140
Views
80
CrossRef citations to date
0
Altmetric
Original Article

Binding of Calcium to Serum Albumin II. Effect of pH via Competitive Hydrogen and Calcium Ion Binding to the Imidazole Groups of Albumin

Pages 75-83 | Received 24 Sep 1971, Accepted 23 Oct 1971, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

P.J. Osther, K. Engel & P. Kildeberg. (2004) Renal response to acute acid loadingAn organ physiological approach. Scandinavian Journal of Urology and Nephrology 38:1, pages 62-68.
Read now
C. B. Kancir, P. H. Petersen & T. Madsen. (1989) Effects of erythrocytes, bicarbonate, temperature and albumin on in vitro ionized calcium variations with pH. Scandinavian Journal of Clinical and Laboratory Investigation 49:5, pages 475-482.
Read now
Alberto Jose Crottogini & Ole Siggaard-Andersen. (1981) Plasma ionized calcium in the critically ill on total parenteral nutrition. Scandinavian Journal of Clinical and Laboratory Investigation 41:1, pages 49-57.
Read now
K. O. Pedersen. (1972) Binding of Calcium to Serum Albumin IV. Effect of Temperature and Thermodynamics of Calcium-Albumin Interaction. Scandinavian Journal of Clinical and Laboratory Investigation 30:1, pages 89-94.
Read now
K. O. Pedersen. (1972) Binding of Calcium to Serum Albumin III. Influence of Ionic Strength and Ionic Medium. Scandinavian Journal of Clinical and Laboratory Investigation 29:4, pages 427-432.
Read now

Articles from other publishers (74)

Visarat Palitnonkiat & Natthida Owattanapanich. (2023) Hypocalcemia in trauma patients: A narrative review. Clinical Critical Care.
Crossref
Rita Gelli & Francesca Ridi. (2023) Reconsidering the role of albumin towards amorphous calcium phosphate-based calciprotein particles formation and stability from a physico-chemical perspective. Colloids and Surfaces B: Biointerfaces 227, pages 113372.
Crossref
Ainhoa Valldecabres & Noelia Silva-del-Río. (2023) Negative dietary cation–anion difference in prepartum dairy cow diets: a pragmatic study in two commercial dairy farms. animal 17:4, pages 100731.
Crossref
Margot DeBot, Angela Sauaia, Terry Schaid & Ernest E. Moore. (2022) Trauma‐induced hypocalcemia. Transfusion 62:S1.
Crossref
Akira Takahashi. (2021) The pathophysiology of leg cramping during dialysis and the use of carnitine in its treatment. Physiological Reports 9:21.
Crossref
Shinichiro Kawaguchi, Shin-ichiro Fujiwara, Rui Murahashi, Hirotomo Nakashima, Sae Matsuoka, Takashi Ikeda, Yumiko Toda, Shoko Ito, Tetsuaki Ban, Takashi Nagayama, Kento Umino, Daisuke Minakata, Hirofumi Nakano, Ryoko Yamasaki, Masahiro Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kazuya Sato, Iekuni Oh, Ken Ohmine & Yoshinobu Kanda. (2021) Risk factors for high-dose methotrexate-induced nephrotoxicity. International Journal of Hematology 114:1, pages 79-84.
Crossref
Ainhoa Valldecabres & Noelia Silva-del-Río. (2021) Effects of postpartum oral calcium supplementation on milk yield, milk composition, and reproduction in multiparous Jersey and Jersey × Holstein crossbreed cows. Journal of Dairy Science 104:1, pages 795-805.
Crossref
Ricky Michael Ditzel, Justin Lee Anderson, William Joseph Eisenhart, Cody Jack Rankin, Devin Robert DeFeo, Sangki Oak & Jeffrey Siegler. (2020) A review of transfusion- and trauma-induced hypocalcemia: Is it time to change the lethal triad to the lethal diamond?. Journal of Trauma and Acute Care Surgery 88:3, pages 434-439.
Crossref
Samah Al-Harthi, Joanna Izabela Lachowicz, Michal Eligiusz Nowakowski, Mariusz Jaremko & Łukasz Jaremko. (2019) Towards the functional high-resolution coordination chemistry of blood plasma human serum albumin. Journal of Inorganic Biochemistry 198, pages 110716.
