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Scandinavian Journal of Gastroenterology Volume 47, 2012 - Issue 3
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Research Article

Predictive biomarkers with potential of converting conventional chemotherapy to targeted therapy in patients with metastatic colorectal cancer

Niels Frank JensenDepartment of Veterinary Disease Biology, Section for Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
,
David Hersi SmithDepartment of Veterinary Disease Biology, Section for Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark;DAKO, Glostrup, Denmark
,
Sune Boris NygårdDepartment of Veterinary Disease Biology, Section for Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
,
Maria Unni RømerDepartment of Veterinary Disease Biology, Section for Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
,
Kirsten Vang NielsenDAKO, Glostrup, Denmark
&
Nils BrünnerDepartment of Veterinary Disease Biology, Section for Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, DenmarkCorrespondence[email protected]
Pages 340-355 | Accepted 11 Nov 2011, Published online: 19 Dec 2011

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Sune Boris Nygård, Ib Jarle Christensen, Signe Lykke Nielsen, Hans Jørgen Nielsen, Nils Brünner & Karen-Lise Garm Spindler. (2013) Assessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer. Scandinavian Journal of Gastroenterology 49:1, pages 84-91.
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Hans J. Nielsen & Nils Brünner. (2012) EDITORIAL. Scandinavian Journal of Gastroenterology 47:3, pages 256-257.
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Articles from other publishers (18)

Wei Qi, Jing Yang, Longbo Zheng, Yun Lu, Ruiqing Liu, Yiheng Ju, Tianye Niu & Dongsheng Wang. (2023) CT‐based radiomics for the identification of colorectal cancer liver metastases sensitive to first‐line irinotecan‐based chemotherapy. Medical Physics 50:5, pages 2705-2714.
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Emmanouil Georgilis, Maria Gavriatopoulou, Diamantis I. Tsilimigras, Panagiotis Malandrakis, Theodosios Theodosopoulos & Ioannis Ntanasis-Stathopoulos. (2023) Optimizing Adjuvant Therapy after Surgery for Colorectal Cancer Liver Metastases: A Systematic Review. Journal of Clinical Medicine 12:6, pages 2401.
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Yuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saito, Chie Takasu, Shinichiro Yamada & Mitsuo Shimada. (2020) HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis. World Journal of Surgical Oncology 18:1.
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Helena Taflin, Elisabeth Odin, Kristoffer Derwinger, Göran Carlsson, Bengt Gustavsson & Yvonne Wettergren. (2018) Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer. Cancer Chemotherapy and Pharmacology 82:6, pages 987-997.
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Egle Kukcinaviciute, Violeta Jonusiene, Ausra Sasnauskiene, Daiva Dabkeviciene, Eigile Eidenaite & Arvydas Laurinavicius. (2018) Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116. Journal of Cellular Biochemistry 119:7, pages 5913-5920.
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Mohamed Elbadawy, Tatsuya Usui, Hideyuki Yamawaki & Kazuaki Sasaki. (2018) Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers 10:6, pages 164.
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Precious Takondwa Makondi, Chi-Ming Chu, Po-Li Wei & Yu-Jia Chang. (2017) Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer. PLOS ONE 12:7, pages e0180616.
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Niels Frank Jensen, Keli Agama, Amit Roy, David Hersi Smith, Thomas D. Pfister, Maria Unni Rømer, Hong-Liang Zhang, James H. Doroshow, Birgitta R. Knudsen, Jan Stenvang, Nils Brünner & Yves Pommier. (2016) Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. Journal of Experimental & Clinical Cancer Research 35:1.
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Lu Jun, Xu Jun & Shi Qin. (2016) Effect of ethanol extract of HPRS, a Traditional Chinese Medicine formula, on HCT116 cell Line. Journal of Traditional Chinese Medicine 36:6, pages 760-767.
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J B Kjersem, M Thomsen, T Guren, J Hamfjord, G Carlsson, B Gustavsson, T Ikdahl, G Indrebø, P Pfeiffer, O Lingjærde, K M Tveit, Y Wettergren & E H Kure. (2015) AGXT and ERCC2 polymorphisms are associated with clinical outcome in metastatic colorectal cancer patients treated with 5-FU/oxaliplatin. The Pharmacogenomics Journal 16:3, pages 272-279.
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Ida Kappel Buhl, Sarah Gerster, Mauro Delorenzi, Thomas Jensen, Peter Buhl Jensen, Fred Bosman, Sabine Tejpar, Arnaud Roth, Nils Brunner, Anker Hansen & Steen Knudsen. (2016) Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data. PLOS ONE 11:5, pages e0155123.
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Adele Faralli, Fredrik Melander, Esben Kjaer Unmack Larsen, Sergey Chernyy, Thomas L. Andresen & Niels B. Larsen. (2016) Multiplexed Dosing Assays by Digitally Definable Hydrogel Volumes. Advanced Healthcare Materials 5:2, pages 244-254.
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Niels F. Jensen, Jan Stenvang, Mette K. Beck, Barbora Hanáková, Kirstine C. Belling, Khoa N. Do, Birgitte Viuff, Sune B. Nygård, Ramneek Gupta, Mads H. Rasmussen, Line S. Tarpgaard, Tine P. Hansen, Eva Budinská, Per Pfeiffer, Fred Bosman, Sabine Tejpar, Arnaud Roth, Mauro Delorenzi, Claus L. Andersen, Maria U. Rømer, Nils Brünner & José M.A. Moreira. (2015) Establishment and characterization of models of chemotherapy resistance in colorectal cancer: Towards a predictive signature of chemoresistance. Molecular Oncology 9:6, pages 1169-1185.
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Y Zheng, J Zhou & Y Tong. (2014) Gene signatures of drug resistance predict patient survival in colorectal cancer. The Pharmacogenomics Journal 15:2, pages 135-143.
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M. López-Gómez, J. Moreno-Rubio, I. Suárez-García, P. Cejas, R. Madero, E. Casado, A. M. Jiménez, M. Sereno, C. Gómez-Raposo, F. Zambrana, M. Merino, D. Fernández-Luengas & J. Feliu. (2014) Gene expression differences in primary colorectal tumors and matched liver metastases: chemotherapy related or tumoral heterogeneity?. Clinical and Translational Oncology 17:4, pages 322-329.
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Thomas Schweiger, György Lang, Walter Klepetko & Konrad Hoetzenecker. (2014) Prognostic factors in pulmonary metastasectomy: spotlight on molecular and radiological markers. European Journal of Cardio-Thoracic Surgery 45:3, pages 408-416.
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Greg YothersMichael J. O'ConnellMark LeeMargarita LopatinKim M. Clark-LangoneCarl MillwardSoonmyung PaikSaima SharifSteven ShakNorman Wolmark. (2013) Validation of the 12-Gene Colon Cancer Recurrence Score in NSABP C-07 As a Predictor of Recurrence in Patients With Stage II and III Colon Cancer Treated With Fluorouracil and Leucovorin (FU/LV) and FU/LV Plus Oxaliplatin. Journal of Clinical Oncology 31:36, pages 4512-4519.
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Da-Qing Chen, Dong-Xiao Yao, Hong-Yang Zhao & Shu-Juan Yang. (2012) DNA Repair Gene ERCC1 and XPD Polymorphisms Predict Glioma Susceptibility and Prognosis. Asian Pacific Journal of Cancer Prevention 13:6, pages 2791-2794.
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