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Original Article

Omeprazole or Ranitidine in the Treatment of Reflux Esophagitis: Results of a Double-Blind, Randomized, Scandinavian Multicenter Study

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Pages 625-632 | Received 02 Dec 1987, Accepted 21 Jan 1988, Published online: 08 Jul 2009

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Read on this site (36)

Birgitte-Elise G. Emken, Lars R. Lundell, Lene Wallin, Helge E. Myrvold, Cecilia Engström, Madeleine Montgomery, Anders R. Malm, Tore Lind & Jan G. Hatlebakk. (2017) Effects of omeprazole or anti-reflux surgery on lower oesophageal sphincter characteristics and oesophageal acid exposure over 10 years. Scandinavian Journal of Gastroenterology 52:1, pages 11-17.
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Carlo Calabrese, Anna Fabbri & Giulio Di Febo. (2007) Long-term management of GERD in the elderly with pantoprazole. Clinical Interventions in Aging 2:1, pages 85-92.
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Ingela Wiklund, Rolf Carlsson, Ingela Wiklund, Rolf Carlsson, Jonas Carlsson & Hans Glise. (2006) Psychological factors as a predictor of treatment response in patients with heartburn: A pooled analysis of clinical trials. Scandinavian Journal of Gastroenterology 41:3, pages 288-293.
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R. Befrits, S. Sjöstedt, R. Tour, C.-E. Leijonmarck, L. Hedenborg & M. Backman. (2004) Long-term effects of eradication of Helicobacter pylori on relapse and histology in gastric ulcer patients: a two-year follow-up study. Scandinavian Journal of Gastroenterology 39:11, pages 1066-1072.
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M. Bortolotti. (2003) Natural history of gastro‐oesophageal reflux disease: the neglected factor. Scandinavian Journal of Gastroenterology 38:12, pages 1204-1208.
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Keith G Tolman, Jane Chandramouli & John C Fang. (2000) Proton pump inhibitors in the treatment of gastro-oesophageal reflux disease. Expert Opinion on Pharmacotherapy 1:6, pages 1171-1194.
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Donald O. Castell & Norton J. Greenberger. (1999) A Practical Approach to Heartburn. Hospital Practice 34:12, pages 89-98.
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R. Carlsson, J. Dent, E. Bolling-Sternevald, F. Johnsson, O. Junghard, K. Lauritsen, S. Riley, L. Lundell. (1998) The Usefulness of a Structured Questionnaire in the Assessment of Symptomatic Gastroesophageal Reflux Disease. Scandinavian Journal of Gastroenterology 33:10, pages 1023-1029.
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M. Viljakka, M. Luostarinen & J. Isolauri. (1997) Incidence of Antireflux Surgery in Finland 1988-1993: Influence of Proton-Pump Inhibitors and Laparoscopic Technique. Scandinavian Journal of Gastroenterology 32:5, pages 415-418.
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T. Lind, T. Havelund, R. Carlsson, O. Anker-Hansen, H. Glise, H. Hernqvist, O. Junghard, K. Lauritsen, L. Lundell, S.A. Pedersen & A. Stubberöd. (1997) Heartburn without Oesophagitis: Efficacy of Omeprazole Therapy and Features Determining Therapeutic Response. Scandinavian Journal of Gastroenterology 32:10, pages 974-979.
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M. Viljakka, J. Nevalainen & J. Isolauri. (1997) Lifetime Costs of Surgical versus Medical Treatment of Severe Gastro-Oesophageal Reflux Disease in Finland. Scandinavian Journal of Gastroenterology 32:8, pages 766-772.
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T. L. Venables, R. D. Newland, A. C. Patel, J. Hole, M. B. Copeman & M. L. Turbitt. (1997) Maintenance Treatment for Gastro-Oesophageal Reflux Disease: A Placebo-Controlled Evaluation of 10 Milligrams Omeprazole Once Daily in General Practice. Scandinavian Journal of Gastroenterology 32:7, pages 627-632.
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A. Blomqvist, H. Lönroth, J. Dalenbäck, M. Ruth, I. Wiklund & L. Lundell. (1996) Quality of Life Assessment after Laparoscopic and Open Fundoplications Results of a Prospective, Clinical Study. Scandinavian Journal of Gastroenterology 31:11, pages 1052-1058.
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G. Van Den Boom, P. M. M. Y. H. Go, W. Hameeteman, B. Dallemagne & A. J. H. A. Ament. (1996) Cost Effectiveness of Medical versus Surgical Treatment in Patients with Severe or Refractory Gastroesophageal Reflux Disease in The Netherlands. Scandinavian Journal of Gastroenterology 31:1, pages 1-9.
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L. Sterk Laursen, T. Havelund, S. Bondesen, J. Hansen, G. Sanchez, E. Sebelin, C. Fenger & K. Lauritsen. (1995) Omeprazole in the Long-Term Treatment of Gastro-oesophageal Reflux Disease: A Double-Blind Randomized Dose-Finding Study. Scandinavian Journal of Gastroenterology 30:9, pages 839-846.
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G. N. J. Tytgat. (1995) The Clinical Use of Cisapride in Gastro-oesophageal Reflux Disease, with Particular Focus on the Long-term Treatment Aspects. Scandinavian Journal of Gastroenterology 30:sup211, pages 39-43.
