Citations (131)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (9)
Muhmmad Nadeem Akhtar, Rabia Saeed, Farhan Saeed, Aasma Asghar, Samia Ghani, Huda Ateeq, Aftab Ahmed, Amara Rasheed, Muhammad Afzaal, Marwa Waheed, Bilal Hussain & Mohd Asif Shah. (2023) Silymarin: a review on paving the way towards promising pharmacological agent. International Journal of Food Properties 26:1, pages 2256-2272.
Read now
Read now
S Sundari, Muthuraja Arumugam & S. Chandra. (2023) Spectroscopic analysis, NBO, HOMO and LUMO analysis of anticancer compound Silibinin: experimental and theoretical approach. Materials Research Innovations 27:1, pages 1-12.
Read now
Read now
Alessio Aghemo, Olga P. Alekseeva, Francesco Angelico, Igor G. Bakulin, Natalia V. Bakulina, Dmitry Bordin, Alexey O. Bueverov, Oxana M. Drapkina, Anton Gillessen, Elvira M. Kagarmanova, Natalia V. Korochanskaya, U. A. Kucheryavii, Leonid B. Lazebnik, Maria A. Livzan, Igor V. Maev, Anatolii I. Martynov, Marina F. Osipenko, Evgenii I. Sas, Antonina Starodubova, Yurii P. Uspensky, Elena V. Vinnitskaya, Emilia P. Yakovenko & Alexey A. Yakovlev. (2022) Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review. Annals of Medicine 54:1, pages 1548-1560.
Read now
Read now
Burak Dumludag, Mehmet Kursat Derici, Osman Sutcuoglu, Betul Ogut, Ozge Tugce Pasaoglu, Ipek Isık Gonul & Ulver Derici. (2022) Role of silymarin (Silybum marianum) in the prevention of colistin-induced acute nephrotoxicity in rats. Drug and Chemical Toxicology 45:2, pages 568-575.
Read now
Read now
M. Saeed, D. Babazadeh, M. Arif, M.A. Arain, Z.A. Bhutto, A.H. Shar, M.U. Kakar, R. Manzoor & S. Chao. (2017) Silymarin: a potent hepatoprotective agent in poultry industry. World's Poultry Science Journal 73:3, pages 483-492.
Read now
Read now
Yingjie Qi, Guofei Li, Yan Zhou, Manman Wang, Kaishun Bi & Ronghua Dai. (2012) DETERMINATION OF FK506 IN RAT BLOOD BY LC-MS/MS AND EFFECT OF SILYMARIN ON ITS PHARMACOKINETICS. Journal of Liquid Chromatography & Related Technologies 35:15, pages 2217-2227.
Read now
Read now
Y. Han, D. Guo, Y. Chen, Z.-R. Tan & H.-H. Zhou. (2009) Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Xenobiotica 39:9, pages 694-699.
Read now
Read now
Amy Busby, Linda La Grange, Joel Edwards & Jolene King. (2002) The Use of a Silymarin/Phospholipid Compound as a Fetoprotectant from Ethanol-Induced Behavioral Deficits. Journal Of Herbal Pharmacotherapy 2:1, pages 39-47.
Read now
Read now
Mary L. Chavez. (2001) Treatment of Hepatitis C with Milk Thistle?. Journal Of Herbal Pharmacotherapy 1:3, pages 79-90.
Read now
Read now
Articles from other publishers (122)
Francesca Casini, Francesca Scaltrito, Maria Teresa Grimaldi, Tudor Lucian Pop, Valeria Calcaterra, Gian Vincenzo Zuccotti, Massimo Pettoello-Mantovani, Pietro Ferrara, Giovanni Corsello & Valentina Fabiano. (2023) Use of complementary and alternative medicine in children affected by oncologic, neurologic and liver diseases: a narrative review. Italian Journal of Pediatrics 49:1.
Crossref
Crossref
Sahil Sharma, Pravin Kumar, Mahendra Singh Ashawat, Vinay Pandit, Chandrapal Singh Verma & Dinesh Kumar Sharma. (2023) Silymarin: A Phytoconstituent with Significant Therapeutic Potential - A
Narrative Review. Current Drug Therapy 18:2, pages 89-97.
Crossref
Crossref
Bipindra Pandey, Rishiram Baral, Atisammodavardhana Kaundinnyayana & Sushil Panta. (2023) Promising hepatoprotective agents from the natural sources: a study of scientific evidence. Egyptian Liver Journal 13:1.
Crossref
Crossref
Hamdi Nsairat, Dima Khater, Fadwa Odeh, Areej M. Jaber, Mazen A.M. Al Sulaibi, Walhan Alshaer, Abeer Al Bawab & Mohammad S. Mubarak. 2023. Advanced and Modern Approaches for Drug Delivery. Advanced and Modern Approaches for Drug Delivery
301
355
.