Crossref
Akira Takahashi. (2019) Carnitine in dialysis patients透析とカルニチン. Nihon Toseki Igakkai Zasshi 52:2, pages 83-91.
Crossref
Joanna Gałęzowska & Ewa Chmielewska. (2018) Thermodynamics of the Interactions of Aminobisphosphonates and Their Calcium Complexes with Bovine Serum Albumin. Chemistry & Biodiversity 15:10, pages e1800272.
Crossref
Qi Qian. (2017) Acid‐base alterations in ESRD and effects of hemodialysis . Seminars in Dialysis 31:3, pages 226-235.
Crossref
Jing-wan Li, Ke Yuan, Sui-cun Shang & Ying Guo. (2017) A safer hypoglycemic agent for type 2 diabetes—Berberine organic acid salt. Journal of Functional Foods 38, pages 399-408.
Crossref
Vaibhav Maheshwari, Alhaji Cherif, Doris Fuertinger, Gudrun Schappacher-Tilp, Priscila Preciado, Stephan Thijssen, David A. Bushinsky & Peter Kotanko. (2017) An in silico method to predict net calcium transfer during hemodialysis. An in silico method to predict net calcium transfer during hemodialysis.
F.M. Trefz, P.D. Constable & I. Lorenz. (2017) Effect of Intravenous Small-Volume Hypertonic Sodium Bicarbonate, Sodium Chloride, and Glucose Solutions in Decreasing Plasma Potassium Concentration in Hyperkalemic Neonatal Calves with Diarrhea. Journal of Veterinary Internal Medicine 31:3, pages 907-921.
Crossref
Lawrence S. Weisberg. (2015) Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus. Clinical Journal of the American Society of Nephrology 10:8, pages 1476-1483.
Crossref
Thomas Langer, Eleonora Scotti, Eleonora Carlesso, Alessandro Protti, Loredana Zani, Monica Chierichetti, Pietro Caironi & Luciano Gattinoni. (2015) Electrolyte shifts across the artificial lung in patients on extracorporeal membrane oxygenation: Interdependence between partial pressure of carbon dioxide and strong ion difference. Journal of Critical Care 30:1, pages 2-6.
Crossref
Alexander J. Donovan, Joseph Kalkowski, Stephanie A. Smith, James H. Morrissey & Ying Liu. (2014) Size-Controlled Synthesis of Granular Polyphosphate Nanoparticles at Physiologic Salt Concentrations for Blood Clotting. Biomacromolecules 15:11, pages 3976-3984.
Crossref
Gopal Basu, Golla Sudhakar & Anjali Mohapatra. (2013) Renal tubular acidosis. Clinical Queries: Nephrology 2:4, pages 166-178.
Crossref
Susumu TakanoHiroshi KajiFujio HayashiKanae HigashiguchiSachie JoukeiYoshiaki KidoJuro TakahashiKayo Osawa. (2012) A Calculation Model for Serum Ionized Calcium Based on an Equilibrium Equation for Complexation. Analytical Chemistry Insights 7, pages ACI.S9681.
Crossref
Michalis Agrafiotis. (2011) Strong ion reserve: a viewpoint on acid base equilibria and buffering. European Journal of Applied Physiology 111:8, pages 1951-1954.
Crossref
Regine Willumeit, Janine Fischer, Frank Feyerabend, Norbert Hort, Ulrich Bismayer, Stefanie Heidrich & Boriana Mihailova. (2011) Chemical surface alteration of biodegradable magnesium exposed to corrosion media. Acta Biomaterialia 7:6, pages 2704-2715.
Crossref
Jean‐Sebastien Rachoin, Lawrence S. Weisberg & Christopher B. McFadden. (2010) Treatment of lactic acidosis: Appropriate confusion. Journal of Hospital Medicine 5:4.
Crossref
Masanori HorieKeiko NishioKatsuhide FujitaShigehisa EndohArisa MiyauchiYoshiro SaitoHitoshi IwahashiKazuhiro YamamotoHideki MurayamaHajime NakanoNaoki NanashimaEtsuo NikiYasukazu Yoshida. (2009) Protein Adsorption of Ultrafine Metal Oxide and Its Influence on Cytotoxicity toward Cultured Cells. Chemical Research in Toxicology 22:3, pages 543-553.
