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Scandinavian Journal of Clinical and Laboratory Investigation Volume 29, 1972 - Issue 4
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Original Article

Binding of Bilirubin to Low-Affinity Sites of Human Serum Albumin in Vitro Followed by Co-Crystallization

R. Brodersen Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
,
L. Funding Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
,
A. O. Pedersen Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
&
H. Röigaard-Petersen Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
Pages 433-446 | Received 02 Nov 1971, Accepted 25 Jan 1972, Published online: 13 May 2010

Citations (35)

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Rolf Brodersen & Leo Stern. (1980) Binding of Bilirubin to Albumin. CRC Critical Reviews in Clinical Laboratory Sciences 11:4, pages 307-399.
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R. Brodersen & L. Funding. (1977) Binding of bilirubin and long-chain fatty acids to human serum albumin with general remarks on displacement of firmly bound ligands. Scandinavian Journal of Clinical and Laboratory Investigation 37:3, pages 257-266.
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H. Hertz. (1975) A Direct Spectrometric Method for Determination of the Concentration of Available Bilirubin Binding Sites in Serum Using Bromphenol Blue. Scandinavian Journal of Clinical and Laboratory Investigation 35:6, pages 545-559.
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D. Bratlid. (1972) The Effect of Free Fatty Acids, Bile Acids, and Hematin on Bilirubin Binding by Human Erythrocytes. Scandinavian Journal of Clinical and Laboratory Investigation 30:1, pages 107-112.
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R. Brodersen. (1972) Localization of Bilirubin Pools in the Non-Jaundiced Rat, with a Note on Bilirubin Dynamics in Normal Human Adults and in Gilbert's Syndrome. Scandinavian Journal of Clinical and Laboratory Investigation 30:1, pages 95-106.
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D. Bratlid & H. E. Rugstad. (1972) Effect of Albumin Binding on Bilirubin Conjugation and Toxicity in Cell Culture of a Clonal Strain of Rat Hepatoma Cells. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 461-465.
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R. Brodersen. (1972) Supersaturation with Bilirubin followed by Colloid Formation and Disposition, with a Hypothesis on the Etiology of Kernicterus. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 447-452.
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Articles from other publishers (28)

