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Scandinavian Journal of Clinical and Laboratory Investigation Volume 72, 2012 - Issue 5
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Research Article

Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension

Martin SergDepartment of Cardiology, University of Tartu, Tartu, Estonia;Department of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, EstoniaCorrespondence[email protected]
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Priit KampusDepartment of Cardiology, University of Tartu, Tartu, Estonia;Department of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia;Heart Clinic of Tartu University Hospital, Tartu, Estonia
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Jaak KalsDepartment of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia;Department of Vascular Surgery, Tartu University Hospital, Tartu, Estonia
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Maksim ZaguraDepartment of Cardiology, University of Tartu, Tartu, Estonia;Department of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia
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Mihkel ZilmerDepartment of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia
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Kersti ZilmerDepartment of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia
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Tiiu KullisaarDepartment of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia
&
Jaan EhaDepartment of Cardiology, University of Tartu, Tartu, Estonia;Heart Clinic of Tartu University Hospital, Tartu, Estonia
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Pages 427-432 | Received 08 Jan 2012, Accepted 27 Apr 2012, Published online: 18 Jun 2012

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Andreja Trpkovic, Ivana Resanovic, Julijana Stanimirovic, Djordje Radak, Shaker A. Mousa, Desanka Cenic-Milosevic, Danimir Jevremovic & Esma R. Isenovic. (2015) Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Critical Reviews in Clinical Laboratory Sciences 52:2, pages 70-85.
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Articles from other publishers (23)