Crossref
Zhensheng Chen, Ian J Griffin, Yana L Kriseman, Lily K Liang & Steven A Abrams. (2003) Inductively Coupled Plasma Mass Spectrometric Analysis of Calcium Isotopes in Human Serum: A Low-Sample-Volume Acid-Equilibration Method. Clinical Chemistry 49:12, pages 2050-2055.
Crossref
Karl S. Roth & James C. M. Chan. (2016) Renal Tubular Acidosis: A New Look at an Old Problem. Clinical Pediatrics 40:10, pages 533-543.
Crossref
Jeffrey A. Kraut & Ira Kurtz. (2001) Use of base in the treatment of severe acidemic states. American Journal of Kidney Diseases 38:4, pages 703-727.
Crossref
A. Klinger, D. Steinberg, D. Kohavi & M. N. Sela. (1997) Mechanism of adsorption of human albumin to titaniumin vitro. Journal of Biomedical Materials Research 36:3, pages 387-392.
Crossref
Michael Kaye, Peter J. Somerville, Graeme Lowe, Maya Ketis & Wolfgang Schneider. (1997) Hypocalcemic tetany and metabolic alkalosis in a dialysis patient: an unusual event. American Journal of Kidney Diseases 30:3, pages 440-444.
Crossref
Khanh Vinh Quoc Luong, MD & Lan Thi Hoang Nguyen, MD. (1997) SOME CHARACTERISTICS OF PRIMARY HYPERPARATHYROIDISM IN VIETNAMESE IMMIGRANTS LIVING IN SOUTHERN CALIFORNIA. Endocrine Practice 3:4, pages 231-235.
Crossref
Khanh Vinh Quoc Luong & Lan Thi Hoang Nguyen. (1997) Some Characteristics of Primary Hyperparathyroidism in Vietnamese Immigrants Living in Southern California. Endocrine Practice 3:4, pages 231-235.
Crossref
J.H. Lin. (1996) Bisphosphonates: A review of their pharmacokinetic properties. Bone 18:2, pages 75-85.
Crossref
Rammohan S. Rao, Michael L. Graver, M. Urivetsky & Steven M. Scharf. (1994) Mechanisms of myocardial depression after bolus injection of sodium bicarbonate. Journal of Critical Care 9:4, pages 255-261.
Crossref
D. James Cooper, Michael J. Herbertson, Heinrich A. Werner & Keith R. Walley. (1993) Bicarbonate Does Not Increase Left Ventricular Contractility During L-Lactic Acidemia in Pigs. American Review of Respiratory Disease 148:2, pages 317-322.
Crossref
A. Ross Morton & Gavril Hercz. (2007) Serum Calcium and Hypoproteinemia in Dialysis Patients. Seminars in Dialysis 5:3, pages 242-243.
Crossref
Wolfgang BaumannHubert Heuer, Harald Darius, Helmut Lohmann, Juergen Meyer, Manuela Schierenberg & Norbert Treese. 1992. Platelet-Activating Factor and Structurally Related Alkyl Ehter Lipids. Platelet-Activating Factor and Structurally Related Alkyl Ehter Lipids 1381 1385 .
I. Vanicky, M. Mars̆ala, J. Murár & J. Mars̆ala. (1992) Prolonged postischemic hyperventilation reduces acute neuronal damage after 15 min of cardiac arrest in the dog. Neuroscience Letters 135:2, pages 167-170.
Crossref
Hubert O. Heuer, Harald Darius, Helmut F. Lohmann, Juergen Meyer, Manuela Schierenberg & Norbert Treese. (1991) Platelet-activating factor type activity in plasma from patients with septicemia and other diseases. Lipids 26:12, pages 1381-1385.
Crossref
K. Kölling. (1991) Die ionisierte Calciumfraktion des Blutes: Abhängigkeit von verschiedenen methodischen Faktoren1. Journal of Veterinary Medicine Series A 38:1-10, pages 629-638.
