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Original Article

EDTA-dependent pseudothrombocytopaenia: A 12-month epidemiological study

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Pages 537-542 | Received 07 Oct 1987, Accepted 29 Feb 1988, Published online: 08 Jul 2009

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Read on this site (6)

Han Li, Bangqin Wang, Leping Ning, Yu Luo & Shulin Xiang. (2020) Transient appearance of EDTA dependent pseudothrombocytopenia in a patient with 2019 novel coronavirus pneumonia. Platelets 31:6, pages 825-826.
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Sara M. Sousa, Teresa M. Sousa, Cristina F. Silva & Carlos C. Mendes. (2020) Pseudothrombocytopenia: a case of platelet satellitism and phagocytosis by neutrophils. Platelets 31:4, pages 541-543.
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Emmanuel Andres, Nassim Dali-Youcef, Khalid Serraj & Jacques Zimmer. (2009) Recognition and management of drug-induced cytopenias: the example of idiosyncratic drug-induced thrombocytopenia. Expert Opinion on Drug Safety 8:2, pages 183-190.
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P. C. M. Bartels, M. Schoorl & A. J. P. F. Lombarts. (1997) Screening for EDTA-dependent deviations in platelet counts and abnormalities in platelet distribution histograms in pseudothrombocytopenia. Scandinavian Journal of Clinical and Laboratory Investigation 57:7, pages 629-636.
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T. A. Hervig, M. Farstad & S. E. Vollset. (1996) Endogenous serotonin in human blood platelets: factors that may influence reference values. Platelets 7:1-2, pages 47-52.
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S. Antonsen & J. M. Beyer. (1989) In vitro granulocyte aggregation: Technical Note. Scandinavian Journal of Clinical and Laboratory Investigation 49:7, pages 685-688.
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Articles from other publishers (42)

