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Inflammatory Bowel Disease

Mucosal cytokine gene expression profiles as biomarkers of response to infliximab in ulcerative colitis

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Pages 538-547 | Received 21 Dec 2011, Accepted 11 Feb 2012, Published online: 10 Apr 2012

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Raja Atreya & Markus F Neurath. (2018) Mechanisms of molecular resistance and predictors of response to biological therapy in inflammatory bowel disease. The Lancet Gastroenterology & Hepatology 3:11, pages 790-802.
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Casper Steenholdt, Klaus Bendtzen, Jørn Brynskov & Mark A. Ainsworth. (2016) Optimizing Treatment with TNF Inhibitors in Inflammatory Bowel Disease by Monitoring Drug Levels and Antidrug Antibodies. Inflammatory Bowel Diseases 22:8, pages 1999-2015.
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Sofia Roth, Marianne R. Spalinger, Claudia Gottier, Luc Biedermann, Jonas Zeitz, Silvia Lang, Achim Weber, Gerhard Rogler & Michael Scharl. (2016) Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. PLOS ONE 11:5, pages e0154817.
Crossref
Casper Steenholdt, Mehmet Coskun, Sine Buhl, Klaus Bendtzen, Mark A. Ainsworth, Jørn Brynskov & Ole H. Nielsen. (2016) Circulating Cytokines and Cytokine Receptors in Infliximab Treatment Failure Due to TNF-α Independent Crohn Disease. Medicine 95:16, pages e3417.
Crossref
Tadakazu Hisamatsu, Ulrike Erben & Anja A. Kühl. (2016) The Role of T-Cell Subsets in Chronic Inflammation in Celiac Disease and Inflammatory Bowel Disease Patients: More Common Mechanisms or More Differences?. Inflammatory Intestinal Diseases 1:2, pages 52-62.
Crossref
Lijun Du, John J. Kim, Jinhua Shen & Ning Dai. (2016) Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability. Gastroenterology Research and Practice 2016, pages 1-9.
Crossref
Johan Burisch & Pia Munkholm. 2016. Telemanagement of Inflammatory Bowel Disease. Telemanagement of Inflammatory Bowel Disease 85 99 .
Dingguo Zhang, Cheng Wei, Jun Yao, Xiaoyan Cai & Lisheng Wang. (2015) Interleukin-10 gene-carrying bifidobacteria ameliorate murine ulcerative colitis by regulating regulatory T cell/T helper 17 cell pathway. Experimental Biology and Medicine 240:12, pages 1622-1629.
Crossref
Stephanie M. Slevin & Laurence J. Egan. (2015) New Insights into the Mechanisms of Action of Anti–Tumor Necrosis Factor-α Monoclonal Antibodies in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 21:12, pages 2909-2920.
Crossref
Aping Yuan, Hang Yang, Haili Qi, Jing Cui, Wei Hua, Can Li, Zhigang Pang, Wei Zheng & Guanglin Cui. (2015) IL-9 antibody injection suppresses the inflammation in colitis mice. Biochemical and Biophysical Research Communications 468:4, pages 921-926.
Crossref
Shoko Sato, Toshimi Chiba, Shotaro Nakamura & Takayuki Matsumoto. (2015) Changes in cytokine profile may predict therapeutic efficacy of infliximab in patients with ulcerative colitis. Journal of Gastroenterology and Hepatology 30:10, pages 1467-1472.
Crossref
M. K. Magnusson, H. Strid, S. Isaksson, A. Bajor, A. Lasson, K.‐A. Ung & L. Öhman. (2015) Cultured blood T‐cell responses predict anti‐ TNF therapy response in patients with ulcerative colitis . Alimentary Pharmacology & Therapeutics 41:11, pages 1149-1161.
Crossref
