66
Views
86
CrossRef citations to date
0
Altmetric
Original Article

Glucagon-Like Peptide-1 7-36 Amide and Peptide YY from the L-Cell of the Ileal Mucosa Are Potent Inhibitors of Vagally Induced Gastric Acid Secretion in Man

, , , , &
Pages 501-505 | Received 12 Jul 1993, Accepted 18 Oct 1993, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Dominic-Luc Webb, Niclas Abrahamsson, Magnus Sundbom & Per M. Hellström. (2017) Bariatric surgery – time to replace with GLP-1?. Scandinavian Journal of Gastroenterology 52:6-7, pages 635-640.
Read now
A. Wettergren, P. Maina, S. Boesby & J. J. Holst. (1997) Glucagon-Like Peptide-1 7-36 Amide and Peptide YY Have Additive Inhibitory Effect on Gastric Acid Secretion in Man. Scandinavian Journal of Gastroenterology 32:6, pages 552-555.
Read now

Articles from other publishers (83)

Mark M. Smits & Jens J. Holst. (2023) Endogenous glucagon‐like peptide (GLP)‐1 as alternative for GLP‐1 receptor agonists: Could this work and how?. Diabetes/Metabolism Research and Reviews 39:8.
Crossref
Sudhir Pandey, Supachoke Mangmool & Warisara Parichatikanond. (2023) Multifaceted Roles of GLP-1 and Its Analogs: A Review on Molecular Mechanisms with a Cardiotherapeutic Perspective. Pharmaceuticals 16:6, pages 836.
Crossref
Jens Juul Holst. (2022) Discovery of the GI Effects of GLP-1: An Historical Perspective. Digestive Diseases and Sciences 67:7, pages 2716-2720.
Crossref
Jens Juul Holst, Daniel Bjørklund Andersen & Kaare Villum Grunddal. (2021) Actions of glucagon‐like peptide‐1 receptor ligands in the gut. British Journal of Pharmacology 179:4, pages 727-742.
Crossref
鑫 李. (2022) Advances in Biological and Clinical Research of GLP-1 Receptor Agonists. Advances in Clinical Medicine 12:04, pages 2979-2988.
Crossref
Simon Veedfald, Jens F Rehfeld, Gerrit van Hall, Lars B Svendsen & Jens J Holst. (2022) Entero-Pancreatic Hormone Secretion, Gastric Emptying, and Glucose Absorption After Frequently Sampled Meal Tests. The Journal of Clinical Endocrinology & Metabolism 107:1, pages e188-e204.
Crossref
Christian Roth & Thomas Reinehr. 2022. Adipositas bei Kindern und Jugendlichen. Adipositas bei Kindern und Jugendlichen 211 221 .
Friederike I. Tam, Maria Seidel, Ilka Boehm, Franziska Ritschel, Klaas Bahnsen, Ronald Biemann, Kerstin Weidner, Veit Roessner & Stefan Ehrlich. (2020) Peptide YY3–36 concentration in acute- and long-term recovered anorexia nervosa. European Journal of Nutrition 59:8, pages 3791-3799.
Crossref
Sanjay Kalra, Ashok Kumar Das, Rakesh Kumar Sahay, Manash Pratim Baruah, Mangesh Tiwaskar, Sambit Das, Sudip Chatterjee, Banshi Saboo, Ganapathi Bantwal, Saptarshi Bhattacharya, Gagan Priya, Manoj Chawla, Kiraninder Brar, Syed Abbas Raza, Azizul Hasan Aamir, Dina Shrestha, Noel Somasundaram, Prasad Katulanda, Faria Afsana, Shahjada Selim, Mohammad Wali Naseri, Ali Latheef & Manilka Sumanatilleke. (2019) Consensus Recommendations on GLP-1 RA Use in the Management of Type 2 Diabetes Mellitus: South Asian Task Force. Diabetes Therapy 10:5, pages 1645-1717.
Crossref
Jens J. Holst, Nicolai J. Wewer Albrechtsen, Mette M. Rosenkilde & Carolyn F. Deacon. 2011. Comprehensive Physiology. Comprehensive Physiology 1339 1381 .
