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Scandinavian Journal of Gastroenterology Volume 47, 2012 - Issue 4
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Liver and Biliary Disease

Carvedilol or propranolol in portal hypertension? A randomized comparison

Lise HobolthDepartment of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, Copenhagen University, Hvidovre, Denmark;Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Hvidovre, DenmarkCorrespondence[email protected]
,
Søren MøllerDepartment of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Hvidovre, Denmark
,
Henning GrønbækDepartment of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark
,
Klaus RoelsgaardDepartment of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark
,
Flemming BendtsenDepartment of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, Copenhagen University, Hvidovre, Denmark
&
Erik Feldager HansenDepartment of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, Copenhagen University, Hvidovre, Denmark
Pages 467-474 | Received 04 Dec 2011, Accepted 02 Feb 2012, Published online: 09 Mar 2012

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Søren Møller, Karen V. Danielsen, Puria Nabilou, Nina Kimer & Flemming Bendtsen. (2023) Beta-adrenergic blockade in cirrhosis – harmful or helpful?. Expert Review of Gastroenterology & Hepatology 17:6, pages 519-529.
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Sheng Chen, Jin-Jun Wang, Qin-Qin Wang, Jun-Wei Hu, Shuang Dong, Li-Juan Hu, Yi-Cheng Jian, Xin-Yan Liu, Gen-Mei Yang & Wu-Jun Xiong. (2015) The effect of carvedilol and propranolol on portal hypertension in patients with cirrhosis: a meta-analysis. Patient Preference and Adherence 9, pages 961-970.
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Søren Møller & Flemming Bendtsen. (2015) Complications of cirrhosis. A 50 years flashback. Scandinavian Journal of Gastroenterology 50:6, pages 763-780.
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Articles from other publishers (35)

Lana Dardari, Maher Taha, Purva Dahat, Stacy Toriola, Travis Satnarine, Zareen Zohara, Ademiniyi Adelekun, Kofi D Seffah, Korlos Salib & Ana P Arcia Franchini. (2023) The Efficacy of Carvedilol in Comparison to Propranolol in Reducing the Hepatic Venous Pressure Gradient and Decreasing the Risk of Variceal Bleeding in Adult Cirrhotic Patients: A Systematic Review. Cureus.
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Sarah‐Louise Gillespie, Timothy P. Hanrahan, Don C. Rockey, Avik Majumdar & Peter C. Hayes. (2023) Review article: controversies surrounding the use of carvedilol and other beta blockers in the management of portal hypertension and cirrhosis. Alimentary Pharmacology & Therapeutics 57:5, pages 454-463.
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Karen Vagner Danielsen, Signe WieseTroels BuskPuria NabilouThit Mynster KronborgClaus Leth PetersenJens Dahlgaard HoveSøren MøllerFlemming Bendtsen. (2022) Cardiovascular Mapping in Cirrhosis From the Compensated Stage to Hepatorenal Syndrome: A Magnetic Resonance Study. American Journal of Gastroenterology 117:8, pages 1269-1278.
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Karen Vagner Danielsen, Jens Dahlgaard Hove, Puria Nabilou, Meng Yin, Jun Chen, Mirabella Zhao, Thomas Kallemose, Ane Søgaard Teisner, Hartwig Roman Siebner, Richard L. Ehman, Søren Møller & Flemming Bendtsen. (2021) Using MR elastography to assess portal hypertension and response to beta‐blockers in patients with cirrhosis. Liver International 41:9, pages 2149-2158.
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Georgios N. Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Sempastien Fillipas-Ntekouan, Andreas Fotopoulos, Spyridon Tsiouris, Xanthi Xourgia, Lampros Lakkas, Konstantinos Pappas, Lampros K. Michalis, Fotini Sergianiti, Gerasimos Baltayiannis, Dimitrios Christodoulou, Christina Koustousi, Nikolaos Aggelis & Haralampos Milionis. (2021) Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites. Journal of Clinical Gastroenterology 55:8, pages 721-729.
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Nikolaj Rittig, Niels Kristian Aagaard, Gerda Elisabeth Villadsen, Thomas Damgaard Sandahl, Niels Jessen, Henning Grønbæk & Jacob George. (2021) Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension. Alimentary Pharmacology & Therapeutics 54:3, pages 320-328.
