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Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 6
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Animal Pharmacokinetics and Metabolism

Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey

D. J. SweenyDepartments of Drug Metabolism and Pharmacokinetics, and Development, Rigel Pharmaceuticals, South San Francisco, CA, USACorrespondence[email protected]
,
W. LiDepartments of Drug Metabolism and Pharmacokinetics, and Development, Rigel Pharmaceuticals, South San Francisco, CA, USA
,
E. GrossbardDepartments of Drug Metabolism and Pharmacokinetics, and Development, Rigel Pharmaceuticals, South San Francisco, CA, USA
&
D. T.W. LauDepartments of Drug Metabolism and Pharmacokinetics, and Development, Rigel Pharmaceuticals, South San Francisco, CA, USA
Pages 415-423 | Received 28 Dec 2009, Accepted 26 Feb 2010, Published online: 23 Apr 2010

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Read on this site (3)

Daan Dierickx & Jens Neefs. (2022) Evaluating fostamatinib disodium as a treatment option for immune thrombocytopenia in adult patients. Expert Opinion on Pharmacotherapy 23:8, pages 885-892.
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Su’an Tang, Qinghong Yu & Changhai Ding. (2022) Investigational spleen tyrosine kinase (SYK) inhibitors for the treatment of autoimmune diseases. Expert Opinion on Investigational Drugs 31:3, pages 291-303.
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Tadeusz Robak & Ewa Robak. (2012) Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders. Expert Opinion on Investigational Drugs 21:7, pages 921-947.
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Articles from other publishers (10)

Ryosuke Matsukane, Kimitaka Suetsugu, Takeshi Hirota & Ichiro Ieiri. (2022) Clinical Pharmacokinetics and Pharmacodynamics of Fostamatinib and Its Active Moiety R406. Clinical Pharmacokinetics 61:7, pages 955-972.
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Yoshiya Tanaka, David Millson, Shigeru Iwata & Shingo Nakayamada. (2021) Safety and efficacy of fostamatinib in rheumatoid arthritis patients with an inadequate response to methotrexate in phase II OSKIRA-ASIA-1 and OSKIRA-ASIA-1X study. Rheumatology 60:6, pages 2884-2895.
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Sumit Kunwar, Ashok Raj Devkota & Dipesh K. C. Ghimire. (2016) Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials. Rheumatology International 36:8, pages 1077-1087.
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Michael E. Weinblatt, Mark C. Genovese, Meilien Ho, Sally Hollis, Krystyna Rosiak-Jedrychowicz, Arthur Kavanaugh, David S. Millson, Gustavo Leon, Millie Wang & Désirée van der Heijde. (2014) Effects of Fostamatinib, an Oral Spleen Tyrosine Kinase Inhibitor, in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate: Results From a Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. Arthritis & Rheumatology 66:12, pages 3255-3264.
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Mark C. Genovese, Désirée M. van der Heijde, Edward C. Keystone, Alberto J. Spindler, Claude Benhamou, Arthur Kavanaugh, Edward Fudman, Kathy Lampl, Chris O’Brien, Emma L. Duffield, Jeffrey Poiley & Michael E. Weinblatt. (2014) A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of 2 Dosing Regimens of Fostamatinib in Patients with Rheumatoid Arthritis with an Inadequate Response to a Tumor Necrosis Factor-α Antagonist. The Journal of Rheumatology 41:11, pages 2120-2128.
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George D. Kitas, Gabriel Abreu, Krystyna Jedrychowicz-Rosiak, Jeffrey L. Miller, Roumen Nakov, Seva Panfilov, Jiri Vencovsky, Millie Wang, Michael E. Weinblatt & William B. White. (2014) The effects of the spleen tyrosine kinase inhibitor fostamatinib on ambulatory blood pressure in patients with active rheumatoid arthritis: results of the OSKIRA-ABPM (ambulatory blood pressure monitoring) randomized trial. Journal of the American Society of Hypertension 8:11, pages 780-790.
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Muhammad Baluom, Elliott B. Grossbard, Tim Mant & David T. W. Lau. (2013) Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies. British Journal of Clinical Pharmacology 76:1, pages 78-88.
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Rajinder Singh, Esteban S. Masuda & Donald G. Payan. (2012) Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors. Journal of Medicinal Chemistry 55:8, pages 3614-3643.
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Muhammad Baluom, Emil Samara, Elliott B. Grossbard & David T.-W. Lau. (2011) Fostamatinib, a Syk-Kinase Inhibitor, Does Not Affect Methotrexate Pharmacokinetics in Patients With Rheumatoid Arthritis. The Journal of Clinical Pharmacology 51:9, pages 1310-1318.
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David J. Sweeny, Weiqun Li, Jeffrey Clough, Somasekhar Bhamidipati, Rajinder Singh, Gary Park, Muhammad Baluom, Elliott Grossbard & David T.-W. Lau. (2010) Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation. Drug Metabolism and Disposition 38:7, pages 1166-1176.
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