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Original Article

Relationship between Reduction of Gastric Acid Secretion and Plasma Gastrin Concentration during Omeprazole Treatment

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Pages 1259-1266 | Received 29 Jun 1988, Accepted 01 Aug 1988, Published online: 08 Jul 2009

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Read on this site (5)

Helge L. Waldum, Gunnar Qvigstad, Reidar Fossmark, Per M. Kleveland & Arne K. Sandvik. (2010) Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint. Scandinavian Journal of Gastroenterology 45:4, pages 389-394.
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M. Valentini, F. Bortoluzzi, C. Cernigoi, G. Toffoli, E. Bertolissi, R. Cannizzaro, M. Sozzi & M. Fornasarig. (1993) Effect of Short- and Long-Term Treatment with Omeprazole on Cell Cycle Distribution in the Gastric Mucosa: Results of a Flow Cytometric Study. Scandinavian Journal of Gastroenterology 28:7, pages 617-621.
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K. E. L. McColl, A. M. El Nujumi, C. A. Dorrian, A. M. I. Macdonald, G. M. Fullarton & J. Harwood. (1992) Helicobacter pylori and Hypergastrinaemia during Proton Pump Inhibitor Therapy. Scandinavian Journal of Gastroenterology 27:2, pages 93-98.
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L. Lundell, L. Backman, P. Ekström, L.-K. Enander, S. Falkmer, O. Fausa, L. Grimelius, N. Havu, T. Lind, H. Lönroth, S. Sandmark, B. Sandzén, P. Unge & I. H. Westin. (1991) Prevention of Relapse of Reflux Esophagitis after Endoscopic Healing: The Efficacy and Safety of Omeprazole Compared with Ranitidine. Scandinavian Journal of Gastroenterology 26:3, pages 248-256.
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L. C. Baak, I. Biemond, J.B.M. J. Jansen & C.B.H. W. Lamers. (1991) Repeated Intravenous Bolus Injections of Omeprazole: Effects on 24-Hour Intragastric pH, Serum Gastrin, and Serum Pepsinogen A and C. Scandinavian Journal of Gastroenterology 26:7, pages 737-746.
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Articles from other publishers (42)