Vladimir Mihailović, Nikola Srećković & Jelena B. Popović-Djordjević. 2023. Handbook of Dietary Flavonoids. Handbook of Dietary Flavonoids
1
45
.
Bing Yang, Xi Yang, Xumei Tan, Liqing Lu, Wei Fan, Lucía Barbier-Torres, Justin Steggerda, Ting Liu & Heping Yang. (2022) Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology 2022, pages 1-18.
Crossref
Crossref
Fatemeh Mohtashaminia, Mohammad Reza Amini, Fatemeh Sheikhhossein, Kurosh Djafarian & Sakineh Shab-Bidar. (2022) Effects berberine–silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN 49, pages 181-186.
Crossref
Crossref
Anton Gillessen, Francesco Angelico, Jun Chen, Lungen Lu, Maria Isabel Lucena, Qingchun Fu, Qing Xie, Raul J. Andrade, Wen Xie, Xiaoyuan Xu, Yanyan Yu, Yi-min Mao & Yuemin Nan. (2022) Silymarin for Treating Toxic Liver Disease: International Consensus Recommendations. Gastro Hep Advances 1:5, pages 882-893.
Crossref
Crossref
Deepa Khatri, Sumit Bahadur Baruwal Chhetri & Hari Prasad Devkota. 2022. Medicinal Plants of the Asteraceae Family. Medicinal Plants of the Asteraceae Family
213
230
.
Desislava Budurova, Denitsa Momekova, Georgi Momekov, Pavletta Shestakova, Hristo Penchev & Stanislav Rangelov. (2021) PEG-Modified tert-Octylcalix[8]arenes as Drug Delivery Nanocarriers of Silibinin. Pharmaceutics 13:12, pages 2025.
Crossref
Crossref
Eduardo H. Armanini, Marcel M. Boiago, Bruno G. de Oliveira Cécere, Paulo V. Oliveira, Carlos J. S. Teixeira, João V. Strapazzon, Nathieli B. Bottari, Anielen D. Silva, Mateus Fracasso, Raquel G. Vendruscolo, Roger Wagner, Eduardo M. Da Gloria, Vitor W. Horn, Ricardo E. Mendes, Matheus D. Baldissera, Marcelo Vedovatto & Aleksandro S. Da Silva. (2021) Protective effects of silymarin in broiler feed contaminated by mycotoxins: growth performance, meat antioxidant status, and fatty acid profiles. Tropical Animal Health and Production 53:4.
Crossref
Crossref
Abhijeet Ramnath Gaikwad, Komal D Ahire, Aachal A Gosavi, K S Salunkhe & Aditi Khalkar. (2021) Gaikwad Abhijeet R. Phytosome as a Novel Drug Delivery System for Bioavailability Enhancement of Phytoconstituents and its Applications: A Review. Journal of Drug Delivery and Therapeutics 11:3, pages 138-152.
Crossref
Crossref
Gökçe Şeker Karatoprak. 2021. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases
209
225
.
Anton Gillessen & Hartmut H.-J. Schmidt. (2020) Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Advances in Therapy 37:4, pages 1279-1301.
Crossref
Crossref
Ludovico Abenavoli, Angelo A. Izzo, Natasa Milić, Carla Cicala, Antonello Santini & Raffaele Capasso. (2018)
Milk thistle (
Silybum marianum
): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases
. Phytotherapy Research 32:11, pages 2202-2213.
Crossref
Crossref
Hayder Gaeed Oufi. (2018) The cytogenetic effects of silibinin alone and in combination with methotrexate in mouse bone marrow. European Journal of Pharmacology 824, pages 179-184.
Crossref
Crossref
Konchok Dorjay, Tasleem Arif & Mohammad Adil. (2018) Silymarin: An interesting modality in dermatological therapeutics. Indian Journal of Dermatology, Venereology and Leprology 84:2, pages 238.
Crossref
Crossref
Michal Bijak, Ewelina Synowiec, Przemyslaw Sitarek, Tomasz Sliwiński & Joanna Saluk-Bijak. (2017) Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models. Nutrients 9:12, pages 1356.
Crossref
Crossref
Michal Bijak. (2017) Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism. Molecules 22:11, pages 1942.
Crossref
Crossref
Devesh Tewari, Andrei Mocan, Emil D. Parvanov, Archana N. Sah, Seyed M. Nabavi, Lukasz Huminiecki, Zheng Feei Ma, Yeong Yeh Lee, Jarosław O. Horbańczuk & Atanas G. Atanasov. (2017) Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families. Frontiers in Pharmacology 8.
