238
Views
51
CrossRef citations to date
0
Altmetric
Research Article

Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum

, , , &
Pages 673-684 | Received 29 Oct 2013, Accepted 03 Dec 2013, Published online: 23 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Saptadip Samanta. (2022) Potential Bioactive Components and Health Promotional Benefits of Tea (Camellia sinensis). Journal of the American Nutrition Association 41:1, pages 65-93.
Read now
Manpreet Singh, Vandana Thakur, Rahul Deshmukh, Amit Sharma, M. S. Rathore, Ajay Kumar & Neeraj Mishra. (2018) Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer’s disease. Journal of Microencapsulation 35:2, pages 137-148.
Read now
Yanru Li, Hua Zhang & Guohui Lu. (2015) The protective effect of procyanidinson tert-butyl hydroperoxide induced human hepatocyte HL7702 cell injury. Animal Cells and Systems 19:6, pages 425-431.
Read now

Articles from other publishers (46)

Qiaoxian Luo, Longbiao Luo, Jinmin Zhao, Yitao Wang & Hua Luo. (2023) Biological Potential and Mechanisms of Tea’s Bioactive Compounds in Tea: An Updated Review. Journal of Advanced Research.
Crossref
Nagwa Ibrahim Shehata, Dina Mohamed Abd EL-Salam, Roqaya Mahmoud Hussein & Sherine Maher Rizk. (2023) Effect of safranal or candesartan on 3-nitropropionicacid-induced biochemical, behavioral and histological alterations in a rat model of Huntington’s disease. PLOS ONE 18:11, pages e0293660.
Crossref
Pei Teng Lum, Mahendran Sekar, Lay Jing Seow, Mohd Farooq Shaikh, Alina Arulsamy, Thaarvena Retinasamy, Siew Hua Gan, Charles Gnanaraj, Norhaizan Mohd Esa, Gobinath Ramachawolran, Vetriselvan Subramaniyan, Suresh V. Chinni & Yuan Seng Wu. (2023) Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington’s disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms. Frontiers in Pharmacology 14.
Crossref
Shivam Kumar, Anupam Awasthi, Khadga Raj & Shamsher Singh. (2023) L-theanine attenuates LPS-induced motor deficit in experimental rat model of Parkinson’s disease: emphasis on mitochondrial activity, neuroinflammation, and neurotransmitters. Psychopharmacology 240:7, pages 1493-1508.
Crossref
Nadjet Mostefa, Noureddine Djebli, Pham Ngoc Khanh, Nguyen Xuan Ha, Hoang Thi Ngoc Anh, Vu Thi Ha, Tran Thu Huong, Dang Viet Anh & Nguyen Manh Cuong. (2023) Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis : in Vivo and in Silico Studies . Chemistry & Biodiversity 20:5.
Crossref
Shahnawaz Ali Bhat, Shakir Ahamad, Nawab John Dar, Yasir Hassan Siddique & Aamir Nazir. (2023) The Emerging Landscape of Natural Small-molecule Therapeutics for Huntington’s Disease. Current Neuropharmacology 21:4, pages 867-889.
Crossref
Dalia E. Ali, Samar M. Bassam, Soha Elatrebi, Esraa S. Habiba, Eman A. Allam, Eman M. Omar, Doaa A. Ghareeb, Shaymaa A. Abdulmalek & Essam Abdel-Sattar. (2023) HR LC-MS/MS metabolomic profiling of Yucca aloifolia fruit and the potential neuroprotective effect on rotenone-induced Parkinson’s disease in rats. PLOS ONE 18:2, pages e0282246.
Crossref
Shakir Ahamad & Shahnawaz A. Bhat. (2022) The Emerging Landscape of Small-Molecule Therapeutics for the Treatment of Huntington’s Disease. Journal of Medicinal Chemistry 65:24, pages 15993-16032.
Crossref
Mathew George, Matthan Tharakan, John Culberson, Arubala P. Reddy & P. Hemachandra Reddy. (2022) Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases. Ageing Research Reviews 82, pages 101756.
Crossref
Ruo-Lan Li, Ling-Yu Wang, Hu-Xinyue Duan, Qing Zhang, Xiaohui Guo, Chunjie Wu & Wei Peng. (2022) Regulation of mitochondrial dysfunction induced cell apoptosis is a potential therapeutic strategy for herbal medicine to treat neurodegenerative diseases. Frontiers in Pharmacology 13.
Crossref
Mahwish Salman, Shahid Adeel, Fatima Batool, Muhammad Usama, Atya Hassan, Meral Ozomay & Mozhgan Hosseinnezhad. 2022. Textile Dyes and Pigments. Textile Dyes and Pigments 295 321 .
