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Original Article

The association of infliximab trough levels with disease activity in pediatric inflammatory bowel disease

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Pages 1110-1117 | Received 05 Jan 2015, Accepted 04 Mar 2015, Published online: 11 Apr 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Raffaella Franca, Debora Curci, Marianna Lucafò, Giuliana Decorti & Gabriele Stocco. (2019) Therapeutic drug monitoring to improve outcome of anti-TNF drugs in pediatric inflammatory bowel disease. Expert Opinion on Drug Metabolism & Toxicology 15:7, pages 527-539.
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Samuele Naviglio, Paolo Giuffrida, Gabriele Stocco, Marco Vincenzo Lenti, Alessandro Ventura, Gino Roberto Corazza & Antonio Di Sabatino. (2018) How to predict response to anti-tumour necrosis factor agents in inflammatory bowel disease. Expert Review of Gastroenterology & Hepatology 12:8, pages 797-810.
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Karen van Hoeve, Ilse Hoffman & Severine Vermeire. (2018) Therapeutic drug monitoring of anti-TNF therapy in children with inflammatory bowel disease. Expert Opinion on Drug Safety 17:2, pages 185-196.
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Articles from other publishers (35)

Joelynn Dailey & Jeffrey S. Hyams. 2023. Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease 103 111 .
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Hsuan Ping Chang, Valentina Shakhnovich, Adam Frymoyer, Ryan Sol Funk, Mara L. Becker, K. T. Park & Dhaval K. Shah. (2021) A population physiologically‐based pharmacokinetic model to characterize antibody disposition in pediatrics and evaluation of the model using infliximab. British Journal of Clinical Pharmacology 88:1, pages 290-302.
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A. Nassar-Sheikh Rashid, D. Schonenberg-Meinema, S. C. Bergkamp, S. Bakhlakh, A. de Vries, T. Rispens, T. W. Kuijpers, G. Wolbink & J. M. van den Berg. (2021) Therapeutic drug monitoring of anti-TNF drugs: an overview of applicability in daily clinical practice in the era of treatment with biologics in juvenile idiopathic arthritis (JIA). Pediatric Rheumatology 19:1.
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Akshay Kapoor & Eileen Crowley. (2021) Advances in Therapeutic Drug Monitoring in Biologic Therapies for Pediatric Inflammatory Bowel Disease. Frontiers in Pediatrics 9.
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Sara Salvador‐Martín, Gemma Pujol‐Muncunill, Ferran Bossacoma, Víctor Manuel Navas‐López, Carmen Gallego‐Fernández, Oscar Segarra, Susana Clemente, Rosana Muñoz‐Codoceo, Javier Viada, Lorena Magallares, Eva Martínez‐Ojinaga, Ana Moreno‐Álvarez, Alfonso Solar‐Boga, Inés Loverdos, Vicente Merino‐Bohórquez, María Jesús Balboa‐Vega, Alejandro Rodriguez‐Martinez, Concepción Alvarez‐Vayo, Cesar Sanchez, Mar Tolin, José Antonio Blanca‐García, Ruth García‐Romero, Francisco Javier Eizaguirre, José Germán Sánchez‐Hernandez, Rafael Gonzalez Caldas, Antonio Millán‐Jimenez, Elena Aznal, Judith Abarca‐Zabalía, María Sanjurjo‐Sáez & Luis Andrés López‐Fernández. (2020) Pharmacogenetics of trough serum anti‐TNF levels in paediatric inflammatory bowel disease. British Journal of Clinical Pharmacology 87:2, pages 447-457.
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Patrick F van Rheenen, Marina Aloi, Amit Assa, Jiri Bronsky, Johanna C Escher, Ulrika L Fagerberg, Marco Gasparetto, Konstantinos Gerasimidis, Anne Griffiths, Paul Henderson, Sibylle Koletzko, Kaija-Leena Kolho, Arie Levine, Johan van Limbergen, Francisco Javier Martin de Carpi, Víctor Manuel Navas-López, Salvatore Oliva, Lissy de Ridder, Richard K Russell, Dror Shouval, Antonino Spinelli, Dan Turner, David Wilson, Eytan Wine & Frank M Ruemmele. (2021) The Medical Management of Paediatric Crohn’s Disease: an ECCO-ESPGHAN Guideline Update. Journal of Crohn's and Colitis 15:2, pages 171-194.
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Mihika B. Dave, Alpa J. Dherai, Devendra C. Desai, Diane R. Mould & Tester F. Ashavaid. (2020) Optimization of infliximab therapy in inflammatory bowel disease using a dashboard approach—an Indian experience. European Journal of Clinical Pharmacology 77:1, pages 55-62.
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Mihika B. Dave, Alpa J. Dherai, Devendra C. Desai, Bhamini G. Keny, Dhanashri N. Shetty, Satish Kulkarni, Kiran Peddy & Tester F. Ashavaid. (2020) Clinical efficacy of infliximab level and anti-infliximab antibody measurement in patients with inflammatory bowel disease: An audit. Indian Journal of Gastroenterology 39:5, pages 426-434.
