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Scandinavian Journal of Infectious Diseases Volume 43, 2011 - Issue 10
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Case Reports

Cefepime neurotoxicity despite renal adjusted dosing

Venu Gopala Reddy GangireddyDepartment of Internal Medicine, Georgia Health Sciences University, Augusta, Georgia, USACorrespondence[email protected]
,
Lauren C. MitchellDepartment of Internal Medicine, Georgia Health Sciences University, Augusta, Georgia, USA
&
Teresa ColemanDepartment of Hematology and Oncology, Georgia Health Sciences University, Augusta, Georgia, USA
Pages 827-829 | Received 06 Apr 2011, Accepted 11 Apr 2011, Published online: 23 May 2011

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Alan Abdulla, Tim M.J. Ewoldt, Ilse M. Purmer, Anouk E. Muller, Diederik Gommers, Henrik Endeman & Birgit C.P. Koch. (2021) A narrative review of predictors for β-lactam antibiotic exposure during empirical treatment in critically ill patients. Expert Opinion on Drug Metabolism & Toxicology 17:4, pages 359-368.
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Zhenbao Liu, Chunyan Wang, Yanfei Liu & Dongming Peng. (2017) Cefepime loaded O-carboxymethyl chitosan microspheres with sustained bactericidal activity and enhanced biocompatibility. Journal of Biomaterials Science, Polymer Edition 28:1, pages 79-92.
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Dénes Zádori, Gábor Veres, Levente Szalárdy, Péter Klivényi & László Vécsei. (2015) Drug-induced movement disorders. Expert Opinion on Drug Safety 14:6, pages 877-890.
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Tomotaka Ugai, Kurimi Morisaki, Kenji Tsuda, Hiroyuki Sugihara, Yuhki Nishida, Masayuki Yamakura, Masami Takeuchi & Kosei Matsue. (2014) Cefepime-induced encephalopathy in patients with haematological malignancies: Clinical features and risk factors. Scandinavian Journal of Infectious Diseases 46:4, pages 272-279.
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JiSheng Zhang, CongYang Huang, Hong Li, Qiang Yao, Jun Xu, JiangZi Yuan, JiaQi Qian & BeiYan Bao. (2013) Antibiotic-induced neurotoxicity in dialysis patients: a retrospective study. Renal Failure 35:6, pages 901-905.
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Articles from other publishers (35)

Malarkodi SuppamutharwyamTunku Muzafar Shah. (2023) Cefepime‐induced delirium. Progress in Neurology and Psychiatry 27:4, pages 30-34.
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T. N. Pushkar, P. N. Vlasov, A. I. Belyakova-Bodina & A. G. Broutian. (2023) Cefepime-induced encephalopathy. Neurology, Neuropsychiatry, Psychosomatics 15:3, pages 76-81.
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Edward T. Qian, Li Wang, Joanna L. Stollings, Jonathan D. Casey, Todd W. Rice & Matthew W. Semler. (2023) Piperacillin-Tazobactam Versus Anti-Pseudomonal Cephalosporins and Renal and Neurologic Outcomes in Critically Ill Adults: A Secondary Analysis of the SMART Trial. Journal of Intensive Care Medicine.
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Saki Bussaka, Takaichi Suehiro, Koji Mitsuiki, Takato Morioka, Tadahisa Shono, Fujio Fujiki & Toshiaki Nakano. (2023) Non-convulsive status epilepticus possibly induced by a rapid correction of severe hyperkalemia: a case report and literature review. BMC Nephrology 24:1.
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Erfan Alijani, Sonal Sekhar Miraj, Shilia Jacob Kurian, Mahadev Rao & Kavitha Saravu. (2023) Cefepime-induced Neurotoxicity: A Retrospective Cohort Study in a South-Indian Tertiary Healthcare Facility. Current Drug Safety 18:1, pages 69-78.
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Gökçe Öztürk & Dilek Kul. (2023) Comparison of carbon paste and boron-doped diamond electrodes for determination of cefepime in pharmaceutical dosage forms and biological samples. Diamond and Related Materials 131, pages 109532.
