277
Views
16
CrossRef citations to date
0
Altmetric
Oncology

Assessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer

, , , , &
Pages 84-91 | Received 17 Sep 2013, Accepted 13 Oct 2013, Published online: 21 Nov 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Pooneh Mokarram, Mohammed Albokashy, Maryam Zarghooni, Mohammad Amin Moosavi, Zahra Sepehri, Qi Min Chen, Andrzej Hudecki, Aliyeh Sargazi, Javad Alizadeh, Adel Rezaei Moghadam, Mohammad Hashemi, Hesam Movassagh, Thomas Klonisch, Ali Akbar Owji, Marek J. Łos & Saeid Ghavami. (2017) New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets. Autophagy 13:5, pages 781-819.
Read now
Mie Grunnet, Dan Calatayud, Nicolai Aa Schultz, Jane P. Hasselby, Morten Mau-Sørensen, Nils Brünner & Jan Stenvang. (2015) TOP1 gene copy numbers are increased in cancers of the bile duct and pancreas. Scandinavian Journal of Gastroenterology 50:4, pages 485-494.
Read now

Articles from other publishers (14)

Ze-Ning Huang, Ying-Qi Huang, Qing-Qi Hong, Peng Zhang, Zi-Zhen Zhang, Liang He, Liang Shang, Lin-Jun Wang, Ya-Feng Sun, Zhi-Xiong Li, Jun-Jie Liu, Fang-Hui Ding, En-De Lin, Yong-An Fu, Shuang-Ming Lin, Jun Lu, Chao-Hui Zheng, Chang-Ming Huang & Ping Li. (2023) Long-term prognostic benefit of adjuvant chemotherapy for patients with hepatoid adenocarcinoma of the stomach after radical resection: A national multicenter study. European Journal of Surgical Oncology 49:11, pages 106975.
Crossref
Henu Kumar Verma, Yashwant Kumar Ratre & Pellegrino Mazzone. 2022. Colon Cancer Diagnosis and Therapy Vol. 3. Colon Cancer Diagnosis and Therapy Vol. 3 123 141 .
Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner, Bent Ejlertsen, Erik Hugger Jakobsen & Dorte Lisbet Nielsen. (2019) Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene. BMC Cancer 19:1.
Crossref
Yakun Wang, Li Sun, Zhongwu Li, Jing Gao, Sai Ge, Cheng Zhang, Jiajia Yuan, Xicheng Wang, Jian Li, Zhihao Lu, Jifang Gong, Ming Lu, Jun Zhou, Zhi Peng, Lin Shen & Xiaotian Zhang. (2019) Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features. Gastric Cancer 22:6, pages 1183-1192.
Crossref
Chunxin Lv, Xiuju Liu, Qiwen Zheng, Hanxiao Chen, Xue Yang, Jia Zhong, Yuyan Wang, Jianchun Duan, Zhijie Wang, Hua Bai, Meina Wu, Jun Zhao, Jie Wang, Ziping Wang, Tongtong An & Minglei Zhuo. (2018) Analysis of topoisomerase I expression and identification of predictive markers for efficacy of topotecan chemotherapy in small cell lung cancer. Thoracic Cancer 9:9, pages 1166-1173.
Crossref
Jesper Andreas Palshof, Estrid Vilma Solyom Høgdall, Tim Svenstrup Poulsen, Dorte Linnemann, Benny Vittrup Jensen, Per Pfeiffer, Line Schmidt Tarpgaard, Nils Brünner, Jan Stenvang, Mette Yilmaz & Dorte Lisbet Nielsen. (2017) Topoisomerase I copy number alterations as biomarker for irinotecan efficacy in metastatic colorectal cancer. BMC Cancer 17:1.
Crossref
Sune Boris Nygård, Ben Vainer, Signe Lykke Nielsen, Fred Bosman, Sabine Tejpar, Arnaud Roth, Mauro Delorenzi, Nils Brünner & Eva Budinska. (2016) DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer. Clinical Cancer Research 22:7, pages 1621-1631.
Crossref
William A. Hammond, Abhisek Swaika & Kabir Mody. (2015) Pharmacologic resistance in colorectal cancer: a review. Therapeutic Advances in Medical Oncology 8:1, pages 57-84.
Crossref
Elisa Paolicchi, Caterina Vivaldi, Veronica De Gregorio, Francesco Crea, Lorenzo Fornaro, Gianluca Masi, Fotios Loupakis, Francesco Graziano, Monica Ronzoni, Vincenzo Ricci, Alfredo Falcone & Romano Danesi. (2016) <b><i>Topoisomerase 1</i></b> Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients. Oncology 91:5, pages 283-288.
Crossref
Zhong-Ze Fang, Dunfang Zhang, Yun-Feng Cao, Cen Xie, Dan Lu, Dong-Xue Sun, Naoki Tanaka, Changtao Jiang, Qianming Chen, Yu Chen, Haina Wang & Frank J. Gonzalez. (2016) Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression. Toxicology and Applied Pharmacology 291, pages 21-27.
Crossref
Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner & Dorte Nielsen. (2015) A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol. BMC Cancer 15:1.
Crossref
Ida Marie Heeholm Sønderstrup, Sune Boris Nygård, Tim Svenstrup Poulsen, Dorte Linnemann, Jan Stenvang, Hans Jørgen Nielsen, Jiri Bartek, Nils Brünner, Peter Nørgaard & Lene Riis. (2015) Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers. Molecular Oncology 9:6, pages 1207-1217.
Crossref
Sebastian Stintzing, Stefan Stremitzer, Ana Sebio & Heinz-Josef Lenz. (2015) Predictive and Prognostic Markers in the Treatment of Metastatic Colorectal Cancer (mCRC). Hematology/Oncology Clinics of North America 29:1, pages 43-60.
Crossref
Joanna Proszek, Amit Roy, Ann-Katrine Jakobsen, Rikke Frøhlich, Birgitta Knudsen & Magnus Stougaard. (2014) Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level. Sensors 14:1, pages 1195-1207.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.