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Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 6
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Animal Pharmacokinetics and Metabolism

The disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS

Mark de SerresPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USACorrespondence[email protected]
,
Lee MossPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA
,
James SigafoosPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA
,
Andrea SeflerPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA
,
Stephen CastellinoPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA
,
Gary BowersPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA
&
Cosette Serabjit-SinghPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA
 show all
Pages 437-445 | Received 22 Jan 2010, Accepted 11 Mar 2010, Published online: 12 Apr 2010

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Mark De Serres, Gary Bowers, Gary Boyle, Claire Beaumont, Steve Castellino, James Sigafoos, Mehul Dave, Andrew Roberts, Vishal Shah, Katie Olson, Dipak Patel, David Wagner, Russell Yeager & Cosette Serabjit-Singh. (2011) Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism. Xenobiotica 41:6, pages 464-475.
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Peng Zhan & Xinyong Liu. (2011) Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005 – 2010). Expert Opinion on Therapeutic Patents 21:5, pages 717-796.
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Articles from other publishers (4)

Zhao Wang, Srinivasulu Cherukupalli, Minghui Xie, Wenbo Wang, Xiangyi Jiang, Ruifang Jia, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Peng Zhan & Xinyong Liu. (2022) Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors. Journal of Medicinal Chemistry 65:5, pages 3729-3757.
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Ronald de Vries, Frank Jacobs, Geert Mannens, Jan Snoeys, Filip Cuyckens, Caly Chien & Peter Ward. (2019) Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes. Drug Metabolism and Disposition 47:5, pages 453-464.
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Philip N. Judson, Anthony Long, Ernest Murray & Mukesh Patel. (2015) Assessing Confidence in Predictions Using Veracity and Utility – A Case Study on the Prediction of Mammalian Metabolism by Meteor Nexus. Molecular Informatics 34:5, pages 284-291.
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Pek Chong, Paul Sebahar, Michael Youngman, Dulce Garrido, Huichang Zhang, Eugene L. Stewart, Robert T. Nolte, Liping Wang, Robert G. Ferris, Mark Edelstein, Kurt Weaver, Amanda Mathis & Andrew Peat. (2012) Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Journal of Medicinal Chemistry 55:23, pages 10601-10609.
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