Emilio G Quetglas. (2015) Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease. World Journal of Gastroenterology 21:44, pages 12519.
Crossref
Konstantinos Papamichael, Ann Gils, Paul Rutgeerts, Barrett G. Levesque, Séverine Vermeire, William J. Sandborn & Niels Vande Casteele. (2015) Role for Therapeutic Drug Monitoring During Induction Therapy with TNF Antagonists in IBD. Inflammatory Bowel Diseases 21:1, pages 182-197.
Crossref
Haili Qi, Hang Yang, Gang Xu, Jingli Ren, Wei Hua, Yingpeng Shi, Malvin Torsvik, Jon Florholmen & Guanglin Cui. (2015) Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice. Immunobiology 220:1, pages 54-59.
Crossref
Ting Wen & Marc E. Rothenberg. 2015. Mucosal Immunology. Mucosal Immunology 883 914 .
Florian Martin, Alain Sewer, Marja Talikka, Yang Xiang, Julia Hoeng & Manuel C Peitsch. (2014) Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models. BMC Bioinformatics 15:1.
Crossref
Jung-Wook Kim, Hyo Jong Kim, Chang Kyun Lee, Jae-Jun Shim, Jae Young Jang, Suk Ho Dong, Byung-Ho Kim, Young Woon Chang & Sung-Gil Chi. (2014) Elevation of PRKCDBP, A Novel Transcriptional Target of TNF-α, and Its Downregulation by Infliximab in Patients with Ulcerative Colitis. Digestive Diseases and Sciences 59:12, pages 2947-2957.
Crossref
Geert R. D'Haens, R. Balfour Sartor, Mark S. Silverberg, Joel Petersson & Paul Rutgeerts. (2014) Future directions in inflammatory bowel disease management. Journal of Crohn's and Colitis 8:8, pages 726-734.
Crossref
K. Subramaniam, A. Richardson, J. Dodd, J. Platten, B. Shadbolt & P. Pavli. (2014) Early predictors of colectomy and long-term maintenance of remission in ulcerative colitis patients treated using anti-tumour necrosis factor therapy. Internal Medicine Journal 44:5, pages 464-470.
Crossref
Shomron Ben-Horin & Yehuda Chowers. (2014) Tailoring anti-TNF therapy in IBD: drug levels and disease activity. Nature Reviews Gastroenterology & Hepatology 11:4, pages 243-255.
Crossref
Yi Fengming & Wu Jianbing. (2014) Biomarkers of Inflammatory Bowel Disease. Disease Markers 2014, pages 1-11.
Crossref
Marc Ferrante, Séverine Vermeire, Gert Van Assche & Paul Rutgeerts. 2014. Medical Therapy of Ulcerative Colitis. Medical Therapy of Ulcerative Colitis 175 184 .
Maria K Magnusson, Rahil Dahlén, Hans Strid, Stefan Isaksson, Magnus Simrén, Anders Lasson, Antal Bajor, Kjell‐Arne Ung & Lena Öhman. (2013) CD25 and TNF receptor II reflect early primary response to infliximab therapy in patients with ulcerative colitis. United European Gastroenterology Journal 1:6, pages 467-476.
Crossref
David J. Gibson, Elizabeth J. Ryan & Glen A. Doherty. (2013) Keeping the Bowel Regular. Inflammatory Bowel Diseases 19:12, pages 2716-2724.
Crossref
R. Dahlén, H. Strid, A. Lundgren, S. Isaksson, S. Raghavan, M. K. Magnusson, M. Simrén, H. Sjövall & L. Öhman. (2013) Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cells in vitro from Patients with Clinically Active Ulcerative Colitis . Scandinavian Journal of Immunology 78:3, pages 275-284.
Crossref
ZHAOGANG DONG, LUTAO DU, XIAOFEI XU, YONGMEI YANG, HAIYAN WANG, AILIN QU, XUN QU & CHUANXIN WANG. (2013) Aberrant expression of circulating Th17, Th1 and Tc1 cells in patients with active and inactive ulcerative colitis. International Journal of Molecular Medicine 31:4, pages 989-997.
Crossref

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