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International Journal of Neuroscience Volume 59, 1991 - Issue 1-3
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Original Article

Evaluation of nk and lak cell activities in neoplastic patients during treatment with morphine

M. Provinciali Gerontol. Res. Dept., Italian Natl. Res. Ctrs. on Aging, (INRCA), Via Birarelli 8, Ancona, Italy
,
G. Di Stefano Gerontol. Res. Dept., Italian Natl. Res. Ctrs. on Aging, (INRCA), Via Birarelli 8, Ancona, Italy
,
W. Raffaeli Reanimation and Antalgic Therapy Div., “Infermi” Hospital, Rimini, Italy
,
G. Pari Reanimation and Antalgic Therapy Div., “Infermi” Hospital, Rimini, Italy
,
F. Desiderio Oncologic Div., “Infermi” Hospital, Rimini, Italy
&
N. Fabris Gerontol. Res. Dept., Italian Natl. Res. Ctrs. on Aging, (INRCA), Via Birarelli 8, Ancona, Italy
Pages 127-133 | Received 28 Dec 1990, Published online: 07 Jul 2009

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Amit Dinda, Michael Gitman & Pravin C Singhal. (2005) Immunomodulatory effect of morphine: therapeutic implications. Expert Opinion on Drug Safety 4:4, pages 669-675.
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Kyle J. Morgan, Andrew Dudas, Wayne L. Furman, M. Beth McCarville, Barry L. Shulkin, Zhaohua Lu, Himani Darji & Doralina L. Anghelescu. (2022) A retrospective investigation of the relationship between neuroblastoma response to anti‐GD2 monoclonal antibodies and exposure to opioids for pain management. Pediatric Blood & Cancer 70:2.
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Valentina Malafoglia, Sara Ilari, Laura Vitiello, Michael Tenti, Eleonora Balzani, Carolina Muscoli, William Raffaeli & Antonello Bonci. (2021) The Interplay between Chronic Pain, Opioids, and the Immune System. The Neuroscientist 28:6, pages 613-627.
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Valentina Malafoglia, Michael Tenti, Sara Ilari, Eleonora Balzani, Andrea Fanelli, Carolina Muscoli, William Raffaeli & Antonello Bonci. (2021) Opportunities and challenges for nonaddictive interventions in chronic pain. Current Opinion in Pharmacology 57, pages 184-191.
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Shane E. Brogan, Jill E. Sindt, Carina M. Jackman, Julia White, Victoria Wilding & Akiko Okifuji. (2020) Prospective Association of Serum Opioid Levels and Clinical Outcomes in Patients With Cancer Pain Treated With Intrathecal Opioid Therapy. Anesthesia & Analgesia 130:4, pages 1035-1044.
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William Raffaeli, Valentina Malafoglia, Antonello Bonci, Michael Tenti, Sara Ilari, Paola Gremigni, Cristina Iannuccelli, Chiara Gioia, Manuela Di Franco, Vincenzo Mollace, Laura Vitiello, Carlo Tomino & Carolina Muscoli. (2020) Identification of MOR-Positive B Cell as Possible Innovative Biomarker (Mu Lympho-Marker) for Chronic Pain Diagnosis in Patients with Fibromyalgia and Osteoarthritis Diseases. International Journal of Molecular Sciences 21:4, pages 1499.
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Dermot P. Maher, Deepa Walia & Nicola M. Heller. (2020) Morphine decreases the function of primary human natural killer cells by both TLR4 and opioid receptor signaling. Brain, Behavior, and Immunity 83, pages 298-302.
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Valentina Malafoglia, Monica Celi, Carolina Muscoli, Sara Ilari, Filomena Lauro, Luigino Antonio Giancotti, Chiara Morabito, Maurizio Feola, Umberto Tarantino & William Raffaeli. (2017) Lymphocyte opioid receptors as innovative biomarkers of osteoarthritic pain, for the assessment and risk management of opioid tailored therapy, before hip surgery, to prevent chronic pain and opioid tolerance/addiction development: OpMarkArt (Opioids-Markers-Arthroprosthesis) study protocol for a randomized controlled trial. Trials 18:1.