Crossref
J. A. Russell. 1991. Update 1991. Update 1991 105 109 .
Claude B. Kancir, Per Hyltoft Petersen, Tommy Madsen & Anders S. Olesen. (1988) In vivo and in vitro ionized calcium variations induced by acute respiratory acid base disturbances. Clinica Chimica Acta 175:3, pages 307-313.
Crossref
J WhicherC Spence. (2016) When is Serum Albumin Worth Measuring?. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 24:6, pages 572-580.
Crossref
C. B. Kancir, Hyltoft Petersen & J. Wandrup. (1987) Plasma ionized calcium during paediatric anaesthesia: Effects of pH and succinylcholine. Canadian Journal of Anaesthesia 34:4, pages 391-394.
Crossref
A. Sawaya, M. Deyme & J.-P. Benoit. (1987) Calcium and thiocyanate interactions with cposslinked albumin microcapsules: influence of the reticulation rate. Biomaterials 8:3, pages 211-216.
Crossref
SVERKER LJUNGHALL, HENRIK JOBORN, LARS BENSON, BENGT FELLSTRÖM, LEIF WIDE & GÖRAN ÅKERSTROM. (2008) Effects of physical exercise on serum calcium and parathyroid hormone. European Journal of Clinical Investigation 14:6, pages 469-473.
Crossref
F J Vanstapel & W D Lissens. (2016) Free Ionised Calcium—A Critical Survey. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 21:5, pages 339-351.
Crossref
P. J. Kerry & Catherine J. Paton. (2012) Increased sensitivity of arachidonic acid‐induced platelet aggregation in the presence of carbon dioxide. British Journal of Pharmacology 81:1, pages 125-130.
Crossref
Girolamo A. Ortolano, R.C. Stuart, Kenneth R. WunschelJr.Jr., Edward A. Kaiser, Rupert P. Hammond & Alvin K. Swonger. (1983) An inexpensive method for the determination of serum ionized calcium. Microchemical Journal 28:3, pages 409-430.
Crossref
Oscar R. Rebolledo & Juan Jose’ Gagliardino. (1983) Glucagon and insulin secretion during acid-base alterations. Acta Diabetologica Latina 20:3, pages 211-220.
Crossref
G.A. Ortolano, A.K. Swonger, E.A. Kaiser & R.P. Hammond. (1983) A calcium hypothesis of antidepressant action. Medical Hypotheses 10:2, pages 207-221.
Crossref
R.W. Marshall & A. Hodgkinson. (1983) Calculation of plasma ionised calcium from total calcium, proteins and pH: comparison with measured values. Clinica Chimica Acta 127:2, pages 305-310.
Crossref
J J Aguanno & J H Ladenson. (1982) Influence of fatty acids on the binding of calcium to human albumin. Correlation of binding and conformation studies and evidence for distinct differences between unsaturated fatty acids and saturated fatty acids.. Journal of Biological Chemistry 257:15, pages 8745-8748.
Crossref
Kiyoshi. Matsumoto, Kimimasa. Yamada & Yutaka. Osajima. (2002) Ascorbate electrode for determination of L-ascorbic acid in food. Analytical Chemistry 53:13, pages 1974-1979.
Crossref
Peter. Anker, Erich. Wieland, Daniel. Ammann, Rene E. Dohner, Robert. Asper & Wilhelm. Simon. (2002) Neutral carrier based ion-selective electrode for the determination of total calcium in blood serum. Analytical Chemistry 53:13, pages 1970-1974.
Crossref
Lambert H.M. Janssen, Marianne T. Van Wilgenburg & Jaap Wilting. (1981) Human serum albumin as an allosteric two-state protein. Evidence from effects of calcium and warfarin on proton binding behaviour. Biochimica et Biophysica Acta (BBA) - Protein Structure 669:2, pages 244-250.
Crossref
Jaap Wilting, Betsy J. 'T Hart & Johan J. De Gier. (1980) The role of albumin conformation in the binding of diazepam to human serum albumin. Biochimica et Biophysica Acta (BBA) - Protein Structure 626:2, pages 291-298.
