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Research Article

Epidemic characteristics of hand, foot, and mouth disease in Shanghai from 2009 to 2010: Enterovirus 71 subgenotype C4 as the primary causative agent and a high incidence of mixed infections with coxsackievirus A16

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Pages 297-305 | Received 24 Jun 2011, Accepted 18 Oct 2011, Published online: 18 Dec 2011

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Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He & Ningshao Xia. (2018) Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population. Emerging Microbes & Infections 7:1, pages 1-15.
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Mark J. Abzug. (2014) The enteroviruses: Problems in need of treatments. Journal of Infection 68, pages S108-S114.
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Crossref
Wei Li, Lina Yi, Juan Su, Jing Lu, Changwen Ke, Hanri Zeng, Dawei Guan, Cong Ma, Wanly Zhang, Hong Xiao, Hui Li, Jinyan Lin & Yonghui Zhang. (2013) Seroprevalence of Human Enterovirus 71 and Coxsackievirus A16 in Guangdong, China, in Pre- and Post-2010 HFMD Epidemic Period. PLoS ONE 8:12, pages e80515.
Crossref
Wei Li, Lina Yi, Juan Su, Jing Lu, Hanri Zeng, Dawei Guan, Cong Ma, Wanly Zhang, Hong xiao, Hui Li, Yonghui Zhang, Jinyan Lin & Changwen Ke. (2013) Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China. BMC Infectious Diseases 13:1.
Crossref
Shuguang Tan, Xiaojuan Tan, Xiaoman Sun, Guangwen Lu, Chun-Chi Chen, Jinghua Yan, Jun Liu, Wenbo Xu & George F. Gao. (2013) VP2 Dominated CD4+ T Cell Responses against Enterovirus 71 and Cross-Reactivity against Coxsackievirus A16 and Polioviruses in a Healthy Population. The Journal of Immunology 191:4, pages 1637-1647.
Crossref
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Crossref
Yunxia Liu, Xianjun Wang, Yanxun Liu, Dapeng Sun, Shujun Ding, Bingbing Zhang, Zhaohui Du & Fuzhong Xue. (2013) Detecting Spatial-Temporal Clusters of HFMD from 2007 to 2011 in Shandong Province, China. PLoS ONE 8:5, pages e63447.
Crossref
Ching-Ying Wang, Shun-Chueh Huang, Zhen-Rung Lai, Yu-Ling Ho, Yu-Jen Jou, Szu-Hao Kung, Yongjun Zhang, Yuan-Shiun Chang & Cheng-Wen Lin. (2013) Eupafolin and Ethyl Acetate Fraction of Kalanchoe gracilis Stem Extract Show Potent Antiviral Activities against Enterovirus 71 and Coxsackievirus A16 . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-11.
Crossref
Hongxia Ni, Bo Yi, Jianhua Yin, Ting Fang, Tianfeng He, Yan Du, Jin Wang, Hongwei Zhang, Lei Xie, Yibo Ding, Wenzhen Gu, Shu Zhang, Yifang Han, Hongjun Dong, Tong Su, Guozhang Xu & Guangwen Cao. (2012) Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008–2011. Journal of Clinical Virology 54:4, pages 342-348.
Crossref
Emily Jane Bek & Peter Charles McMinn. (2012) The Pathogenesis and Prevention of Encephalitis due to Human Enterovirus 71. Current Infectious Disease Reports 14:4, pages 397-407.
Crossref

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