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Original Article

Comparison of Immunomodulative Effects of the Histamine-2 Receptor Antagonists Cimetidine, Ranitidine, and Famotidine on Peripheral Blood Mononuclear Cells in Gastric Cancer Patients

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Pages 265-271 | Received 21 Mar 1994, Accepted 17 Jun 1994, Published online: 08 Jul 2009

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Yizhi Zhang, Zhoujia Chen, Xuerui Luo, Bin Wu, Bin Li & Bin Wang. (2016) Cimetidine down-regulates stability of Foxp3 protein via Stub1 in Treg cells. Human Vaccines & Immunotherapeutics 12:10, pages 2512-2518.
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Domenico Ciliberto, Nicoletta Staropoli, Francesca Caglioti, Simona Gualtieri, Lucia Fiorillo, Silvia Chiellino, Antonina Maria De Angelis, Francesco Mendicino, Cirino Botta, Michele Caraglia, Pierfrancesco Tassone & Pierosandro Tagliaferri. (2015) A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate?. Cancer Biology & Therapy 16:8, pages 1148-1159.
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G. Van Der Pompe, M.H. Antoni & C.J. Heijnen. (1998) The effects of surgical stress and psychological stress on the immune function of operative cancer patients. Psychology & Health 13:6, pages 1015-1026.
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Articles from other publishers (24)

