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Scandinavian Journal of Gastroenterology Volume 22, 1987 - Issue 1
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Original Article

Metronidazole Pharmacokinetics in Patients with Hepatic Encephalopathy

S. Loft Medical Dept. F, Gentofte University Hospital, Hellerup, Denmark
,
J. Sonne Medical Dept. F, Gentofte University Hospital, Hellerup, Denmark
,
M. Døssing Medical Dept. F, Gentofte University Hospital, Hellerup, Denmark
&
P. Buch Andreasen Medical Dept. F, Gentofte University Hospital, Hellerup, Denmark
Pages 117-123 | Received 28 Jul 1986, Accepted 05 Sep 1986, Published online: 08 Jul 2009

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Ki Tae Suk & Dong Joon Kim. (2019) Gut microbiota: novel therapeutic target for nonalcoholic fatty liver disease. Expert Review of Gastroenterology & Hepatology 13:3, pages 193-204.
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Mirashini Swaminathan, Mark Alexander Ellul & Timothy JS Cross. (2018) Hepatic encephalopathy: current challenges and future prospects. Hepatic Medicine: Evidence and Research 10, pages 1-11.
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MA Pena, JF Horga & P Zapater. (2016) Variations of pharmacokinetics of drugs in patients with cirrhosis. Expert Review of Clinical Pharmacology 9:3, pages 441-458.
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Articles from other publishers (31)

