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Research Articles

An evaluation of the interference of hydroxycobalamin with chemistry and co-oximetry tests on nine commonly used instruments

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Pages 378-386 | Received 21 Dec 2010, Accepted 07 Mar 2011, Published online: 18 Apr 2011

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Rikke Wehner Rasmussen, David Straarup, Ole Thorlacius-Ussing, Aase Handberg & Peter Astrup Christensen. (2021) Fully automatic d-lactate assay using a modified commercially available method. Scandinavian Journal of Clinical and Laboratory Investigation 81:4, pages 312-317.
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Tara B. Hendry-Hofer, Alyssa E. Witeof, Patrick C. Ng, Sari B. Mahon, Matthew Brenner, Gerry R. Boss & Vikhyat S. Bebarta. (2020) Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity. Clinical Toxicology 58:1, pages 29-35.
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R. Pace, M. Bon Homme, R. S. Hoffman & D. Lugassy. (2014) Effects of hydroxocobalamin on carboxyhemoglobin measured under physiologic and pathologic conditions. Clinical Toxicology 52:7, pages 647-650.
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M. E. Sutter, M. E. Clarke, J. Cobb, G. P. Daubert, V. S. Rathore, L. S. Aston, R. H. Poppenga, J. B. Ford, K. P. Owen & T. E. Albertson. (2012) Blood leak alarm interference by hydoxocobalamin is hemodialysis machine dependent. Clinical Toxicology 50:10, pages 892-895.
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John P. Thompson & Timothy C. Marrs. (2012) Hydroxocobalamin in cyanide poisoning. Clinical Toxicology 50:10, pages 875-885.
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Articles from other publishers (18)

Jamel Ortoleva & Alexander D. Shapeton. (2023) Seeing Red: Hydroxocobalamin and Result Interference. Journal of Cardiothoracic and Vascular Anesthesia 37:8, pages 1339-1342.
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Grant Cagle & Rebecca A. Greene. (2023) Hydroxocobalamin Interference With Chromogenic Anti-Xa Assay in a Patient on Mechanical Circulatory Support. Journal of Cardiothoracic and Vascular Anesthesia 37:7, pages 1241-1244.
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Noussaiba Benhamza, Imane Merimi, El-houcine Sebbar & Mohammed Choukri. (2023) Verification of the analytical performance of the serum aminotransferase assay on Architect ci8200. Materials Today: Proceedings 72, pages 3724-3729.
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Madeline A Sauer, Natalie M Rizzo & Nicole V Tolan. (2022) Impact of Cyanokit Administration on Point-of-Care Glucose and Laboratory Test Accuracy. Clinical Chemistry 68:4, pages 504-508.
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Steven Dang, Albert K. Tsui, Richard Herndon, Cheryl Babiak, Artur Szkotak, Anna K. Füzéry & Joshua E. Raizman. (2021) Hydroxocobalamin interference in routine laboratory tests: Development of a protocol for identifying samples and reporting results from patients treated with CyanokitTM. Clinical Biochemistry 91, pages 31-38.
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Joshua Mastenbrook, Rachel Zamihovsky, Nathan Brunken & Thomas Olsen. (2021) Intraosseous administration of hydroxocobalamin after enclosed structure fire cardiac arrest. BMJ Case Reports 14:3, pages e239523.
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Alexis R. Peedin & Julie K. Karp. (2020) Hydroxocobalamin mimicking intravascular hemolysis in therapeutic plasma exchange. Journal of Clinical Apheresis 36:1, pages 177-178.
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Jorge L. Sepulveda. 2019. Accurate Results in the Clinical Laboratory. Accurate Results in the Clinical Laboratory 141 163 .
Christopher R. McCudden, Joannes F.M. Jacobs, David Keren, Hélène Caillon, Thomas Dejoie & Kristian Andersen. (2018) Recognition and management of common, rare, and novel serum protein electrophoresis and immunofixation interferences. Clinical Biochemistry 51, pages 72-79.
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Laura Fueyo, Juan Robles, Irene Aguilar, Aina M. Yáñez, Magdalena Socias & Magdalena Parera. (2017) Hemolysis index to detect degree of hydroxocobalamin interference with common laboratory tests. Journal of Clinical Laboratory Analysis 31:5, pages e22089.
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Wisit Cheungpasitporn, John Hui, Kianoush B. Kashani, Erica D. Wittwer, Robert C. AlbrightJrJr & John J. Dillon. (2017) High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clinical Kidney Journal 10:3, pages 357-362.
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Steven C. Curry & Meghan B. Spyres. 2017. Critical Care Toxicology. Critical Care Toxicology 1929 1949 .
Kinjynarah Fifi, Marie-Aude Robert de Rancher, Charles-Emmanuel Carteret, François-Xavier Maquart & Jean-Baptiste Oudart. (2016) Unexpected Case of Bright Pink–Colored Plasma. Clinical Chemistry 62:8, pages 1162-1163.
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Randy D. Kearns, Kathe M. Conlon, Annette F. Matherly, Kevin K. Chung, Vikhyat S. Bebarta, Jacob J. Hansen, Leopoldo C. Cancio, Michael Peck & Tina L. Palmieri. (2016) Guidelines for Burn Care Under Austere Conditions. Journal of Burn Care & Research 37:5, pages e427-e439.
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Pratistha Ranjitkar & Dina N. Greene. (2015) Therapeutic concentrations of hydroxocobalamin interferes with several spectrophotometric assays on the Beckman Coulter DxC and AU680 chemistry analyzers. Clinica Chimica Acta 450, pages 110-114.
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Steven C. Curry & Meghan B. Spyres. 2016. Critical Care Toxicology. Critical Care Toxicology 1 21 .
C. Brunel, C. Widmer, M. Augsburger, F. Dussy & T. Fracasso. (2012) Antidote treatment for cyanide poisoning with hydroxocobalamin causes bright pink discolouration and chemical–analytical interferences. Forensic Science International 223:1-3, pages e10-e12.
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Michael C Reade, Suzanne R Davies, Peter T Morley, Jennifer Dennett & Ian C Jacobs. (2012) Review article: Management of cyanide poisoning. Emergency Medicine Australasia 24:3, pages 225-238.
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