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Original Article

Protection against Acetaminophen-Induced Liver Injury in Vivo by an Iron Chelator, Deferoxamine

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Pages 61-67 | Received 10 Jan 1994, Accepted 25 Apr 1994, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Gyul Moon, Sho Kobayashi, Ye Aung Naing, Ken-ichi Yamada, Mitsunori Yamakawa & Junichi Fujii. (2020) Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice. Free Radical Research 54:8-9, pages 606-619.
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Chun-Yu Liu, Min Wang, Hong-Min Yu, Fang-Xuan Han, Qiong-Shi Wu, Xing-Jun Cai, Hiroshi Kurihara, Yong-Xing Chen, Yi-Fang Li & Rong-Rong He. (2020) Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro. Bioscience, Biotechnology, and Biochemistry 84:8, pages 1621-1628.
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Jack A. Hinson, Angela B. Reid, Sandra S. McCullough & Laura P. James. (2004) Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition. Drug Metabolism Reviews 36:3-4, pages 805-822.
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Articles from other publishers (44)

Rolf Teschke. (2022) Treatment of Drug-Induced Liver Injury. Biomedicines 11:1, pages 15.
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Olamide B. Adelusi, Anup Ramachandran, John J. Lemasters & Hartmut Jaeschke. (2022) The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice. Toxicology and Applied Pharmacology 445, pages 116043.
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Baolin Niu, Xiaohong Lei, Qingling Xu, Yi Ju, Dongke Xu, Liya Mao, Jing Li, Yufan Zheng, Ning Sun, Xin Zhang, Yimin Mao & Xiaobo Li. (2021) Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury. Cell Biology and Toxicology 38:3, pages 505-530.
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Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen, Giselle Sanchez-Guerrero, David S. Umbaugh, Wen-Xing Ding & Anup Ramachandran. (2021) Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls. Acta Pharmaceutica Sinica B 11:12, pages 3740-3755.
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Anup Ramachandran & Hartmut Jaeschke. (2021) Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development. Antioxidants & Redox Signaling 35:9, pages 718-733.
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Hartmut Jaeschke, Olamide B. Adelusi & Anup Ramachandran. (2021) Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?. Gene Expression 20:3, pages 169-178.
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Yoichi Ishitsuka, Yuki Kondo & Daisuke Kadowaki. (2020) Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?. Biological and Pharmaceutical Bulletin 43:2, pages 195-206.
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Hartmut Jaeschke, Anup Ramachandran, Xiaojuan Chao & Wen-Xing Ding. (2019) Emerging and established modes of cell death during acetaminophen-induced liver injury. Archives of Toxicology 93:12, pages 3491-3502.
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Sam Seok ChoJi Hye YangKyu Hwa SeoSang Mi ShinEun Young ParkSeung Sik ChoGeon Ung JoJi Hyun EoJong Seok ParkDeuk Sil OhJin Beom KimChun-Soo NaSae Kwang KuIl Je ChoSung Hwan Ki. (2019) Cudrania Tricuspidata Extract and Its Major Constituents Inhibit Oxidative Stress-Induced Liver Injury . Journal of Medicinal Food 22:6, pages 602-613.
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Vida Nazemian, Somayeh Kalanaky, Homa Manaheji, Etrat Houshmandi, Mola Mohammadi, Jalal Zaringhalam & Somayeh Mirjafai. (2019) Anti-hyperalgesia effect of nanchelating based nano particle, RAc1, can be mediated via liver hepcidin expression modulation during persistent inflammation. International Immunopharmacology 69, pages 337-346.
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H. Jaeschke & A. Ramachandran. 2018. Comprehensive Toxicology. Comprehensive Toxicology 277 295 .
Sudip Banerjee, Stepan B. Melnyk, Kimberly J. Krager, Nukhet Aykin-Burns, Sandra S. McCullough, Laura P. James & Jack A. Hinson. (2017) Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. Toxicology Reports 4, pages 134-142.
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Reza Karimi Shervedani, Fatemeh Yaghoobi, Mostafa Torabi & Marzieh Samiei Foroushani. (2016) Nanobioconjugated System Formed of Folic Acid–Deferrioxamine–Ga(III) on Gold Surface: Preparation, Characterization, and Activities for Capturing of Mouse Breast Cancer Cells 4T1. The Journal of Physical Chemistry C 120:40, pages 23212-23220.
