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Original Article

Analysis of Plasma Bile Acid Profiles in Patients with Liver Diseases Associated with Cholestasis

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Pages 593-600 | Received 29 Nov 1979, Accepted 21 Jan 1980, Published online: 23 Feb 2010

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Neel Deferm, Tom De Vocht, Bing Qi, Pieter Van Brantegem, Eva Gijbels, Mathieu Vinken, Peter de Witte, Thomas Bouillon & Pieter Annaert. (2019) Current insights in the complexities underlying drug-induced cholestasis. Critical Reviews in Toxicology 49:6, pages 520-548.
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S. Stahl, M. R. Davies, D. I. Cook & M. J. Graham. (2008) Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis. Xenobiotica 38:7-8, pages 725-777.
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E. Krag & E. H. Thaysen. (1996) Bile Acids in Health and Disease. Scandinavian Journal of Gastroenterology 31:sup216, pages 73-81.
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A. Bremmelgaard. (1983) Bile acids in plasma of patients without kidneys. Scandinavian Journal of Clinical and Laboratory Investigation 43:7, pages 603-607.
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K. Linnet & H. Kelbæk. (1982) The Patterns of Glycine and Taurine Conjugates of Bile Acids in Serum in Hepatobiliary Disease. Scandinavian Journal of Gastroenterology 17:7, pages 919-924.
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A. Norlander & A. Norman. (1982) Bile Acid Metabolism in Non-Jaundiced Patients with Malignant Liver Tumours. Scandinavian Journal of Gastroenterology 17:7, pages 849-853.
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Articles from other publishers (43)