Joe D. Pagan, Laura Petroski-Rose, Alana Mann & Ashlee Hauss. (2020) Omeprazole Reduces Calcium Digestibility in Thoroughbred Horses. Journal of Equine Veterinary Science 86, pages 102851.
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Ronit Zilberboim & Adrianne Bendich. 2015. Preventive Nutrition. Preventive Nutrition 553 595 .
Yu-Xiao Yang. (2012) Chronic Proton Pump Inihibitor Therapy and Calcium Metabolism. Current Gastroenterology Reports 14:6, pages 473-479.
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Marcus Zulian Teixeira. (2011) Rebound acid hypersecretion after withdrawal of gastric acid suppressing drugs: new evidence of similitude. Homeopathy 100:3, pages 148-156.
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Weijiang Zhang, Jingtao Wu & Stuart N. Atkinson. (2009) Effects of Dexlansoprazole MR, a Novel Dual Delayed Release Formulation of a Proton Pump Inhibitor, on Plasma Gastrin Levels in Healthy Subjects. The Journal of Clinical Pharmacology 49:4, pages 444-454.
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M. SINGH, G. DHINDSA, S. FRIEDLAND & G. TRIADAFILOPOULOS. (2007) Long-term use of proton pump inhibitors does not affect the frequency, growth, or histologic characteristics of colon adenomas. Alimentary Pharmacology & Therapeutics 26:7, pages 1051-1061.
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Yu–Xiao Yang, Sean Hennessy, Kathleen Propert, Wei–Ting Hwang, Alireza Sedarat & James D. Lewis. (2007) Chronic Proton Pump Inhibitor Therapy and the Risk of Colorectal Cancer. Gastroenterology 133:3, pages 748-754.
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M. F. Erdogan, A. Gursoy & M. Kulaksizoglu. (2014) Long-term effects of elevated gastrin levels on calcitonin secretion. Journal of Endocrinological Investigation 29:9, pages 771-775.
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Michael Stock & Florian Otto. (2005) Gene deregulation in gastric cancer. Gene 360:1, pages 1-19.
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L. D. Allgood, J. M. Grender, M. J. Shaw & D. A. Peura. (2005) Comparison of Prilosec OTCTM (omeprazole magnesium 20.6 mg) to placebo for 14 days in the treatment of frequent heartburn. Journal of Clinical Pharmacy and Therapeutics 30:2, pages 105-112.
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Hyung-Keun Roh, Pum-Soo Kim, Don-Haeng Lee, Gunnel Tybring, Mohamed Sagar, Chang-Shin Park, Rein Seensalu & Leif Bertilsson. (2004) Omeprazole Treatment of Korean Patients: Effects on Gastric pH and Gastrin Release in Relation to CYP2C19 Geno- and Phenotypes. Pharmacology and Toxicology 95:3, pages 112-119.
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Anamika Pradeep, Chandan Sharma, Pradeep Sathyanarayana, Chris Albanese, John V Fleming, Timothy C Wang, M Michael Wolfe, Kenneth M Baker, Richard G Pestell & Basabi Rana. (2004) Gastrin-mediated activation of cyclin D1 transcription involves β-catenin and CREB pathways in gastric cancer cells. Oncogene 23:20, pages 3689-3699.
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DHRUV SUD, IAN M. P. JOSEPH & DENISE KIRSCHNER. (2011) PREDICTING EFFICACY OF PROTON PUMP INHIBITORS IN REGULATING GASTRIC ACID SECRETION. Journal of Biological Systems 12:01, pages 1-34.
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Jean-Francois Marier, Marie-Claude Dubuc, Eric Drouin, Fernando Alvarez, Murray P. Ducharme & Jean-Louis Brazier. (2004) Pharmacokinetics of Omeprazole in Healthy Adults and in Children with Gastroesophageal Reflux Disease. Therapeutic Drug Monitoring 26:1, pages 3-8.
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Giovanni Vitale, Antonio Ciccarelli, Michele Caraglia, Maurizio Galderisi, Riccardo Rossi, Salvatore Del Prete, Alberto Abbruzzese & Giovanni Lupoli. (2002) Comparison of Two Provocative Tests for Calcitonin in Medullary Thyroid Carcinoma: Omeprazole vs Pentagastrin. Clinical Chemistry 48:9, pages 1505-1510.
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S A Watson, T M Morris, D F McWilliams, J Harris, S Evans, A Smith & P A Clarke. (2002) Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence. British Journal of Cancer 87:5, pages 567-573.
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Jia-Qing Huang & Richard H. Hunt. (2001) Pharmacological and pharmacodynamic essentials of H2-receptor antagonists and proton pump inhibitors for the practising physician. Best Practice & Research Clinical Gastroenterology 15:3, pages 355-370.
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K. H. Moore, P. Barry, J. Burn & G. Falk. (2001) Adenocarcinoma of the rat esophagus in the presence of a proton pump inhibitor: a pilot study. Diseases of the Esophagus 14:1, pages 17-22.
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Kenneth E.L. McColl, Derek Gillen & Emad El-Omar. (2000) The role of gastrin in ulcer pathogenesis. Best Practice & Research Clinical Gastroenterology 14:1, pages 13-26.
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Thjodleifsson & Cockburn. (1999) Review article: rabeprazole’s tolerability profile in clinical trials. Alimentary Pharmacology & Therapeutics 13, pages 17-23.
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Sanduleanu, Stridsberg, Jonkers, Hameeteman, Biemond, Lundqvist, Lamers & Stockbrügger. (1999) Serum gastrin and chromogranin A during medium- and long-term acid suppressive therapy: a case-control study. Alimentary Pharmacology & Therapeutics 13:2, pages 145-153.