Abbas Mohammadipour. (2022) A focus on natural products for preventing and cure of mitochondrial dysfunction in Parkinson’s disease. Metabolic Brain Disease 37:4, pages 889-900.
Crossref
Mamali Das & Kasi Pandima Devi. 2022. Plant Antioxidants and Health. Plant Antioxidants and Health 599 618 .
Pei Teng Lum, Mahendran Sekar, Siew Hua Gan, Srinivasa Reddy Bonam & Mohd. Farooq Shaikh. (2021) Protective Effect of Natural Products against Huntington’s Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action. ACS Chemical Neuroscience 12:3, pages 391-418.
Crossref
Mamali Das & Kasi Pandima Devi. 2020. Plant Antioxidants and Health. Plant Antioxidants and Health 1 20 .
Mamali Das & Kasi Pandima Devi. 2020. Plant Antioxidants and Health. Plant Antioxidants and Health 1 20 .
Muhammad Saeed, Muhammad Sajjad Khan, Asghar Ali Kamboh, Mahmoud Alagawany, Asmaa F. Khafaga, Ahmed E. Noreldin, Muhammad Qumar, Muhammad Safdar, Mubashar Hussain, Mohamed E. Abd El-Hack & Sun Chao. (2020) L-theanine: an astounding sui generis amino acid in poultry nutrition. Poultry Science 99:11, pages 5625-5636.
Crossref
Ling Chen, Wen-jun Xiao, Qiong-xian Yan, Zhi-hua Gong, Sheng Zhang, Li Zeng, Ming Yang & Yan-he Zhou. (2020) Protective effects of l-theanine on rats with dextran sulfate sodium-induced inflammatory bowel disease. Archives of Pharmacal Research 43:8, pages 821-862.
Crossref
Hsiang-Chien Tseng, Mao-Hsien Wang, Kuo-Chi Chang, Hung-Sheng Soung, Chih-Hsiang Fang, Yi-Wen Lin, Keng-Yuan Li, Chih-Chuan Yang & Cheng-Chia Tsai. (2019) Protective Effect of (−)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats. Neurotoxicity Research 37:3, pages 669-682.
Crossref
Abhijit Dey, Banadipa Nanda, Samapika Nandy, Anuradha Mukherjee & Devendra Kumar Pandey. 2020. Bioactive Natural Products. Bioactive Natural Products 27 79 .
Edward J. Calabrese, Tarun N. Bhatia, Vittorio Calabrese, Gaurav Dhawan, James Giordano, Yannic N. Hanekamp, Rachna Kapoor, Walter J. Kozumbo & Rehana K. Leak. (2019) Cytotoxicity models of Huntington’s disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies. Pharmacological Research 150, pages 104371.
Crossref
Satarupa Deb, Ankumoni Dutta, Banashree Chetia Phukan, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Pallab Bhattacharya, Rajib Paul & Anupom Borah. (2019) Neuroprotective attributes of L-theanine, a bioactive amino acid of tea, and its potential role in Parkinson's disease therapeutics. Neurochemistry International 129, pages 104478.
Crossref
Jackson Williams, Domenico Sergi, Andrew J. McKune, Ekavi N. Georgousopoulou, Duane D. Mellor & Nenad Naumovski. (2019) The beneficial health effects of green tea amino acid l -theanine in animal models: Promises and prospects for human trials . Phytotherapy Research 33:3, pages 571-583.
Crossref
Hung-Sheng Soung, Mao-Hsien Wang, Kuo-Chi Chang, Cheng-Neng Chen, Yi Chang, Chih-Chuan Yang & Hsiang-Chien Tseng. (2018) L-Theanine Decreases Orofacial Dyskinesia Induced by Reserpine in Rats. Neurotoxicity Research 34:3, pages 375-387.
Crossref
Sunaina Sharma, Puneet Kumar & Rahul Deshmukh. (2018) Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats. Neurochemistry International 116, pages 104-111.
Crossref
Eshita Sharma, Robin Joshi & Ashu Gulati. (2018) l-Theanine: An astounding sui generis integrant in tea. Food Chemistry 242, pages 601-610.
Crossref
Muhammad Saeed, Muhammad Naveed, Muhammad Arif, Mohib Ullah Kakar, Robina Manzoor, Mohamed Ezzat Abd El-Hack, Mahmoud Alagawany, Ruchi Tiwari, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Kuldeep Dhama, Hafiz M.N. Iqbal, Maryam Dadar & Chao Sun. (2017) Green tea (Camellia sinensis) and l-theanine: Medicinal values and beneficial applications in humans—A comprehensive review. Biomedicine & Pharmacotherapy 95, pages 1260-1275.