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Gozun Maan, Koichi Keitoku, Nobuhiko Kimura, Haruki Sawada, Andrew Pham, Jihun Yeo, Hideharu Hagiya & Yoshito Nishimura. (2022) Cefepime-induced neurotoxicity: systematic review. Journal of Antimicrobial Chemotherapy 77:11, pages 2908-2921.
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Marco A. PATRUNO, Silvano DRAGONIERI, Francesca ADDANTE, Stefano PATRUNO, Piero PORTINCASA & Pierluigi CARRATÙ. (2022) A successfully home-treated adverse reaction to cefepime in a geriatric patient. Minerva Respiratory Medicine 61:3.
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Natalie A. Haddad, Diana J. Schreier, Jennifer E. Fugate, Ognjen Gajic, Sara E. Hocker, Calvin J. Ice, Sarah B. Leung, Kristin C. Mara, Alejandro A. Rabinstein, Andrew D. Rule & Erin F. Barreto. (2022) Incidence and Predictive Factors Associated with Beta-Lactam Neurotoxicity in the Critically Ill: A Retrospective Cohort Study. Neurocritical Care 37:1, pages 73-80.
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Gwendolyn M. Pais, Jack Chang, Erin F. Barreto, Gideon Stitt, Kevin J. Downes, Mohammad H. Alshaer, Emily Lesnicki, Vaidehi Panchal, Maria Bruzzone, Argyle V. Bumanglag, Sara N. Burke & Marc H. Scheetz. (2022) Clinical Pharmacokinetics and Pharmacodynamics of Cefepime. Clinical Pharmacokinetics 61:7, pages 929-953.
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Michael L. Behal, Jenni K. Thomas, Melissa L. Thompson Bastin & Breanne M. Mefford. (2021) Cefepime Induced Neurotoxicity Following A Regimen Dose-Adjusted for Renal Function: Case Report and Review of the Literature. Hospital Pharmacy 57:3, pages 385-391.
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Mosunmoluwa Oyenuga, Abayomi Oyenuga, Abdul Rauf, Omotola Balogun & Niranjan Singh. (2021) New Onset Non-Convulsive Status Epilepticus Despite Cefepime Renal Dose Adjustment. Cureus.
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Tarun D. Singh, John C. O’Horo, Courtney N. Day, Jay Mandrekar & Alejandro A. Rabinstein. (2020) Cefepime is Associated with Acute Encephalopathy in Critically Ill Patients: A Retrospective Case–Control Study. Neurocritical Care 33:3, pages 695-700.
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Pitchaya Wanleenuwat, Nanthushan Suntharampillai & Piotr Iwanowski. (2020) Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations. Seizure 81, pages 167-174.
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Luis Rafael Moscote-Salazar, Amrita Ghosh, Ranabir Pal, Sumit Raj, Md Moshiur Rahman & Amit Agrawal. (2020) Neurotoxicity Associated with Cefepime: An Update to Neurocritical Care: A Narrative Review. Journal of Translational Critical Care Medicine 2:2, pages 28-35.
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Se-Jin Lee. (2019) Cefepime-induced neurotoxicity. Journal of Neurocritical Care 12:2, pages 74-84.
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Ramadan Ali, Hassan Refat H. Ali, Hany A. Batakoushy, Sayed M. Derayea & Mohamed M. Elsutohy. (2019) A reductant colorimetric method for the rapid detection of certain cephalosporins via the production of gold and silver nanoparticles. Microchemical Journal 146, pages 864-871.
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Jessica J. Grahl, Joanna L. Stollings, Shayan Rakhit, Anna K. Person, Li Wang, Jennifer L. Thompson, Pratik P. Pandharipande, E. Wesley Ely & Mayur B. Patel. (2018) Antimicrobial exposure and the risk of delirium in critically ill patients. Critical Care 22:1.
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Ying Han, Yangmin Zheng, Jingpu Zhang & Changqin Hu. (2018) Neurobehavioral Effects of Cephalosporins: Assessment of Locomotors Activity, Motor and Sensory Development in Zebrafish. Frontiers in Pharmacology 9.
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Lauren E. Payne, David J. Gagnon, Richard R. Riker, David B. Seder, Elizabeth K. Glisic, Jane G. Morris & Gilles L. Fraser. (2017) Cefepime-induced neurotoxicity: a systematic review. Critical Care 21:1.
