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Scandinavian Journal of Gastroenterology Volume 46, 2011 - Issue 4
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Gastrointestinal Cancer

Impact of MTHFR gene C677T polymorphism on Bcl-2 gene methylation and protein expression in colorectal cancer

Qinghui Zhu Experimental Center for Medical Science Research of Teaching Hospital of Jiangsu University, Shanghai People's Hospital of Putuo District, Shanghai, PR China; School of Basic Medicine and Medical Technology, Jiangsu University, Zhenjiang, Jiangsu Province, PR ChinaCorrespondence[email protected]
,
Zhonggan Jin Experimental Center for Medical Science Research of Teaching Hospital of Jiangsu University, Shanghai People's Hospital of Putuo District, Shanghai, PR China; School of Basic Medicine and Medical Technology, Jiangsu University, Zhenjiang, Jiangsu Province, PR China
,
Ya Yuan Experimental Center for Medical Science Research of Teaching Hospital of Jiangsu University, Shanghai People's Hospital of Putuo District, Shanghai, PR China
,
Qing Lu Experimental Center for Medical Science Research of Teaching Hospital of Jiangsu University, Shanghai People's Hospital of Putuo District, Shanghai, PR China
,
Danhong Ge Experimental Center for Medical Science Research of Teaching Hospital of Jiangsu University, Shanghai People's Hospital of Putuo District, Shanghai, PR China
&
Ming Zong Clinical Laboratory of Orient Hospital Affiliated to Tongji University, Shanghai, PR China
Pages 436-445 | Received 30 Aug 2010, Accepted 29 Oct 2010, Published online: 06 Dec 2010

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Kristian Bjøro. (2011) This Month in Scandinavian Journal of Gastroenterology. Scandinavian Journal of Gastroenterology 46:4, pages 387-388.
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Tasneem Fatima, Usman Afzal, Saeeda Shaharyar, Shagufta Khan, Mussarat Ashraf, Wardah Rafaqat, Muhammad Rohan Kayani & Rehana Rehman. (2022) MTHFR-c 677C>T polymorphism and male infertility: An analysis in a cohort of Pakistani men. Revista Internacional de Andrología 20:4, pages 274-280.
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Abolfazl Yari, Seyed Mahdi Emami Meybodi, Zahra Miri Karam, Arash Samoudi, Fatemeh Hashemi, Mostafa Aalipour, Maryam Fekri Soofi Abadi & Shahriar Dabiri. (2021) Association of MTHFR 677C>T and 1298A>C genetic polymorphisms with colorectal cancer: Genotype and haplotype analysis in a Southeast Iranian population. Gene Reports 25, pages 101399.
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Lin Wan, Yuhong Li, Zhengrong Zhang, Zuoli Sun, Yi He & Rena Li. (2018) Methylenetetrahydrofolate reductase and psychiatric diseases. Translational Psychiatry 8:1.
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Lingyan Xu, Zhiqiang Qin, Feng Wang, Shuhui Si, Lele Li, Peinan Lin, Xiao Han, Xiaomin Cai, Haiwei Yang & Yanhong Gu. (2017) Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis. Bioscience Reports 37:6.
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Sofia Fragkioudaki, Adrianos Nezos, Vassilis L. Souliotis, Ilenia Chatziandreou, Angelica A. Saetta, Nikolaos Drakoulis, Athanasios G. Tzioufas, Michael Voulgarelis, Petros P. Sfikakis, Michael Koutsilieris, Mary K. Crow, Haralampos M. Moutsopoulos & Clio P. Mavragani. (2017) MTHFR gene variants and non-MALT lymphoma development in primary Sjogren’s syndrome. Scientific Reports 7:1.
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Vandana Rai. (2016) Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations. Asian Pacific Journal of Cancer Prevention 16:18, pages 8093-8100.
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Luciano Delgado-Plasencia, Hugo Álvarez-Argüelles, Eduardo Salido-Ruiz, M. Elisa Castro-Peraza, Alberto Bravo-Gutiérrez, Antonia Fernández-Peralta, Juan González-Aguilera, Antonio Alarcó-Hernández & Vicente Medina-Arana. (2015) MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer. Pathology - Research and Practice 211:12, pages 989-995.
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X.-P. Guo, Y. Wang, H. Zhao, S.-D. Song, J. Zhou & Y. Han. (2013) Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects. Clinical and Translational Oncology 16:7, pages 623-629.
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Min Tang, Shang-Qian Wang, Bian-Jiang Liu, Qiang Cao, Bing-Jie Li, Peng-Chao Li, Yong-Fei Li, Chao Qin & Wei Zhang. (2014) The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case–control studies. Molecular Biology Reports 41:7, pages 4659-4673.
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Isabela Tatiana Sales de Arruda, Darlene Camati Persuhn & Naila Francis Paulo de Oliveira. (2013) The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells. Genetics and Molecular Biology 36:4, pages 490-493.
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MENGMENG ZHAO, XUELIAN LI, CHENGZHONG XING & BAOSEN ZHOU. (2013) Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta-analysis. Biomedical Reports 1:5, pages 781-791.
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Jing Lin, Jin-qiang Hou, Han-dan Xiang, Yi-yong Yan, Yu-chao Gu, Jia-heng Tan, Ding Li, Lian-quan Gu, Tian-miao Ou & Zhi-shu Huang. (2013) Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: Implications for epigenetic regulation. Biochemical and Biophysical Research Communications 433:4, pages 368-373.
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Zan Teng, Lei Wang, Shuang Cai, Ping Yu, Jin Wang, Jing Gong & Yunpeng Liu. (2013) The 677C>T (rs1801133) Polymorphism in the MTHFR Gene Contributes to Colorectal Cancer Risk: A Meta-Analysis Based on 71 Research Studies. PLoS ONE 8:2, pages e55332.
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Youngmi Cho, Nancy D Turner, Laurie A Davidson, Robert S Chapkin, Raymond J Carroll & Joanne R Lupton. (2012) A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas. Experimental Biology and Medicine 237:12, pages 1387-1393.
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Shan Zhong, Jia-He Yang, Kai Liu, B. H. Jiao & Zhi-Jie Chang. (2012) Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians. Tumor Biology 33:6, pages 2041-2051.
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Sung-Min Moon, Soo-A Kim, Jung-Hoon Yoon & Sang-Gun Ahn. (2012) HOXC6 Is Deregulated in Human Head and Neck Squamous Cell Carcinoma and Modulates Bcl-2 Expression. Journal of Biological Chemistry 287:42, pages 35678-35688.
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Xuewen Sheng, Yanxi Zhang, Erjiang Zhao, Su Lu, Xiaoli Zheng, Hong Ge & Weiquan Lu. (2012) MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case–control studies. Molecular Biology Reports 39:10, pages 9669-9679.
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Shailendra Kapoor. (2012) Emerging Role of Polymorphisms of the MTHFR Gene in Systemic Carcinogenesis Besides Their Role in Migraines. Headache: The Journal of Head and Face Pain 52:8, pages 1322-1323.
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Zhen Yang, Xie-Fu Zhang, Hong-Xiang Liu, Yong-Shun Hao & Chun-Lin Zhao. (2012) MTHFR C677T Polymorphism and Colorectal Cancer Risk in Asians, a Meta-analysis of 21 Studies. Asian Pacific Journal of Cancer Prevention 13:4, pages 1203-1208.
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Deborah A. Kennedy, Seth J. Stern, Ilan Matok, Myla E. Moretti, Moumita Sarkar, Thomasin Adams-Webber & Gideon Koren. (2012) Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis . Journal of Cancer Epidemiology 2012, pages 1-24.
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