Goncalo Serrano, Nausikaa Devriendt, Hilde de Rooster & Dominique Paepe. (2022) Comparison of diet, lactulose, and metronidazole combinations in the control of pre‐surgical clinical signs in dogs with congenital extrahepatic portosystemic shunts. Journal of Veterinary Internal Medicine 36:4, pages 1258-1266.
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Swati Chouhan, Prajna Anirvan & Shivaram Prasad Singh. 2022. Pharmacotherapy for Liver Cirrhosis and Its Complications. Pharmacotherapy for Liver Cirrhosis and Its Complications 49 67 .
Caterina Zoratti, Rita Moretti, Lisa Rebuzzi, Irma Valeria Albergati, Antonietta Di Somma, Giuliana Decorti, Stefano Di Bella, Lory Saveria Crocè & Mauro Giuffrè. (2021) Antibiotics and Liver Cirrhosis: What the Physicians Need to Know. Antibiotics 11:1, pages 31.
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Vikash G. Lala, Bilal Bobat, Mark Haagensen, Prakash Kathan & Adam Mahomed. (2021) Metronidazole-induced encephalopathy. South African Journal of Radiology 25:1.
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Valentin al Jalali & Markus Zeitlinger. (2020) Systemic and Target-Site Pharmacokinetics of Antiparasitic Agents. Clinical Pharmacokinetics 59:7, pages 827-847.
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Samuel Selorm Fiati Kenston, Xin Song, Zhou Li & Jinshun Zhao. (2018) Mechanistic insight, diagnosis, and treatment of ammonia‐induced hepatic encephalopathy. Journal of Gastroenterology and Hepatology 34:1, pages 31-39.
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Min Seok Cho, Sang Yeol Kim, Ki Tae Suk & Byung-Yong Kim. (2018) Modulation of gut microbiome in nonalcoholic fatty liver disease: pro-, pre-, syn-, and antibiotics. Journal of Microbiology 56:12, pages 855-867.
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Jawaid Shaw & Jasmohan S. Bajaj. 2017. Liver Disorders. Liver Disorders 481 506 .
Scott C. Matherly & Jasmohan S. Bajaj. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 2107 2128 .
Jenana HalilovicBrett H. Heintz. (2014) Antibiotic dosing in cirrhosis. American Journal of Health-System Pharmacy 71:19, pages 1621-1634.
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Justyna R. Sarna, Sarah Furtado & A. Keith W. Brownell. (2014) Neurologic Complications of Metronidazole. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 40:6, pages 768-776.
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Kavish R. Patidar & Jasmohan S. Bajaj. (2013) Antibiotics for the treatment of hepatic encephalopathy. Metabolic Brain Disease 28:2, pages 307-312.
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C F Rose. (2012) Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy. Clinical Pharmacology & Therapeutics 92:3, pages 321-331.
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John P. Knorr, Imran Javed, Neha Sahni, Ceylan Z. Cankurtaran & Jorge A. Ortiz. (2012) Metronidazole-Induced Encephalopathy in a Patient with End-Stage Liver Disease. Case Reports in Hepatology 2012, pages 1-4.
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Keith J. Foster, Sonia Lin & Charles J. Turck. (2010) Current and Emerging Strategies for Treating Hepatic Encephalopathy. Critical Care Nursing Clinics of North America 22:3, pages 341-350.
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Praveen Sharma, Barjesh Chander Sharma & Shiv Kumar Sarin. (2010) Predictors of nonresponse to lactulose in patients with cirrhosis and hepatic encephalopathy. European Journal of Gastroenterology & Hepatology 22:5, pages 526-531.
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Jorge L. Herrera. 2009. Practical Management of Liver Diseases. Practical Management of Liver Diseases 215 234 .
Scott J. Bergman, Cristian Speil, Michael Short & Janak Koirala. (2007) Pharmacokinetic and Pharmacodynamic Aspects of Antibiotic Use in High-Risk Populations. Infectious Disease Clinics of North America 21:3, pages 821-846.
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J. Michael Henderson. 2007. Textbook of Hepatology. Textbook of Hepatology 728 760 .
N. M. BASS. (2007) Review article: the current pharmacological therapies for hepatic encephalopathy. Alimentary Pharmacology & Therapeutics 25, pages 23-31.
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Yong-Han PaikKwan Sik LeeKwang-Hyub HanKun Hoon SongMyoung Hwan KimByung Soo MoonSang Hoon AhnSe Joon LeeHyo Jin ParkDong Ki LeeChae Yoon ChonSang In LeeYoung Myoung Moon. (2005) Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study. Yonsei Medical Journal 46:3, pages 399.
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David C. Madoff, Michael J. Wallace, Kamran Ahrar & Richard R. Saxon. (2004) TIPS-related Hepatic Encephalopathy: Management Options with Novel Endovascular Techniques. RadioGraphics 24:1, pages 21-36.
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S.F Solga. (2003) Probiotics can treat hepatic encephalopathy. Medical Hypotheses 61:2, pages 307-313.
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Andres T Blei & Juan Córdoba. (2001) Hepatic encephalopathy. American Journal of Gastroenterology 96:7, pages 1968-1976.
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Andres T Blei. (2000) Diagnosis and treatment of hepatic encephalopathy. Best Practice & Research Clinical Gastroenterology 14:6, pages 959-974.
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Da Silva, David, Muscará, Sousa, Ferraz, De Nucci, Polimeno & Pedrazzoli. (2001) Plasma hydroxy‐metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol‐induced liver injury. Alimentary Pharmacology & Therapeutics 13:10, pages 1335-1341.
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Mary Jo Kasten. (1999) Clindamycin, Metronidazole, and Chloramphenicol. Mayo Clinic Proceedings 74:8, pages 825-833.
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MN Muscara, J. PedrazzoliJrJr, EL Miranda, JG Ferraz, E. Hofstatter, G. Leite, AF Magalhaes, S. Leonardi & G. De Nucci. (2012) Plasma hydroxy‐metronidazole/metronidazole ratio in patients with liver disease and in healthy volunteers.. British Journal of Clinical Pharmacology 40:5, pages 477-480.
Crossref
W. David Hager & Robert P. Rapp. (1992) METRONIDAZOLE. Obstetrics and Gynecology Clinics of North America 19:3, pages 497-510.
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Steffen Loft. (1990) Metronidazole and Antipyrine as Probes for the Study of Foreign Compound Metabolism. Pharmacology & Toxicology 66, pages 1-31.
Crossref
Gerald Y. Minuk. 1989. Modern Concepts in Gastroenterology Volume 2. Modern Concepts in Gastroenterology Volume 2 89 107 .

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