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Scandinavian Journal of Gastroenterology Volume 16, 1981 - Issue 5
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Original Article

Gastric Cytoprotection in Man by Prostaglandin E2

H. Ruppin Dept. of Medicine. University of Erlangen-Nürnberg, Erlangen, West Germany, and Dept. of Experimental Biology, The Upjohn Company, Kalamazoo, Michigan, USA
,
B. Person Dept. of Medicine. University of Erlangen-Nürnberg, Erlangen, West Germany, and Dept. of Experimental Biology, The Upjohn Company, Kalamazoo, Michigan, USA
,
A. Robert Dept. of Medicine. University of Erlangen-Nürnberg, Erlangen, West Germany, and Dept. of Experimental Biology, The Upjohn Company, Kalamazoo, Michigan, USA
&
W. Domschke Dept. of Medicine. University of Erlangen-Nürnberg, Erlangen, West Germany, and Dept. of Experimental Biology, The Upjohn Company, Kalamazoo, Michigan, USA
Pages 647-652 | Received 26 Nov 1980, Accepted 26 Feb 1981, Published online: 22 Feb 2010

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J. W. Konturek, K. Hengst, S. J. Konturek & W. Domschke. (1997) Epidermal Growth Factor in Gastric Ulcer Healing by Nocloprost, a Stable Prostaglandin E2 Derivative. Scandinavian Journal of Gastroenterology 32:10, pages 980-984.
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M. Leivonen & E. Kivilaakso. (1991) Peptic Ulcer Bleeding Today: Risk Factors and Characteristics of the Disease. Scandinavian Journal of Gastroenterology 26:10, pages 1013-1019.
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M. M. Cohen. (1989) How Does One Demonstrate Cytoprotection in Man?. Scandinavian Journal of Gastroenterology 24:sup164, pages 247-251.
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G. Coremans, G. Vantrappen, J. A. Businger & P. Demol. (1989) Efficacy and Safety of Rioprostil, 300 μg b.d., in the Treatment of Duodenal Ulcer: A Double-Blind, Controlled Multicentre Clinical Study vs. Ranitidine. Scandinavian Journal of Gastroenterology 24:sup164, pages 198-206.
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L. B. Svendsen, O. Hart Hansen, J. K. Larsen, Aa. Johansen & F. Stener Jørgensen. (1987) The Effect of Acetyl Salicylic Acid and Indomethacin on Cell Proliferation Kinetics in the Human Gastric Mucosa. Scandinavian Journal of Rheumatology 16:2, pages 107-111.
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K. Berstad, H. Vergin, S. Postius, R. Weberg, I. Szelenyi & A. Berstad. (1987) Gastric Prostaglandin E2 Release Induced by Aluminium Hydroxide and Aluminium Hydroxide-Containing Antacids in Rats: Effect of Low Doses and Citric Acid. Scandinavian Journal of Gastroenterology 22:7, pages 884-888.
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A. Uribe, B. Tribukait & C. Johansson. (1987) Cell Cycle Distribution of Proliferative and Functional Cells of the Rat Jejunum after Treatment with Oral E2 Prostaglandins. Scandinavian Journal of Gastroenterology 22:2, pages 177-184.
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W. Domschke, J. Hagel, H. Ruppin & B. Kaduk. (1986) Antacids and Gastric Mucosal Protection. Scandinavian Journal of Gastroenterology 21:sup125, pages 144-150.
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R. Arnold, H. Koop, H. Schwarting, K. Tuch & B. Willemer. (1986) Effect of Acid Inhibition on Gastric Endocrine Cells. Scandinavian Journal of Gastroenterology 21:sup125, pages 14-21.
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A. Uribe, C. Rubio & C. Johansson. (1986) Cell Kinetics of Rat Gastrointestinal Mucosa Autoradiographic Study after Treatment with 15(R) 15-Methyl-Prostaglandin E2. Scandinavian Journal of Gastroenterology 21:2, pages 246-252.