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Nikolaus Pfisterer, Lukas W Unger & Thomas Reiberger. (2021) Clinical algorithms for the prevention of variceal bleeding and rebleeding in patients with liver cirrhosis. World Journal of Hepatology 13:7, pages 731-746.
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Sanchit Sharma, Samagra Agarwal, Deepak Gunjan, Kanav Kaushal, Abhinav Anand, Srikant Mohta, Shalimar & Anoop Saraya. (2021) Long-term Outcomes with Carvedilol versus Propranolol in Patients with Index Variceal Bleed: 6-year Follow-up Study. Journal of Clinical and Experimental Hepatology 11:3, pages 343-353.
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Enrico Maria Zardi, Chiara Giorgi, Aldo Dobrina, Elena Vecile & Domenico Maria Zardi. (2020) Analogies and differences between cirrhotic cardiomyopathy and hepatopulmonary syndrome. Medicinal Research Reviews 41:2, pages 739-753.
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Sergi Guixé-Muntet, Chang-Peng Zhu, Wei-Fen Xie & Jordi Gracia-Sancho. (2020) Novel therapeutics for portal hypertension and fibrosis in chronic liver disease. Pharmacology & Therapeutics 215, pages 107626.
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Philip D. J. Dunne, Rohit Sinha, Adrian J. Stanley, Neil Lachlan, Hamish Ireland, Aman Shams, Ram Kasthuri, Ewan H. Forrest & Peter C. Hayes. (2020) Randomised clinical trial: standard of care versus early-transjugular intrahepatic porto-systemic shunt (TIPSS) in patients with cirrhosis and oesophageal variceal bleeding. Alimentary Pharmacology & Therapeutics 52:1, pages 98-106.
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Jiao Yang, Ke Ge, Ling Chen & Jian-Le Yang. (2019) The efficacy comparison of carvedilol plus endoscopic variceal ligation and traditional, nonselective β-blockers plus endoscopic variceal ligation in cirrhosis patients for the prevention of variceal rebleeding: a meta-analysis. European Journal of Gastroenterology & Hepatology 31:12, pages 1518-1526.
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Antony P Zacharias, Rebecca Jeyaraj, Lise Hobolth, Flemming Bendtsen, Lise Lotte Gluud & Marsha Y Morgan. (2018) Carvedilol versus traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices. Cochrane Database of Systematic Reviews 2018:10.
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Satish Maharaj, Karan Seegobin, Julio Perez-Downes, Belinda Bajric, Simone Chang & Pramod Reddy. (2017) Severe carvedilol toxicity without overdose – caution in cirrhosis. Clinical Hypertension 23:1.
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J. Arlt, W. Wei, C. Xie, A. Homeyer, U. Settmacher, U. Dahmen & O. Dirsch. (2017) Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction. BMC Pharmacology and Toxicology 18:1.
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Thomas Reiberger, Andreas Püspök, Maria Schoder, Franziska Baumann-Durchschein, Theresa Bucsics, Christian Datz, Werner Dolak, Arnulf Ferlitsch, Armin Finkenstedt, Ivo Graziadei, Stephanie Hametner, Franz Karnel, Elisabeth Krones, Andreas Maieron, Mattias Mandorfer, Markus Peck-Radosavljevic, Florian Rainer, Philipp Schwabl, Vanessa Stadlbauer, Rudolf Stauber, Herbert Tilg, Michael Trauner, Heinz Zoller, Rainer Schöfl & Peter Fickert. (2017) Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III). Wiener klinische Wochenschrift 129:S3, pages 135-158.
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Ankit Bhardwaj, Chandan Kumar Kedarisetty, Chitranshu Vashishtha, Ajeet Singh Bhadoria, Ankur Jindal, Guresh Kumar, Ashok Choudhary, S M Shasthry, Rakhi Maiwall, Manoj Kumar, Vikram Bhatia & Shiv Kumar Sarin. (2017) Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial. Gut 66:10, pages 1838-1843.
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Vipin Gupta, Ramakant Rawat, Shalimar & Anoop Saraya. (2016) Carvedilol versus propranolol effect on hepatic venous pressure gradient at 1 month in patients with index variceal bleed: RCT. Hepatology International 11:2, pages 181-187.