Kai-li Fu, Pan Chen, Yan-ying Zhou, Yi-ming Jiang, Yue Gao, Hui-zhen Zhang, Li-huan Guan, Cong-hui Wang, Jun-ling Liu, Min Huang & Hui-chang Bi. (2021) Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice. Acta Pharmacologica Sinica 43:4, pages 933-940.
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Pan Chen, Dongshun Li, Yixin Chen, Jiahong Sun, Kaili Fu, Lihuan Guan, Huizhen Zhang, Yiming Jiang, Xi Li, Xuezhen Zeng, Xiao Chen, Min Huang & Huichang Bi. (2017) p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. British Journal of Pharmacology 174:23, pages 4345-4361.
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Bhowmik Salil Kumar, Bong Chul Chung, Oh-Seung Kwon & Byung Hwa Jung. (2012) Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics. Journal of Applied Toxicology 32:7, pages 505-520.
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Yazen Alnouti. (2009) Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification. Toxicological Sciences 108:2, pages 225-246.
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Jiarong Chen, Tomohiro Terada, Ken Ogasawara, Toshiya Katsura & Ken-ichi Inui. (2008) Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. American Journal of Physiology-Renal Physiology 295:1, pages F247-F252.
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S Teng & M Piquette‐Miller. (2009) Hepatoprotective role of PXR activation and MRP3 in cholic acid‐induced cholestasis. British Journal of Pharmacology 151:3, pages 367-376.
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Carmela Gnerre, Sharon Bl??ttler, Michel R Kaufmann, Renate Looser & Urs A Meyer. (2004) Regulation of CYP3A4 by the bile acid receptor FXR. Pharmacogenetics 14:10, pages 635-645.
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Catherine Stedman, Graham Robertson, Sally Coulter & Christopher Liddle. (2004) Feed-forward Regulation of Bile Acid Detoxification by CYP3A4. Journal of Biological Chemistry 279:12, pages 11336-11343.
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Sükrettin Güldütuna, Guido Zimmer, Maria Leuschner, Susan Bhatti, Amelie Elze, Barbara Deisinger, Michael Hofmann & Ulrich Leuschner. (1999) The effect of bile salts and calcium on isolated rat liver mitochondria. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1453:3, pages 396-406.
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Geneviève Escher, Andrea Nawrocki, Thomas Staub, Bannikuppe S. Vishwanath, Brigitte M. Frey, Jürg Reichen & Felix J. Frey. (1998) Down-regulation of hepatic and renal 11β-hydroxysteroid dehydrogenase in rats with liver cirrhosis. Gastroenterology 114:1, pages 175-184.
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Charles O. Mills, Piotr Milkiewicz, David P. Molloy, Debbie J. Baxter & Elwyn Elias. (1997) Synthesis, physical and biological properties of lithocholyl-lysyl-fluorescein: a fluorescent monohydroxy bile salt analogue with cholestatic properties1Dr. C.O. Mills Jr. would like to dedicate this paper to his late father, C.O. Mills Sr. who died on 18th November 1996.1. Biochimica et Biophysica Acta (BBA) - General Subjects 1336:3, pages 485-496.
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Aldo V. Greco & Geltrude Mingrone. (1993) Serum bile acid concentrations in mild liver cirrhosis. Clinica Chimica Acta 221:1-2, pages 183-189.
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Sükrettin Güldütuna, Guido Zimmer, Matthias Imhof, Susan Bhatti, Tiangeng You & Ulrich Leuschner. (1993) Molecular aspects of membrane stabilization by ursodeoxycholate. Gastroenterology 104:6, pages 1736-1744.
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Suresht K. Aggarwal, Ashok K. Batta, Gerald Salen & Sarah Shefer. (1992) Synthesis of 3α,6β,7a,12β- and 3α,6β,7β,12β-tetrahydroxy-5β-cholanoic acids. Steroids 57:3, pages 107-111.
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Andrea Crosignani, Mauro Podda, Pier Maria Battezzati, Emanuela Bertolini, Massimo Zuin, David Watson & Kenneth D. R. Setchell. (1991) Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 14:6, pages 1000-1007.
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Douglas M. Heuman, W. Michael Pandak, Philip B. Hylemon & Z. Reno Vlahcevic. (1991) Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts:In vitro studies in rat hepatocytes and human erythrocytes. Hepatology 14:5, pages 920-926.
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Tomoo Kosuge, Tomoe Beppu, Shigeo Iwasaki, Tohru Itoh & Yasuo Idezuki. (1990) Bile acid profile and decrement rate of serum total bilirubin after biliary drainage. Gastroenterologia Japonica 25:6, pages 732-738.
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R Nuber, H Maucher & EF Stange. (1990) Size exclusion chromatography for extraction of serum bile acids.. Journal of Lipid Research 31:8, pages 1517-1522.
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F Stellaard, S A Langelaar, R M Kok & C Jakobs. (1989) Determination of plasma bile acids by capillary gas-liquid chromatography-electron capture negative chemical ionization mass fragmentography.. Journal of Lipid Research 30:10, pages 1647-1652.
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Junichi Shoda, Toshiaki Osuga, Reijiro Mahara, Masahiko Tohma, Kenji Matsuura, Naomi Tanaka, Yasushi Matsuzaki & Hiroshi Miyazaki. (1989) Altered metabolism of bile acids in cholestasis: Determination of 1β- and 6α-hydroxylated metabolites. Journal of Chromatography B: Biomedical Sciences and Applications 488:2, pages 315-328.
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Yukihiko Adachi, Tatsuo Nanno, Tadashi Itoh, Yoshiaki Kurumi, Kazutoshi Yamazaki, Yoshihide Sawada & Toshio Yamamoto. (1988) Determination of individual serum bile acids in chronic liver diseases: Fasting levels and results of oral chenodeoxycholic acid tolerance test. Gastroenterologia Japonica 23:4, pages 401-407.
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J Shoda, R Mahara, T Osuga, M Tohma, S Ohnishi, H Miyazaki, N Tanaka & Y Matsuzaki. (1988) Similarity of unusual bile acids in human umbilical cord blood and amniotic fluid from newborns and in sera and urine from adult patients with cholestatic liver diseases. Journal of Lipid Research 29:7, pages 847-858.
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Shigeo Suzuki, Saburo Nakazawa, Sumihiko Okuyama, Kazutada Okumura & Kenji Takagi. (1988) Change in serum and biliary esterified bile acids in patients with extrahepatic cholestasis during percutaneous transhepatic cholangiodrainage. Gastroenterologia Japonica 23:2, pages 165-173.
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Masahiko Iwanaga, Akira Nakagawara, Susumu Matsuo & Keiichi Ikeda. (1987) Impaired polymorphonuclear leukocyte function in biliary atresia:Role of bilirubin and bile acids. Journal of Pediatric Surgery 22:10, pages 967-972.
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Nobuo Yamaga, Koichi Adachi, Kyutaro Shimizu, Shigeki Miyake, Fuminobu Sumi, Ikuo Miyagawa & Hajime Goto. (1986) Bile acids of patients with renal failure receiving chronic hemodialysis. Steroids 48:5-6, pages 427-438.
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