56
Views
77
CrossRef citations to date
0
Altmetric
Original Article

In Vitro Susceptibility of Respiratory Isolates of Aspergillus species to Itraconazole and Amphotericin B. Acquired Resistance to Itraconazole

Pages 509-512 | Received 05 Feb 1997, Accepted 06 Jun 1997, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Zoltán Palicz, Tamás Gáll, Éva Leiter, Sándor Kollár, Ilona Kovács, Kornél Miszti-Blasius, István Pócsi, László Csernoch & Péter Szentesi. (2016) Application of a low molecular weight antifungal protein from Penicillium chrysogenum (PAF) to treat pulmonary aspergillosis in mice. Emerging Microbes & Infections 5:1, pages 1-9.
Read now
Jodi Lestner & William W Hope. (2013) Itraconazole: an update on pharmacology and clinical use for treatment of invasive and allergic fungal infections. Expert Opinion on Drug Metabolism & Toxicology 9:7, pages 911-926.
Read now
Bahrie Bellete, Helene Raberin, Jerome Morel, Pierre Flori, Jamal Hafid & Roger Tran Manhsung. (2010) Acquired resistance to voriconazole and itraconazole in a patient with pulmonary aspergilloma. Medical Mycology 48:1, pages 197-200.
Read now
C. Lass-Flörl, M. Cuenca-Estrella, D. W. Denning & J. L. Rodriguez-Tudela. (2006) Antifungal susceptibility testing in Aspergillus spp. according to EUCAST methodology. Medical Mycology 44:sup1, pages 319-325.
Read now
Erja Chryssanthou. (1998) Resistance of Aspergillus fumigatus to Itraconazole. Scandinavian Journal of Infectious Diseases 30:6, pages 643-643.
Read now
Paul E. Verweij, Andreas Voss, Jacques F. G. M. Meis. (1998) Resistance of Aspergillus fumigatus to Itraconazole. Scandinavian Journal of Infectious Diseases 30:6, pages 642-642.
Read now

Articles from other publishers (70)

Nathan P. Wiederhold. (2023) Epidemiology and Prevalence of Azole-Resistant Aspergillus fumigatus: What Is Our Understanding of the Situation?. Current Fungal Infection Reports.
Crossref
Luis Mancera, Manuel J. Arroyo, Gema Méndez, Omar Belgacem, Belén Rodríguez‐Sánchez & Marina Oviaño. 2023. Microbiological Identification using MALDI‐TOF and Tandem Mass Spectrometry. Microbiological Identification using MALDI‐TOF and Tandem Mass Spectrometry 45 70 .
Hamid Badali, Connie Cañete-Gibas, Dora McCarthy, Hoja Patterson, Carmita Sanders, Marjorie P. David, James Mele, Hongxin Fan & Nathan P. Wiederhold. (2022) Species Distribution and Antifungal Susceptibilities of Aspergillus Section Fumigati Isolates in Clinical Samples from the United States . Journal of Clinical Microbiology 60:5.
Crossref
Alireza Abdolrasouli & Darius Armstrong-James. 2022. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 40 57 .
Nathan P Wiederhold. (2021) Antifungal Susceptibility Testing: A Primer for Clinicians. Open Forum Infectious Diseases 8:11.
Crossref
A. Arastehfar, A. Carvalho, J. Houbraken, L. Lombardi, R. Garcia-Rubio, J.D. Jenks, O. Rivero-Menendez, R. Aljohani, I.D. Jacobsen, J. Berman, N. Osherov, M.T. Hedayati, M. Ilkit, D. Armstrong-James, T. Gabaldón, J. Meletiadis, M. Kostrzewa, W. Pan, C. Lass-Flörl, D.S. Perlin & M. Hoenigl. (2021) Aspergillus fumigatus and aspergillosis: From basics to clinics . Studies in Mycology 100:1, pages 100115-100115.
Crossref
Ashley V. Nywening, Jeffrey M. Rybak, Phillip David Rogers & Jarrod R. Fortwendel. (2020) Mechanisms of triazole resistance in Aspergillus fumigatus . Environmental Microbiology 22:12, pages 4934-4952.
Crossref
A. Jeanvoine, S. Rocchi, A.P. Bellanger, G. Reboux & L. Millon. (2020) Azole-resistant Aspergillus fumigatus: A global phenomenon originating in the environment?. Médecine et Maladies Infectieuses 50:5, pages 389-395.