Metin Guclu, Sinem Kiyici, Zulfiye Gul & Sinan Cavun. (2018) Exenatide treatment causes suppression of serum fasting ghrelin levels in patients with type 2 diabetes mellitus. Endocrine Connections 7:1, pages 193-198.
Crossref
Motoi Kobashi, Satoshi Mizutani, Masako Fujita, Yoshihiro Mitoh, Yuichi Shimatani & Ryuji Matsuo. (2017) Central glucagon like peptide-1 inhibits reflex swallowing elicited by the superior laryngeal nerve via caudal brainstem in the rat. Brain Research 1671, pages 26-32.
Crossref
Chris de Graaf, Dan Donnelly, Denise Wootten, Jesper Lau, Patrick M. Sexton, Laurence J. Miller, Jung-Mo Ahn, Jiayu Liao, Madeleine M. Fletcher, Dehua Yang, Alastair J. H. Brown, Caihong Zhou, Jiejie Deng & Ming-Wei Wang. (2016) Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews 68:4, pages 954-1013.
Crossref
Figen Topyildiz, Sinem Kiyici, Zulfiye Gul, Deniz Sigirli, Metin Guclu, Gurcan Kisakol & Sinan Cavun. (2016) Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women. Journal of Diabetes Research 2016, pages 1-7.
Crossref
Hannelouise Kissow. (2015) Glucagon-like peptides 1 and 2. Current Opinion in Supportive & Palliative Care 9:2, pages 196-202.
Crossref
Elena-Dana Baraboi, Wei Li, Sébastien M. Labbé, Marie-Claude Roy, Pierre Samson, Frédéric-Simon Hould, Stéphane Lebel, Simon Marceau, Laurent Biertho & Denis Richard. (2015) Metabolic Changes Induced by the Biliopancreatic Diversion in Diet-Induced Obesity in Male Rats: The Contributions of Sleeve Gastrectomy and Duodenal Switch. Endocrinology 156:4, pages 1316-1329.
Crossref
Tongzhi Wu, Christopher K. Rayner & Michael Horowitz. 2016. Metabolic Control. Metabolic Control 137 171 .
Kirstin A. Carswell, Royce P. Vincent, Ajay P. Belgaumkar, Roy A. Sherwood, Stephanie A. Amiel, Ameet G. Patel & Carel W. le Roux. (2013) The Effect of Bariatric Surgery on Intestinal Absorption and Transit Time. Obesity Surgery 24:5, pages 796-805.
Crossref
K Pabreja, M A Mohd, C Koole, D Wootten & S G B Furness. (2014) Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology 171:5, pages 1114-1128.
Crossref
Niels-Erik Viby, Marie S. Isidor, Katrine B. Buggeskov, Steen S. Poulsen, Jacob B. Hansen & Hannelouise Kissow. (2013) Glucagon-Like Peptide-1 (GLP-1) Reduces Mortality and Improves Lung Function in a Model of Experimental Obstructive Lung Disease in Female Mice. Endocrinology 154:12, pages 4503-4511.
Crossref
J J Holst. (2013) Incretin hormones and the satiation signal. International Journal of Obesity 37:9, pages 1161-1168.
Crossref
Eleftheria Diakogiannaki, Fiona M. Gribble & Frank Reimann. (2012) Nutrient detection by incretin hormone secreting cells. Physiology & Behavior 106:3, pages 387-393.
Crossref
Guillermo A. Gomez, Ella W. Englander & George H. GreeleyJrJr. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 155 198 .
Stefan Trapp & Kazunari Hisadome. (2011) Glucagon-like peptide 1 and the brain: Central actions–central sources?. Autonomic Neuroscience 161:1-2, pages 14-19.
Crossref
Remy Burcelin, Cendrine Cabou, Christophe Magnan & Pierre Gourdy. 2011. Metabolic Syndrome. Metabolic Syndrome 279 325 .
Ruth Gutierrez-Aguilar & Stephen C Woods. (2011) Nutrition and L and K-enteroendocrine cells. Current Opinion in Endocrinology, Diabetes & Obesity 18:1, pages 35-41.
Crossref
Filip K. Knop. (2010) Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?. American Journal of Physiology-Endocrinology and Metabolism 299:1, pages E10-E13.
Crossref
E.J. Verspohl. (2009) Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacology & Therapeutics 124:1, pages 113-138.
