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Scandinavian Journal of Clinical and Laboratory Investigation Volume 30, 1972 - Issue 3
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Original Article

Protein-Bound Calcium in Human Serum. Quantitative Examination of Binding and its Variables by a Molecular Binding Model and Clinical Chemical Implications for Measurement of Ionized Calcium

K. O. Pedersen Dept. of Clinical Chemistry Århus Kommunehospital, 8000, Århus C, Denmark
Pages 321-329 | Received 01 Jun 1972, Accepted 28 Jul 1972, Published online: 08 Jul 2009

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Keith Roland Johnson, Gary Charles Mascall, Alan Thomas Howarth & D. A. Heath. (1984) Differential Laboratory Diagnosis of Hypercalcemia. CRC Critical Reviews in Clinical Laboratory Sciences 21:1, pages 51-97.
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M. P. D. Heining, D. M. Band & R. A. F. Linton. (1983) The effect of temperature on plasma ionized calcium measured in whole blood in vitro. Scandinavian Journal of Clinical and Laboratory Investigation 43:8, pages 709-714.
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Kaj O. Pedersen. (1978) An analysis of measured and calculated calcium quantities in serum. Scandinavian Journal of Clinical and Laboratory Investigation 38:7, pages 659-667.
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Alastair C. Kennedy, Bahgat F. Allam, Iain T. Boyle, George Nuki, Patrick J. Rooney & W. Watson Buchanan. (1975) Abnormalities in mineral metabolism suggestive of parathyroid over-activity in rheumatoid arthritis. Current Medical Research and Opinion 3:6, pages 345-358.
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Articles from other publishers (35)