Rukhsana Gul, Meshail Okla, Amer Mahmood, Shahid Nawaz, Amina Fallata, Arwa Bazighifan, Musaad Alfayez & Assim A. Alfadda. (2023) Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts. Current Issues in Molecular Biology 45:11, pages 9316-9327.
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Esra Nurlu Temel, Mehtap Savran, Yalcın Erzurumlu, Nursel Hasseyid, Halil Ibrahim Buyukbayram, Gozde Okuyucu, Mehmet Abdulkadir Sevuk, Ozlem Ozmen & Ayse Coskun Beyan. (2023) The β1 Adrenergic Blocker Nebivolol Ameliorates Development of Endotoxic Acute Lung Injury. Journal of Clinical Medicine 12:5, pages 1721.
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Yide He, Rongwen Zhu, Yujie Cai, Yiqun Zhang, Yunhai Zhang, Shunlong Pan, Rudolf J. Schneider & Yongjun Zhang. (2022) Transcriptomics and protein biomarkers reveal the detoxifying mechanisms of UV radiation for nebivolol toward zebrafish (Danio rerio) embryos/larvae. Aquatic Toxicology 249, pages 106241.
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Julia Krzemińska, Magdalena Wronka, Ewelina Młynarska, Beata Franczyk & Jacek Rysz. (2022) Arterial Hypertension—Oxidative Stress and Inflammation. Antioxidants 11:1, pages 172.
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Vinícius Bocchino Seleme, Gustavo Lenci Marques, Antonio Eduardo Matoso Mendes, Inajara Rotta, Milena Pereira, Emilton Lima Júnior & Claudio L. Pereira da Cunha. (2020) Nebivolol for the Treatment of Essential Systemic Arterial Hypertension: A Systematic Review and Meta-Analysis. American Journal of Cardiovascular Drugs 21:2, pages 165-180.
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K. Uma priya, Ch. Venkataramaiah, N. Y. Sreedhar & C. Naga Raju. (2021) Design, synthesis, characterization and in vitro, in vivo and in silico antimicrobial and antiinflammatory activities of a new series of sulphonamide and carbamate derivatives of a nebivolol intermediate . RSC Advances 11:7, pages 3897-3916.
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Gisele Facholi Bomfim, Stefany Bruno Assis Cau, Alexandre Santos Bruno, Aline Garcia Fedoce & Fernando S Carneiro. (2018) Hypertension: a new treatment for an old disease? Targeting the immune system. British Journal of Pharmacology 176:12, pages 2028-2048.
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Annabella Braschi. (2019) Potential Protective Role of Blood Pressure-Lowering Drugs on the Balance between Hemostasis and Fibrinolysis in Hypertensive Patients at Rest and During Exercise. American Journal of Cardiovascular Drugs 19:2, pages 133-171.
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Thomas J. van 't Erve. (2018) Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α. Redox Biology 17, pages 284-296.
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Gabriel T. do Vale, Natália A. Gonzaga, Janaina A. Simplicio & Carlos R. Tirapelli. (2017) Nebivolol prevents ethanol-induced reactive oxygen species generation and lipoperoxidation in the rat kidney by regulating NADPH oxidase activation and expression. European Journal of Pharmacology 799, pages 33-40.
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Mazhar Hussain, Muhammad Saeed, Muhammad Zafar Majeed Babar, Moazzam Ali Atif & Lubna Akhtar. (2017) Nebivolol Attenuates Neutrophil Lymphocyte Ratio: A Marker of Subclinical Inflammation in Hypertensive Patients. International Journal of Hypertension 2017, pages 1-6.
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Kyle J. DiehlBrian L. StaufferCaitlin A. DowTyler D. BammertDanielle L. BrunjesJared J. GreinerChristopher A. DeSouza. (2016) Chronic Nebivolol Treatment Suppresses Endothelin-1–Mediated Vasoconstrictor Tone in Adults With Elevated Blood Pressure. Hypertension 67:6, pages 1196-1204.
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Justin Fongemie & Erika Felix-Getzik. (2015) A Review of Nebivolol Pharmacology and Clinical Evidence. Drugs 75:12, pages 1349-1371.
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Salim S. Hayek, Joseph C. Poole, Robert Neuman, Alanna A. Morris, Mohamed Khayata, Nino Kavtaradze, Matthew L. Topel, Jose G. Binongo, Qunna Li, Dean P. Jones, Edmund K. Waller & Arshed A. Quyyumi. (2015) Differential effects of nebivolol and metoprolol on arterial stiffness, circulating progenitor cells, and oxidative stress. Journal of the American Society of Hypertension 9:3, pages 206-213.
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Elen Rizzi, Danielle A. Guimaraes, Carla S. Ceron, Cibele M. Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F. Gerlach & Jose E. Tanus-Santos. (2014) β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free Radical Biology and Medicine 73, pages 308-317.
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Ana Paula Cabral de Faria, Vanessa Fontana, Rodrigo Modolo, Natália Ruggeri Barbaro, Andréa Rodrigues Sabbatini, Isabella Fagian Pansani, Silvia E. Ferreira-Melo & Heitor Moreno. (2014) Plasma 8-isoprostane levels are associated with endothelial dysfunction in resistant hypertension. Clinica Chimica Acta 433, pages 179-183.
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Augusto C. MontezanoRhian M. Touyz. (2014) Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research. Antioxidants & Redox Signaling 20:1, pages 164-182.
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Rhian M. Touyz. 2014. Cellular and Molecular Pathobiology of Cardiovascular Disease. Cellular and Molecular Pathobiology of Cardiovascular Disease 257 275 .
Timothy J. Werner, Nabil E. Boutagy, Kristin L. Osterberg, Jose M. Rivero & Kevin P. Davy. (2013) Singular and combined effects of nebivolol and lifestyle modification on large artery stiffness in hypertensive adults. Therapeutic Advances in Cardiovascular Disease 7:6, pages 285-292.
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Andreas Jekell, Karin Malmqvist, N. Håkan Wallén, David Mörtsell & Thomas Kahan. (2013) Markers of Inflammation, Endothelial Activation, and Arterial Stiffness in Hypertensive Heart Disease and the Effects of Treatment. Journal of Cardiovascular Pharmacology 62:6, pages 559-566.
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Carla S. Ceron, Elen Rizzi, Danielle A. Guimarães, Alisson Martins-Oliveira, Raquel F. Gerlach & Jose E. Tanus-Santos. (2013) Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension. Free Radical Biology and Medicine 65, pages 47-56.
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Francesco Fici, Turgay Celik, Sevket Balta, Atila Iyisoy, Murat Unlu, Sait Demitkol, Halil Yaman, Gianmaria Brambilla, Ejder Kardesoglu, Selim Kilic, Mehemet Yokusoglu & Guido Grassi. (2013) Comparative Effects of Nebivolol and Metoprolol on Red Cell Distribution Width and Neutrophil/Lymphocyte Ratio in Patients With Newly Diagnosed Essential Hypertension. Journal of Cardiovascular Pharmacology 62:4, pages 388-393.
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. (2013) European Perspectives. Circulation 127:4.
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