M. Tomicic, T. Sotonica Piria, J. Bingulac-Popovic, I. Babic, R. Stimac & T. Vuk. (2022) Transient pseudothrombocytopenia (PTCP) in the neonate due to the mother. Transfusion Clinique et Biologique 29:3, pages 257-260.
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Audrey E. Spelde, Donat R. Spahn & Prakash A. Patel. 2022. Perioperative Medicine. Perioperative Medicine 101 120 .
Amit Gulati, Aparna Tiwari, Vijay Shetty, Ifeanyi Nwosu & Sakshi Khurana. (2021) Tirofiban: A Rare Cause of Thrombocytopenia in a Patient Undergoing Percutaneous Coronary Intervention. Cureus.
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Benjamin Lardinois, Julien Favresse, Bernard Chatelain, Giuseppe Lippi & François Mullier. (2021) Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications. Journal of Clinical Medicine 10:4, pages 594.
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Emma Strous, Arne Vanhoudt, Anja Smolenaars, Gerdien van Schaik, Matthijs Schouten, Henrik de Pater, Bjorn Roelofs & Mirjam Nielen. (2021) Observational Study on Variation of Longitudinal Platelet Counts in Calves over the First 14 Days of Life and Reference Intervals from Cross-Sectional Platelet and Leukocyte Counts in Dairy Calves up to Two Months of Age. Animals 11:2, pages 347.
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Peter Schuff-Werner, Joe Mansour & Angela Gropp. (2020) Pseudo-thrombocytopenia (PTCP). A challenge in the daily laboratory routine?. Journal of Laboratory Medicine 44:5, pages 295-304.
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Le Zhong, Juskaran Chadha & Ali Ameri. (2020) A Curious Case of Pseudothrombocytopenia due to In Vitro Agglutination . Case Reports in Hematology 2020, pages 1-3.
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C. Ronald MacKenzie & Raymond D. Pastore. 2020. Perioperative Care of the Orthopedic Patient. Perioperative Care of the Orthopedic Patient 307 314 .
Vineet Meghrajani, Nitin Sabharwal, Vinod Namana, Moustafa Elsheshtawy & Bernard Topi. (2018) A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion. Case Reports in Hematology 2018, pages 1-6.
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Pia Bükmann Larsen, Jonas Vikeså & Lennart Friis-Hansen. (2017) EDTA-induced pseudothrombocytosis and citrate-induced platelet agglutination in a patient with Waldenstrom macroglobulinemia. Clinical Case Reports 5:8, pages 1243-1247.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 15 18 .
Jianhua Lin, Yaoling Luo, Shaoyu Yao, Miansheng Yan, Jianpei Li, Wenting Ouyang & Miaohuan Kuang. (2015) Discovery and Correction of Spurious Low Platelet Counts due to EDTA-Dependent Pseudothrombocytopenia. Journal of Clinical Laboratory Analysis 29:5, pages 419-426.
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Michael Nagler, Peter Keller, Daniel Siegrist & Lorenzo Alberio. (2014) A case of EDTA-dependent pseudothrombocytopenia: simple recognition of an underdiagnosed and misleading phenomenon. BMC Clinical Pathology 14:1.
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Shanthi Kumari B, Somasekar D S, Bharath G & Gairik Kundu. (2014) A SURVEY ON THE INCIDENCE OF PSEUDO - THROMBOCYTOPENIA IN THE IN - PATIENTS. Journal of Evidence Based Medicine and Healthcare 1:3, pages 118-122.
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C. Ronald MacKenzie. 2014. Perioperative Care of the Orthopedic Patient. Perioperative Care of the Orthopedic Patient 231 237 .
Peter Schuff‐Werner, Michael Steiner, Sebastian Fenger, Hans‐Jürgen Gross, Alexa Bierlich, Katrin Dreissiger, Steffen Mannuß, Gabriele Siegert, Maximilian Bachem & Peter Kohlschein. (2013) Effective estimation of correct platelet counts in pseudothrombocytopenia using an alternative anticoagulant based on magnesium salt. British Journal of Haematology 162:5, pages 684-692.
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Kui Hyun Yoon. (2013) A Case of Platelet Satellitism with Platelet Phagocytosis by Neutrophils and Platelet-neutrophil Agglutination. Laboratory Medicine Online 3:4, pages 259.
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James N. George. 2013. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 117 131 .
Nicola Bizzaro. 2013. Platelets. Platelets 989 997 .
Marc Zandecki, Franck Genevieve, Jérémie Gérard & Alban Godon. 2012. Laboratory Hematology Practice. Laboratory Hematology Practice 66 78 .
Emmanuel Andrès, Helen Fothergill & Mustapha Mecili. 2011. Autoimmune Diseases. Autoimmune Diseases 259 273 .
Irfan Yavasoglu, Bilal Acar, Gurhan Kadikoylu & Zahit Bolaman. (2010) Platelet Aggregation Tests Are Affected in Pseudothrombocytopenia: Table 1. Laboratory Medicine 41:8, pages 483-485.
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K. Serraj, M. Mecili, M. Aouni, A. Maaouni & E. Andrès. (2009) Les thrombopénies médicamenteuses idiosyncrasiques. La Revue de Médecine Interne 30:10, pages 866-871.
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M. ZANDECKI, F. GENEVIEVE, J. GERARD & A. GODON. (2007) Spurious counts and spurious results on haematology analysers: a review. Part I: platelets. Clinical and Laboratory Haematology 29:1, pages 4-20.
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Giuseppe Banfi, Gian Luca Salvagno & Giuseppe Lippi. (2007) The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clinical Chemical Laboratory Medicine 45:5.
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James N. George & Kiarash Kojouri. 2007. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 123 138 .
Nicola Bizzaro. 2007. Platelets. Platelets 999 1007 .
. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 1200 1203 .
Bakul I Dalal & Malcolm L Brigden. (2002) Artifacts that may be present on a blood film. Clinics in Laboratory Medicine 22:1, pages 81-100.
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J.J.M.L. Hoffmann. (2001) EDTA-induced pseudo-neutropenia resolved with kanamycin. Clinical & Laboratory Haematology 23:3, pages 193-196.
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Kay A. Criswell, Michael A. Breider & Michael R. Bleavins. (2001) EDTA-Dependent Platelet Phagocytosis. American Journal of Clinical Pathology 115:3, pages 376-384.
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Jean-Pierre Gelinas, Lanu V Stoddart & Edward L Snyder. (2001) Thrombocytopenia and Critical Care Medicine. Journal of Intensive Care Medicine 16:1, pages 1-21.
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Jean-Pierre GelinasLanu V. StoddartEdward L. Snyder. (2016) Thrombocytopenia and Critical Care Medicine. Journal of Intensive Care Medicine 16:1, pages 1-21.
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David C Sane, Lakshmi V Damaraju, Eric J Topol, Catherine F Cabot, Mary Ann Mascelli, Robert A Harrington, Maarten L Simoons & Robert M Califf. (2000) Occurrence and clinical significance of pseudothrombocytopenia during abciximab therapy. Journal of the American College of Cardiology 36:1, pages 75-83.
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Mujahid A. Rizvi, Shehla Rizvi Shah, Gary E. Raskob & James N. George. (1999) Drug-induced thrombocytopenia. Current Opinion in Hematology 6:5, pages 349-353.
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Labrini C. Dalamangas & Thomas F. Slaughter. (1998) Ethylenediaminetetraacetic Acid-Dependent Pseudothrombocytopenia in a Cardiac Surgical Patient. Anesthesia & Analgesia 86:6, pages 1210-1211.
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Labrini C. Dalamangas & Thomas F. Slaughter. (1998) Ethylenediaminetetraacetic Acid-Dependent Pseudothrombocytopenia in a Cardiac Surgical Patient. Anesthesia & Analgesia 86:6, pages 1210-1211.
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Mary K. Boudreaux. (1996) Platelets and Coagulation. Veterinary Clinics of North America: Small Animal Practice 26:5, pages 1065-1087.
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Nicola Bizzaro. (2006) EDTA‐dependent pseudothrombocytopenia: A clinical and epidemiological study of 112 cases, with 10‐year follow‐up. American Journal of Hematology 50:2, pages 103-109.
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Federico Silvestri, Luigi Virgolini, Chiara Savignano, Francesco Zaja, Marinella Velisig & Michele Baccarani. (2009) Incidence and Diagnosis of EDTA‐Dependent Pseudothrombocytopenia in a Consecutive Outpatient Population Referred for Isolated Thrombocytopenia. Vox Sanguinis 68:1, pages 35-39.
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C. G. Christopoulos & S. J. Machin. (2008) A new type of pseudothrombocytopenia: EDTA‐mediated agglutination of platelets bearing Fab fragments of a chimaeric antibody. British Journal of Haematology 87:3, pages 650-652.
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R.H.B. Meyboom & I.A. Jaffe. 1990. 194 204 .

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