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Inflammatory bowel disease

Mucosal healing at 3 months predicts long-term endoscopic remission in anti-TNF-treated luminal Crohn's disease

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Pages 543-551 | Received 04 Dec 2012, Accepted 10 Jan 2013, Published online: 12 Mar 2013

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Ze-min Han, Bing-xia Chen, Qian Zhou, Hong-bin Liu, Pei-chun Xu & Fa-chao Zhi. (2021) Predictors of infliximab-induced deep remission in treatment-naïve patients with isolated small bowel Crohn’s disease. Scandinavian Journal of Gastroenterology 56:12, pages 1422-1426.
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Gil Y. Melmed, Dermot McGovern, Stefan Schreiber, Gordana Kosutic, Marshall Spearman, Jason Coarse & William J. Sandborn. (2016) Early remission status predicts long-term outcomes in patients with Crohn’s disease treated with certolizumab pegol. Current Medical Research and Opinion 32:12, pages 1937-1941.
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Amon Asgharpour, Jianfeng Cheng & Stephen J Bickston. (2013) Adalimumab treatment in Crohn’s disease: an overview of long-term efficacy and safety in light of the EXTEND trial. Clinical and Experimental Gastroenterology 6, pages 153-160.
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Crossref
Matthew P. MoyJess L. KaplanChristopher J. MoranHarland S. WinterMichael S. Gee. (2016) MR Enterographic Findings as Biomarkers of Mucosal Healing in Young Patients With Crohn Disease. American Journal of Roentgenology 207:4, pages 896-902.
Crossref
Z. Grover, C. Burgess, R. Muir, C. Reilly & P. J. Lewindon. (2016) Early Mucosal Healing with Exclusive Enteral Nutrition is Associated with Improved Outcomes in Newly Diagnosed Children with Luminal Crohn’s disease. Journal of Crohn's and Colitis 10:10, pages 1159-1164.
Crossref
Elena Dubcenco, Guangyong Zou, Larry Stitt, Jeffrey P. Baker, Khursheed N. Jeejeebhoy, Gabor Kandel, Young-in Kim, Samir C. Grover, John W. D. McDonald, Lisa M. Shackelton, Reena Khanna, Geert D’Haens, William J. Sandborn, Brian G. Feagan & Barrett G. Levesque. (2016) Effect of Standardised Scoring Conventions on Inter-rater Reliability in the Endoscopic Evaluation of Crohn’s Disease. Journal of Crohn's and Colitis 10:9, pages 1006-1014.
Crossref
Andrew R. Reinink, Terrence C. Lee & Peter D. R. Higgins. (2016) Endoscopic Mucosal Healing Predicts Favorable Clinical Outcomes in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 22:8, pages 1859-1869.
Crossref
Anton Shavrov, Anastasia Y. Kharitonova, Elisabeth M. Davis, Brian Claggett, Dmitriy A. Morozov, Daniel K. Brown, Andrey A. Shavrov & Julia J. Liu. (2016) A Pilot Study of Confocal Laser Endomicroscopy to Predict Barrier Dysfunction and Relapse in Pediatric Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology & Nutrition 62:6, pages 873-878.
Crossref
Cary G. Sauer, Jeremy P. Middleton, Courtney McCracken, Jonathan Loewen, Kiery Braithwaite, Adina Alazraki, Diego R. Martin & Subra Kugathasan. (2016) Magnetic Resonance Enterography Healing and Magnetic Resonance Enterography Remission Predicts Improved Outcome in Pediatric Crohn Disease. Journal of Pediatric Gastroenterology & Nutrition 62:3, pages 378-383.
Crossref
Caroline Meyer Olesen, Mehmet Coskun, Laurent Peyrin-Biroulet & Ole Haagen Nielsen. (2016) Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases. Pharmacology & Therapeutics 159, pages 110-119.
Crossref
S. C. Shah, J.-F. Colombel, B. E. Sands & N. Narula. (2016) Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn's disease. Alimentary Pharmacology & Therapeutics 43:3, pages 317-333.