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Samuel Deshayes, Antoine Coquerel & Renaud Verdon. (2017) Neurological Adverse Effects Attributable to β-Lactam Antibiotics: A Literature Review. Drug Safety 40:12, pages 1171-1198.
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Ayesha A Appa, Rupali Jain, Robert M Rakita, Shahin Hakimian & Paul S Pottinger. (2017) Characterizing Cefepime Neurotoxicity: A Systematic Review. Open Forum Infectious Diseases 4:4.
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Cigdem Isitan, Andrew Ferree & Anna DePold Hohler. (2017) Cefepime induced neurotoxicity: A case series and review of the literature. eNeurologicalSci 8, pages 40-43.
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Lee-Ann Wagner & Jeffrey C. Fink. (2017) Ensuring Patient Safety During the Transition to ESRD. Seminars in Nephrology 37:2, pages 194-208.
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Stijn Jonckheere, Nikolaas De Neve, Hans De Beenhouwer, Mario Berth, An Vermeulen, Jan Van Bocxlaer & Pieter Colin. (2016) A model-based analysis of the predictive performance of different renal function markers for cefepime clearance in the ICU. Journal of Antimicrobial Chemotherapy 71:9, pages 2538-2546.
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Holly Lindsay, Stephanie Gruner & Julienne Brackett. (2016) Cefepime-Induced Neurotoxicity Despite Dose Adjustment for Renal Disease: A Brief Report and Review of the Literature. Journal of the Pediatric Infectious Diseases Society, pages piw022.
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Yusuke Toda, Mineo Yamazaki, Tomohiro Ota, Yosuke Fujisawa & Kazumi Kimura. (2016) A case of Cefepime encephalopathy, being difficult to distinguish from non-convulsive status epilepticus during the treatment of bacterial meningitis. Rinsho Shinkeigaku 56:10, pages 678-683.
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Young R. Lee, Danni McMahan, Catherine McCall & Gregory K. Perry. (2015) Complicated Intra-Abdominal Infections: The Old Antimicrobials and the New Players. Drugs 75:18, pages 2097-2117.
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Mieke Carlier, Veronique Stove, Steven C. Wallis, Jan J. De Waele, Alain G. Verstraete, Jeffrey Lipman & Jason A. Roberts. (2015) Assays for therapeutic drug monitoring of β-lactam antibiotics: A structured review. International Journal of Antimicrobial Agents 46:4, pages 367-375.
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Mieke Carlier, Jason A. Roberts, Veronique Stove, Alain G. Verstraete, Jeffrey Lipman & Jan J. De Waele. (2015) A Simulation Study Reveals Lack of Pharmacokinetic/Pharmacodynamic Target Attainment in De-escalated Antibiotic Therapy in Critically Ill Patients. Antimicrobial Agents and Chemotherapy 59:8, pages 4689-4694.
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Laila-Yasmin Mani, Sébastien Kissling, Dragana Viceic, Bruno Vogt, Michel Burnier, Thierry Buclin & Delphine Renard. (2015) Intermittent hemodialysis treatment in cefepime-induced neurotoxicity: Case report, pharmacokinetic modeling, and review of the literature. Hemodialysis International 19:2, pages 333-343.
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Marjorie Beumier, Giuseppe Casu, Maya Hites, Lucie Seyler, Frederic Cotton, Jean-Louis Vincent, Frédérique Jacobs & Fabio Taccone. (2014) β-lactam antibiotic concentrations during continuous renal replacement therapy. Critical Care 18:3, pages R105.
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Steven W. Johnson & D. Byron May. (2014) Ceftaroline. Infectious Diseases in Clinical Practice 22:1, pages 8-17.
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Jennifer E Fugate, Ejaaz A Kalimullah, Sara E Hocker, Sarah L Clark, Eelco FM Wijdicks & Alejandro A Rabinstein. (2013) Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy. Critical Care 17:6.
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Akihiro Tanaka, Kenshi Takechi, Shinichi Watanabe, Mamoru Tanaka, Katsuya Suemaru & Hiroaki Araki. (2013) Comparison of the prevalence of convulsions associated with the use of cefepime and meropenem. International Journal of Clinical Pharmacy 35:5, pages 683-687.
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