Crossref
Hamid Badali & Nathan P. Wiederhold. (2019) Antifungal Resistance Testing and Implications for Management. Current Fungal Infection Reports 13:4, pages 274-283.
Crossref
Ambre Chapuis, Elizabeth Ballou & Donna MacCallum. (2019) A Bright Future for Fluorescence Imaging of Fungi in Living Hosts. Journal of Fungi 5:2, pages 29.
Crossref
A. Hamprecht, F. Morio, O. Bader, P. Le Pape, J. Steinmann & E. Dannaoui. (2017) Azole Resistance in Aspergillus fumigatus in Patients with Cystic Fibrosis: A Matter of Concern?. Mycopathologia 183:1, pages 151-160.
Crossref
H. Guegan & J.-P. Gangneux. (2017) Résistance aux azolés chez Aspergillus. Journal des Anti-infectieux 19:3-4, pages 110-118.
Crossref
Eric Dannaoui, Frédéric Gabriel, Manuel Gaboyard, Gaëlle Lagardere, Lucile Audebert, Gilles Quesne, Sandrine Godichaud, Paul E. Verweij, Isabelle Accoceberry & Marie-Elisabeth Bougnoux. (2017) Molecular Diagnosis of Invasive Aspergillosis and Detection of Azole Resistance by a Newly Commercialized PCR Kit. Journal of Clinical Microbiology 55:11, pages 3210-3218.
Crossref
Raquel Sabino. 2017. Exposure to Microbiological Agents in Indoor and Occupational Environments. Exposure to Microbiological Agents in Indoor and Occupational Environments 393 402 .
P. H. Chandrasekar & Elias K. Manavathu. 2017. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 1099 1118 .
Paul E Verweij, Jianhua Zhang, Alfons J M Debets, Jacques F Meis, Frank L van de Veerdonk, Sijmen E Schoustra, Bas J Zwaan & Willem J G Melchers. (2016) In-host adaptation and acquired triazole resistance in Aspergillus fumigatus : a dilemma for clinical management. The Lancet Infectious Diseases 16:11, pages e251-e260.
Crossref
Olga Rivero-Menendez, Ana Alastruey-Izquierdo, Emilia Mellado & Manuel Cuenca-Estrella. (2016) Triazole Resistance in Aspergillus spp.: A Worldwide Problem?. Journal of Fungi 2:3, pages 21.
Crossref
Shawn R. Lockhart & Elizabeth L. Berkow. (2016) Hot Topics in Antifungal Susceptibility Testing: a New Drug, a Bad Bug, Sweeping Caspofungin Testing under the Rug, and Solving the Epidemiological Cutoff Value Shrug. Clinical Microbiology Newsletter 38:13, pages 103-108.
Crossref
Mojtaba Nabili, Tahereh Shokohi, Maryam Moazeni, Sadegh Khodavaisy, Masoud Aliyali, Parisa Badiee, Hossein Zarrinfar, Ferry Hagen & Hamid Badali. (2016) High prevalence of clinical and environmental triazole-resistant Aspergillus fumigatus in Iran: is it a challenging issue?. Journal of Medical Microbiology 65:6, pages 468-475.
Crossref
Mohammad T. Albataineh, Deanna A. Sutton, Annette W. Fothergill & Nathan P. Wiederhold. (2016) Update from the Laboratory. Infectious Disease Clinics of North America 30:1, pages 13-35.
Crossref
Alessandro Busca, Anna Maria Tortorano & Livio Pagano. (2015) Reviewing the importance and evolution of fungal infections and potential antifungal resistance in haematological patients. Journal of Global Antimicrobial Resistance 3:4, pages 237-241.
Crossref
Maria-Manuel Azevedo, Isabel Faria-Ramos, Luísa Costa Cruz, Cidália Pina-Vaz & Acácio Gonçalves Rodrigues. (2015) Genesis of Azole Antifungal Resistance from Agriculture to Clinical Settings. Journal of Agricultural and Food Chemistry 63:34, pages 7463-7468.
Crossref
F. Choukri, F. Botterel, E. Sitterlé, L. Bassinet, F. Foulet, J. Guillot, J. M. Costa, N. Fauchet & E. Dannaoui. (2015) Prospective evaluation of azole resistance in Aspergillus fumigatus clinical isolates in France: Table 1. . Medical Mycology 53:6, pages 593-596.
Crossref
Anuradha Chowdhary, Cheshta Sharma, Ferry Hagen & Jacques F Meis. (2014) Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms . Future Microbiology 9:5, pages 697-711.