Peter Constable, Florian M. Trefz & Henry Stämpfli. (2019) Effects of pH and the plasma or serum concentrations of total calcium, chloride, magnesium, l ‐lactate, and albumin on the plasma ionized calcium concentration in calves . Journal of Veterinary Internal Medicine 33:4, pages 1822-1832.
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J. Danner, M.D. Ridgway, S.I. Rubin & K. Le Boedec. (2017) Development of a Multivariate Predictive Model to Estimate Ionized Calcium Concentration from Serum Biochemical Profile Results in Dogs. Journal of Veterinary Internal Medicine 31:5, pages 1392-1402.
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Tineke M. De Schutter, Geert J. Behets, Hilde Geryl, Mirjam E. Peter, Sonja Steppan, Kristina Gundlach, Jutta Passlick-Deetjen, Patrick C. D'Haese & Ellen Neven. (2013) Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia. Kidney International 83:6, pages 1109-1117.
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Susumu TakanoHiroshi KajiFujio HayashiKanae HigashiguchiSachie JoukeiYoshiaki KidoJuro TakahashiKayo Osawa. (2012) A Calculation Model for Serum Ionized Calcium Based on an Equilibrium Equation for Complexation. Analytical Chemistry Insights 7, pages ACI.S9681.
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Jill Adamski, Adrienne Carruth Griffin, Christa Eisenmann, Michael C. Milone & Bruce S. Sachais. (2010) Increased risk of citrate reactions in patients with multiple myeloma during peripheral blood stem cell leukapheresis. Journal of Clinical Apheresis 25:4, pages 188-194.
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PAOLO FERRARI, RICHARD SINGER, AANCHAL AGARWAL, ANNE HURN, MARY A TOWNSEND & PAUL CHUBB. (2009) Serum phosphate is an important determinant of corrected serum calcium in end-stage kidney disease. Nephrology 14:4, pages 383-388.
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Kehinde U. Onifade, Amin A. Mohammad, John R. Petersen & Anthony O. Okorodudu. (2005) Ionized calcium: indications and advantages of its measurement Bestimmung des ionisierten Calciums: Indikationen und Vorteile. LaboratoriumsMedizin 29:4, pages 235-240.
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Michael Kaye, Peter J. Somerville, Graeme Lowe, Maya Ketis & Wolfgang Schneider. (1997) Hypocalcemic tetany and metabolic alkalosis in a dialysis patient: an unusual event. American Journal of Kidney Diseases 30:3, pages 440-444.
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Jacqueline C. Kent, Peter G. Arthur, Robert W. Retallack & Peter E. Hartmann. (2009) Calcium, phosphate and citrate in human milk at initiation of lactation. Journal of Dairy Research 59:2, pages 161-167.
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C J Pearce, T J Hine & K Peek. (2016) Hypercalcaemia Due to Calcium Binding by a Polymeric IgA x -paraprotein . Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 28:3, pages 229-234.
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Lori J. Sokoll & Bess Dawson-Hughes. (1989) Effect of menopause and aging on serum total and ionized calcium and protein concentrations. Calcified Tissue International 44:3, pages 181-185.
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R. G. HanssenF. P. LafeberG. FlikS. E. Wendelaar Bonga. (1989) Ionic and total calcium levels in the blood of the European eel (Anguilla anguilla): effects of stanniectomy and hypocalcin replacement therapy. Journal of Experimental Biology 141:1, pages 177-186.
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B M Buckley & L J Russell. (2016) The Measurement of Ionised Calcium in Blood Plasma. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 25:5, pages 447-465.
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Jean M McGinlay & R B Payne. (2016) Serum Albumin by Dye-Binding: Bromocresol Green or Bromocresol Purple? The Case for Conservatism. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 25:4, pages 417-421.
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J P Ashby, D J Wright & M G Rinsler. (2016) The Adjusted Serum Calcium Concept—A Reappraisal. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 23:5, pages 533-537.
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Trevor F. White, John R. Farndon, Sergio C. Conceicao, Michael F. Laker, Michael K. Ward & David N.S. Kerr. (1986) Serum calcium status in health and disease: A comparison of measured and derived parameters. Clinica Chimica Acta 157:2, pages 199-213.
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F J Vanstapel & W D Lissens. (2016) Free Ionised Calcium—A Critical Survey. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 21:5, pages 339-351.
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Mary D Gardner, Frances J Dryburgh, J A Fyffe & A S Jenkins. (2016) Predictive Value of Derived Calcium Figures Based on the Measurement of Ionised Calcium. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 18:2, pages 106-109.
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Angela Fairney. (2016) The Use of Biochemical Tests in the Diagnosis of Disorders of Calcium Metabolism. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 17:4, pages 161-169.
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MOGENS G. SIMESEN. 1980. Clinical Biochemistry of Domestic Animals. Clinical Biochemistry of Domestic Animals 575 648 .
Patricia H. Duncan, John Savory & Hillel J. Gitelman. (1979) Effects of hemodialysis on protein-bound calcium. Kidney International 15:3, pages 283-285.
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G.D. Ryan & J.R.L. Masarei. (1979) Validity of “corrected” calcium values. Clinica Chimica Acta 91:3, pages 329-335.
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H. E. Nielsen, C. K. Christensen & K. J. Olsen. (2009) Serum Calcitonin in Patients with Chronic Renal Disease. Acta Medica Scandinavica 205:1-6, pages 615-618.
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Leif Mosekilde, Hans Hvid Hansen, Merete Sanvig Christensen, Birger Lund, Ole Helmer Sørensen, Flemming Melsen & Anthony W. Normany. (2009) Fractional Intestinal Calcium Absorption in Epileptics on Anticonvulsant Therapy.. Acta Medica Scandinavica 205:1-6, pages 405-409.
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R B Payne, M E Carver & D B Morgan. (1979) Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual.. Journal of Clinical Pathology 32:1, pages 56-60.
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Delbert J. Eatough, Trescott E. Jensen, Lee D. Hansen, Hans F. Loken & Selwyn J. Rehfeld. (1978) The binding of Ca2+ and Mg2+ to human serium albumin: A calorimetric study. Thermochimica Acta 25:3, pages 289-297.
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S.C. Conceicao, M.K. Ward, F. Alvarez-Ude, P. Aljama, P. Smith & D.N.S. Kerr. (1978) Determination of serum ionised calcium by ion-exchange electrode in normal subjects. Clinica Chimica Acta 86:2, pages 143-151.
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H. E. NIELSEN, M. S. CHRISTENSEN, F. MELSEN, F. K. RØMER & H. E. HANSEN. (1977) EFFECT OF lα-HYDROXYVITAMIN D 3 ON PARATHYROID FUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE . Clinical Endocrinology 7:s1, pages 67s-72s.
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H. E. Nielsen, F. Melsen & M. S. Christensen. (2009) Aseptic Necrosis of Bone Following Renal Transplantation. Acta Medica Scandinavica 202:1-6, pages 27-32.
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Leif Mosekilde, Flemming Melsen, Merete Sanvig Christensen, Birger Lund & Ole Helmer Sørensen. (2009) Effect of Long-term Vitamin D2 Treatment on Bone Morphometry and Biochemical Values in Anticonvulsant Osteomalacia. Acta Medica Scandinavica 201:1-6, pages 303-307.
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M. S. Christensen, O. Brandsborg & N. J. Christensen. 1977. Phosphate Metabolism. Phosphate Metabolism 363 368 .
L. Mosekilde, F. Melsen & M. S. Christensen. (1976) Interrelationships between bone morphometry, thyroid function tests and serum parathyroid hormone in hyperthyroidism. Calcified Tissue Research 22:S1, pages 229-235.
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Leif Mosekilde & Flemming Melsen. (2009) Anticonvulsant Osteomalacia Determined by Quantitative Analysis of Bone Changes. Acta Medica Scandinavica 199:1-6, pages 349-356.
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J.W. Eastman, S.J. Rehfeld & H. Loken. (1975) Ultrafiltrable calcium and the conformation of albumin. Clinica Chimica Acta 58:3, pages 233-237.
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Mogens Hørder. (1973) Inorganic pyrophosphate-phosphohydrolytic activity in human serum. Catalytic properties of the ionic species of PPi and MgPPi complexes. Biochimica et Biophysica Acta (BBA) - Enzymology 321:1, pages 329-335.
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