Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 8
Submit an article Journal homepage
444
Views
9
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes

Noriaki YodaDepartment of Drug Metabolism, Drug Safety Research Center, Tokushima Research Institute, Tokushima, JapanCorrespondence[email protected]
,
Chie EmotoDepartment of Drug Metabolism, Drug Safety Research Center, Tokushima Research Institute, Tokushima, Japan
,
Shoichi DateThird Institute of New Drug Discovery, Tokushima, Japan
,
Satoshi KondoDepartment of Drug Metabolism, Drug Safety Research Center, Tokushima Research Institute, Tokushima, Japan
,
Masateru MiyakeFormulation Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan
,
Satoru NakazatoThird Institute of New Drug Discovery, Tokushima, Japan
,
Ken UmeharaDepartment of Drug Metabolism, Drug Safety Research Center, Tokushima Research Institute, Tokushima, Japan
&
Eiji KashiyamaDepartment of Drug Metabolism, Drug Safety Research Center, Tokushima Research Institute, Tokushima, Japan
 show all
Pages 719-730 | Received 15 Nov 2011, Accepted 09 Jan 2012, Published online: 12 Feb 2012

Citations (9)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Ying Peng, Hui Wu, Xueyuan Zhang, Fengyi Zhang, Huanhuan Qi, Yunxi Zhong, Yu Wang, Hua Sang, Guangji Wang & Jianguo Sun. (2015) A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug–drug interaction evaluation. Xenobiotica 45:11, pages 961-977.
Read now

Articles from other publishers (8)

Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe & Kouichi Yoshinari. (2023) Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver . Drug Metabolism and Disposition 51:1, pages 67-80.
Crossref
Jagannatha V. Mysore, Karyn Colman, Warren Harvey & Robert A. Kaiser. 2023. Spontaneous Pathology of the Laboratory Non-Human Primate. Spontaneous Pathology of the Laboratory Non-Human Primate 1 6 .
Daigo Asano, Syoya Hamaue, Hamim Zahir, Hideyuki Shiozawa, Yumi Nishiya, Takako Kimura, Miho Kazui, Naotoshi Yamamura, Marie Ikeguchi, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Toshiyuki Watanabe, Chizuko Yahara, Nobuaki Watanabe & Kouichi Yoshinari. (2022) CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate . Drug Metabolism and Disposition 50:3, pages 235-242.
Crossref
Mohamed Ahmed Fathi, Guofeng Han, Ruifen Kang, Dan Shen, Jiakun Shen & Chunmei Li. (2020) Disruption of cytochrome P450 enzymes in the liver and small intestine in chicken embryos in ovo exposed to glyphosate. Environmental Science and Pollution Research 27:14, pages 16865-16875.
Crossref
Takanori Akazawa, Yasuo Uchida, Eisuke Miyauchi, Masanori Tachikawa, Sumio Ohtsuki & Tetsuya Terasaki. (2017) High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human. Molecular Pharmaceutics 15:1, pages 127-140.
Crossref
Fang Xie, Xinxin Ding & Qing-Yu Zhang. (2016) An update on the role of intestinal cytochrome P450 enzymes in drug disposition. Acta Pharmaceutica Sinica B 6:5, pages 374-383.
Crossref
Sindhuja Selvakumar, Priyadeep Bhutani, Kaushik Ghosh, Prasad Krishnamurthy, Sanjith Kallipatti, Sabariya Selvam, Manjunath Ramarao, Sandhya Mandlekar, Michael W. Sinz, A. David Rodrigues & Murali Subramanian. (2014) Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System. Drug Metabolism and Disposition 42:3, pages 369-376.
Crossref
E. J. Vallender & G. M. Miller. (2013) Nonhuman Primate Models in the Genomic Era: A Paradigm Shift. ILAR Journal 54:2, pages 154-165.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.