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J W Boland, K McWilliams, S H Ahmedzai & A G Pockley. (2014) Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review. British Journal of Cancer 111:5, pages 866-873.
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Gabriele Campana, Donatella Sarti, Santi Spampinato & William Raffaeli. (2010) Long-term intrathecal morphine and bupivacaine upregulate MOR gene expression in lymphocytes. International Immunopharmacology 10:9, pages 1149-1152.
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William Raffaeli, Boaz Gedaliahu Samolsky Dekel, Melotti Rita, Donatella Righetti, Alessandro Caminiti, Marco Balestri, Donatella Sarti & Fanelli Guido. (2009) Long-term intrathecal morphine influence on major compounds of the endocrine system in elderly population. European Journal of Pain Supplements 3:S2, pages 71-76.
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P. Forget & M. De Kock. (2009) L’anesthésie, l’analgésie et la modulation sympathique augmentent-elles l’incidence des récidives néoplasiques après chirurgie ? Une revue de la littérature centrée sur la modulation de l’activité des lymphocytes natural killer. Annales Françaises d'Anesthésie et de Réanimation 28:9, pages 751-768.
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George B. Stefano, Richard M. Kream, Kirk J. Mantione, Melinda Sheehan, Patrick Cadet, Wei Zhu, Thomas V. Bilfinger & Tobias Esch. (2008) Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: Implications for cancer biology. Seminars in Cancer Biology 18:3, pages 199-210.
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W. Raffaeli, J. Andruccioli, D. Righetti, A. Caminiti & M. Balestri. (2006) Intraspinal Therapy for the Treatment of Chronic Pain: A Review of the Literature Between 1990 and 2005 and Suggested Protocol for Its Rational and Safe Use. Neuromodulation: Technology at the Neural Interface 9:4, pages 290-308.
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P. Sacerdote, L. Gaspani, G. Rossoni, A.E. Panerai & M. Bianchi. (2001) Effect of the opioid remifentanil on cellular immune response in the rat. International Immunopharmacology 1:4, pages 713-719.
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E. Collin & M. Pohl. (2001) Morphiniques et système immunitaire. Douleur et Analgésie 14:1, pages 63-66.
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Paola Sacerdote, Mauro Bianchi, Leda Gaspani, Barbara Manfredi, Antonio Maucione, Giovanni Terno, Mario Ammatuna & Alberto E. Panerai. (2000) The Effects of Tramadol and Morphine on Immune Responses and Pain After Surgery in Cancer Patients. Anesthesia & Analgesia 90:6, pages 1411-1414.
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S. B. Cheknev. (1998) Involvement of natural killer cells in endogenous biological retranslation. Bulletin of Experimental Biology and Medicine 126:2, pages 751-761.
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William J. Brinkman, David M. Hall, Jin-Liang Suo & Richard J. Weber. 1998. Drugs of Abuse, Immunomodulation, and Aids. Drugs of Abuse, Immunomodulation, and Aids 43 49 .
M. Provinciali, G. Di Stefano, S. Stronati, W. Raffaeli, G. Pari & N. Fabris. (1996) Role of prolactin in the modulation of NK and lak cell activity after short- or long-term morphine administration in neoplastic patients. International Journal of Immunopharmacology 18:10, pages 577-586.
Crossref
Daniel J. J. Carr, Mace Scott, Linda L. Brockunier, Jerome R. Bagely & Charles P. France. 1996. AIDS, Drugs of Abuse, and the Neuroimmune Axis. AIDS, Drugs of Abuse, and the Neuroimmune Axis 5 11 .
Nicola Fabris. 1996. Immunopharmacology Reviews Volume 2. Immunopharmacology Reviews Volume 2 315 352 .
Daniel J.J. Carr & Michael Serou. (1995) Exogenous and endogenous opioids as biological response modifiers. Immunopharmacology 31:1, pages 59-71.
Crossref
Gayle A. Olson, Richard D. Olson & Abba J. Kastin. (1992) Endogenous opiates: 1991. Peptides 13:6, pages 1247-1287.
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