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Isabel Pinto Pais, Maria C. Espinheira, Eunice Trindade & Jorge Amil Dias. (2020) Optimizing Antitumor Necrosis Factor Treatment in Pediatric Inflammatory Bowel Disease With Therapeutic Drug Monitoring. Journal of Pediatric Gastroenterology & Nutrition 71:1, pages 12-18.
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Dwight A. Winter, Maria E. Joosse, Saskia N. de Wildt, Jan Taminiau, Lissy de Ridder & Johanna C. Escher. (2020) Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Infliximab in Pediatric Inflammatory Bowel Disease: A Systematic Review and Revised Dosing Considerations. Journal of Pediatric Gastroenterology & Nutrition 70:6, pages 763-776.
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Olivier Courbette, Camille Aupiais, Jérôme Viala, Jean-Pierre Hugot, Xavier Roblin, Sophie Candon, Baptiste Louveau, Lucienne Chatenoud & Christine Martinez-Vinson. (2020) Trough Levels of Infliximab at Week 6 Are Predictive of Remission at Week 14 in Pediatric Crohn's Disease. Journal of Pediatric Gastroenterology & Nutrition 70:3, pages 310-317.
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Yoel Gofin, Manar Matar, Raanan Shamir & Amit Assa. (2019) Therapeutic Drug Monitoring Increases Drug Retention of Anti–Tumor Necrosis Factor Alpha Agents in Pediatric Patients With Crohn’s Disease. Inflammatory Bowel Diseases.
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Debora Curci, Marianna Lucafò, Adriana Cifù, Matteo Bramuzzo, Stefano Martelossi, Diego Favretto, Francesca De Pellegrin, Martina Fabris, Fulvia Vascotto, Samuele Naviglio, Alessandro Ventura, Gabriele Stocco & Giuliana Decorti. (2019) Determination of Serum Infliximab Concentration by Point-of-care Devices in Children With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology & Nutrition 69:4, pages 474-479.
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Ben Kang, So Yoon Choi, Young Ok Choi, Soo-Youn Lee, Sun-Young Baek, Insuk Sohn, Byung-Ho Choe, Hae Jeong Lee & Yon Ho Choe. (2019) Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease. Journal of Crohn's and Colitis 13:2, pages 189-197.
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Samuele Naviglio, Doriana Lacorte, Marianna Lucafò, Adriana Cifù, Diego Favretto, Eva Cuzzoni, Tania Silvestri, Martina Pozzi Mucelli, Oriano Radillo, Giuliana Decorti, Martina Fabris, Matteo Bramuzzo, Andrea Taddio, Gabriele Stocco, Patrizia Alvisi, Alessandro Ventura & Stefano Martelossi. (2019) Causes of Treatment Failure in Children With Inflammatory Bowel Disease Treated With Infliximab: A Pharmacokinetic Study. Journal of Pediatric Gastroenterology & Nutrition 68:1, pages 37-44.
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Karen van Hoeve, Erwin Dreesen, Ilse Hoffman, Gert Van Assche, Marc Ferrante, Ann Gils & Séverine Vermeire. (2018) Higher Infliximab Trough Levels Are Associated With Better Outcome in Paediatric Patients With Inflammatory Bowel Disease. Journal of Crohn's and Colitis 12:11, pages 1316-1325.
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B Gorovits, D J Baltrukonis, I Bhattacharya, M A Birchler, D Finco, D Sikkema, M S Vincent, S Lula, L Marshall & T P Hickling. (2018) Immunoassay methods used in clinical studies for the detection of anti-drug antibodies to adalimumab and infliximab. Clinical and Experimental Immunology 192:3, pages 348-365.
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Travis Piester, Adam Frymoyer, Megan Christofferson, Helen Yu, Dorsey Bass & K T Park. (2018) A Mobile Infliximab Dosing Calculator for Therapy Optimization in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 24:2, pages 227-234.
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Vini Deora, Justin Kozak, Mohamed El-Kalla, Hien Q. Huynh & Wael El-Matary. (2017) Therapeutic drug monitoring was helpful in guiding the decision-making process for children receiving infliximab for inflammatory bowel disease. Acta Paediatrica 106:11, pages 1863-1867.
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Sara MuriasLorena MagallaresFatima Albizuri, Dora Pascual-SalcedoErwin Dreesen & Denis Mulleman. (2017) Current Practices for Therapeutic Drug Monitoring of Biopharmaceuticals in Pediatrics. Therapeutic Drug Monitoring 39:4, pages 370-378.
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LB Ramsey, T Mizuno, AA Vinks & PA Margolis. (2017) Learning Health Systems as Facilitators of Precision Medicine. Clinical Pharmacology & Therapeutics 101:3, pages 359-367.
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Adam Frymoyer, Travis L. Piester & K.T. Park. (2016) Infliximab Dosing Strategies and Predicted Trough Exposure in Children With Crohn Disease. Journal of Pediatric Gastroenterology & Nutrition 62:5, pages 723-727.
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