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Scandinavian Journal of Gastroenterology Volume 48, 2013 - Issue 3
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Esophagus

Randomized clinical trial: inhibition of the TRPV1 system in patients with nonerosive gastroesophageal reflux disease and a partial response to PPI treatment is not associated with analgesia to esophageal experimental pain

Anne Lund KrarupMech-Sense, Department of Gastroenterology and Hepatology, Aarhus University Hospital, Aalborg, Denmark;Department of Internal Medicine, Randers Hospital, Randers, DenmarkCorrespondence[email protected]
,
Lars NyAstraZeneca R&D, Mölndal, Sweden
,
Jenny GunnarssonDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
,
Frederik Hvid-JensenDepartment of Surgery L, Aarhus Hospital, Aarhus University Hospital, Aarhus, Denmark
,
Sofia ZetterstrandAstraZeneca R&D, Mölndal, Sweden
,
Magnus SimrénDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
,
Peter Funch-JensenInstitute of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
,
Mark Berner HansenAstraZeneca R&D, Mölndal, Sweden
&
Asbjørn Mohr DrewesMech-Sense, Department of Gastroenterology and Hepatology, Aarhus University Hospital, Aalborg, Denmark
 show all
Pages 274-284 | Received 09 Oct 2012, Accepted 22 Nov 2012, Published online: 16 Jan 2013

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Fehmi Ates, David O Francis & Michael F Vaezi. (2014) Refractory gastroesophageal reflux disease: advances and treatment. Expert Review of Gastroenterology & Hepatology 8:6, pages 657-667.
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Articles from other publishers (51)

Akinari Sawada, Daniel Sifrim & Yasuhiro Fujiwara. (2023) Esophageal Reflux Hypersensitivity: A Comprehensive Review. Gut and Liver 17:6, pages 831-842.
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Miao Zhang, Yueming Ma, Xianglu Ye, Ning Zhang, Lei Pan & Bing Wang. (2023) TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduction and Targeted Therapy 8:1.
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Lia P. Iglesias, Daniele C. Aguiar & Fabrício A. Moreira. (2020) TRPV1 blockers as potential new treatments for psychiatric disorders. Behavioural Pharmacology 33:1, pages 2-14.
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Francesco Rettura, Francesco Bronzini, Michele Campigotto, Christian Lambiase, Andrea Pancetti, Ginevra Berti, Santino Marchi, Nicola de Bortoli, Frank Zerbib, Edoardo Savarino & Massimo Bellini. (2021) Refractory Gastroesophageal Reflux Disease: A Management Update. Frontiers in Medicine 8.
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Dhyanesh Patel, Ronnie Fass & Michael Vaezi. (2021) Untangling Nonerosive Reflux Disease From Functional Heartburn. Clinical Gastroenterology and Hepatology 19:7, pages 1314-1326.
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Mingwei Yu, Crystal Chang, Bradley J. Undem & Shaoyong Yu. (2021) Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus. Molecules 26:13, pages 3929.
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Shirley Sonmez, Cathal Coyle, Daniel Sifrim & Philip Woodland. (2020) Duration of adhesion of swallowed alginates to distal oesophageal mucosa: implications for topical therapy of oesophageal diseases. Alimentary Pharmacology & Therapeutics 52:3, pages 442-448.
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Andras Garami, Yury P. Shimansky, Zoltan Rumbus, Robson C.L. Vizin, Nelli Farkas, Judit Hegyi, Zsolt Szakacs, Margit Solymar, Alexandra Csenkey, Dan A. Chiche, Ram Kapil, Donald J. Kyle, Wade D. Van Horn, Peter Hegyi & Andrej A. Romanovsky. (2020) Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis. Pharmacology & Therapeutics 208, pages 107474.
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Fahmi Shibli, Yoshitaka Kitayama & Ronnie Fass. (2020) Novel Therapies for Gastroesophageal Reflux Disease: Beyond Proton Pump Inhibitors. Current Gastroenterology Reports 22:4.
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Thomas Voets, Joris Vriens & Rudi Vennekens. (2019) Targeting TRP Channels – Valuable Alternatives to Combat Pain, Lower Urinary Tract Disorders, and Type 2 Diabetes?. Trends in Pharmacological Sciences 40:9, pages 669-683.
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Yu-Min Kung, Wen-Hung Hsu, Meng-Chieh Wu, Jiunn-Wei Wang, Chung-Jung Liu, Yu-Chung Su, Chao-Hung Kuo, Fu-Chen Kuo, Deng-Chyang Wu & Yao-Kuang Wang. (2017) Recent Advances in the Pharmacological Management of Gastroesophageal Reflux Disease. Digestive Diseases and Sciences 62:12, pages 3298-3316.
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F. Bonfiglio, P. G. Hysi, W. Ek, V. Karhunen, N. V. Rivera, M. Männikkö, H. Nordenstedt, M. Zucchelli, F. Bresso, F. Williams, H. Tornblom, P. K. Magnusson, N. L. Pedersen, J. Ronkainen, P. T. Schmidt & M. D'Amato. (2016) A meta‐analysis of reflux genome‐wide association studies in 6750 Northern Europeans from the general population. Neurogastroenterology & Motility 29:2.
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Adam D. Farmer, James K. Ruffle & Qasim Aziz. (2017) The Role of Esophageal Hypersensitivity in Functional Esophageal Disorders. Journal of Clinical Gastroenterology 51:2, pages 91-99.
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Christina Brock, Hans Gregersen, C. Prakash Gyawali, Christian Lottrup, Manuele Furnari, Edoardo Savarino, Luis Novais, Jens Brøndum Frøkjaer, Serhat Bor & Asbjørn Mohr Drewes. (2016) The sensory system of the esophagus--what do we know?. Annals of the New York Academy of Sciences 1380:1, pages 91-103.
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Hiroto Miwa, Takashi Kondo & Tadayuki Oshima. (2016) Gastroesophageal reflux disease-related and functional heartburn. Current Opinion in Gastroenterology 32:4, pages 344-352.
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Emidio Scarpellini, Daphne Ang, Ans Pauwels, Adriano De Santis, Tim Vanuytsel & Jan Tack. (2016) Management of refractory typical GERD symptoms. Nature Reviews Gastroenterology & Hepatology 13:5, pages 281-294.
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Xiaoyun Yu, Mingran Yu, Yingzhe Liu & Shaoyong Yu. (2015) TRP channel functions in the gastrointestinal tract. Seminars in Immunopathology 38:3, pages 385-396.
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Jan Tack, Tim Vanuytsel & Ans Pauwels. (2016) Established and Emerging Treatment Options for Functional Heartburn and Chest Pain. Current Treatment Options in Gastroenterology 14:1, pages 19-27.
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