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Naoki Yamamoto, Takahiro Yamasaki, Taro Takami, Koichi Uchida, Koichi Fujisawa, Toshihiko Matsumoto, Issei Saeki, Shuji Terai & Isao Sakaida. (2016) Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib. Journal of Clinical Biochemistry and Nutrition 58:3, pages 202-209.
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Takahiro YAMASAKI. (2016) From Tracing the History of Medical Therapies to the Development of Novel Therapies for Hepatocellular Carcinoma肝細胞癌に対する内科治療の足跡~革新的治療法の開発. Yamaguchi Medical Journal 65:1, pages 15-22.
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Samar F. Darwish, Wesam M. El-Bakly, Reem N. El-Naga, Azza S. Awad & Ebtehal El-Demerdash. (2015) Antifibrotic mechanism of deferoxamine in concanavalin A induced-liver fibrosis: Impact on interferon therapy. Biochemical Pharmacology 98:1, pages 231-242.
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Takahiro Yamasaki, Issei Saeki & Isao Sakaida. (2014) Efficacy of iron chelator deferoxamine for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma patients refractory to current treatments. Hepatology International 8:S2, pages 492-498.
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Junichi Zaitsu, Takahiro Yamasaki, Issei Saeki, Yohei Harima, Takuya Iwamoto, Yumiko Harima, Toshihiko Matsumoto, Yohei Urata, Isao Hidaka, Yoshio Marumoto, Tsuyoshi Ishikawa, Taro Takami, Naoki Yamamoto, Seiji Kaino, Koichi Uchida, Shuji Terai & Isao Sakaida. (2014) Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma. Hepatology Research 44:5, pages 481-490.
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Jack A. Hinson. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 305 329 .
Takahiro Yamasaki & Isao Sakaida. (2012) Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma and future treatments for the poor responders. Hepatology Research 42:4, pages 340-348.
Crossref
Takahiro Yamasaki, Shuji Terai & Isao Sakaida. (2011) Deferoxamine for Advanced Hepatocellular Carcinoma. New England Journal of Medicine 365:6, pages 576-578.
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Tsutomu Sato, Masayoshi Kobune, Kazuyuki Murase, Yukari Kado, Tetsuro Okamoto, Shingo Tanaka, Shohei Kikuchi, Hiroyuki Nagashima, Yutaka Kawano, Kohichi Takada, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto & Junji Kato. (2011) Iron chelator deferasirox rescued mice from Fas-induced fulminant hepatitis. Hepatology Research 41:7, pages 660-667.
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Ayyasamy Manimaran, Souvendra Nath Sarkar & Palanisamy Sankar. (2011) Repeated preexposure or coexposure to arsenic differentially alters acetaminophen-induced oxidative stress in rat kidney. Environmental Toxicology 26:3, pages 250-259.
Crossref
Yuan Ren, Fengjun Deng, Hang Zhu, Weiren Wan, Jufeng Ye & Bingde Luo. (2010) Effect of epigallocatechin-3-gallate on iron overload in mice with alcoholic liver disease. Molecular Biology Reports 38:2, pages 879-886.
Crossref
Douglas B. Kell. (2010) Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples. Archives of Toxicology 84:11, pages 825-889.
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Kazuyoshi Kon, Jae-Sung Kim, Akira Uchiyama, Hartmut Jaeschke & John J. Lemasters. (2010) Lysosomal Iron Mobilization and Induction of the Mitochondrial Permeability Transition in Acetaminophen-Induced Toxicity to Mouse Hepatocytes. Toxicological Sciences 117:1, pages 101-108.
Crossref
Ayyasamy Manimaran, Souvendra Nath Sarkar & Palanisamy Sankar. (2010) Influence of repeated preexposure to arsenic on acetaminophen-induced oxidative stress in liver of male rats. Food and Chemical Toxicology 48:2, pages 605-610.