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Hiroyuki MIKI, Hirotaka YAMADA, Nozomi YOSHIKAWA & Keiji MITAMURA. (1999) Effect of Omeprazole Ingestion on Healing of Gastric Ulcers and Serum Gastrin Concentration in Rats. The Showa University Journal of Medical Sciences 11:2, pages 105-114.
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Jia-Qing Huang & Richard H. Hunt. 1999. Proton Pump Inhibitors. Proton Pump Inhibitors 63 78 .
Murat Faik Erdoğan, Sevim Güllü, Nilgün Başkal, Ali Riza Uysal, Nuri Kamel & Gürbüz i Erdoğan. (1997) Omeprazole: Calcitonin Stimulation Test for the Diagnosis Follow-Up and Family Screening in Medullary Thyroid Carcinoma. The Journal of Clinical Endocrinology & Metabolism 82:3, pages 897-899.
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Yoseph Caraco, Per-Olaf Lagerstrom & Alastair J.J. Wood. (1996) Ethnic and genetic determinants of omeprazole disposition and effect*. Clinical Pharmacology & Therapeutics 60:2, pages 157-167.
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Akira Tari, Masanori Hamada, Toshiki Kamiyasu, Youichi Fukino, Masaharu Sumii, Ken Haruma, Koji Sumii, Masaki Inoue & Goro Kajiyama. (1996) Effects of pirenzepine on omeprazole-induced hypergastrinemia and acid suppression in peptic ulcer patients. Journal of Gastroenterology 31:2, pages 167-170.
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R. F. McCloy, R. Arnold, K. D. Bardhan, D. Cattan, E. Klinkenberg-Knol, P. N. Maton, R. H. Riddell, P. Sipponen & A. Walan. (1995) Pathophysiological effects of long-term acid suppression in man. Digestive Diseases and Sciences 40:S2, pages 96S-120S.
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Bengt Hallerbäck, Peter Unge, Lasse Carling, Björn Edwin, Hans Glise, Nilu Havu, Ebbe Lyrenäs & Kjell Lundberg. (1994) Omeprazole or ranitidine in long-term treatment of reflux esophagitis. Gastroenterology 107:5, pages 1305-1311.
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Vincenzo Savarino, Giuseppe Sandro Mela, Patrizia Zentilin, Patrizia Cutela, Maria Raffaella Mele, Daniele Perilli, Ambrogio Vassallo, Adriana Zambotti, Carlo Mansi & Guido Celle. (1994) Antisecretory effects of three omeprazole regimens for maintenance treatment in duodenal ulcer. Digestive Diseases and Sciences 39:7, pages 1473-1482.
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J L Meijer, J B Jansen, L F Crobach, I Biemond & C B Lamers. (1993) Inhibition of omeprazole induced hypergastrinaemia by SMS 201-995, a long acting somatostatin analogue in man.. Gut 34:9, pages 1186-1190.
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R. COLLINS, S. BEATTIE, H. X. XIA & C. O'MORAIN. (2007) Short report: high‐dose omeprazole and amoxycillin in the treatment of Helicobacter pylori‐associated duodenal ulcer . Alimentary Pharmacology & Therapeutics 7:3, pages 313-315.
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Robert D. Shamburek & Mitchell L. Schubert. (1993) Pharmacology of gastric acid inhibition. Baillière's Clinical Gastroenterology 7:1, pages 23-54.
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J. Calam, R. A. Goodlad, C. Y. Lee, B. Ratcliffe, M. E. Coates, G. W. H. Stamp & N. A. Wright. 1993. Helicobacter pylori and Gastroduodenal Pathology. Helicobacter pylori and Gastroduodenal Pathology 90 97 .
Robert D. Shamburek & Mitchell L. Schubert. (1992) CONTROL OF GASTRIC ACID SECRETION. Gastroenterology Clinics of North America 21:3, pages 527-550.
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Roger G. Berlin. (1991) Omeprazole: Gastrin and gastric data (August 1991). Digestive Diseases and Sciences 36:10, pages 1501-1502.
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L C Baak, J B Jansen, I Biemond & C B Lamers. (1991) Weekend treatment with 20 and 40 mg omeprazole: effect on intragastric pH, fasting and postprandial serum gastrin, and serum pepsinogens.. Gut 32:9, pages 977-982.
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Hans Simon Merki, Clive H. Wilder-Smith, Robert P. Walt & Fred Halter. (1991) The cephalic and gastric phases of gastric secretion during H2-antagonist treatment. Gastroenterology 101:3, pages 599-606.
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Tiziana D'Adda, Francesco P. Pilato, Marco Lazzaroni, Flavio Robutti, Gabriele Bianchi-Porro & Cesare Bordi. (1991) Ultrastructural morphometry of gastric endocrine cells before and after omeprazole. Gastroenterology 100:6, pages 1563-1570.
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John A. Oates, Alastair J.J. Wood & Paul N. Maton. (1991) Omeprazole. New England Journal of Medicine 324:14, pages 965-975.
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T. Lind, C. Cederberg, M. Olausson & L. Olbe. (1990) 24-Hour intragastric acidity and plasma gastrin after omeprazole treatment and after proximal gastric vagotomy in duodenal ulcer patients. Gastroenterology 99:6, pages 1593-1598.
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C. H. Wilder-Smith, T. Ernst, M. Gennoni, B. Zeyen, F. Halter & H. S. Merki. (1990) Tolerance to oral H2-receptor antagonists. Digestive Diseases and Sciences 35:8, pages 976-983.
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H. KOOP, M. KLEIN & R. ARNOLD. (2007) Serum gastrin levels during long‐term omeprazole treatment. Alimentary Pharmacology & Therapeutics 4:2, pages 131-138.
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