635
Views
46
CrossRef citations to date
0
Altmetric
Esophagus

Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro

, , &
Pages 1118-1126 | Received 15 Apr 2013, Accepted 11 Jul 2013, Published online: 19 Sep 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Hang Viet Dao, Long Bao Hoang, Binh Phuc Nguyen, Hoa Lan Nguyen, Robert Goldberg, Jeroan Allison, Thi Minh An Dao, Tomoaki Matsumura & Long Van Dao. (2023) Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible?. Clinical and Experimental Gastroenterology 16, pages 45-54.
Read now
Aekkacha Moonwiriyakit, Nutthapoom Pathomthongtaweechai, Peter R. Steinhagen, Papasara Chantawichitwong, Wilasinee Satianrapapong & Pawin Pongkorpsakol. (2023) Tight junctions: from molecules to gastrointestinal diseases. Tissue Barriers 11:2.
Read now
Laura Ceriotti, Paolo Buratti, Enrico Stefano Corazziari & Marisa Meloni. (2022) Protective Mechanisms of Liquid Formulations for Gastro-Oesophageal Reflux Disease in a Human Reconstructed Oesophageal Epithelium Model. Medical Devices: Evidence and Research 15, pages 143-152.
Read now
Marisa Meloni, Paolo Buratti, Francesco Carriero & Laura Ceriotti. (2021) In Vitro Modelling of Barrier Impairment Associated with Gastro-Oesophageal Reflux Disease (GERD). Clinical and Experimental Gastroenterology 14, pages 361-373.
Read now
Danling Liu, Tingting Qian, Shan Sun & Jack J Jiang. (2020) Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract. Journal of Inflammation Research 13, pages 1291-1304.
Read now

Articles from other publishers (41)

Rhonda F. Souza. 2023. Esophageal Disease and the Role of the Microbiome. Esophageal Disease and the Role of the Microbiome 13 34 .
Tina L. Samuels, Ke YanNishma Patel, Kate Plehhova, Cathal Coyle, Bryan P. HurleyNikki Johnston. (2022) Alginates for Protection Against Pepsin‐Acid Induced Aerodigestive Epithelial Barrier Disruption . The Laryngoscope 132:12, pages 2327-2334.
Crossref
Hong Liu, Zhancheng Zhang, Shenli Zhou, Xianfang Liu, Guodong Li, Bing Song & Wei Xu. (2021) Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway. Cancer Gene Therapy 29:6, pages 665-682.
Crossref
Daniel Sifrim & Roberto Penagini. 2021. The Esophagus. The Esophagus 394 418 .
Shere Paris & Rhonda F. Souza. 2021. The Esophagus. The Esophagus 376 393 .
Noriaki Manabe, Takatoki Yamamoto, Michiya Matsusaki, Mitsuru Akashi & Ken Haruma. (2021) Measurement of low-grade inflammation of the esophageal mucosa with electrical conductivity shows promise in assessing PPI responsiveness in patients with GERD. American Journal of Physiology-Gastrointestinal and Liver Physiology 321:1, pages G29-G40.
Crossref
D. N. Andreev, A. V. Zaborovsky & E. G. Lobanova. (2021) Gastroesophageal reflux disease: new approaches to optimizing pharmacotherapy. Meditsinskiy sovet = Medical Council:5, pages 30-37.
Crossref
Suzy Huijghebaert, Guido Vanham, Myriam Van Winckel & Karel Allegaert. (2021) Does Trypsin Oral Spray (Viruprotect®/ColdZyme®) Protect against COVID-19 and Common Colds or Induce Mutation? Caveats in Medical Device Regulations in the European Union. International Journal of Environmental Research and Public Health 18:10, pages 5066.
Crossref
Dorofeyev AE. (2021) Mucus barrier correction as a target in complex treatment of gastroesophageal reflux disease. Gastroenterology & Hepatology: Open Access 12:1, pages 22-26.
Crossref
C. Prakash Gyawali, Irene Sonu, Laren Becker & Jerzy Sarosiek. (2020) The esophageal mucosal barrier in health and disease: mucosal pathophysiology and protective mechanisms. Annals of the New York Academy of Sciences 1482:1, pages 49-60.
Crossref
Carmelo Scarpignato, Michio Hongo, Justin C. Y. Wu, Christian Lottrup, Adriana Lazarescu, Ellen Stein & Richard H. Hunt. (2020) Pharmacologic treatment of GERD: Where we are now, and where are we going?. Annals of the New York Academy of Sciences 1482:1, pages 193-212.
Crossref
Leandi Krüger, Tiffany A. Pridgen, Ellie R. Taylor, Katherine S. Garman & Anthony T. Blikslager. (2020) Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus. American Journal of Physiology-Gastrointestinal and Liver Physiology 318:4, pages G613-G623.