Crossref
J. Wilting, W.F. van der Giesen, L.H. Janssen, M.M. Weideman, M. Otagiri & J.H. Perrin. (1980) The effect of albumin conformation on the binding of warfarin to human serum albumin. The dependence of the binding of warfarin to human serum albumin on the hydrogen, calcium, and chloride ion concentrations as studied by circular dichroism, fluorescence, and equilibrium dialysis.. Journal of Biological Chemistry 255:7, pages 3032-3037.
Crossref
A C Kennedy, R F Allam, P J Rooney, M E Watson, A Fairney, K D Buchanan & C J Hillyard. (1979) Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications.. Annals of the Rheumatic Diseases 38:5, pages 401-412.
Crossref
. (1979) SERUM-CALCIUM. The Lancet 313:8121, pages 858-859.
Crossref
. (1979) Philadelphia Chromosome Positive Leukæmias. The Lancet 313:8121, pages 857-858.
Crossref
Delbert J. Eatough, Trescott E. Jensen, Lee D. Hansen, Hans F. Loken & Selwyn J. Rehfeld. (1978) The binding of Ca2+ and Mg2+ to human serium albumin: A calorimetric study. Thermochimica Acta 25:3, pages 289-297.
Crossref
W. Scholtan, H. Rosenkranz & M. Scheer. (1978) Binding of sisomicin and streptomycin to human albuminBindung von Sisomicin und Streptomycin an Humanalbumin. V. Wirkung von Kalzium-Ionen. Infection 6:4, pages 162-165.
Crossref
W. Scholtan & H. Rosenkranz. (1978) Ionic binding of aminoglycosides to human serum albumin in the absence of divalent cationsIonogene Bindung von Aminoglykosiden an Humanalbumin in Abwesenheit von divalenten Kationen. Infection 6:3, pages 130-136.
Crossref
Carlos Eduardo Leme & Helio Bernardes Silva. (1977) Interaction of calcium ions with serum albumin in chronic renal failure. Clinica Chimica Acta 77:3, pages 287-294.
Crossref
M. Basset, G. Defaye & E.M. Chambaz. (1977) Study of steroid-protein interactions by electron spin resonance spectroscopy. Binding of a spin-labelled dihydrotestosterone to bovine serum albumin. Biochimica et Biophysica Acta (BBA) - Protein Structure 491:2, pages 434-446.
Crossref
S.S. Tang & M.M. Frojmovic. (1977) The effects of pCO2 and pH on platelet shape change and aggregation for human and rabbit platelet-rich plasma. Thrombosis Research 10:1, pages 135-145.
Crossref
Peter W. Carr, Earl B. Smith, Stephen R. Betso & Robert H. Callicott. (1976) A thermochemical investigation of the binding of 12-phosphotungstic acid and chloride ion to bovine serum albumin. Thermochimica Acta 15:1, pages 105-121.
Crossref
K. Paschen. 1976. Ionic Actions on Vascular Smooth Muscle. Ionic Actions on Vascular Smooth Muscle 6 11 .
J.W. Eastman, S.J. Rehfeld & H. Loken. (1975) Ultrafiltrable calcium and the conformation of albumin. Clinica Chimica Acta 58:3, pages 233-237.
Crossref
K.T. Izutsu, S.P. Felton, I.A. Siegel, J.I. Nicholls, J. Crawford, J. McGough & W.T. Yoda. (1974) An investigation of the ionic calcium assay based on the jellyfish protein aequorin. Analytical Biochemistry 58:2, pages 479-484.
Crossref
P. Han & N. G. Ardlie. (2008) The Influence pH, Temperature, and Calcium on Platelet Aggregation: Maintenance of Environmental pH and Platelet Function for in Vitro Studies in Plasma Stored at 37° C. British Journal of Haematology 26:3, pages 373-389.
Crossref
R.M. Frye, H. Lees & G.A. Rechnitz. (1974) Magnesium-albumin binding measurements using ion-selective membrane electrodes. Clinical Biochemistry 7:1-4, pages 258-270.
Crossref
Michael T. Ryan. (2002) Influence of steroid binding on the tryptic hydrolysis of serum albumin. Biochemistry 12:12, pages 2221-2230.
Crossref
B.E. Chapman, T.E. MacDermott & W.J. O'Sullivan. (1973) Studies on manganese complexes of human serum albumin. Bioinorganic Chemistry 3:1, pages 27-38.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.