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C. Johansson, A. Aly, R. Befrits, B. Smedfors & A. Uribe. (1985) Protection of the Gastroduodenal Mucosa by Prostaglandins. Scandinavian Journal of Gastroenterology 20:sup110, pages 41-48.
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Stanislaw J. Konturek. (1985) Gastric Cytoprotection. Scandinavian Journal of Gastroenterology 20:5, pages 543-553.
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S. Domschke, A. Dembiński & W. Domschke. (1983) Partial Prevention of Ethanol Damage of Human Gastroduodenal Mucosa by Prostaglandin E2 in Vitro. Scandinavian Journal of Gastroenterology 18:1, pages 113-116.
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A. Robert. 1985. Peptic Ulcer Disease: Basic and Clinical Aspects. Peptic Ulcer Disease: Basic and Clinical Aspects 297 316 .
G. N. J. Tijtgat. 1985. Peptic Ulcer Disease: Basic and Clinical Aspects. Peptic Ulcer Disease: Basic and Clinical Aspects 143 153 .
C. JOHANSSON, R. BEFRITS, O. WISÉN & A. KALLNER. (2008) Effect of graded 15(R)15 methyl prostaglandin E 2 and of indomethacin on the gastric secretory and plasma gastrin response to modified shamfeeding . Acta Physiologica Scandinavica 122:3, pages 421-426.
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S.J. Konturek, T. Brzozowski, T. Radecki & I. Pastucki. (1984) Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-amino-analogue (HOE 892) in consious rats. Prostaglandins 28:4, pages 443-453.
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John L. Wallace, David R. McCready, Beth C. Chin, Norman S. Track & Max M. Cohen. (1984) Prostaglandin biosynthesis by gastric mucosa. I. Studies in rat. Clinical Biochemistry 17:3, pages 179-182.
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S. J. Konturek. 1984. IUPHAR 9th International Congress of Pharmacology London 1984. IUPHAR 9th International Congress of Pharmacology London 1984 341 344 .
J. N. Hunt, J. L. Smith, C. L. Jiang & L. Kessler. (1983) Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion. Digestive Diseases and Sciences 28:10, pages 897-902.
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S. A. Müller-Lissner, F. Pace, H. F. Weiser, J. R. Siewert, A. L. Blum, E. Erckenbrecht, W. Berges, J. Erckenbrecht, M. Wienbeck, T. Sauerbruch, R. Wirsching, B. Leisner, M. Weinzierl, M. Pfahler, G. Paumgartner, P.-H. Althoff, A. Hellstern, G. Wöhrle, M. Classen, R.-D. Hanrath, W.-P. Fritsch, T. Scholten, J. E. Müller, G. Strohmeyer, J. Caspari, S. Domschke, A. Dembiński, W. Domschke, H. G. Dammann, P. Müller, B. Simon, A. Sonnenberg, C. West, S. Panzer, S. Meryn, H. Lochs, P. Nowotny, P. Herzog, B. Ebener, K. H. Holtermüller, W. Rösch, J. Schaudi, K. Elster, B. Lembcke, U. R. Fölsch, W. F. Caspary, W. Creutzfeldt, M. M. Körner, H. Heckers, F. W. Melcher, F. W. Schmahl, H.-P. Buscher, H. Sauerbier, W. Kramer, G. Kurz, W. Gerok, F. Stellaard, C. Brunhölzl, W. E. Hansen, H. Maurer, H. Haberland, J. Vollmar, C. Bräuning, S. Matern, A. Schill, R. Ritz, W. Lehnert, H. Matern, R. Raedsch, A. Stiehl, P. Czygan, S. Walker, B. Kommerell, K. Kutz, O. Leiss, K. Bergmann, J. Dlugosz, M. V. Singer, V. Eyßelein, H. Wentz, H. Goebell, J. Lohse, R. Krämer, M. Dörner, K. Wurster, H. Kaess, C. Niederau, V. Häger, H. Weiss, W. Sommer, A. Weiss, R. Rethel, W. Keller, H. Malchow, K. Ewe, J. W. Brandes, H. Ehms, H. J. Jesdinsky, U. Karbach, P. Schramm, C. Bossaller, O. Schober, W. Wellmann, L. Lehr, J. Schölmerich, M.-S. Becher, E. Köttgen, P. Hoppe-Seyler, E. Löhle, J. P. Vuilleumier, B. M. Peskar, H. Weiler, E. E. Kröner, W. Kruis, J. Holl, W. Paulus & P. Schüßler. 1982. Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin 513 605 .

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