Crossref
Crossref
Aline Maria Stolf, Cibele Campos Cardoso & Alexandra Acco. (2017) Effects of Silymarin on Diabetes Mellitus Complications: A Review. Phytotherapy Research 31:3, pages 366-374.
Crossref
Crossref
Claus Hellerbrand, Jörn M. Schattenberg, Philipp Peterburs, Anja Lechner & Reto Brignoli. (2016) The potential of silymarin for the treatment of hepatic disorders. Clinical Phytoscience 2:1.
Crossref
Crossref
Anna Gajos-Michniewicz & Malgorzata Czyz. (2016) Modulation of WNT/β-catenin pathway in melanoma by biologically active components derived from plants. Fitoterapia 109, pages 283-292.
Crossref
Crossref
Mahmood Bahmani, Hedayatollah Shirzad, Samira Rafieian & Mahmoud Rafieian-Kopaei. (2015)
Silybum marianum
: Beyond Hepatoprotection
. Journal of Evidence-Based Complementary & Alternative Medicine 20:4, pages 292-301.
Crossref
Crossref
Sonia A Lozano-Sepulveda. (2015) Oxidative stress modulation in hepatitis C virus infected cells. World Journal of Hepatology 7:29, pages 2880.
Crossref
Crossref
Manish V. Patel, Kalapi B. Patel, Shivenarain Gupta, Andreas Michalsen, Elmar Stapelfeldt & Christian S. Kessler. (2015) A Complex Multiherbal Regimen Based on Ayurveda Medicine for the Management of Hepatic Cirrhosis Complicated by Ascites: Nonrandomized, Uncontrolled, Single Group, Open-Label Observational Clinical Study. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-12.
Crossref
Crossref
Le Thi Thanh Thuy, Hoang Hai & Norifumi Kawada. 2015. Studies on Hepatic Disorders. Studies on Hepatic Disorders
389
413
.
Pilar Pais & Massimo D’Amato. (2014) In Vivo Efficacy Study of Milk Thistle Extract (ETHIS-094™) in STAM™ Model of Nonalcoholic Steatohepatitis. Drugs in R&D 14:4, pages 291-299.
Crossref
Crossref
Anton Gillessen, Wolfgang A. Herrmann, Markus Kemper, Helmut Morath & Klaus Mann. (2014) Einfluss von Silymarin auf Lebergesundheit und LebensqualitätEffect of silymarin on liver health and quality of life. Results of a non-interventional study. MMW - Fortschritte der Medizin 156:S21, pages 120-126.
Crossref
Crossref
Weiquan Zhao, Guang Yang, Fanyi Zhong, Nan Yang, Xin Zhao, Yunpeng Qi & Guorong Fan. (2014) Isolation and purification of diastereoisomeric flavonolignans from silymarin by binary-column recycling preparative high-performance liquid chromatography. Journal of Separation Science 37:17, pages 2300-2306.
Crossref
Crossref
Hayder Gaeed Oufi & Nada Naji Al-Shawi. (2014) The effects of different doses of silibinin in combination with methotrexate on testicular tissue of mice. European Journal of Pharmacology 730, pages 36-40.
Crossref
Crossref
Mahmood Rasool, Javed Iqbal, Arif Malik, Hafiza Sobia Ramzan, Muhammad Saeed Qureshi, Muhammad Asif, Mahmood Husain Qazi, Mohammad Amjad Kamal, Adeel Gulzar Ahmed Chaudhary, Mohammed Hussain Al-Qahtani, Siew Hua Gan & Sajjad Karim. (2014)
Hepatoprotective Effects of
Silybum marianum
(Silymarin) and
Glycyrrhiza glabra
(Glycyrrhizin) in Combination: A Possible Synergy
. Evidence-Based Complementary and Alternative Medicine 2014, pages 1-9.
Crossref
Crossref
Yuan XIE, Hai-Ping HAO, Hong WANG, Zhao-Xian WANG & Guang-Ji WANG. (2013) Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation. Chinese Journal of Natural Medicines 11:6, pages 645-652.
Crossref
Crossref
Stephen J. Polyak, Peter Ferenci & Jean-Michel Pawlotsky. (2013) Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection. Hepatology 57:3, pages 1262-1271.
Crossref
Crossref
E.S. Hackett, D.C. Twedt & D.L. Gustafson. (2012) Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver Disease. Journal of Veterinary Internal Medicine 27:1, pages 10-16.
Crossref
Crossref
Michael T. Murray. 2013. Textbook of Natural Medicine. Textbook of Natural Medicine
1026
1031
.
. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy
353
961
.