Crossref
Naoto Saigusa, Jun-ichi Saigusa, Tadashi Yokoyama, Takaaki Oosawa, Seiji Ishiguro, Masaru Shinozaki, Manabu Kikuchi & Yasuhisa Yokoyama. (2016) “Top Down Therapy” for Patients with Crohn's Disease who Initially Presented with Anorectal Fistula May Improve Perianal and Bowel Disease. Nippon Daicho Komonbyo Gakkai Zasshi 69:8, pages 424-429.
Crossref
Matthew P. Moy, Jenny Sauk & Michael S. Gee. (2016) The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response. Gastroenterology Research and Practice 2016, pages 1-13.
Crossref
Parakkal Deepak & David H. Bruining. (2015) Update on the Medical Management of Crohn’s Disease. Current Gastroenterology Reports 17:11.
Crossref
Uri Kopylov, Doron Yablecovitch, Adi Lahat, Sandra Neuman, Nina Levhar, Tomer Greener, Eyal Klang, Noa Rozendorn, Marianne M Amitai, Shomron Ben-Horin & Rami Eliakim. (2015) Detection of Small Bowel Mucosal Healing and Deep Remission in Patients With Known Small Bowel Crohn’s Disease Using Biomarkers, Capsule Endoscopy, and Imaging. American Journal of Gastroenterology 110:9, pages 1316-1323.
Crossref
Kazuhiro Morise. (2015) Clinical utility of a new endoscopic scoring system for Crohn’s disease. World Journal of Gastroenterology 21:34, pages 9974.
Crossref
Barry Hall, Grainne Holleran & Deirdre McNamara. (2015) Small Bowel Crohn's Disease: An Emerging Disease Phenotype?. Digestive Diseases 33:1, pages 42-51.
Crossref
Barry Hall, Grainne Holleran, Jun-Liong Chin, Sinead Smith, Barbara Ryan, Nasir Mahmud & Deirdre McNamara. (2014) A prospective 52week mucosal healing assessment of small bowel Crohn's disease as detected by capsule endoscopy. Journal of Crohn's and Colitis 8:12, pages 1601-1609.
Crossref
Barry J. Hall, Grainne E. Holleran, Sinead M. Smith, Nasir Mahmud & Deirdre A. McNamara. (2014) A prospective 12-week mucosal healing assessment of small bowel Crohn’s disease as detected by capsule endoscopy. European Journal of Gastroenterology & Hepatology 26:11, pages 1253-1259.
Crossref
Marta Sobczak, Adam Fabisiak, Natalia Murawska, Ewelina Wesołowska, Paulina Wierzbicka, Marcin Wlazłowski, Marta Wójcikowska, Hubert Zatorski, Marta Zwolińska & Jakub Fichna. (2014) Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases. Pharmacological Reports 66:5, pages 766-775.
Crossref
Pauliina Molander, Martti Färkkilä, Ari Ristimäki, Kimmo Salminen, Helena Kemppainen, Timo Blomster, Ritva Koskela, Airi Jussila, Henna Rautiainen, Markku Nissinen, Johanna Haapamäki, Perttu Arkkila, Urpo Nieminen, Juha Kuisma, Jari Punkkinen, Kaija-Leena Kolho, Harri Mustonen & Taina Sipponen. (2014) Does fecal calprotectin predict short-term relapse after stopping TNFα-blocking agents in inflammatory bowel disease patients in deep remission?. Journal of Crohn's and Colitis.
Crossref
Byron P. Vaughn, Sveta Shah & Adam S. Cheifetz. (2014) The Role of Mucosal Healing in the Treatment of Patients With Inflammatory Bowel Disease. Current Treatment Options in Gastroenterology 12:1, pages 103-117.
Crossref
Ingrid Ordás, Jordi Rimola, Sonia Rodríguez, José M. Paredes, María J. Martínez-Pérez, Esther Blanc, Juan A. Arévalo, Marta Aduna, Montserrat Andreu, Alexander Radosevic, Anna M. Ramírez-Morros, Susana Pinó, Marta Gallego, Aranzazu Jauregui-Amezaga, Elena Ricart & Julián Panés. (2014) Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn's Disease. Gastroenterology 146:2, pages 374-382.e1.
Crossref
Mark R. Frey & D. Brent Polk. (2013) ErbB receptors and their growth factor ligands in pediatric intestinal inflammation. Pediatric Research 75:1-2, pages 127-132.
Crossref

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