Crossref
Andrew Su, Colleen H. Parker & Jeffrey L. Conklin. 2020. Clinical and Basic Neurogastroenterology and Motility. Clinical and Basic Neurogastroenterology and Motility 79 88 .
Y. Y. Shaukovich, V. I. Shyshko, Y. R. Matsiuk & V. A. Basinski. (2019) Morphological features of esophageal mucosa damage in patients with the gastroesophageal reflux disease associated with the obstructive sleep apnea/hypopnea syndrome. Proceedings of the National Academy of Sciences of Belarus, Medical series 16:4, pages 434-442.
Crossref
Melanie A. Ruffner, Li Song, Kelly Maurer, Lihua Shi, Margaret C. Carroll, Joshua X. Wang, Amanda B. Muir, Jonathan M. Spergel & Kathleen E. Sullivan. (2019) Toll‐like receptor 2 stimulation augments esophageal barrier integrity. Allergy 74:12, pages 2449-2460.
Crossref
K. Nesteruk, M.C.W. Spaander, I. Leeuwenburgh, M.P. Peppelenbosch & G.M. Fuhler. (2019) Achalasia and associated esophageal cancer risk: What lessons can we learn from the molecular analysis of Barrett's–associated adenocarcinoma?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1872:2, pages 188291.
Crossref
Joanne C. Masterson, Kathryn A. Biette, Juliet A. Hammer, Nathalie Nguyen, Kelley E. Capocelli, Bejan J. Saeedi, Rachel F. Harris, Shahan D. Fernando, Lindsay B. Hosford, Caleb J. Kelly, Eric L. Campbell, Stefan F. Ehrentraut, Faria N. Ahmed, Hiroshi Nakagawa, James J. Lee, Eóin N. McNamee, Louise E. Glover, Sean P. Colgan & Glenn T. Furuta. (2019) Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis. Journal of Clinical Investigation 129:8, pages 3224-3235.
Crossref
Y. Ya. Shaukovich. (2019) The Role of E-Cadherin in the Assessment of Esophageal Mucosal Damage in Patients with Gastroesophageal Reflux Disease Associated with Obstructive Sleep Apnea/Hypopnea Syndrome. Russian Journal of Gastroenterology, Hepatology, Coloproctology 29:3, pages 25-32.
Crossref
David Y. Kim, Glenn T. Furuta, Nathalie Nguyen, Eisuke Inage & Joanne C. Masterson. (2019) Epithelial Claudin Proteins and Their Role in Gastrointestinal Diseases. Journal of Pediatric Gastroenterology & Nutrition 68:5, pages 611-614.
Crossref
Rena Yadlapati & Abraham Khan. 2019. Gastrointestinal and Liver Disorders in Women’s Health. Gastrointestinal and Liver Disorders in Women’s Health 35 57 .
Peter HegyiJozsef MaléthJulian R. WaltersAlan F. HofmannStephen J. Keely. (2018) Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease. Physiological Reviews 98:4, pages 1983-2023.
Crossref
Oliviero Sacco, Michela Silvestri, Michele Ghezzi, Antonino Capizzi & Giovanni A. Rossi. (2018) Airway inflammation and injury in children with prevalent weakly acidic gastroesophageal refluxes. Respiratory Medicine 143, pages 42-47.
Crossref
Anna Casselbrant, John M. Söfteland, Mats Hellström, Mantas Malinauskas & Mihai Oltean. (2018) Luminal Polyethylene Glycol Alleviates Intestinal Preservation Injury Irrespective of Molecular Size. Journal of Pharmacology and Experimental Therapeutics 366:1, pages 29-36.
Crossref
Christopher H. Blevins, Prasad G. Iyer, Marcelo F. Vela & David A. Katzka. (2018) The Esophageal Epithelial Barrier in Health and Disease. Clinical Gastroenterology and Hepatology 16:5, pages 608-617.
Crossref
N Nguyen, S D Fernando, K A Biette, J A Hammer, K E Capocelli, D A Kitzenberg, L E Glover, S P Colgan, G T Furuta & J C Masterson. (2018) TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis. Mucosal Immunology 11:2, pages 415-426.
Crossref
Tae-Geun Gweon, Jong-Hyung Park, Byung-Wook Kim, Yang Kyu Choi, Joon Sung Kim, Sung Min Park, Chang Whan Kim, Hyung-Gil Kim & Jun-Won Chung. (2018) Additive Effects of Rebamipide Plus Proton Pump Inhibitors on the Expression of Tight Junction Proteins in a Rat Model of Gastro-Esophageal Reflux Disease. Gut and Liver 12:1, pages 46-50.