Shireesha Manturthi, Dwaipayan Bhattacharya, Kalyani Rajesh Sakhare, Kumar Pranav Narayan & Srilakshmi V. Patri. (2022) Cimetidine-Based Cationic Amphiphiles for In Vitro Gene Delivery Targetable to Colon Cancer. ACS Omega 7:35, pages 31388-31402.
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Matteo Borro, Simone Negrini, Andrew Long, Sharon Chinthrajah & Giuseppe Murdaca. (2021) H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?. Clinical and Molecular Allergy 19:1.
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Jana Krüger, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Lennart Koepke, Konstantin M.J. Sparrer, Tatjana Weil, Desiree Schütz, Thomas Seufferlein, Thomas F.E. Barth, Steffen Stenger, Sandra Heller, Jan Münch & Alexander Kleger. (2021) Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids. Cellular and Molecular Gastroenterology and Hepatology 11:4, pages 935-948.
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Ritwik Ghosh, Subhankar Chatterjee, Souvik Dubey & Carl J. Lavie. (2020) Famotidine Against SARS-CoV2: A Hope or Hype?. Mayo Clinic Proceedings 95:8, pages 1797-1799.
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Abdollah Jafarzadeh, Maryam Nemati, Hossain Khorramdelazad & Zuhair Mohammad Hassan. (2019) Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases. International Immunopharmacology 70, pages 156-166.
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Leon Fisher & Alexander Fisher. (2017) Acid-Suppressive Therapy and Risk of Infections: Pros and Cons. Clinical Drug Investigation 37:7, pages 587-624.
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Tatsuya Fujikawa, Hidenori Shiraha, Yutaka Nakanishi, Nobuyuki Takaoka, Naoki Ueda, Mayumi Suzuki & Yasushi Shiratori. (2007) Cimetidine inhibits epidermal growth factor-induced cell signaling. Journal of Gastroenterology and Hepatology 22:3, pages 436-443.
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Dimitri Flieger, Michael Varvenne, Rolf Kleinschmidt & Ingo G.H. Schmidt-Wolf. (2007) Influence of immunomodulatory drugs on the cytotoxicity induced by monoclonal antibody 17-1A and interleukin-2. Cellular Immunology 246:1, pages 26-33.
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Yoshiyuki Takeuchi, Naotsuka Okayama, Kenro Imaeda, Masahiro Okouchi, Hitoshi Omi, Seiji Imai, Masaya Akao, Yutaka Takeda, Tatsuya Hukutomi & Makoto Itoh. (2007) Effects of histamine 2 receptor antagonists on endothelial–neutrophil adhesion and surface expression of endothelial adhesion molecules induced by high glucose levels. Journal of Diabetes and its Complications 21:1, pages 50-55.
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H. Hasturk, A. Kantarci, N. Ebrahimi, C. Andry, M. Holick, V. L. Jones & T. E. Van Dyke. (2006) Topical H2 Antagonist Prevents Periodontitis in a Rabbit Model. Infection and Immunity 74:4, pages 2402-2414.
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Nan-Hong Tang, Yan-Ling Chen, Xiao-Qian Wang, Xiu-Jin Li, Feng-Zhi Yin & Xiao-Zhong Wang. (2004) Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion. World Journal of Gastroenterology 10:1, pages 62.
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Eiki Tayama, Nobuhiko Hayashida, Shuji Fukunaga, Keiichiro Tayama, Toru Takaseya, Ryouichi Hiratsuka & Shigeaki Aoyagi. (2001) High-dose cimetidine reduces proinflammatory reaction after cardiac surgery with cardiopulmonary bypass. The Annals of Thoracic Surgery 72:6, pages 1945-1949.
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Alex A. Fisher & David G. Le Couteur. (2001) Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists. Drug Safety 24:1, pages 39-57.
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D. Yip, A.H. Strickland, C.S. Karapetis, C.A. Hawkins & P.G. Harper. (2000) Immunomodulation therapy in colorectal carcinoma. Cancer Treatment Reviews 26:3, pages 169-190.
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Aaron R. Sasson, Reza Gamagami, Zili An, Xiaoen Wang, A.R. Moossa & Robert M. Hoffman. (1999) Cimetidine: An inhibitor or promoter of tumor growth?. International Journal of Cancer 81:5, pages 835-838.
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Hiroyasu Ishikura, Hisanori Fukui, Naoshi Takeyama & Takaya Tanaka. (1999) Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity. Blood 93:5, pages 1782-1783.
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Hiroyasu Ishikura, Hisanori Fukui, Naoshi Takeyama & Takaya Tanaka. (1999) Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity. Blood 93:5, pages 1782-1783.
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Michael D. Freedman. (1999) Stress ulcer prevention and histamine-2-receptor antagonists. Critical Care Medicine 27:1, pages 13-14.
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Junya Katoh, Kouji Tsuchiya, Hiroshi Osawa, Wataru Sato, Gouki Matsumura, Yoshinao Iida, Shoji Suzuki, Shigeru Hosaka, Shinpei Yoshii & Yusuke Tada. (1998) Cimetidine reduces impairment of cellular immunity after cardiac operations with cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 116:2, pages 312-318.
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Grant E. O'Keefe, Larry M. Gentilello & Ronald V. Maier. (1998) Incidence of Infectious Complications Associated With the Use of Histamine2-Receptor Antagonists in Critically III Trauma Patients. Annals of Surgery 227:1, pages 120-125.
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H. A. Wotherspoon, J. R. Anderson, C. G. Morran, G. D. Murray & C. S. McArdle. (1997) Randomized controlled trial of an H 2 -receptor antagonist in gastric cancer . British Journal of Surgery 84:8, pages 1168-1169.
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H. A. Wotherspoon, J. R. Anderson, C. G. Morran, G. D. Murray & C. S. McArdle. (1997) Randomized controlled trial of an H2-receptor antagonist in gastric cancer. British Journal of Surgery 84:8, pages 1168-1169.
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Joseph J. Drabick, Douglas B. Tang, E.E. Moran, Andrew F. Trofa, Janet S. Foster & Wendell D. Zollinger. (1997) A randomized, placebo-controlled study of oral cimetidine as an immunopotentiator of parenteral immunization with a group B meningococcal vaccine. Vaccine 15:10, pages 1144-1148.
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Warwick Adams & David Morris. (1996) Cimetidine and colorectal cancer. Diseases of the Colon & Rectum 39:1, pages 111-112.
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