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A. L. Hillman. (1994) Economic Analysis of Alternative Treatments for Persistent Gastro-Oesophageal Reflux Disease. Scandinavian Journal of Gastroenterology 29:sup201, pages 98-102.
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T. Havelund, L. S. Laursen & K. Lauritsen. (1994) Efficacy of Omeprazole in Lower Grades of Gastro-Oesophageal Reflux Disease. Scandinavian Journal of Gastroenterology 29:sup201, pages 69-73.
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J-P. Galmiche & S. Bruley Des Varannes. (1994) Symptoms and Disease Severity in Gastro-Oesophageal Reflux Disease. Scandinavian Journal of Gastroenterology 29:sup201, pages 62-68.
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J. G. Hatlebakk, A. Berstad, L. Carling, L. E. Svedberg, P. Unge, P. Ekström, L. Halvorsen, A. Stallemo, N. Hovdenak, R. Trondstad, E. Kittang & O. J. Lange. (1993) Lansoprazole versus Omeprazole in Short-Term Treatment of Reflux Oesophagitis Results of a Scandinavian Multicentre Trial. Scandinavian Journal of Gastroenterology 28:3, pages 224-228.
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P. Bytzer, T. Havelund & J. Moller Hansen. (1993) Interobserver Variation in the Endoscopic Diagnosis of Reflux Esophagitis. Scandinavian Journal of Gastroenterology 28:2, pages 119-125.
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B. I. Hirschowitz. (1992) Acid and Pepsin Secretion in Patients with Esophagitis Refractory to Treatment with H2 Antagonists. Scandinavian Journal of Gastroenterology 27:6, pages 449-452.
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G. N. J. Tytgat, O. J. Anker Hansen, L. Carling, G. H. De Groot, H. Geldof, H. Glise, P. Efskind, L. Elsborg, A. L. Karvonen, B. Ohlin, O. H. Solhaug & B. Vermeersch &. (1992) Effect of Cisapride on Relapse of Reflux Oesophagitis, Healed with an Antisecretory Drug. Scandinavian Journal of Gastroenterology 27:3, pages 175-183.
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E. C. Klinkenberg-Knol. (1991) Recent Advances in the Management of Gastro-Oesophageal Reflux Disease. Scandinavian Journal of Gastroenterology 26:sup188, pages 101-107.
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T. Lind, C. Cederberg, J.-P. Idström, H. Lönroth, L. Olbe & L. Lundell. (1991) 24-Hour Intragastric Acidity and Plasma Gastrin during Long-Term Treatment with Omeprazole or Ranitidine in Patients with Reflux Esophagitis. Scandinavian Journal of Gastroenterology 26:6, pages 620-626.
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L. Lundell, L. Backman, P. Ekström, L.-K. Enander, S. Falkmer, O. Fausa, L. Grimelius, N. Havu, T. Lind, H. Lönroth, S. Sandmark, B. Sandzén, P. Unge & I. H. Westin. (1991) Prevention of Relapse of Reflux Esophagitis after Endoscopic Healing: The Efficacy and Safety of Omeprazole Compared with Ranitidine. Scandinavian Journal of Gastroenterology 26:3, pages 248-256.
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L. Elsborg & F. Jørgensen. (1991) Sucralfate versus Cimetidine in Reflux Oesophagitis: A Double-Blind Clinical Study. Scandinavian Journal of Gastroenterology 26:2, pages 146-150.
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J. B. M. J. Jansen & C. B. H. W. Lamers. (1990) High Doses of Ranitidine in Patients with Reflux Oesophagitis. Scandinavian Journal of Gastroenterology 25:sup178, pages 42-46.
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G. N. J. Tytgat, C. Y. Nio & R. H. Schotborgh. (1990) Reflux Esophagitis. Scandinavian Journal of Gastroenterology 25:sup175, pages 1-12.
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P. G. Farup, R. Weberg, A. Berstad, S. Wetterhus, O. Dahlberg, J. Dybdahl, G. Fyllingen, K. S. Kannelønning & O. J. Lange. (1990) Low-Dose Antacids versus 400 mg Cimetidine Twice Daily for Reflux Oesophagitis. Scandinavian Journal of Gastroenterology 25:3, pages 315-320.
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E. J. S. Boyd & J. R. Wood. (1989) H2-Receptor Antagonists in the Treatment of Reflux Oesophagitis. Scandinavian Journal of Gastroenterology 24:sup171, pages 136-143.
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H. P. M. Festen. (1989) Profound Gastric Acid Inhibition: Advantages and Potential Hazards. Scandinavian Journal of Gastroenterology 24:sup171, pages 99-105.
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P. Zeitoun. (1989) Comparison of Omeprazole with Ranitidine in the Treatment of Reflux Oesophagitis. Scandinavian Journal of Gastroenterology 24:sup166, pages 83-87.
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H. Glise. (1989) Healing, Relapse Rates and Prophylaxis of Reflux Esophagitis. Scandinavian Journal of Gastroenterology 24:sup156, pages 57-64.
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K. G. Wormsley. (1988) Risks of Therapeutic Achlorhydria. Scandinavian Journal of Gastroenterology 23:sup153, pages 35-51.
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