. Hackett, Armin Nikpour, Ernest Somerville, Andrew Bleasel, Carol Ireland, Daniel F. Ghougassian, Craig S. Anderson & Nick Glozier. (2020) Course and impact of sleep disturbance in newly diagnosed epilepsy: A prospective registry study. Clinical Neurology and Neurosurgery 195, pages 105963.
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Anthoulla MohamudallyKatherine Clark. (2020) Levetiracetam at the End of Life: A Case Report and Discussion. Journal of Palliative Medicine 23:7, pages 995-997.
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Bshra Ali A. Alsfouk, Martin J. Brodie, Matthew Walters, Patrick Kwan & Zhibin Chen. (2020) Tolerability of Antiseizure Medications in Individuals With Newly Diagnosed Epilepsy. JAMA Neurology 77:5, pages 574.
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Muhammed Rashid, Asha K Rajan, Manik Chhabra & Ananth Kashyap. (2020) Levetiracetam and cutaneous adverse reactions: A systematic review of descriptive studies. Seizure 75, pages 101-109.
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Raj G. KumarKristen B. BreslinAnne C. RitterYvette P. ConleyAmy K. Wagner. (2019) Variability with Astroglial Glutamate Transport Genetics Is Associated with Increased Risk for Post-Traumatic Seizures. Journal of Neurotrauma 36:2, pages 230-238.
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Ali Ercan Altınöz, Şengül Tosun Altınöz, Başak Güzel Biltekin & Murat Can Kaya. (2019) Levetiracetam induced hypomania: a case report. Therapeutic Advances in Drug Safety 10, pages 204209861987675.
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Cerine C. Hansen, Hanna Ljung, Eylert Brodtkorb & Arne Reimers. (2018) Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs: Focus on Topiramate, Levetiracetam, and Perampanel. Behavioural Neurology 2018, pages 1-18.
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Tony Wu, Siew-Na Lim, Jing-Jane Tsai, Yao-Chung Chuang, Chin-Wei Huang, Chun-Chieh Lin, Chang-Hung Hsu, Hong-Chung Fung & Chih-Hong Lee. (2018) A randomized, double-blind, double-dummy, multicenter trial comparing the efficacy and safety of extended- and immediate-release levetiracetam in people with partial epilepsy. Seizure 62, pages 84-90.
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Hussein Algahtani, Siham Marghalani, Mohamed Satti & Bader Shirah. (2017) Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect. Journal of Epilepsy Research 7:2, pages 106-108.
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Yu-Xing Ge, Xiang-Zhu Tian, Ying-Ying Lin & Xue-Yuan Liu. (2016) Chronic treatment with levetiracetam reverses deficits in hippocampal LTP in vivo in experimental temporal lobe epilepsy rats. Neuroscience Letters 628, pages 194-200.
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Fa-Yun Hu, Wei Wang, Jie-Chuan Ren, Dong-Mei An, Jia-Ni Chen & Dong Zhou. (2016) Levetiracetam-induced cutaneous adverse drug reactions were not associated with HLA genes in a small sample of Chinese patients with epilepsy. Epilepsy Research 124, pages 12-15.
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Jun Ju, Li-Ping Zou, Xiu-Yu Shi, Lin-Yan Hu & Ling-Yu Pang. (2016) Levetiracetam. American Journal of Therapeutics 23:2, pages e624-e627.
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