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Nina Kimer, Julie Steen Pedersen, Troels Malte Busk, Lise Lotte Gluud, Lise Hobolth, Aleksander Krag, Søren Møller & Flemming Bendtsen. (2016) Rifaximin has no effect on hemodynamics in decompensated cirrhosis: A randomized, double‐blind, placebo‐controlled trial. Hepatology 65:2, pages 592-603.
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Eula Plana Tetangco, Rogelio G. Silva & Edgar V. Lerma. (2016) Portal hypertension: Etiology, evaluation, and management. Disease-a-Month 62:12, pages 411-426.
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Vijendra Kirnake, Anil Arora, Varun Gupta, Praveen Sharma, Vikas Singla, Naresh Bansal, Mohan Goyal, Romesh Chawlani & Ashish Kumar. (2016) Hemodynamic Response to Carvedilol is Maintained for Long Periods and Leads to Better Clinical Outcome in Cirrhosis: A Prospective Study. Journal of Clinical and Experimental Hepatology 6:3, pages 175-185.
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Tong Li, Wenbo Ke, Ping Sun, Xiang Chen, Ajay Belgaumkar, Yuanjian Huang, Wenjing Xian, Jinjin Li & Qichang Zheng. (2016) Carvedilol for portal hypertension in cirrhosis: systematic review with meta-analysis. BMJ Open 6:5, pages e010902.
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Enrico Maria Zardi, Domenico Maria Zardi, Diana Chin, Chiara Sonnino, Aldo Dobrina & Antonio Abbate. (2016) Cirrhotic cardiomyopathy in the pre- and post-liver transplantation phase. Journal of Cardiology 67:2, pages 125-130.
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Dhiraj Tripathi, Adrian J Stanley, Peter C Hayes, David Patch, Charles Millson, Homoyon Mehrzad, Andrew Austin, James W Ferguson, Simon P Olliff, Mark Hudson & John M Christie. (2015) UK guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut 64:11, pages 1680-1704.
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Lise Hobolth, Flemming Bendtsen & Lise Lotte Gluud. (2015) Carvedilol versus non-selective beta-blockers for portal hypertension in cirrhosis. Cochrane Database of Systematic Reviews.
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Nancy Aguilar-Olivos, Miguel Motola-Kuba, Roberto Candia, Marco Arrese, Nahúm Méndez-Sánchez, Misael Uribe & Norberto C Chávez-Tapia. (2014) Hemodynamic effect of Carvedilol vs. propranolol in cirrhotic patients: Systematic review and meta-analysis. Annals of Hepatology 13:4, pages 420-428.
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Dhiraj Tripathi & Peter C. Hayes. (2014) Beta-blockers in portal hypertension: new developments and controversies. Liver International 34:5, pages 655-667.
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E. Sinagra, G. Perricone, M. D'Amico, F. Tinè & G. D'Amico. (2014) Systematic review with meta-analysis: the haemodynamic effects of carvedilol compared with propranolol for portal hypertension in cirrhosis. Alimentary Pharmacology & Therapeutics 39:6, pages 557-568.
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Lise Hobolth, Flemming Bendtsen, Erik F. Hansen & Søren Møller. (2014) Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: A randomised study. Digestive and Liver Disease 46:3, pages 251-256.
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Søren Møller. (2014) Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects. World Journal of Gastroenterology 20:42, pages 15499.
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Flemming Bendtsen, Søren Møller & Aleksander Krag. 2014. Variceal Hemorrhage. Variceal Hemorrhage 213 228 .
Erwin Biecker. (2013) Gastrointestinal Bleeding in Cirrhotic Patients with Portal Hypertension. ISRN Hepatology 2013, pages 1-20.
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Jens H. Henriksen & Søren Møller. (2013) Ascites. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 5:1, pages 1-116.
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Ki Tae Suk, Dae Yong Kim, Kyoung Min Sohn & Dong Joon Kim. 2013. 33 122 .
Karen Bonefeld, Lise Hobolth, Anders Juul & Søren Møller. (2012) The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade. Growth Hormone & IGF Research 22:6, pages 212-218.
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