Crossref
Tina Vilsbøll, Jens J. Holst & Filip K. Knop. (2009) The spectrum of antidiabetic actions of GLP-1 in patients with diabetes. Best Practice & Research Clinical Endocrinology & Metabolism 23:4, pages 453-462.
Crossref
j. schirra, m. nicolaus, h. j. woerle, c. struckmeier, m. katschinski & b. göke. (2009) GLP-1 regulates gastroduodenal motility involving cholinergic pathways. Neurogastroenterology & Motility 21:6, pages 609-e22.
Crossref
t. edholm, k. cejvan, s. m. Abdel-halim, s. efendic, p. t. schmidt & p. m. hellström. (2009) The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility. Neurogastroenterology & Motility 21:3, pages 313-321.
Crossref
Kasper Aaboe, Thure Krarup, Sten Madsbad & Jens Juul Holst. (2008) GLP‐1: physiological effects and potential therapeutic applications. Diabetes, Obesity and Metabolism 10:11, pages 994-1003.
Crossref
C Holdstock, B Zethelius, M Sundbom, F A Karlsson & B Edén Engström. (2008) Postprandial changes in gut regulatory peptides in gastric bypass patients. International Journal of Obesity 32:11, pages 1640-1646.
Crossref
Claude Knauf, Patrice D. Cani, Dong-Hoon Kim, Miguel A. Iglesias, Chantal Chabo, Aurélie Waget, André Colom, Sophie Rastrelli, Nathalie M. Delzenne, Daniel J. Drucker, Randy J. Seeley & Remy Burcelin. (2008) Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing. Diabetes 57:10, pages 2603-2612.
Crossref
Adil E. Bharucha, Nisha Charkoudian, Christopher N. Andrews, Michael Camilleri, David Sletten, Alan R. Zinsmeister & Phillip A. Low. (2008) Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295:3, pages R874-R880.
Crossref
Michael A. Nauck & Juris J. Meier. 2008. Pancreatic Beta Cell in Health and Disease. Pancreatic Beta Cell in Health and Disease 335 378 .
Darleen A. Sandoval, Bin Gong & Stephen N. Davis. (2007) Forebrain and hindbrain effects of ethanol on counterregulatory responses to hypoglycemia in conscious rats. Metabolism 56:12, pages 1623-1628.
Crossref
Jens Juul Holst. (2007) The Physiology of Glucagon-like Peptide 1. Physiological Reviews 87:4, pages 1409-1439.
Crossref
C. N. andrews, A. E. bharucha, M. camilleri, P. A. low, B. M. seide, D. D. burton, K. K. nickander, K. L. baxter & A. R. zinsmeister. (2007) Effects of glucagon-like peptide-1 and sympathetic stimulation on gastric accommodation in humans. Neurogastroenterology & Motility 19:9, pages 716-723.
Crossref
J. Miholic, M. Hoffmann, J.J. Holst, J. Lenglinger, M. Mittlböck, H. Bergmann & G. Stacher. (2007) Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication. Surgical Endoscopy 21:2, pages 309-314.
Crossref
Diego Pérez-Tilve, Lucas González-Matías, Mayte Alvarez-Crespo, Roberto Leiras, Sulay Tovar, Carlos Diéguez & Federico Mallo. (2007) Exendin-4 Potently Decreases Ghrelin Levels in Fasting Rats. Diabetes 56:1, pages 143-151.
Crossref
Jutta Keller, Jens Juul Holst & Peter Layer. (2006) Inhibition of human pancreatic and biliary output but not intestinal motility by physiological intraileal lipid loads. American Journal of Physiology-Gastrointestinal and Liver Physiology 290:4, pages G704-G709.
Crossref
Juris J Meier. (2006) Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls. World Journal of Gastroenterology 12:12, pages 1874.
Crossref
Ella W. Englander & George H. GreeleyJr.Jr.. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 121 159 .
Rachel Fetner, James McGinty, Colleen Russell, F. Xavier Pi-Sunyer & Blandine Laferrère. (2005) Incretins, diabetes, and bariatric surgery: a review. Surgery for Obesity and Related Diseases 1:6, pages 589-597.
Crossref
Philip J. Larsen & Jens Juul Holst. (2005) Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter. Regulatory Peptides 128:2, pages 97-107.