Crossref
Muhammad Saeed, Mohamed Ezzat Abd El-Hac, Mahmoud Alagawany, Muhammad Naveed, Muhammad Asif Arain, Muhammad Arif, Rab Nawaz Soomro, MohibUllah Kakar, Robina Manzoor, Ruchi Tiwari, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Kuldeep Dhama, Hafiz Muhammad Nasir Iqbal & Chao Sun. (2017) Phytochemistry, Modes of Action and Beneficial Health Applications of Green Tea (Camellia sinensis) in Humans and Animals. International Journal of Pharmacology 13:7, pages 698-708.
Crossref
Sumit Jamwal, Shamsher Singh, Jaskamal Singh Gill & Puneet Kumar. (2017) L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level. European Journal of Pharmacology 811, pages 171-179.
Crossref
Rajsekhar Adhikary & Vivekananda Mandal. (2017) l -theanine: A potential multifaceted natural bioactive amide as health supplement. Asian Pacific Journal of Tropical Biomedicine 7:9, pages 842-848.
Crossref
Abhijit Dey. 2017. Neuroprotective Natural Products. Neuroprotective Natural Products 185 246 .
Jaskamal Singh Gill, Sumit Jamwal, Puneet Kumar & Rahul Deshmukh. (2017) Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington’s like symptoms in rats: Possible neurotransmitters modulation. Pharmacological Reports 69:2, pages 306-313.
Crossref
Sumit Jamwal & Puneet Kumar. (2016) L-theanine, a Component of Green Tea Prevents 3-Nitropropionic Acid (3-NP)-Induced Striatal Toxicity by Modulating Nitric Oxide Pathway. Molecular Neurobiology 54:3, pages 2327-2337.
Crossref
Shamsher Singh & Puneet Kumar. (2016) Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats. Inflammopharmacology 25:1, pages 69-79.
Crossref
Peiling Ben, Zhengping Zhang, Yanyan Zhu, Aiying Xiong, Yanhong Gao, Jianyun Mu, Zhimin Yin & Lan Luo. (2016) l -Theanine attenuates cadmium-induced neurotoxicity through the inhibition of oxidative damage and tau hyperphosphorylation. NeuroToxicology 57, pages 95-103.
Crossref
Dongsoo Kim, Hyongjun Jeon, Sun Ryu, Sungtae Koo, Ki-Tae Ha & Seungtae Kim. (2016) Proteomic Analysis of the Effect of Korean Red Ginseng in the Striatum of a Parkinson’s Disease Mouse Model. PLOS ONE 11:10, pages e0164906.
Crossref
Surekha Ramachandran & Sumathi Thangarajan. (2016) A novel therapeutic application of solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) on 3-nitroproponic acid induced Huntington’s disease-like symptoms in wistar rats. Chemico-Biological Interactions 256, pages 25-36.
Crossref
Nidhika Sharma, Sumit Jamwal & Puneet Kumar. (2016) Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats. Pathophysiology 23:2, pages 123-134.
Crossref
Yanli Deng, Wenjun Xiao, Ling Chen, Qiulin Liu, Zunying Liu & Zhihua Gong. (2016) In vivo antioxidative effects of l-theanine in the presence or absence of Escherichia coli-induced oxidative stress. Journal of Functional Foods 24, pages 527-536.
Crossref
Sumit Jamwal & Puneet Kumar. (2016) Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters. Physiology & Behavior 155, pages 180-187.
Crossref
Thangarajan Sumathi, Deivasigamani Asha, Ganesan Nagarajan, Arivazhagan Sreenivas & Rajendran Nivedha. (2016) l-Theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain. Environmental Toxicology and Pharmacology 42, pages 99-117.
Crossref
Sumit Jamwal, Shamsher Singh, Navneet Kaur & Puneet Kumar. (2015) Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism. Neurotoxicity Research 28:2, pages 171-184.
Crossref
Shamsher Singh, Sumit Jamwal & Puneet Kumar. (2015) Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism. Neurochemical Research 40:8, pages 1758-1766.
Crossref
Aline Alves Courtes, Letícia Priscila Arantes, Rômulo Pillon Barcelos, Ingrid Kich da Silva, Aline Augusti Boligon, Margareth Linde Athayde, Robson Luiz Puntel & Félix Alexandre Antunes Soares. (2015) Protective Effects of Aqueous Extract of Luehea divaricata against Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-11.
Crossref
Navneet Kaur, Sumit Jamwal, Rahul Deshmukh, Vinod Gauttam & Puneet Kumar. (2015) Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats. Toxicology Reports 2, pages 1222-1232.
Crossref
J. Chakraborty, D.N. Nthenge-Ngumbau, U. Rajamma & K.P. Mohanakumar. (2014) Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease. Behavioural Brain Research 264, pages 91-104.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.