Ana María Rivas-Estilla, Owen Lloyd Bryan-Marrugo, Karina Trujillo-Murillo, Diana Pérez-Ibave, Claudia Charles-NiñoCesar Pedroza-RoldanClara Ríos-Ibarra, Eda Ramírez-Valles, Rocío Ortiz-LópezMaría Cristina Islas-Carbajal, Natalia Nieto & Ana Rosa Rincón-Sánchez. (2012) Cu/Zn superoxide dismutase (SOD1) induction is implicated in the antioxidative and antiviral activity of acetylsalicylic acid in HCV-expressing cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 302:11, pages G1264-G1273.
Crossref
Crossref
José Moltó, Marta Valle, Cristina Miranda, Samandhy Cedeño, Eugenia Negredo & Bonaventura Clotet. (2012) Effect of Milk Thistle on the Pharmacokinetics of Darunavir-Ritonavir in HIV-Infected Patients. Antimicrobial Agents and Chemotherapy 56:6, pages 2837-2841.
Crossref
Crossref
Ashwani K. Singal, Sarat C. Jampana & Steven A. Weinman. (2011) Antioxidants as therapeutic agents for liver disease. Liver International 31:10, pages 1432-1448.
Crossref
Crossref
K.A. Skorupski, G.M. Hammond, A.M. Irish, M.S. Kent, T.A. Guerrero, C.O. Rodriguez & D.W. Griffin. (2011) Prospective Randomized Clinical Trial Assessing the Efficacy of Denamarin for Prevention of CCNU‐Induced Hepatopathy in Tumor‐Bearing Dogs. Journal of Veterinary Internal Medicine 25:4, pages 838-845.
Crossref
Crossref
M Ang-Lee & D Basila. 2011. Traditional Chinese Medicine. Traditional Chinese Medicine
5
31
.
Ludovico Abenavoli, Raffaele Capasso, Natasa Milic & Francesco Capasso. (2010) Milk thistle in liver diseases: past, present, future. Phytotherapy Research 24:10, pages 1423-1432.
Crossref
Crossref
Ajay Semalty, Mona Semalty, Mohan Singh Maniyari Rawat & Federico Franceschi. (2010) Supramolecular phospholipids–polyphenolics interactions: The PHYTOSOME® strategy to improve the bioavailability of phytochemicals. Fitoterapia 81:5, pages 306-314.
Crossref
Crossref
Roy L. Hawke, Sarah J. Schrieber, Tedi A. Soule, Zhiming Wen, Philip C. Smith, K. Rajender Reddy, Abdus S. Wahed, Steven H. Belle, Nezam H. Afdhal, Victor J. Navarro, Josh Berman, Qi‐Ying Liu, Edward Doo & Michael W. Fried. (2013) Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C. The Journal of Clinical Pharmacology 50:4, pages 434-449.
Crossref
Crossref
Y. I. Brel, A. A. Lyzikov & E. S. Pitkevich. (2009) HETRBAL PREPARATIONS FROM MILK THISTLE: MECHANISMS OF ACTION AND APPLICATION IN LIVER DISEASES. Health and Ecology Issues:4, pages 36-42.
Crossref
Crossref
Yang Han, Dong Guo, Yao Chen, Yu Chen, Zhi-Rong Tan & Hong-Hao Zhou. (2009) Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers. European Journal of Clinical Pharmacology 65:6, pages 585-591.
Crossref
Crossref
Christine A. Haller. 2009. Pharmacology and Therapeutics. Pharmacology and Therapeutics
1237
1245
.
Paul Angulo, Roberta A. Jorgensen, Kris V. Kowdley & Keith D. Lindor. (2007) Silymarin in the Treatment of Patients with Primary Sclerosing Cholangitis: An Open-Label Pilot Study. Digestive Diseases and Sciences 53:6, pages 1716-1720.
Crossref
Crossref
Pablo Muriel & Yadira Rivera‐Espinoza. (2007) Beneficial drugs for liver diseases. Journal of Applied Toxicology 28:2, pages 93-103.
Crossref
Crossref
R. Saller, R. Brignoli, J. Melzer & R. Meier. (2008) An Updated Systematic Review with Meta-Analysis for the Clinical Evidence of Silymarin. Forschende Komplementärmedizin / Research in Complementary Medicine 15:1, pages 9-20.
Crossref
Crossref
Andrea Rambaldi, Bradly P Jacobs & Christian Gluud. (2007) Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Database of Systematic Reviews 2009:1.
Crossref
Crossref
Heather GreenleeKathy Abascal, Eric Yarnell & Elena Ladas. (2016)
Clinical Applications of
Silybum marianum
in Oncology
. Integrative Cancer Therapies 6:2, pages 158-165.
Crossref
Crossref
Janice Post-WhiteElena J. Ladas & Kara M. Kelly. (2016)
Advances in the Use of Milk Thistle (
Silybum marianum
)
. Integrative Cancer Therapies 6:2, pages 104-109.