Crossref
Whitney M. Holden, J. Scott Fites, Laura K. Reinert & Louise A. Rollins-Smith. (2014) Nikkomycin Z is an effective inhibitor of the chytrid fungus linked to global amphibian declines. Fungal Biology 118:1, pages 48-60.
Crossref
Edith Vermeulen, Katrien Lagrou & Paul E. Verweij. (2013) Azole resistance in Aspergillus fumigatus. Current Opinion in Infectious Diseases 26:6, pages 493-500.
Crossref
Jan W. M. van der Linden, Simone M. T. Camps, Greetje A. Kampinga, Jan P. A. Arends, Yvette J. Debets-Ossenkopp, Pieter J. A. Haas, Bart J. A. Rijnders, Ed J. Kuijper, Frank H. van Tiel, János Varga, Anna Karawajczyk, J. Zoll, Willem J. G. Melchers & Paul E. Verweij. (2013) Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles. Clinical Infectious Diseases 57:4, pages 513-520.
Crossref
Pilar Escribano, Teresa Peláez, Patricia Muñoz, Emilio Bouza & Jesús Guinea. (2013) Is Azole Resistance in Aspergillus fumigatus a Problem in Spain?. Antimicrobial Agents and Chemotherapy 57:6, pages 2815-2820.
Crossref
L. Lelièvre, M. Groh, C. Angebault, A.-C. Maherault, E. Didier & M.-E. Bougnoux. (2013) Azole resistant Aspergillus fumigatus: An emerging problem. Médecine et Maladies Infectieuses 43:4, pages 139-145.
Crossref
Virginie Planche, Sebastien Ducroz, Alexandre Alanio, Marie-Elisabeth Bougnoux, Olivier Lortholary & Eric Dannaoui. (2012) In Vitro Combination of Anidulafungin and Voriconazole against Intrinsically Azole-Susceptible and -Resistant Aspergillus spp . Antimicrobial Agents and Chemotherapy 56:8, pages 4500-4503.
Crossref
Teresa Pelaez, Paloma Gijón, Eleonora Bunsow, Emilio Bouza, Waldo Sánchez-Yebra, Maricela Valerio, Beatriz Gama, Manuel Cuenca-Estrella & Emilia Mellado. (2012) Resistance to Voriconazole Due to a G448S Substitution in Aspergillus fumigatus in a Patient with Cerebral Aspergillosis. Journal of Clinical Microbiology 50:7, pages 2531-2534.
Crossref
Paul Bowyer, Juan Mosquera, Michael Anderson, Mike Birch, Michael Bromley & David W. Denning. (2012) Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus. FEMS Microbiology Letters 332:1, pages 10-19.
Crossref
Margherita Bertuzzi & Elaine M. Bignell. (2011) Sensory perception in fungal pathogens: Applications of the split-ubiquitin Membrane Yeast Two-Hybrid (MYTH) technique. Fungal Biology Reviews 25:4, pages 165-171.
Crossref
Shawn R. Lockhart, João P. Frade, Kizee A. Etienne, Michael A. Pfaller, Daniel J. Diekema & S. Arunmozhi Balajee. (2011) Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene . Antimicrobial Agents and Chemotherapy 55:9, pages 4465-4468.
Crossref
Alexandre Alanio, Catherine Cordonnier & Stéphane Bretagne. (2011) Azole Resistance in Aspergillus fumigatus—Current Epidemiology and Future Perspectives. Current Fungal Infection Reports 5:3, pages 168-178.
Crossref
Eveline Snelders, Willem JG Melchers & Paul E Verweij. (2011) Azole resistance in Aspergillus fumigatus : a new challenge in the management of invasive aspergillosis? . Future Microbiology 6:3, pages 335-347.
Crossref
A Mayr & C Lass-Flörl. (2011) Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature. European Journal of Medical Research 16:4, pages 153.
Crossref
Lies M.E. Vanhee, Dana Perman, Hans J. Nelis & Tom Coenye. (2010) Rapid quantification of itraconazole-resistant Aspergillus fumigatus in air. Journal of Microbiological Methods 81:2, pages 197-199.
Crossref
Paul E. Verweij, Susan J. Howard, Willem J.G. Melchers & David W. Denning. (2009) Azole-resistance in Aspergillus: Proposed nomenclature and breakpoints. Drug Resistance Updates 12:6, pages 141-147.
Crossref
Cornelia Lass-Flörl. (2009) Azole resistance in aspergillosis: The next threat?. Current Fungal Infection Reports 3:4, pages 236-242.