Crossref
Jörg Schirra & Burkhard Göke. (2005) The physiological role of GLP-1 in human: incretin, ileal brake or more?. Regulatory Peptides 128:2, pages 109-115.
Crossref
Carolyn F. Deacon. (2005) What do we know about the secretion and degradation of incretin hormones?. Regulatory Peptides 128:2, pages 117-124.
Crossref
Naciye Isbil-Buyukcoskun & Guldal Gulec. (2005) Investigation of the mechanisms involved in the central effects of glucagon-like peptide-1 on ethanol-induced gastric mucosal lesions. Regulatory Peptides 128:1, pages 57-62.
Crossref
Juris J. Meier & Michael A. Nauck. (2005) Glucagon-like peptide 1(GLP-1) in biology and pathology. Diabetes/Metabolism Research and Reviews 21:2, pages 91-117.
Crossref
Adrian Vella, Michael Camilleri & Robert A Rizza. (2004) The gastrointestinal tract and glucose tolerance. Current Opinion in Clinical Nutrition and Metabolic Care 7:4, pages 479-484.
Crossref
Naciye Isbil-Buyukcoskun & Guldal Gulec. (2004) Effects of centrally injected GLP-1 in various experimental models of gastric mucosal damage. Peptides 25:7, pages 1179-1183.
Crossref
Patrick Tso & Min Liu. (2004) Ingested fat and satiety. Physiology & Behavior 81:2, pages 275-287.
Crossref
Jens Juul Holst. 2004. Dipeptidyl Aminopeptidases in Health and Disease. Dipeptidyl Aminopeptidases in Health and Disease 263 279 .
Umberto Laforenza, Giulia Gastaldi, Guido Rindi, Andrew B Leiter, Emanuela Cova, Annalisa Marchetti, Maria Elena Candusso, Michele Autelli, Maria Novella Orsenigo & Ulderico Ventura. (2003) PYY-Tag Transgenic Mice Displaying Abnormal (H+-K+)ATPase Activity and Gastric Mucosal Barrier Impairment. Laboratory Investigation 83:1, pages 47-54.
Crossref
Keishi Kawakubo, Hong Yang & Yvette Taché. (2002) Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 283:5, pages G1035-G1041.
Crossref
Jens Juul Holst. (2002) Therapy of type 2 diabetes mellitus based on the actions of glucagon‐like peptide‐1. Diabetes/Metabolism Research and Reviews 18:6, pages 430-441.
Crossref
Silvia Delgado-Aros, Doe-Young Kim, Duane D. Burton, George M. Thomforde, Debra Stephens, Benjamin H. Brinkmann, Adrian Vella & Michael Camilleri. (2002) Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans. American Journal of Physiology-Gastrointestinal and Liver Physiology 282:3, pages G424-G431.
Crossref
Iradj Sobhani, Marion Buyse, Héalène Goïot, Nina Weber, Jean–Pierre Laigneau, Dominique Henin, Jean–Claude Soulé & André Bado. (2002) Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 122:2, pages 259-263.
Crossref
Daniel J. Drucker. (2002) Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122:2, pages 531-544.
Crossref
Hong Yang. (2002) Central and peripheral regulation of gastric acid secretion by peptide YY. Peptides 23:2, pages 349-358.
Crossref
Timothy J. Kieffer, Mehboob A. Hussain & Joel F. Habener. 2011. Comprehensive Physiology. Comprehensive Physiology 197 265 .
A Flint, A Raben, AK Ersbøll, JJ Holst & A Astrup. (2001) The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity. International Journal of Obesity 25:6, pages 781-792.
Crossref
Makoto Nishizawa, Hajime Nakabayashi, Koichi Kawai, Tomohiko Ito, Satoshi Kawakami, Atsushi Nakagawa, Akira Niijima & Kenzo Uchida. (2000) The hepatic vagal reception of intraportal GLP-1 is via receptor different from the pancreatic GLP-1 receptor. Journal of the Autonomic Nervous System 80:1-2, pages 14-21.
Crossref
M. Katschinski. (2000) Nutritional implications of cephalic phase gastrointestinal responses. Appetite 34:2, pages 189-196.
Crossref
A Flint, A Raben, JF Rehfeld, JJ Holst & A Astrup. (2000) The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans. International Journal of Obesity 24:3, pages 288-298.