Crossref
Crossref
Prajjal K. Singha, Somenath Roy & Satyahari Dey. (2007) Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice. Journal of Ethnopharmacology 111:1, pages 13-21.
Crossref
Crossref
F. Stickel & D. Schuppan. (2007) Herbal medicine in the treatment of liver diseases. Digestive and Liver Disease 39:4, pages 293-304.
Crossref
Crossref
Sumita Verma & Paul J. Thuluvath. (2007) Complementary and Alternative Medicine in Hepatology: Review of the Evidence of Efficacy. Clinical Gastroenterology and Hepatology 5:4, pages 408-416.
Crossref
Crossref
Görenek Levent, Acar Ali, Aydın Ahmet, Eyigun Can Polat, Çetinkaya Aytaç, Eken Ayşe & Sayal Ahmet. (2006) Oxidative stress and antioxidant defense in patients with chronic hepatitis C patients before and after pegylated interferon alfa-2b plus ribavirin therapy. Journal of Translational Medicine 4:1.
Crossref
Crossref
Carmen Hoh, David Boocock, Tim Marczylo, Rajinder Singh, David P. Berry, Ashley R. Dennison, David Hemingway, Andrew Miller, Kevin West, Stephanie Euden, Giuseppe Garcea, Peter B. Farmer, William P. Steward & Andreas J. Gescher. (2006) Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences. Clinical Cancer Research 12:9, pages 2944-2950.
Crossref
Crossref
Edward Mills, Jean-Jacques Dugoua, Dan Perri & Gideon Koren. 2006. Herbal Medicines in Pregnancy and Lactation. Herbal Medicines in Pregnancy and Lactation
27
28
.
Adam Gordon, Daryl A Hobbs, D Scott Bowden, Michael J Bailey, Joanne Mitchell, Andrew JP Francis & Stuart K Roberts. (2006)
Effects of
Silybum marianum
on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C
. Journal of Gastroenterology and Hepatology 21:1, pages 275-280.
Crossref
Crossref
Alla Melhem, Mirela Stern, Oren Shibolet, Eran Israeli, Zvi Ackerman, Orit Pappo, Nilla Hemed, Mina Rowe, Hana Ohana, George Zabrecky, Robert Cohen & Yaron Ilan. (2005) Treatment of Chronic Hepatitis C Virus Infection via Antioxidants. Journal of Clinical Gastroenterology 39:8, pages 737-742.
Crossref
Crossref
Hiroyuki Kohno, Rikako Suzuki, Shigeyuki Sugie, Hiroyuki Tsuda & Takuji Tanaka. (2005) Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl–Induced Prostate Carcinogenesis in Male F344 Rats. Clinical Cancer Research 11:13, pages 4962-4967.
Crossref
Crossref
Karen R Ball & Kris V Kowdley. (2005) A Review of Silybum marianum (Milk Thistle) as a Treatment for Alcoholic Liver Disease. Journal of Clinical Gastroenterology 39:6, pages 520-528.
Crossref
Crossref
Vanesa D'Andrea, Leonardo M. Pérez & Enrique J. Sánchez Pozzi. (2005) Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide. Life Sciences 77:6, pages 683-692.
Crossref
Crossref
A Rambaldi, BP Jacobs, G Iaquinto & C Gluud. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Zeping Hu, Xiaoxia Yang, Paul Chi Lui Ho, Sui Yung Chan, Paul Wan Sia Heng, Eli Chan, Wei Duan, Hwee Ling Koh & Shufeng Zhou. (2005) Herb-Drug Interactions. Drugs 65:9, pages 1239-1282.
Crossref
Crossref
Ichiro Shimizu. 2005. Fibrogenesis: Cellular and Molecular Basis. Fibrogenesis: Cellular and Molecular Basis
122
142
.
Uzma Siddiqui, Elizabeth H Weinshel & Edmund J Bini. (2004) Prevalence and Predictors of Herbal Medication Use in Veterans with Chronic Hepatitis C. Journal of Clinical Gastroenterology 38:7, pages 605-610.
Crossref
Crossref
Chitra Sridar, Theunis C. Goosen, Ute M. Kent, J. Andrew Williams & Paul F. Hollenberg. (2004) SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES. Drug Metabolism and Disposition 32:6, pages 587-594.
Crossref
Crossref
Volker Schulz, Rudolf Hänsel, Mark Blumenthal & Varro E. TylerVolker Schulz, Rudolf Hänsel, Mark Blumenthal & Varro E. Tyler. 2004. Rational Phytotherapy. Rational Phytotherapy
225
290
.
Volker Schulz & Rudolf HänselVolker Schulz & Rudolf Hänsel. 2004. Rationale Phytotherapie. Rationale Phytotherapie
239
311
.
