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Case Reports

Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: Role of intracellular tenofovir diphosphate levels and review of the literature

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Pages 821-826 | Received 18 Mar 2011, Accepted 21 Mar 2011, Published online: 12 May 2011

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Clark D Kebodeaux, Alexandria Garavaglia Wilson, Daron L Smith & Scott Martin Vouri. (2013) A review of cardiovascular and renal function monitoring: a consideration of older adults with HIV. HIV/AIDS - Research and Palliative Care 5, pages 263-274.
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Mrinmayee Joshi, Brendan Clark & Todd A. Lee. (2023) Fanconi Syndrome in Patients With Human Immunodeficiency Virus Treated With Tenofovir-Based Antiretroviral Therapy: A Systematic Literature Review. Annals of Pharmacotherapy.
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Yu-Shan Huang, Chien-Yu Cheng, Bo-Huang Liou, Po-Liang Lu, Shu-Hsing Cheng, Yuan-Ti Lee, Chun-Eng Liu, Hsin-Yun Sun, Chia-Jui Yang, Hung-Jen Tang, Shih-Ping Lin, Mao-Wang Ho, Sung-Hsi Huang, Hung-Chin Tsai, Chen-Hsiang Lee & Chien-Ching Hung. (2020) Efficacy and safety of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide as maintenance treatment in HIV/HBV-coinfected patients. JAIDS Journal of Acquired Immune Deficiency Syndromes Publish Ahead of Print.
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Nayra do Socorro Caldas Carvalho de Almeida Teixeira, Beatriz de Mello Pereira, Iara Katrynne Fonsêca Oliveira, Carlos Henrique Ribeiro Lima, Cecília Maria Resende Gonçalves de Carvalho, Ivone Freires de Oliveira Costa Nunes, Dorcas Lamounier Costa & Adriana de Azevedo Paiva. (2019) Effect of vitamin D3 supplementation on HIV-infected adults: a systematic reviewVitamin Dӡ Supplementation on HIV-Infected Adults: A Systematic Review. Nutrición Hospitalaria.
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A. Bertholet-Thomas, A. Servais, H. Liang, C. Acquaviva, C. Vianey-Saban, G. Deschênes, P. Cochat, A. Labbé, J. Bacchetta & S. Lemoine. (2018) Cistinosis y síndrome de Fanconi. EMC - Pediatría 53:3, pages 1-12.
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Yu-Shan Huang, Chieh-Kai Chan, Mao-Song Tsai, Kuan-Yeh Lee, Shu-Wen Lin, Sui-Yuan Chang, Chien-Ching Hung & Shan-Chwen Chang. (2017) Kidney dysfunction associated with tenofovir exposure in human immunodeficiency virus-1-infected Taiwanese patients. Journal of Microbiology, Immunology and Infection 50:5, pages 595-603.
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Wasin Bunpeth, Ouppatham Supasyndh & Bancha Satirapoj. (2017) Renal Injury and Dysfunction among HIV Positive Patients Receiving Tenofovir Based Anti-Retroviral Therapy. Journal of Southeast Asian Medical Research 1:1, pages 6-11.
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Hans-Jürgen Stellbrink. (2017) Gesundheitsvorsorge bei HIV-InfiziertenTreatment of HIV-infected patients: metabolism, bone, cardiovascular — what is part of routine care?. MMW - Fortschritte der Medizin 159:S2, pages 14-23.
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L. Hamzah, S. Jose, J.W. Booth, A. Hegazi, M. Rayment, A. Bailey, D.I. Williams, B.M. Hendry, P. Hay, R. Jones, J.B. Levy, D.R. Chadwick, M. Johnson, C.A. Sabin & F.A. Post. (2017) Treatment-limiting renal tubulopathy in patients treated with tenofovir disoproxil fumarate. Journal of Infection 74:5, pages 492-500.
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A Calcagno, J Cusato, L Marinaro, L Trentini, C Alcantarini, M Mussa, M Simiele, A D'Avolio, G Di Perri & S Bonora. (2015) Clinical pharmacology of tenofovir clearance: a pharmacokinetic/pharmacogenetic study on plasma and urines. The Pharmacogenomics Journal 16:6, pages 514-518.
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Shunsuke Goto, Hideki Fujii, Keiji Kono, Kentaro Watanabe, Kentaro Nakai & Shinichi Nishi. (2016) Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia. Clinical Kidney Journal 9:5, pages 677-681.
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Corinne Isnard-Bagnis, Blandine Aloy, Gilbert Deray & Jérôme Tourret. (2016) Néphrotoxicité du ténofovir. Néphrologie & Thérapeutique 12:3, pages 179-189.
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Lourdes Mateo, Susana Holgado, Maria Luisa Mariñoso, Ricard Pérez-Andrés, Anna Bonjoch, Joan Romeu & Alejandro Olivé. (2014) Hypophosphatemic osteomalacia induced by tenofovir in HIV-infected patients. Clinical Rheumatology 35:5, pages 1271-1279.
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Marie B. Demay & Stephen M. Krane. 2016. Endocrinology: Adult and Pediatric. Endocrinology: Adult and Pediatric 1230 1243.e4 .
Alice K. Pau & Jomy M. George. (2014) Antiretroviral Therapy. Infectious Disease Clinics of North America 28:3, pages 371-402.
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Ramesh Saeedi, Shi Yuan Jiang, Daniel T. Holmes & David L. Kendler. (2014) Fibroblast Growth Factor 23 is Elevated in Tenofovir-Related Hypophosphatemia. Calcified Tissue International 94:6, pages 665-668.
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Anchalee Avihingsanon, Tanakorn Apornpong, Reshmie A Ramautarsing, Sasiwimol Ubolyam, Pisit Tangkijvanich, Jintanat Ananworanich, Joep MA Lange, Gail Matthews, Sharon R Lewin & Kiat Ruxrungtham. (2014) Decline in Serum 25 Hydroxyvitamin D Levels in HIV–Hbv-Coinfected Patients after Long-Term Antiretroviral Therapy. Antiviral Therapy 19:1, pages 41-49.
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I.D. Ramsay, J.M. Lestner & C.I.S. Barker. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 503 550 .
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C. Wu, H. Zhang, Y. Qian, L. Wang, X. Gu & Z. Dai. (2013) Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. Journal of Clinical Pharmacy and Therapeutics 38:4, pages 321-326.
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Andrew M. Hall. (2012) Update on tenofovir toxicity in the kidney. Pediatric Nephrology 28:7, pages 1011-1023.
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Jose M. Miro, Federico Cofan, Joan C. Trullas, Christian Manzardo, Carlos Cervera, Montserrat Tuset, Federico Oppenheimer, Mercedes Brunet, Asuncion Moreno, Josep M. Campistol & Jose M. Gatell. (2012) Renal Dysfunction in the Setting of HIV/AIDS. Current HIV/AIDS Reports 9:3, pages 187-199.
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