Crossref
Kenichiro Okimoto, Makoto Arai, Hideaki Ishigami, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Tomoaki Matsumura, Tomoo Nakagawa, Tatsuro Katsuno, Masaki Suzuki, Yukio Nakatani & Osamu Yokosuka. (2018) A Prospective Study of Eosinophilic Esophagitis and the Expression of Tight Junction Proteins in Patients with Gastroesophageal Reflux Disease Symptoms. Gut and Liver 12:1, pages 30-37.
Crossref
G. I. Lukina, N. I. Krikheli, A. V. Ivannikova & Y. A. Gioeva. (2018) Subjective, functional and microbiological parameters of the oral cavity in gastroesophageal reflux patients with acidic and subacidic refluctant. Stomatologiya 97:3, pages 23.
Crossref
Tomoaki Matsumura, Makoto Arai, Hideaki Ishigami, Mai Fujie, Kentaro Ishikawa, Naoki Akizue, Takashi Taida, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa & Naoya Kato. (2018) Evaluation of Esophageal Mucosal Integrity in Patients with Gastroesophageal Reflux Disease. Digestion 97:1, pages 31-37.
Crossref
Sohaib Abu-Farsakh, Tongtong Wu, Amy Lalonde, Jun Sun & Zhongren Zhou. (2017) High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5. BMC Gastroenterology 17:1.
Crossref
Mihai Oltean, Lucian Jiga, Mats Hellström, John Söfteland, Marius Papurica, Teodora Hoinoiu, Mihai Ionac & Anna Casselbrant. (2017) A sequential assessment of the preservation injury in porcine intestines. Journal of Surgical Research 216, pages 149-157.
Crossref
Tadayuki Oshima & Hiroto Miwa. (2016) Gastrointestinal mucosal barrier function and diseases. Journal of Gastroenterology 51:8, pages 768-778.
Crossref
Leila Kia, John E. Pandolfino & Peter J. Kahrilas. (2016) Biomarkers of Reflux Disease. Clinical Gastroenterology and Hepatology 14:6, pages 790-797.
Crossref
Nicolas A. PardonMaria VicarioHanne VanheelTim VanuytselLaurens J. CeulemansMichael Vieth, Marcel Jimenez, Jan TackRicard Farré. (2016) A weakly acidic solution containing deoxycholic acid induces esophageal epithelial apoptosis and impairs integrity in an in vivo perfusion rabbit model. American Journal of Physiology-Gastrointestinal and Liver Physiology 310:7, pages G487-G496.
Crossref
Junya Honda, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Takeharu Shiroki, Yutaka Kondo, Waku Hatta, Kaname Uno, Naoki Asano, Tomoyuki Koike & Tooru Shimosegawa. (2015) Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression. Digestive Diseases and Sciences 61:4, pages 1028-1038.
Crossref
G. L. Falk & S. J. Vivian. (2016) Laryngopharyngeal reflux: diagnosis, treatment and latest research. European Surgery 48:2, pages 74-91.
Crossref
Sayak Ghatak, Marie Reveiller, Liana Toia, Andrei I. Ivanov, Zhongren Zhou, Eileen M. Redmond, Tony E. Godfrey & Jeffrey H. Peters. (2015) Bile Salts at Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling. Journal of Gastrointestinal Surgery 20:3, pages 500-509.
Crossref
María Inés Pinto-Sánchez, Fabio D. Nachman, Claudia Fuxman, Guido Iantorno, Hui Jer Hwang, Andrés Ditaranto, Florencia Costa, Gabriela Longarini, Xuan Yu Wang, Xianxi Huang, Horacio Vázquez, María L. Moreno, Sonia Niveloni, Premysl Bercik, Edgardo Smecuol, Roberto Mazure, Claudio Bilder, Eduardo C. Mauriño, Elena F. Verdu & Julio C. Bai. (2016) Altered Esophageal Mucosal Structure in Patients with Celiac Disease. Canadian Journal of Gastroenterology and Hepatology 2016, pages 1-9.
Crossref
L. Zhang, G. Liu, X. Han, J. Liu, G.‐X. Li, D.‐W. Zou & Z.‐S. Li. (2015) Inhibition of p38 MAPK activation attenuates esophageal mucosal damage in a chronic model of reflux esophagitis . Neurogastroenterology & Motility 27:11, pages 1648-1656.
Crossref
Philip Woodland, Rubina Aktar, Engelbert Mthunzi, Chung Lee, Madusha Peiris, Sean L. Preston, L. Ashley Blackshaw & Daniel Sifrim. (2015) Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:6, pages G525-G531.
Crossref
Mihai Oltean, Mats Hellström, Catalin Ciuce, Changlian Zhu & Anna Casselbrant. (2015) Luminal solutions protect mucosal barrier during extended preservation. Journal of Surgical Research 194:1, pages 289-296.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.