Jose Berger & Kris V. Kowdley. (2003) Is Silymarin Hepatoprotective in Alcoholic Liver Disease?. Journal of Clinical Gastroenterology 37:4, pages 278-279.
Crossref
Crossref
J. F. Van Pelt, C. Verslype, T. Crabbe, Z. Zaman & J. Fevery. (2003) PRIMARY HUMAN HEPATOCYTES ARE PROTECTED AGAINST PROLONGED AND REPEATED EXPOSURE TO ETHANOL BY SILIBININ-DIHEMISUCCINATE. Alcohol and Alcoholism 38:5, pages 411-414.
Crossref
Crossref
Elena J. Ladas & Kara M. Kelly. (2003) Milk Thistle: Is There a Role for Its Use as an Adjunct Therapy in Patients with Cancer?. The Journal of Alternative and Complementary Medicine 9:3, pages 411-416.
Crossref
Crossref
Sheldon R. Pinnell. (2003) Cutaneous photodamage, oxidative stress, and topical antioxidant protection. Journal of the American Academy of Dermatology 48:1, pages 1-22.
Crossref
Crossref
Hiroyuki Kohno, Takuji Tanaka, Kunihiro Kawabata, Yoshinobu Hirose, Shigeyuki Sugie, Hiroyuki Tsuda & Hideki Mori. (2002) Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane‐induced colon carcinogenesis in male F344 rats. International Journal of Cancer 101:5, pages 461-468.
Crossref
Crossref
Bradly P Jacobs, Cathi Dennehy, Gilbert Ramirez, Jodi Sapp & Valerie A Lawrence. (2002) Milk thistle for the treatment of liver disease. The American Journal of Medicine 113:6, pages 506-515.
Crossref
Crossref
Doris B. Strader, Bruce R. Bacon, Karen L. Lindsay, Douglas R. Brecque, Timothy Morgan, Elizabeth C. Wright, Jeff Allen, M. Farooq Khokar, Jay H. Hoofnagle & Leonard B. Seeff. (2002) Use of complementary and alternative medicine in patients with liver disease. The American Journal of Gastroenterology 97:9, pages 2391-2397.
Crossref
Crossref
F. Fraschini, G. Demartini & D. Esposti. (2002) Pharmacology of Silymarin. Clinical Drug Investigation 22:1, pages 51-65.
Crossref
Crossref
Pham Quang Vinh, Shigeyuki Sugie, Takuji Tanaka, Akira Hara, Yasuhiro Yamada, Masaki Katayama, Takashi Deguchi & Hideki Mori. (2005)
Chemopreventive Effects of a Flavonoid Antioxidant Silymarin on
N
‐Butyl‐
N
‐(4‐ hydroxybutyl)nitrosamine‐induced Urinary Bladder Carcinogenesis in Male ICR Mice
. Japanese Journal of Cancer Research 93:1, pages 42-49.
Crossref
Crossref
L. Langmead & D. S. Rampton. (2001) Review article: herbal treatment in gastrointestinal and liver disease-benefits and dangers. Alimentary Pharmacology & Therapeutics 15:9, pages 1239-1252.
Crossref
Crossref
Dharam Agarwal & Helmut SeitzTatjana Arslic. 2001. Alcohol in Health and Disease. Alcohol in Health and Disease
453
471
.
Lori A. Giese. (2001) Complementary Healthcare Practices. Gastroenterology Nursing 24:2, pages 95-97.
Crossref
Crossref
Reinhard Saller, Remy Meier & Reto Brignoli. (2001) The Use of Silymarin in the Treatment of Liver Diseases. Drugs 61:14, pages 2035-2063.
Crossref
Crossref
P Angulo. (2000) Silymarin in the Treatment of Patients With Primary Biliary Cirrhosis With a Suboptimal Response to Ursodeoxycholic Acid. Hepatology 32:5, pages 897-900.
Crossref
Crossref
Géza Csomós & Ulrich Leuschner. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Michael Trauner, Peter Fickert & Rudolf Stauber. 2000. Handbook of Alcoholism. Handbook of Alcoholism
183
194
.
Ichiro Shimizu. (2002) Sho‐saiko‐to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma. Journal of Gastroenterology and Hepatology 15:s1, pages 84-90.
Crossref
Crossref
Doris B. Strader & Hyman J. Zimmerman. 2000. Hepatitis C. Hepatitis C
427
451
.
Jifu Zhao & Rajesh Agarwal. (1999) Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 20:11, pages 2101-2108.
Crossref
Crossref
Burton M. Berkson. (1999) A conservative triple antioxidant approach to the treatment of hepatitis CEine konservative dreifache antioxidante Methode zur Behandlung von Hepatitis C. Eine Kombination von Alpha-Liponsäure (thioctic acid), Silymarin und Selenium: Drei Krankenberichte. Medizinische Klinik 94:S3, pages 84-89.