Namita Roy-Chowdhury, Xia Wang & Jayanta Roy-Chowdhury. 2020. Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics. Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics 507 553 .
Sanjiv B. Amin. (2016) Bilirubin Binding Capacity in the Preterm Neonate. Clinics in Perinatology 43:2, pages 241-257.
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Iryna Goncharova, Sergey Orlov & Marie Urbanová. (2013) The location of the high- and low-affinity bilirubin-binding sites on serum albumin: Ligand-competition analysis investigated by circular dichroism. Biophysical Chemistry 180-181, pages 55-65.
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Iryna Goncharova, Sergey Orlov & Marie Urbanová. (2013) Chiroptical Properties of Bilirubin-Serum Albumin Binding Sites. Chirality 25:4, pages 257-263.
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Namita Roy Chowdhury, Jayanta Roy Chowdhury & Yesim Avsar. 2013. Emery and Rimoin's Principles and Practice of Medical Genetics. Emery and Rimoin's Principles and Practice of Medical Genetics 1 34 .
Sanjiv B. Amin & Charles E. Ahlfors. (2008) Bilirubin-binding Capacity in Premature Infants. Pediatrics 121:4, pages 872-873.
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Charles E. Ahlfors & Oded Herbsman. (2003) Unbound Bilirubin in a Term Newborn With Kernicterus. Pediatrics 111:5, pages 1110-1112.
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Charles E. Ahlfors. (2001) Benzyl alcohol, kernicterus, and unbound bilirubin. The Journal of Pediatrics 139:2, pages 317-319.
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Kathryn M. Ivanetlch, Alfred E.A. Thumser, Susan E. Phillips & Cynthia N.T. Sikakana. (1990) Reversible inhibition of rat hepatic glutathione s-transferase 1–2 by bilirubin. Biochemical Pharmacology 40:7, pages 1563-1568.
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Helmut Marko, Norbert Müller & Heinz Falk. (1989) UV-VIS and CD-spectroscopic investigations of intermolecular interactions of bile pigments with small proteinsUV-VIS und CD-spektroskopische Untersuchungen intermolekularer Wechselwirkungen von Gallenpigmenten mit kleinen Proteinen. Monatshefte für Chemie - Chemical Monthly 120:2, pages 163-168.
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J Vázquez, M García-Calvo, F Valdivieso, F Mayor & F MayorJrJr. (1988) Interaction of bilirubin with the synaptosomal plasma membrane.. Journal of Biological Chemistry 263:3, pages 1255-1265.
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Gideon Blauer. (1986) Complexes of bilirubin with proteins. Biochimica et Biophysica Acta (BBA) - General Subjects 884:3, pages 602-604.
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Charles E. Ahlfors & Doreen DiBiasio-Erwin. (1986) Rate constants for dissociation of bilirubin from its binding sites in neonatal (cord) and adult sera. The Journal of Pediatrics 108:2, pages 295-298.
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Warren B. Karp, Sarvepalli B. Subramanyam, Chen-K. Ho & Alex F. Robertson. (1985) Drugs Affecting Bilirubin Uptake by Human Erythrocyte Ghosts. The American Journal of the Medical Sciences 289:6, pages 236-239.
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C.‐K. HO, A. F. ROBERTSON & W. B. KARP. (2008) Hematin and Bilirubin Binding to Human Serum Albumin and Newborn Serum. Acta Paediatrica 74:3, pages 372-377.
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J. Donald OSTROW & Lillian Celic. (1984) Bilirubin Chemistry, Ionization and Solubilization by Bile Salts. Hepatology 4:S2, pages 38S-45S.
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G. Blauer. (1983) Optical Activity of Bile Pigments. Israel Journal of Chemistry 23:2, pages 201-209.
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J J Aguanno & J H Ladenson. (1982) Influence of fatty acids on the binding of calcium to human albumin. Correlation of binding and conformation studies and evidence for distinct differences between unsaturated fatty acids and saturated fatty acids.. Journal of Biological Chemistry 257:15, pages 8745-8748.
Crossref
Charles E. Ahlfors. (1981) Competitive interaction of biliverdin and bilirubin only at the primary bilirubin binding site on human albumin. Analytical Biochemistry 110:2, pages 295-307.
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R. Brodersen. (1979) Bilirubin. Solubility and interaction with albumin and phospholipid. Journal of Biological Chemistry 254:7, pages 2364-2369.
Crossref
ANTONY F. McDONAGH. 1979. The Porphyrins. The Porphyrins 293 491 .
William J. Cashore, Lawrence M. Gartner, William Oh & Leo Stern. (1978) Clinical application of neonatal bilirubin-binding determinations: Current status. The Journal of Pediatrics 93:5, pages 827-833.
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R. BRODERSEN. (2008) PREVENTION OF KERNICTERUS, BASED ON RECENT PROGRESS IN BILIRUBIN CHEMISTRY. Acta Paediatrica 66:5, pages 625-634.
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David A. Lightner, Alexander Cu, Antony F. McDonagh & Lucita A. Palma. (1976) On the autoxidation of bilirubin. Biochemical and Biophysical Research Communications 69:3, pages 648-657.
Crossref
Lawrence M. Gartner & Kwang Sun Lee. (1976) Commentary: The bronze baby syndrome. The Journal of Pediatrics 88:3, pages 465-466.
Crossref
M. Pays & M. Beljean. (1975) Microdetermination of unbound bilirubin in sera. Application to the prevention of kernicterus by estimating the bilirubin-binding capacity of serum albumin. Clinica Chimica Acta 59:2, pages 121-128.
Crossref
G. Blauer. 1974. Large Molecules. Large Molecules 69 129 .
Karel P.M. Heirwegh, Jules A.T.P. Meuwissen & Johan Fevery. 1973. Advances in Clinical Chemistry Volume 16. Advances in Clinical Chemistry Volume 16 239 289 .

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