Crossref
Susan J. Howard, Dasa Cerar, Michael J. Anderson, Ahmed Albarrag, Matthew C. Fisher, Alessandro C. Pasqualotto, Michel Laverdiere, Maiken C. Arendrup, David S. Perlin & David W. Denning. (2009) Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure1 . Emerging Infectious Diseases 15:7, pages 1068-1076.
Crossref
P. H. Chandrasekar & Elias K. Manavathu. 2009. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 953 965 .
Jesús Guinea, Sandra Recio, Teresa Peláez, Marta Torres-Narbona & Emilio Bouza. (2008) Clinical Isolates of Aspergillus Species Remain Fully Susceptible to Voriconazole in the Post-Voriconazole Era . Antimicrobial Agents and Chemotherapy 52:9, pages 3444-3446.
Crossref
Cornelia Lass-Flörl & Susanne Perkhofer. (2008) In vitro susceptibility-testing in Aspergillus species . Mycoses 51:5, pages 437-446.
Crossref
Laura Alcazar-Fuoli, Emilia Mellado, Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella & Juan L. Rodriguez-Tudela. (2008) Aspergillus Section Fumigati : Antifungal Susceptibility Patterns and Sequence-Based Identification . Antimicrobial Agents and Chemotherapy 52:4, pages 1244-1251.
Crossref
Laura Alcazar-Fuoli, Emilia Mellado, Guillermo Garcia-Effron, Jordi F. Lopez, Joan O. Grimalt, J. Manuel Cuenca-Estrella & Juan L. Rodriguez-Tudela. (2008) Ergosterol biosynthesis pathway in Aspergillus fumigatus. Steroids 73:3, pages 339-347.
Crossref
P. Montravers, V. Chterev, P. Augustin & L. Etchegoyen. (2008) Nouvelles approches thérapeutiques des infections fongiques : place des nouvelles molécules. Antibiotiques 10:1, pages 25-34.
Crossref
E. Mellado, G. Garcia-Effron, L. Alcázar-Fuoli, W. J. G. Melchers, P. E. Verweij, M. Cuenca-Estrella & J. L. Rodríguez-Tudela. (2007) A New Aspergillus fumigatus Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of cyp51A Alterations . Antimicrobial Agents and Chemotherapy 51:6, pages 1897-1904.
Crossref
E. Dannaoui, D. Garcia-Hermoso, J. M. Naccache, I. Meneau, D. Sanglard, C. Bouges-Michel, D. Valeyre & O. Lortholary. (2006) Use of voriconazole in a patient with aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus. Journal of Medical Microbiology 55:10, pages 1457-1459.
Crossref
Laura Alcazar-Fuoli, Emilia Mellado, Guillermo Garcia-Effron, Maria J. Buitrago, Jordi F. Lopez, Joan O. Grimalt, J. Manuel Cuenca-Estrella & Juan L. Rodriguez-Tudela. (2006) Aspergillus fumigatus C-5 Sterol Desaturases Erg3A and Erg3B: Role in Sterol Biosynthesis and Antifungal Drug Susceptibility . Antimicrobial Agents and Chemotherapy 50:2, pages 453-460.
Crossref
G. Chamilos & D.P. Kontoyiannis. (2005) Update on antifungal drug resistance mechanisms of Aspergillus fumigatus. Drug Resistance Updates 8:6, pages 344-358.
Crossref
G. Garcia-Effron, E. Mellado, A. Gomez-Lopez, L. Alcazar-Fuoli, M. Cuenca-Estrella & Juan L. Rodriguez-Tudela. (2005) Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene ( cyp51A ) of Aspergillus fumigatus . Antimicrobial Agents and Chemotherapy 49:5, pages 2119-2121.
Crossref
Pedro García-Martos, Lidia García-Agudo, Jesús Gutiérrez-Calzada, Jesús Ruiz-Aragón, Abel Saldarreaga & Pilar Marín. (2005) Actividad in vitro de anfotericina B, itraconazol y voriconazol frente a 20 especies de Aspergillus empleando el método de microdilución Sensititre®. Enfermedades Infecciosas y Microbiología Clínica 23:1, pages 15-18.
Crossref
Jian Chen, Houmin Li, Ruoyu Li, Dingfang Bu & Zhe Wan. (2005) Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma. Journal of Antimicrobial Chemotherapy 55:1, pages 31-37.