Crossref
Crossref
Detlef Schuppan, Ji-Dong Jia, Benno Brinkhaus & Eckhart G. Hahn. (1999) Herbal products for liver diseases: A therapeutic challenge for the new millennium. Hepatology 30:4, pages 1099-1104.
Crossref
Crossref
L La Grange, M Wang, R Watkins, D Ortiz, M.E Sanchez, J Konst, C Lee & E Reyes. (1999) Protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver. Journal of Ethnopharmacology 65:1, pages 53-61.
Crossref
Crossref
Christian J Bode. (1999) Re: Flora et al. Silymarin for the Therapy of Liver Disease. American Journal of Gastroenterology 94:2, pages 545-546.
Crossref
Crossref
Nathan M. Bass. (1999) Is there any use for nontraditional or alternative therapies in patients with chronic liver disease?. Current Gastroenterology Reports 1:1, pages 50-56.
Crossref
Crossref
JAMES A. DUKE. (1999) The Herbal Sling vs. the Magic Bullet. Journal of Medicinal Food 2:2, pages 73-76.
Crossref
Crossref
Kevin D. Mullen & S. Dasarathy. (1998) POTENTIAL NEW THERAPIES FOR ALCOHOLIC LIVER DISEASE. Clinics in Liver Disease 2:4, pages 851-881.
Crossref
Crossref
Giulio Marchesini, Giampaolo Bianchi & Andrea Fabbri. (1998) LONG-TERM MANAGEMENT OF ALCOHOLIC LIVER DISEASE. Clinics in Liver Disease 2:4, pages 821-838.
Crossref
Crossref
Albert Parés, Ramón Planas, Miguel Torres, Joan Caballería, Josep M. Viver, Doroteo Acero, Juliá Panés, Joaquim Rigau, Justiniano Santos & Joan Rodés. (1998) Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. Journal of Hepatology 28:4, pages 615-621.
Crossref
Crossref
Kenneth Flora, Martin Hahn, Hugo Rosen & Kent Benner. (1998) Milk Thistle ( Silybum marianum ) for the Therapy of Liver Disease. American Journal of Gastroenterology 93:2, pages 139-143.
Crossref
Crossref
Volker Schulz, Rudolf Hänsel & Varro E. TylerVolker Schulz, Rudolf Hänsel & Varro E. Tyler. 1998. Rational Phytotherapy. Rational Phytotherapy
167
220
.
W. Blaschek, R. Hänsel, K. Keller, J. Reichling, H. Rimpler & G. Schneider. 1998. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis
469
600
.
K. Kraft. (1997) Artichoke leaf extract — Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts. Phytomedicine 4:4, pages 369-378.
Crossref
Crossref
Adriane Fugh-Berman. (1997) CLINICAL TRIALS OF HERBS. Primary Care: Clinics in Office Practice 24:4, pages 889-903.
Crossref
Crossref
Volker Schulz & Rudolf HänselVolker Schulz & Rudolf Hänsel. 1996. Rationale Phytotherapie. Rationale Phytotherapie
183
243
.
A. Comoglio, A. Tomasi, S. Malandrino, G. Poli & E. Albano. (1995) Scavenging effect of silipide, a new silybin-phospholipid complex, on ethanol-derived free radicals. Biochemical Pharmacology 50:8, pages 1313-1316.
Crossref
Crossref
T. M. Worner & P. Manu. 1995. The Pharmacology of Alcohol Abuse. The Pharmacology of Alcohol Abuse
395
413
.
Giuseppe Palasciano, Piero Portincasa, Vincenzo Palmieri, Daniela Ciani, Gianluigi Vendemiale & Emanuele Altomare. (1994) The effect of silymarin on plasma levels of malon-dialdehyde in patients receiving long-term treatment with psychotropic drugs. Current Therapeutic Research 55:5, pages 537-545.
Crossref
Crossref
B. Rosslenbroich, S. Schmidt & P.F. Matthiessen. (1994) Unconventional medicine in Germany. Complementary Therapies in Medicine 2:2, pages 61-69.