Crossref
H. Jaeschke. 2010. Comprehensive Toxicology. Comprehensive Toxicology 319 337 .
Jack A. Hinson, Dean W. Roberts & Laura P. James. 2010. Adverse Drug Reactions. Adverse Drug Reactions 369 405 .
Hao Yin, Linling Cheng, Michael Holt, Numsen HailJrJr, Robert MacLaren & Cynthia Ju. (2010) Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology, pages NA-NA.
Crossref
John J. Lemasters, Akira Uchiyama, Jae‐Sung Kim, Kazuyoshi Kon & Hartmut Jaeschke. 2009. The Liver. The Liver 511 520 .
Victor Raj Mohan Chandrasekaran, Dur-Zong Hsu & Ming-Yie Liu. (2009) THE PROTECTIVE EFFECT OF SESAMOL AGAINST MITOCHONDRIAL OXIDATIVE STRESS AND HEPATIC INJURY IN ACETAMINOPHEN-OVERDOSED RATS. Shock 32:1, pages 89-93.
Crossref
Lorne J. Hofseth. (2008) Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer. Cancer Letters 268:1, pages 10-30.
Crossref
Haiyan Jin, Shuji Terai & Isao Sakaida. (2007) The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis. Journal of Gastroenterology 42:6, pages 475-484.
Crossref
Premila Abraham. (2005) MEGA DOSE OF VITAMIN C AUGMENTS THE NEPHROTOXICITY OF PARACETAMOL. Nephrology 10:6, pages 623-624.
Crossref
Shigang Xiong, Hongyun She, Chin K. Sung & Hidekazu Tsukamoto. (2003) Iron-dependent activation of NF-κB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol 30:2, pages 107-113.
Crossref
Hongyun She, Shigang Xiong, Min Lin, Ebrahim Zandi, Cecilia Giulivi & Hidekazu Tsukamoto. (2002) Iron activates NF-κB in Kupffer cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 283:3, pages G719-G726.
Crossref
Tadashi Hasegawa, Minoru Nakano, Takashi Hashimoto, Katsuya Hiraishi, Keiji Suzuki & Hiroyuki Kuwano. (2001) Sinusoidal endothelial cell injury by superoxide anion and iron in the Propionibacterium acnes ‐pretreated and lipopolysaccharide‐stimulated rat liver . Liver 21:6, pages 415-424.
Crossref
Felicity A. Nicholls-Grzemski, G. Brian Belling, Brian G. Priestly, Ian C. Calder & Philip C. Burcham. (2000) Clofibrate pretreatment in mice confers resistance against hepatic lipid peroxidation. Journal of Biochemical and Molecular Toxicology 14:6, pages 335-345.
Crossref
Jennifer G. Schnellmann, Neil R. Pumford, Donna F. Kusewitt, Thomas J. Bucci & Jack A. Hinson. (1999) Deferoxamine delays the development of the hepatotoxicity of acetaminophen in mice. Toxicology Letters 106:1, pages 79-88.
Crossref
Jie Liu, Yaping Liu, Curtis D. Klaassen, Stacey E. Shehin-Johnson, Angela Lucas & Steven D. Cohen. 1999. Metallothionein IV. Metallothionein IV 547 552 .
Nafissa Rakba, Fouad Aouad, Christophe Henry, Catherine Caris, Isabelle Morel, Paul Baret, Jean-Louis Pierre, Pierre Brissot, Roberta J Ward, Gérard Lescoat & Robert R Crichton. (1998) Iron Mobilisation and Cellular Protection by a New Synthetic Chelator O-Trensox. Biochemical Pharmacology 55:11, pages 1797-1806.
Crossref
Yoshiyuki Minamide, Toshiharu Horie, Atsuko Tomaru & Shoji Awazu. (1998) Spontaneous Chemiluminescence Production, Lipid Peroxidation, and Covalent Binding in Rat Hepatocytes Exposed to Acetaminophen. Journal of Pharmaceutical Sciences 87:5, pages 640-646.
Crossref
Franziska Boess, Martin Bopst, Roland Althaus, Stacey Polsky, Steven D. Cohen, Hans-Pietro Eugster & Urs A. Boelsterli. (1998) Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-? gene knockout mice. Hepatology 27:4, pages 1021-1029.
Crossref

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