Crossref
E. Mellado, G. Garcia-Effron, L. Alcazar-Fuoli, M. Cuenca-Estrella & J. L. Rodriguez-Tudela. (2004) Substitutions at Methionine 220 in the 14α-Sterol Demethylase (Cyp51A) of Aspergillus fumigatus Are Responsible for Resistance In Vitro to Azole Antifungal Drugs . Antimicrobial Agents and Chemotherapy 48:7, pages 2747-2750.
Crossref
Rama Ramani, Madhurama Gangwar & Vishnu Chaturvedi. (2003) Flow Cytometry Antifungal Susceptibility Testing of Aspergillus fumigatus and Comparison of Mode of Action of Voriconazole vis-à-vis Amphotericin B and Itraconazole . Antimicrobial Agents and Chemotherapy 47:11, pages 3627-3629.
Crossref
T. M. Diaz-Guerra, E. Mellado, M. Cuenca-Estrella & J. L. Rodriguez-Tudela. (2003) A Point Mutation in the 14α-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus . Antimicrobial Agents and Chemotherapy 47:3, pages 1120-1124.
Crossref
Paul A. Mann, Raulo M. Parmegiani, Shui-Qing Wei, Cara A. Mendrick, Xin Li, David Loebenberg, Beth DiDomenico, Roberta S. Hare, Scott S. Walker & Paul M. McNicholas. (2003) Mutations in Aspergillus fumigatus Resulting in Reduced Susceptibility to Posaconazole Appear To Be Restricted to a Single Amino Acid in the Cytochrome P450 14α-Demethylase . Antimicrobial Agents and Chemotherapy 47:2, pages 577-581.
Crossref
Sofia Perea & Thomas F. Patterson. (2002) Antifungal Resistance in Pathogenic Fungi. Clinical Infectious Diseases 35:9, pages 1073-1080.
Crossref
John W Slaven, Michael J Anderson, Dominique Sanglard, Graham K Dixon, Jacques Bille, Ian S Roberts & David W Denning. (2002) Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate. Fungal Genetics and Biology 36:3, pages 199-206.
Crossref
Emilia Mellado, Manuel Cuenca-Estrella & Juan Luis Rodríguez-Tudela. (2002) Importancia clínica de los mecanismos de resistencia de los hongos filamentosos a los antifúngicos. Enfermedades Infecciosas y Microbiología Clínica 20:10, pages 523-530.
Crossref
L. Joseph Wheat, Mitchell Goldman & George A. Sarosi. 2002. Clinical Approach to Infection in the Compromised Host. Clinical Approach to Infection in the Compromised Host 215 247 .
Eric Dannaoui, Florence Persat, Elisabeth Borel, Marie-Antoinette Piens & Stéphane Picot. (2001) Sterol composition of itraconazole-resistant and itraconazole-susceptible isolates of Aspergillus fumigatus . Canadian Journal of Microbiology 47:8, pages 706-710.
Crossref
E. Mellado, T. M. Diaz-Guerra, M. Cuenca-Estrella & J. L. Rodriguez-Tudela. (2001) Identification of Two Different 14-α Sterol Demethylase-Related Genes ( cyp51A and cyp51B ) in Aspergillus fumigatus and Other Aspergillus species . Journal of Clinical Microbiology 39:7, pages 2431-2438.
Crossref
Anne Beauvais & Jean-Paul Latgé. (2001) Membrane and cell wall targets in Aspergillus fumigatus. Drug Resistance Updates 4:1, pages 38-49.
Crossref
C.B. Moore, N. Sayers, J. Mosquera, J. Slaven & D.W. Denning. (2000) Antifungal Drug Resistance in Aspergillus. Journal of Infection 41:3, pages 203-220.
Crossref
Sherif B. Mossad & David L. Longworth. 2000. Current Controversies in Bone Marrow Transplantation. Current Controversies in Bone Marrow Transplantation 279 294 .
Eric Dannaoui, Florence Persat, Marie-France Monier, Elisabeth Borel, Marie-Antoinette Piens & Stéphane Picot. (1999) Use of spectrophotometric reading for in vitro antifungal susceptibility testing of Aspergillus spp. . Canadian Journal of Microbiology 45:10, pages 871-874.
Crossref
Jean-Paul Latgé. (1999) Aspergillus fumigatus and Aspergillosis . Clinical Microbiology Reviews 12:2, pages 310-350.
Crossref
Adrian I. Popp, Mary H. White, Tariq Quadri, Louise Walshe & Donald Armstrong. (1999) Amphotericin B with and without itraconazole for invasive aspergillosis: A three-year retrospective study. International Journal of Infectious Diseases 3:3, pages 157-160.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.