Crossref
Crossref
Margitta Albinus, Gudrun Amschler, Uwe Amschler, Erwin von Angerer, Wolfgang Barthel, Andrea Bauer, Kurt Bauer, Jürgen Beckmann, Winfried Beil, Jürgen Beitz, Petra Berscht, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bracher, Helmut Bräunlich, Kerstin Brinkmann, Franz von Bruchhausen, Kay Brune, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Siegfried Ebel, Kurt Eger, Peter Emig, Thomas Erker, Maria S. Fernandez-Alfonso, August Wilhelm Frahm, Margarete Frahm, Klaus-Jürgen Freundt, Detlef Geffken, Ulrich Geis, Erika Glusa, Berthold Göber, Jochen Gödicke, Margarete Goppelt-Strübe, Wilhelm Gössling, Annette Graul, Sibylle Greiner, Adolf Grisk, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Axel Haberkorn, Eberhard Hackenthal, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Andreas Hensel, Sibylle Hoedt-Schmidt, Hermann Hoffmann, Ute Hoffmann-Schollmayer, Ulrike Holzgrabe, Martin Hug, Wolfgang Ibrom, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Nasser Khudeir, Werner Kiefer, Doris Kleinsorge, Christoph Klett, Stephanie Klett, Martin Klingmüller, H.-P. Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, Gottfried Kreutz, Reinhard Kroker, Dorothea Landsiedel-Maier, Jochen Lehmann, Marion Sylvia Lehner, Stefan Leiner, Hans Löwe, Johannes Mann, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Hans-Jürgen Mest, Frank Peter Meyer, J. Mollière, Rudolf Morgenstern, Wolfgang Morick, Joachim Mössner, Christa Müller, Daniel Müller, Klaus Müller, Walter Müller, Alexander Mülsch, Tilo Netzer, Michael Neugebauer, Ulf Niemeyer, Peter Nuhn, Bernd Nürnberg, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Martina Pickert, Andreas Pies, Klaus Pietrzik, Detlef Preiss, Helmut Priewer, Olaf Queckenberg, Eberhard Reimann, Jörg Remien, Rainer Rettig, Andreas Reymann, Joachim Richter, Hans Rommelspacher, Ulrich Rose, Gerhard Rücker, Klaus Schaefer, Helmut Schlager, Werner Schleicher, Hildegard Schleinitz, Wolfgang Schlichter, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Helmut Schwilden, Monika Serke, Gisela Skopp, Marcus Spohn, Ralf Stahlmann, Johannes-Peter Stasch, Christian Steffen, Jürgen Steinmeyer, Karl-Heinz Surborg, Ulf Sürig, Istvan Szelenyi, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Franz-Josef Volk, Heinz Walther, Horst Weber, Judith Wede, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Hilke Winterhoff, Reinhold Wintersteiger, Frauke Woltmann, Diaa Youssef & A. Ziegler. 1994. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis
545
764
.
Rita Carini, Adriana Comoglio, Emanuele Albano & Giuseppe Poli. (1992) Lipid peroxidation and irreversible damage in the rat hepatocyte model. Biochemical Pharmacology 43:10, pages 2111-2115.
Crossref
Crossref
Marisa Conti, Salvatore Malandrino & Maria Josè Magistretti. (1992) Protective Activity of Silipide on Liver Damage in Rodents. Japanese Journal of Pharmacology 60:4, pages 315-321.
Crossref
Crossref
F. H. Kemper & B. Uehleke. 1992. Naturheilverfahren. Naturheilverfahren
275
380
.
G. Nassuato, R.M. Iemmolo, M. Strazzabosco, F. Lirussi, R. Deana, M.A. Francesconi, M. Muraca, D. Passera, A. Fragasso, R. Orlando, G. Csomós & L. Okolicsányi. (1991) Effect of Silibinin on biliary lipid composition experimental and clinical study. Journal of Hepatology 12:3, pages 290-295.
Crossref
Crossref
Rudolf HänselRudolf Hänsel. 1991. Phytopharmaka. Phytopharmaka
178
185
.
Philippe Lettéron, Gilles Labbe, Claude Degott, Alain Berson, Bernard Fromenty, Marcel Delaforge, Dominique Larrey & Dominique Pessayre. (1990) Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Biochemical Pharmacology 39:12, pages 2027-2034.
Crossref
Crossref
P. Ferenci, B. Dragosics, H. Dittrich, H. Frank, L. Benda, H. Lochs, S. Meryn, W. Base & B. Schneider. (1989) Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. Journal of Hepatology 9:1, pages 105-113.
Crossref
Crossref
John B. Saunders. (1989) Treatment of alcoholic liver disease. Baillière's Clinical Gastroenterology 3:1, pages 39-65.
Crossref
Crossref
P. Ferenci, B. Dragosics, H. Dittrich, H. Frank, H. Lochs, H. Pamperl & S. Meryn. 1987. Assessment and Management of Hepatobiliary Disease. Assessment and Management of Hepatobiliary Disease
377
383
.
J. C. Bode. 1987. Assessment and Management of Hepatobiliary Disease. Assessment and Management of Hepatobiliary Disease
365
376
.
MARSHA Y. MORGAN. (2009) Hepatoprotective Agents in Alcoholic Liver Disease. Acta Medica Scandinavica 218:S703, pages 225-233.
Crossref
Crossref