Crossref
Timothy James KiefferJoel Francis Habener. (1999) The Glucagon-Like Peptides. Endocrine Reviews 20:6, pages 876-913.
Crossref
Moustapha Hassan, Anja Eskilsson, Christina Nilsson, Cathrine Jonsson, Hans Jacobsson, Essam Refai, Stig Larsson & Suad Efendic. (1999) In vivo dynamic distribution of 131I-glucagon-like peptide-1 (7–36) amide in the rat studied by gamma camera. Nuclear Medicine and Biology 26:4, pages 413-420.
Crossref
Guillermo Gomez, Vidyavathi Udupi & George H. GreeleyJr.Jr.. 1999. Gastrointestinal Endocrinology. Gastrointestinal Endocrinology 551 576 .
Patricia L. Brubaker & Daniel J. Drucker. 1999. Gastrointestinal Endocrinology. Gastrointestinal Endocrinology 493 514 .
JEAN CHRISTOPHE. (1998) Is There Appetite after GLP-1 and PACAP?. Annals of the New York Academy of Sciences 865:1 VIP, PACAP, A, pages 323-335.
Crossref
André Wettergren, Morten Wøjdemann & Jens Juul Holst. (1998) Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow. American Journal of Physiology-Gastrointestinal and Liver Physiology 275:5, pages G984-G992.
Crossref
Andre Wettergren, Lone Pridal, Morten Wøjdemann & Jens Juul Holst. (1998) Amidated and non-amidated glucagon-like peptide-1 (GLP-1): non-pancreatic effects (cephalic phase acid secretion) and stability in plasma in humans. Regulatory Peptides 77:1-3, pages 83-87.
Crossref
A. Wettergren, M. Wøjdemann & J.J. Holst. (1998) The Inhibitory Effect of Glucagon-Like Peptide-1 (7-36)amide on Antral Motility is Antagonized by Its N-Terminally Truncated Primary Metabolite GLP-1 (9-36)amide. Peptides 19:5, pages 877-882.
Crossref
Leslie C. Fung, Connie Chisholm & Gordon R. Greenberg. (1998) Glucagon-Like Peptide-1-(7–36) Amide and Peptide YY Mediate Intraduodenal Fat-Induced Inhibition of Acid Secretion in Dogs*. Endocrinology 139:1, pages 189-194.
Crossref
Neşe I˙meryüz, Berrak Ç. Yeğen, Ayhan Bozkurt, Tamer Coşkun, Maria L. Villanueva-Peñacarrillo & Nefise B. Ulusoy. (1997) Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms. American Journal of Physiology-Gastrointestinal and Liver Physiology 273:4, pages G920-G927.
Crossref
J. J. Holst. (1997) ENTEROGLUCAGON. Annual Review of Physiology 59:1, pages 257-271.
Crossref
JENS JUUL HOLST, MAJ-BRIT TOFT-NIELSEN, CATHRINE ØRSKOV, MICHAEL NAUCK & BEHREND WILLMS. (2006) On the Effects of Glucagon-Like Peptide-1 on Blood Glucose Regulation in Normal and Diabetic Subjects. Annals of the New York Academy of Sciences 805:1, pages 729-736.
Crossref
A. Ben-Hamida, W. K. Man & J. Spencer. (2014) The effect of some gastrointestinal peptides on pentagastrin-stimulated acid secretion and oxyntic mucosal histamine in rats. Inflammation Research 45:S1, pages S46-S47.
Crossref
J. J. Holst, M. A. Nauck, C. F. Deacon & C. Ørskov. 1996. Glucagon III. Glucagon III 311 326 .
B. Göke, R. Göke, H.-C. Fehmann & H.-P. Bode. 1996. Glucagon III. Glucagon III 275 309 .
Laurent Gros, Frédéric Hollande, Bernard Thorens, Alain Kervran & Dominique Bataille. (1995) Comparative effects of GLP-1-(7-36) amide, oxyntomodulin and glucagon on rabbit gastric parietal cell function. European Journal of Pharmacology: Molecular Pharmacology 288:3, pages 319-327.
Crossref
Jens Juul Holst. (1994) Glucagonlike peptide 1: A newly discovered gastrointestinal hormone. Gastroenterology 107:6, pages 1848-1855.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.